Central amygdala ERK signaling pathway is critical to incubation of cocaine craving

Nature Neuroscience

Volumn 8, Issue 2, 2005, Pages 212-219

  Lu, Lin ^a   Hope, Bruce T ^a   Dempsey, Jack ^a   Liu, Shirley Y ^a   Bessert, Jennifer M ^a   Shaham, Yavin ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; MITOGEN ACTIVATED PROTEIN KINASE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; COCAINE DEPENDENCE; CONTROLLED STUDY; DISEASE MODEL; DRUG WITHDRAWAL; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RELAPSE; SIGNAL TRANSDUCTION; TIME;

AMYGDALA; ANESTHETICS, LOCAL; ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BUTADIENES; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CUES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXTINCTION, PSYCHOLOGICAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOOD; INJECTIONS, INTRAVENOUS; MALE; N-METHYLASPARTATE; NITRILES; PHOSPHORYLATION; RATS; RATS, LONG-EVANS; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SIGNAL TRANSDUCTION; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS;

EID: 13244275191     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1383     Document Type: Article

References (50)

1. O'Brien, C.P. A range of research-based pharmacotherapies for addiction. Science 278, 66-70 (1997).
2. Gawin, F.H. & Kleber, H.D. Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations. Arch. Gen. Psychiatry 43, 107-113 (1986).
3. Grimm, J.W., Hope, B.T., Wise, R.A. & Shaham, Y. Incubation of cocaine craving after withdrawal. Nature 412, 141-142 (2001).
4. Lu, L., Grimm, J.W., Dempsey, J. & Shaham, Y. Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months. Psychopharmacology (Berl.) 176, 101-108 (2004).
5. Neisewander, J.L. et al. Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment. J. Neurosci. 20, 798-805 (2000).
6. Nestler, E.J. Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2, 119-128 (2001).
7. Kalivas, P.W. Glutamate systems in cocaine addiction. Curr. Opin. Pharmacol. 4, 23-29 (2004).
8. Stewart, J. Pathways to relapse: factors controlling the reinitiation of drug seeking after abstinence. Nebr. Symp. Motiv. 50, 197-234 (2004).
9. Everitt, B.J. &Wolf, M.E. Psychomotor stimulant addiction: a neural systems perspective. J. Neurosci. 22, 3312-3320 (2002).
10. Grimm, J.W. et al. Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J. Neurosci. 23, 742-747 (2003).
11. Lu, L., Grimm, J.W., Shaham, Y. & Hope, B.T. Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats. J. Neurochem. 85, 1604-1613 (2003).
12. Lu, L., Dempsey, J., Liu, S.Y., Bossert, J.M. & Shaham, Y. A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J. Neurosci. 24, 1604-1611 (2004).
13. Lu, L., Grimm, J.W., Hope, B.T. & Shaham, Y. Incubation of cocaine craving after withdrawal: a review of preclinical data. Neuropharmacology 47 (Suppl. 1), 214-226 (2004).
14. Berhow, M.T., Hiroi, N. & Nestler, E.J. Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J. Neurosci. 16, 4707-4715 (1996).
15. Valjent, E. et al. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J. Neurosci. 20, 8701-8709 (2000).
16. Licata, S.C. & Pierce, R.C. The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitization. J. Neurochem. 85, 14-22 (2003).
17. Thomas, G.M. & Huganir, R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 5, 173-183 (2004).
18. Adams, J.P. & Sweatt, J.D. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu. Rev. Pharmacol. Toxicol. 42, 135-163 (2002).
19. Schafe, G.E. et al. Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. J. Neurosci. 20, 8177-8187 (2000).
20. Lu, K.T., Walker, D.L. & Davis, M. Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J. Neurosci. 21, RC162 (2001).
21. LeDoux, J.E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184 (2000).
22. Gallagher, M. & Chiba, A.A. The amygdala and emotion. Curr. Opin. Neurobiol. 6, 221-227 (1996).
23. Everitt, B.J. et al. Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems. Ann. NY Acad. Sci. 877, 412-438 (1999).
24. See, R.E. Neural substrates of conditioned-cued relapse to drug-seeking behavior. Pharmacol. Biochem. Behav. 71, 517-529 (2002).
25. Shaham, Y., Shalev, U., Lu, L., De Wit, H. & Stewart, J. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl.) 168, 3-20 (2003).
26. Shalev, U., Grimm, J.W. & Shaham, Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54, 1-42 (2002).
27. Balleine, B.W. & Dickinson, A. Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37, 407-419 (1998).
28. Davies, S.P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105 (2000).
29. Fiore, R.S., Murphy, T.H., Sanghera, J.S., Pelech, S.L. & Baraban, J.M. Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. J. Neurochem. 61, 1626-1633 (1993).
30. Jentsch, J.D. & Taylor, J.R. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharamacology 146, 373-390 (1999).
31. Burns, L.H., Robbins, T.W. & Everitt, B.J. Differential effects of excitotoxic lesions of the basolateral amygdala, ventral subiculum and medial prefrontal cortex on responding with conditioned reinforcement and locomotor activity potentiated by intra-accumbens infusions of D-amphetamine. Behav. Brain Res. 55, 167-183 (1993).
32. Robledo, P., Robbins, T.W. & Everitt, B.J. Effects of excitotoxic lesions of the central amygdaloid nucleus on the potentiation of reward-related stimuli by intra-accumbens amphetamine. Behav. Neurosci. 110, 981-990 (1996).
33. Wolf, M.E., Sun, X., Mangiavacchi, S. & Chao, S.Z. Psychomotor stimulants and neuronal plasticity. Neuropharmacology 47 (Suppl. 1), 61-79 (2004).
34. Holland, P.C. & Gallagher, M. Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus-potentiated feeding and Pavlovian-instrumental transfer. Eur. J. Neurosci. 17, 1680-1694 (2003).
35. Ungless, M.A., Whistler, J.L., Malenka, R.C. & Bonci, A. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411, 583-587 (2001).
36. Thomas, M.J., Beurrier, C., Bonci, A. & Malenka, R.C. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat. Neurosci. 4, 1217-1223 (2001).
37. Baker, D.A. et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat. Neurosci. 6, 743-749 (2003).
38. Wise, R.A. & Hoffman, D.C. Localization of drug reward mechanisms by intracranial injections. Synapse 10, 247-263 (1992).
39. Overton, D.A. Experimental methods for the study of state-dependent learning. Fed. Proc. 33, 1800-1813 (1974).
40. Whitelaw, R.B., Markou, A., Robbins, T.W. & Everitt, B.J. Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement. Psychopharmacology (Berl.) 127, 213-224 (1996).
41. Davis, M., Walker, D.L. & Myers, K.M. Role of the amygdala in fear extinction measured with potentiated startle. Ann. NY Acad. Sci. 985, 218-232 (2003).
42. Berman, D.E. & Dudai, Y. Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex. Science 291, 2417-2419 (2001).
43. Nestler, E.J. Common molecular and cellular substrates of addiction and memory. Neurobiol. Learn. Mem. 78, 637-647 (2002).
44. Robinson, T.E. & Berridge, K.C. Addiction. Annu. Rev. Psychol. 54, 25-53 (2003).
45. Sweatt, J.D. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J. Neurochem. 76, 1-10 (2001).
46. Grant, S. et al. Activation of memory circuits during cue-elicited cocaine craving. Proc. Natl. Acad. Sci. USA 93, 12040-12045 (1996).
47. Eysenck, H.J. A theory of the incubation of anxiety-fear responses. Behave. Res. Ther. 6, 309-321 (1968).
48. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, San Diego, 1998).
49. Hayes, R.J., Vorel, S.R., Spector, J., Liu, X. & Gardner, E.L. Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat. Psychopharmacology (Berl.) 168, 75-83 (2003).
50. Kelleher, R.J. III, Govindarajan, A., Jung, H.Y., Kang, H. & Tonegawa, S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116, 467-479 (2004).