Increased operant responding for ethanol in male C57BL/6J mice: Specific regulation by the ERK1/2, but not JNK, MAP kinase pathway

Psychopharmacology

Volumn 204, Issue 1, 2009, Pages 135-147

  Faccidomo, Sara ^a   Besheer, Joyce ^a   Stanford, P Crystal ^a   Hodge, Clyde W ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol drinking; AS 601245; ERK MAPK; Motor activity; Operant conditioning; Progressive ratio; Protein kinase; Reinforcement; Self administration; SL 327

Indexed keywords

(1,3 BENZOTHIAZOL 2 YL)[2 [2 (3 PYRIDINYL)ETHYLAMINO] 4 PYRIMIDINYL]ACETONITRILE; ALCOHOL; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; SUCROSE;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELF ADMINISTRATION; ENZYME ACTIVITY; ENZYME REGULATION; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; MOTIVATION; MOTOR ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; SIGNAL TRANSDUCTION;

ACETONITRILES; ALCOHOL DRINKING; AMINOACETONITRILE; ANIMALS; BEHAVIOR, ANIMAL; BENZOTHIAZOLES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SUCROSE; SWEETENING AGENTS;

EID: 67349249771     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1444-9     Document Type: Article

References (102)

1. JP Adams JD Sweatt 2002 Molecular psychology: roles for the ERK MAP kinase cascade in memory Annu Rev Pharmacol Toxicol 42 135 163 (Pubitemid 34160523)
2. JP Adams ED Roberson JD English JC Selcher JD Sweatt 2000 MAPK regulation of gene expression in the central nervous system Acta Neurobiol Exp (Wars) 60 377 394 (Pubitemid 30659915)
3. MP Arolfo L Yao AS Gordon I Diamond PH Janak 2004 Ethanol operant self-administration in rats is regulated by adenosine A2 receptors Alcohol Clin Exp Res 28 1308 1316 (Pubitemid 39238288)
4. CM Atkins JC Selcher JJ Petraitis JM Trzaskos JD Sweatt 1998 The MAPK cascade is required for mammalian associative learning Nat Neurosci 1 602 609 (Pubitemid 128406370)
5. RK Bachtell NO Tsivkovskaia AE Ryabinin 2002 Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms J Pharmacol Exp Ther 302 516 524
6. P Backstrom D Bachteler S Koch P Hyytia R Spanagel 2004 mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior Neuropsychopharmacology 29 921 928 (Pubitemid 38526792)
7. J Besheer RA Stevenson CW Hodge 2006 mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats Eur J Pharmacol 551 71 75 (Pubitemid 44648053)
8. J Besheer S Faccidomo JJ Grondin CW Hodge 2008 Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats Alcohol Clin Exp Res 32 209 221
9. LR Bevilaqua DS Kerr JH Medina I Izquierdo M Cammarota 2003 Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task Eur J Neurosci 17 897 902 (Pubitemid 36315261)
10. T Borsello K Croquelois JP Hornung PG Clarke 2003 N-methyl-d-aspartate- triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway Eur J Neurosci 18 473 485 (Pubitemid 37041099)
11. TG Boulton MH Cobb 1991 Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies Cell Regul 2 357 371
12. G Brown DN Stephens 2002 Effects of cocaine on responding for ethanol or sucrose under a progressive ratio schedule Behav Pharmacol 13 157 162 (Pubitemid 34450701)
13. S Carboni A Hiver C Szyndralewiez P Gaillard JP Gotteland PA Vitte 2004 AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties J Pharmacol Exp Ther 310 25 32 (Pubitemid 38812691)
14. S Carboni U Boschert P Gaillard JP Gotteland JY Gillon PA Vitte 2008 AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils Br J Pharmacol 153 157 163
15. S Carnicella V Kharazia J Jeanblanc PH Janak D Ron 2008 GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse Proc Natl Acad Sci U S A 105 8114 8119
16. V Cestari M Costanzi C Castellano C Rossi-Arnaud 2006 A role for ERK2 in reconsolidation of fear memories in mice Neurobiol Learn Mem 86 133 143 (Pubitemid 44287572)
17. LJ Chandler 2003 Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanol Pharmacol Ther 99 311 326 (Pubitemid 37311197)
18. LJ Chandler G Sutton 2005 Acute ethanol inhibits extracellular signal-regulated kinase, protein kinase B, and adenosine 3:5-cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner Alcohol Clin Exp Res 29 672 682 (Pubitemid 40547872)
19. RH Chen C Sarnecki J Blenis 1992 Nuclear localization and regulation of erk- and rsk-encoded protein kinases Mol Cell Biol 12 915 927
20. ES Choe JQ Wang 2001 Group I metabotropic glutamate receptors control phosphorylation of CREB, Elk-1 and ERK via a CaMKII-dependent pathway in rat striatum Neurosci Lett 313 129 132 (Pubitemid 33022587)
21. ES Choe KT Chung L Mao JQ Wang 2002 Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors Neuropsychopharmacology 27 565 575 (Pubitemid 34103014)
22. CM Crews RL Erikson 1992 Purification of a murine protein-tyrosine/ threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product Proc Natl Acad Sci U S A 89 8205 8209
23. CL Czachowski BH Legg HH Samson 2003 Assessment of sucrose and ethanol reinforcement: the across-session breakpoint procedure Physiol Behav 78 51 59 (Pubitemid 36110552)
24. S Davis P Vanhoutte C Pages J Caboche S Laroche 2000 The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo J Neurosci 20 4563 4572 (Pubitemid 30396622)
25. S Duvarci K Nader JE LeDoux 2005 Activation of extracellular signal-regulated kinase-mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning Eur J Neurosci 21 283 289 (Pubitemid 40193898)
26. D Economidou L Mattioli C Cifani M Perfumi M Massi V Cuomo L Trabace R Ciccocioppo 2006 Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats Psychopharmacology (Berl) 183 394 403 (Pubitemid 41721140)
27. A Ettenberg HO Pettit FE Bloom GF Koob 1982 Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems Psychopharmacology (Berl) 78 204 209
28. MF Favata KY Horiuchi EJ Manos AJ Daulerio DA Stradley WS Feeser DE Van Dyk WJ Pitts RA Earl F Hobbs RA Copeland RL Magolda PA Scherle JM Trzaskos 1998 Identification of a novel inhibitor of mitogen-activated protein kinase kinase J Biol Chem 273 18623 18632 (Pubitemid 28334795)
29. SM Ferguson S Fasano P Yang R Brambilla TE Robinson 2006 Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity Neuropsychopharmacology 31 2660 2668
30. MM Ford JC Eldridge HH Samson 2004 Determination of an estradiol dose-response relationship in the modulation of ethanol intake Alcohol Clin Exp Res 28 20 28 (Pubitemid 38114020)
31. MM Ford JD Nickel TJ Phillips DA Finn 2005 Neurosteroid modulators of GABA(A) receptors differentially modulate ethanol intake patterns in male C57BL/6J mice Alcohol Clin Exp Res 29 1630 1640 (Pubitemid 41395612)
32. P Gaillard I Jeanclaude-Etter V Ardissone S Arkinstall Y Cambet M Camps C Chabert D Church R Cirillo D Gretener S Halazy A Nichols C Szyndralewiez PA Vitte JP Gotteland 2005 Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase J Med Chem 48 4596 4607 (Pubitemid 40993420)
33. TV Gerdjikov GM Ross RJ Beninger 2004 Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats Behav Neurosci 118 740 750 (Pubitemid 38970496)
34. BF Grant DA Dawson FS Stinson SP Chou MC Dufour RP Pickering 2004 The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002 Drug Alcohol Depend 74 223 234 (Pubitemid 38759777)
35. SS Grewal RD York PJ Stork 1999 Extracellular-signal-regulated kinase signalling in neurons Curr Opin Neurobiol 9 544 553 (Pubitemid 29484377)
36. RJ Hendrickson PA Cahill IH [tmp] McKillop JV Sitzmann EM Redmond 1998 Ethanol inhibits mitogen activated protein kinase activity and growth of vascular smooth muscle cells in vitro Eur J Pharmacol 362 251 259 (Pubitemid 29002968)
37. T Herdegen FX Claret T Kallunki A Martin-Villalba C Winter T Hunter M Karin 1998 Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury J Neurosci 18 5124 5135 (Pubitemid 28311930)
38. CW Hodge HH Samson M Haraguchi 1992 Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding Pharmacol Biochem Behav 43 249 254
39. CW Hodge AM Chappelle HH Samson 1995 GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats Alcohol Clin Exp Res 19 1486 1493 (Pubitemid 26005698)
40. CW Hodge MF Miles AC Sharko RA Stevenson JR Hillmann V Lepoutre J Besheer JP Schroeder 2006 The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice Psychopharmacology (Berl) 183 429 438 (Pubitemid 41721144)
41. TY Huang CH Lin 2006 Role of amygdala MAPK activation on immobility behavior of forced swim rats Behav Brain Res 173 104 111 (Pubitemid 44572022)
42. S Impey K Obrietan DR Storm 1999 Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity Neuron 23 11 14 (Pubitemid 29262459)
43. PH Janak JE Redfern HH Samson 1998 The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone Alcohol Clin Exp Res 22 1106 1112 (Pubitemid 28409004)
44. HS Kalluri MK Ticku 2002 Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain Eur J Pharmacol 439 53 58 (Pubitemid 34286606)
45. SP Kelley MA Nannini AM Bratt CW Hodge 2001 Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration Peptides 22 515 522 (Pubitemid 32250255)
46. GF Koob HO Pettit A Ettenberg FE Bloom 1984 Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat J Pharmacol Exp Ther 229 481 486
47. GF Koob HT Le I Creese 1987 The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat Neurosci Lett 79 315 320 (Pubitemid 17125800)
48. M Krishna H Narang 2008 The complexity of mitogen-activated protein kinases (MAPKs) made simple Cell Mol Life Sci 65 22 3525 3544
49. KO Kuroda MJ Meaney N Uetani Y Fortin A Ponton T Kato 2007 ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice Mol Cell Neurosci 36 121 131 (Pubitemid 47418608)
50. KD Lominac Z Kapasova RA Hannun C Patterson LD Middaugh KK Szumlinski 2006 Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties Drug Alcohol Depend 85 142 156 (Pubitemid 44441668)
51. L Lu BT Hope J Dempsey SY Liu JM Bossert Y Shaham 2005 Central amygdala ERK signaling pathway is critical to incubation of cocaine craving Nat Neurosci 8 212 219 (Pubitemid 40194052)
52. L Lu E Koya H Zhai BT Hope Y Shaham 2006 Role of ERK in cocaine addiction Trends Neurosci 29 695 703
53. A Markou F Weiss LH Gold SB Caine G Schulteis GF Koob 1993 Animal models of drug craving Psychopharmacology (Berl) 112 163 182 (Pubitemid 23278275)
54. C Mazzucchelli R Brambilla 2000 Ras-related and MAPK signalling in neuronal plasticity and memory formation Cell Mol Life Sci 57 604 611 (Pubitemid 30311431)
55. C Mazzucchelli C Vantaggiato A Ciamei S Fasano P Pakhotin W Krezel H Welzl DP Wolfer G Pages O Valverde A Marowsky A Porrazzo PC Orban R Maldonado MU Ehrengruber V Cestari HP Lipp PF Chapman J Pouyssegur R Brambilla 2002 Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory Neuron 34 807 820 (Pubitemid 34628742)
56. BA [tmp] McMillen MS Crawford CM Kulers HL Williams 2005 Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats Alcohol 40 494 497 (Pubitemid 41599998)
57. JM Mitchell MT Liang HL Fields 2005 A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats Psychopharmacology (Berl) 182 384 392 (Pubitemid 41464650)
58. PK Mukherjee MA DeCoster FZ Campbell RJ Davis NG Bazan 1999 Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death J Biol Chem 274 6493 6498 (Pubitemid 29111065)
59. National Research Council (1996) Guide for the care and use of laboratory animals. National Academy Press, Washington
60. J Ortiz HW Harris X Guitart RZ Terwilliger JW Haycock EJ Nestler 1995 Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine J Neurosci 15 1285 1297
61. SM Oster JE Toalston KA Kuc TJ Pommer JM Murphy L Lumeng RL Bell WJ [tmp] McBride ZA Rodd 2006 Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines Alcohol 38 155 164 (Pubitemid 44189158)
62. GL Quirarte LD Reid IS de la Teja ML Reid MA Sanchez A Diaz-Trujillo A Aguilar-Vazquez RA Prado-Alcala 2007 Estradiol valerate and alcohol intake: dose-response assessments BMC Pharmacol 7 3 (Pubitemid 46443933)
63. LD Reid PW Marinelli SM Bennett LT Fiscale SP Narciso CJ Oparowski ML Reid BA Merrigan J Moricone CL Hubbell C Gianoulakis 2002 One injection of estradiol valerate induces dramatic changes in rats' intake of alcoholic beverages Pharmacol Biochem Behav 72 601 616
64. NR Richardson DC Roberts 1996 Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy J Neurosci Methods 66 1 11 (Pubitemid 26180064)
65. MJ Robinson MH Cobb 1997 Mitogen-activated protein kinase pathways Curr Opin Cell Biol 9 180 186 (Pubitemid 27135985)
66. ZA Rodd RL Bell KA Kuc JM Murphy L Lumeng TK Li WJ [tmp] McBride 2003 Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats Neuropsychopharmacology 28 1614 1621 (Pubitemid 41070862)
67. Russo SJ, Mazei-Robison MS, Ables JL, Nestler EJ (2008) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology (in press)
68. V Sabino P Cottone L Steardo H Schmidhammer EP Zorrilla 2007 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats Psychopharmacology (Berl) 192 537 546 (Pubitemid 46870748)
69. J Salzmann C Marie-Claire S Le Guen BP Roques F Noble 2003 Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice Br J Pharmacol 140 831 838 (Pubitemid 37464064)
70. HH Samson 1986 Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats Alcohol Clin Exp Res 10 436 442 (Pubitemid 16034366)
71. PP Sanna C Simpson R Lutjens G Koob 2002 ERK regulation in chronic ethanol exposure and withdrawal Brain Res 948 186 191 (Pubitemid 35283780)
72. GE Schafe CM Atkins MW Swank EP Bauer JD Sweatt JE LeDoux 2000 Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning J Neurosci 20 8177 787
73. JP Schroeder DH Overstreet CW Hodge 2005 The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats Psychopharmacology (Berl) 179 262 270 (Pubitemid 40576714)
74. JP Schroeder M Spanos JR Stevenson J Besheer M Salling CW Hodge 2008 Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP Neuropharmacology 55 546 554
75. MA Schwarzschild RL Cole SE Hyman 1997 Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons J Neurosci 17 3455 3466 (Pubitemid 27200575)
76. R Seger EG Krebs 1995 The MAPK signaling cascade FASEB J 9 726 735
77. JC Selcher CM Atkins JM Trzaskos R Paylor JD Sweatt 1999 A necessity for MAP kinase activation in mammalian spatial learning Learn Mem 6 478 490 (Pubitemid 29503844)
78. V Sgambato P Vanhoutte C Pages M Rogard R Hipskind MJ Besson J Caboche 1998 In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain J Neurosci 18 214 226 (Pubitemid 28046783)
79. AC Sharko CW Hodge 2007 Acute ethanol challenge modulates extracellular-signal regulated kinase phosphorylation in vivo Alcohol Clin Exp Res 31 193A
80. X Shi JF [tmp] McGinty 2006 Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum Neuroscience 138 1289 1298 (Pubitemid 43363545)
81. RS Sinnott TJ Phillips DA Finn 2002 Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice Psychopharmacology (Berl) 162 438 447
82. M Spanos CW Hodge 2008 Neuroadaptive changes in ERK1/2 activity associated with alcohol self-administration in mice Alcohol Clin Exp Res 32 162A 162A
83. D Stafford MG LeSage JR Glowa 1998 Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review Psychopharmacology (Berl) 139 169 184 (Pubitemid 28439514)
84. JD Sweatt 2004 Mitogen-activated protein kinases in synaptic plasticity and memory Curr Opin Neurobiol 14 311 317 (Pubitemid 38759861)
85. GM Thomas RL Huganir 2004 MAPK cascade signalling and synaptic plasticity Nat Rev Neurosci 5 173 183 (Pubitemid 38252474)
86. DM Tomkins GA Higgins EM Sellers 1994 Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake Psychopharmacology (Berl) 115 173 179 (Pubitemid 24207779)
87. R Treisman 1996 Regulation of transcription by MAP kinase cascades Curr Opin Cell Biol 8 205 215 (Pubitemid 26109094)
88. R Tsuji M Guizzetti LG Costa 2003 In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain Neuroreport 14 1395 1399 (Pubitemid 36936733)
89. RR Ulm JR Volpicelli LA Volpicelli 1995 Opiates and alcohol self-administration in animals J Clin Psychiatry 56 Suppl 7 5 14
90. G Vacca S Serra G Brunetti MA Carai GL Gessa G Colombo 2002 Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716 Eur J Pharmacol 445 55 59 (Pubitemid 34628432)
91. E Valjent C Pages D Herve JA Girault J Caboche 2004 Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain Eur J Neurosci 19 1826 1836 (Pubitemid 38482570)
92. E Valjent AG Corbille J Bertran-Gonzalez D Herve JA Girault 2006 Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference Proc Natl Acad Sci U S A 103 2932 2937 (Pubitemid 43306651)
93. E Valjent JC Corvol JM Trzaskos JA Girault D Herve 2006 Role of the ERK pathway in psychostimulant-induced locomotor sensitization BMC Neurosci 7 20
94. P Vanhoutte JV Barnier B Guibert C Pages MJ Besson RA Hipskind J Caboche 1999 Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices Mol Cell Biol 19 136 146 (Pubitemid 29018416)
95. JR Weeks RJ Collins 1976 Changes in morphine self-administration in rats induced by prostaglandin E1 and naloxone Prostaglandins 12 11 19
96. JH Woods DA Downs J Carney 1975 Behavioral functions of narcotic antagonists: response-drug contingencies Fed Proc 34 1777 1784
97. WL Woolverton 1986 Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys Pharmacol Biochem Behav 24 531 535 (Pubitemid 16145188)
98. TH Wu CH Lin 2008 IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions Behav Brain Res 193 183 191
99. L Yang L Mao H Chen M Catavsan J Kozinn A Arora X Liu JQ Wang 2006 A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway J Neurosci 26 971 980 (Pubitemid 43237089)
100. T Zghoul C Abarca C Sanchis-Segura U Albrecht G Schumann R Spanagel 2007 Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice Psychopharmacology (Berl) 190 13 19
101. H Zhai Y Li X Wang L Lu 2008 Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement Cell Mol Neurobiol 28 157 172 (Pubitemid 350197692)
102. M Zhang AE Kelley 2002 Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens Psychopharmacology (Berl) 159 415 423 (Pubitemid 34143366)