Theoretical investigation of passive intestinal membrane permeability using Monte Carlo method to generate drug-like molecule population

International Journal of Pharmaceutics

Volumn 373, Issue 1-2, 2009, Pages 55-61

  Sugano, Kiyohiko ^a  

^a Research Formulation   (United Kingdom)

Author keywords

Drug like; Oral absorption; Paracellular; Permeability; Simulation; Transcellular; Unstirred water layer

Indexed keywords

AMILORIDE; ATENOLOL; CARBAMAZEPINE; CIMETIDINE; CREATININE; DESIPRAMINE; DRUG ANALOG; FLUINDOSTATIN; FUROSEMIDE; HYDROCHLOROTHIAZIDE; KETOPROFEN; METOPROLOL; NAPROXEN; OCTANOL; PHENAZONE; PIROXICAM; PROPRANOLOL; RANITIDINE; TERBUTALINE;

ARTICLE; DIFFUSION COEFFICIENT; DOG; DRUG ABSORPTION; HUMAN; INTESTINE MUCOSA PERMEABILITY; MOLECULAR WEIGHT; MONTE CARLO METHOD; NONHUMAN; PARTITION COEFFICIENT; PH; PKA; PRIORITY JOURNAL; RAT STRAIN; SPECIES DIFFERENCE;

ALGORITHMS; ANIMALS; CELL MEMBRANE; COMPUTER SIMULATION; DIFFUSION; DOGS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; MONTE CARLO METHOD; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; RATS; SOLUBILITY;

EID: 67349159812     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.02.002     Document Type: Article

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