Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons

Brain Research

Volumn 756, Issue 1-2, 1997, Pages 231-240

  Klette, Kevin L ^a,b   Lin, Yu ^b   Clapp, Larry E ^b,c   DeCoster, Mark A ^d   Moreton, J E ^e   Tortella, Frank C ^b  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

^d LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Ligand; Intracellular calcium; KCl; Metabotropic; Neuronal culture; Neuroprotection; NMDA; trans ACPD

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1,3 BIS(2 METHYLPHENYL)GUANIDINE; 2 AMINO 5 PHOSPHONOVALERIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; CALCIUM CHANNEL; CALCIUM ION; CYCLAZOCINE; DEXTROMETHORPHAN; DIZOCILPINE; HALOPERIDOL; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; N ALLYLNORMETAZOCINE; N METHYL DEXTRO ASPARTIC ACID; PENTAZOCINE; PENTOXYVERINE; PRECLAMOL;

ANIMAL CELL; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELECTIVITY; EMBRYO; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

ANIMALS; CALCIUM; CELLS, CULTURED; CYCLOLEUCINE; LIGANDS; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION;

EID: 0030903679     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00142-X     Document Type: Article

References (41)

1. Beart, P.M., O'Shea, R.D. and Mallack, D.T., Regulation of σ receptors: high and low affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-di(2-tolyl)guanidine, J. Neurochem., 53 (1989) 779-788.
2. Birse, E.F., Eaton, S.A., Jane, D.E., St. J. Jones, P.L., Porter, R.H.P., Pook, P.C.-K., Sunter, D.C., Udvarhelyi, P.M., Wharton, B., Roberts, P.J., Salt, T.E. and Watkins, J.C., Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system, J. Neurosci., 52 (1993) 481-488.
3. Bowen, W.D., Kirschner, B.N., Newman, A.M. and Rice, K.C., Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain, Eur. J. Pharmacol., 149 (1988) 399-400.
4. Bowen, W.D. and Tolentino, P.J., Activation of sigma receptors results in down-regulation of muscarinic cholinergic receptors. In J.M. van Ree, A.M. Mulder, V.M. Wiegant and T.B. van Wimersma (Eds.), New Leads in Opioid Research, Proceedings of the International Narcotics Research Conference, ICS No. 914, Excerpta Medica/Elsevier, Amsterdam, 1990, pp. 212-213.
5. Bowen, W.D. and Tolentino, P.J., Heterologous down-regulation of cholinergic receptors by sigma receptor activation, Soc. Neurosci. Abstr., 16 (1990) 802.
6. Bowen, W.D., Tolentino, P.J., Hsu, K.K., Cutts, J.M. and Naidu, S.S., Inhibition of the cholinergic phosphoinositide response by sigma ligands: distinguishing a sigma receptor-mediated mechanism from a mechanism involving direct cholinergic receptor antagonism. In J.M. Kamenka and E.F. Domino (Eds.), Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromodulation and Neuroprotection? NPP Books, Ann Arbor, MI, 1992, pp. 155-167.
7. Bowen, W.D., Tolentino, P.J., Kirschner, B.N., Varghese, P., de Costa, B.R. and Rice, K.C., Sigma receptors and signal transduction: negative modulation of signaling through phosphoinositide-linked receptor systems. In E.B. DeSouza, E.D. London and D.H. Clouet (Eds.), Sigma, PCP, and NMDA Receptor Systems, National Institute on Drug Abuse Research Monograph Series, Government Printing Office, Washington, DC, 1993, pp. 64-81.
8. Connick, J.H., Hanlon, G., Roberts, J., France, L., Fox, P.K. and Nicholson, C.D., Multiple σ binding sites in guinea-pig and rat brain membranes: G-protein interactions, Br. J. Pharmacol., 107 (1992) 726-731.
9. 2+ induced by excitatory amino acids in CA1 hippocampal neurons, Science, 240 (1988) 649-653.
10. DeCoster, M.A., Koenig, M.L., Hunter, J.C. and Tortella, F.C., Calcium dynamics in neurons treated with toxic and non-toxic concentrations of glutamate, NeuroReport, 3 (1992) 773-776.
11. DeCoster, M.A., Klette, K.L., Knight, E.S. and Tortella, F.C., σ Receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures, Brain Res., 671 (1995) 45-53.
12. DeLoore, K.L., Lesage, A.S., Peeters, L. and Leysen, J.E., Various sigma ligands exert long-term protection against glutamate toxicity in primary hippocampal neurons; apparent non involvement of identified σ-2 sites, Neurosci. Res. Commun., 14 (1994) 43-51.
13. Dohlman, H.G., Thorner, J., Caron, M.C. and Lefkowitz, R.L., Model systems for the study of seven-transmembrane-segment receptors, Annu. Rev. Biochem., 60 (1991) 653-688.
14. Ellis, Y. and Davies, J.A., The effects of sigma ligands on the release of glutamate from rat striatal slices, Arch. Pharmacol., 350 (1994) 143-148.
15. Gasic, G.P. and Hollmann, M., Molecular neurobiology of glutamate receptors, Annu. Rev. Physiol., 54 (1992) 507-536.
16. Gerber, G., Kangrga, I., Ryu, P.D., Larew, J.S.A. and Randic, M., Multiple effects of phorbol esters in the rat spinal dorsal horn, J. Neurosci., 9 (1989) 3606-3617.
17. Gotti, B., Benavides, J., MacKenzie, E.T. and Scatton, B., The pharmacotherapy of focal cortical ischaemia in the mouse, Brain Res., 522 (1990) 290-307.
18. 1-binding site, Proc. Natl. Acad. Sci. USA, 93 (1996) 8072-8077.
19. 2+ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons, J. Pharmacol. Exp. Ther., 275 (1995) 207-214.
20. 2+ mobilization in rat cerebellar neurons, Eur. J. Pharmacol., 186 (1990) 363-365.
21. Itzhak, Y., Multiple affinity binding states of receptors: effect of GTP-binding protein-modifying agents, Mol. Pharmacol., 36 (1989) 512-517.
22. Kelso, S.R., Nelson, R.E. and Leonard, J.P., Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes, J. Physiol., 449 (1992) 705-718.
23. Kirschner, B.N., Hellewell, S.B., Newman, A.M., Rice, K.C. and Bowen, W.D., Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in brain synaptoneurosomes, Soc. Neurosci. Abstr., 14 (1988) 86.
24. Klette, K.L., DeCoster, M.A., Moreton, J.E. and Tortella, F.C., Role of calcium in sigma mediated neuroprotection in rat primary cortical neurons, Brain Res., 704 (1995) 31-41.
25. Lockhart, B.P., Soulard, P., Benicourt, C., Privat, A. and Junien, J.-L., Distinct neuroprotective profiles for σ ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies, Brain Res., 675 (1995) 110-120.
26. MacDonald, J.F., Mody, I. and Salter, M.W., Regulation of NMDA receptors revealed by intracellular dialysis of murine neurons in culture, J. Physiol., 414 (1989) 17-34.
27. 2+ influx elicited by glutamate: role in neuronal death, Mol. Pharmacol., 36 (1989) 106-111.
28. 2+ in mammalian neurons, Trends Pharmacol. Sci., 11 (1990) 254-260.
29. Mody, I., Salter, M.W. and MacDonald, J.F., Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons, Neurosci. Lett., 93 (1988) 73-78.
30. Monnet, F.P., DeBonnel, G., Junien, J. and De Montigny, C., In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands, J. Pharmacol. Exp. Ther., 261 (1992) 123-130.
31. Pin, J.-P. and Duvoisin, R., The metabotropic glutamate receptors: structure and functions, Neuropharmacology, 34 (1995) 1-26.
32. Poignet, H., Nowicki, J.P. and Scatton, B., Lack of neuroprotective effect of some σ ligands in a model of focal cerebral ischemia in the mouse, Brain Res., 596 (1992) 320-324.
33. Rane, S.G. and Dunlap, K., Kinase-C activator 1,2-oleoylacetyl triglycerol attenuates voltage dependent calcium current in sensory neurons, Proc. Natl. Acad. Sci. USA, 83 (1986) 184-188.
34. Rao, T.S., Mick, S.J., Cler, J.A., Emmet, M.R., Dilworth, V.M., Contreras, P.C., Gray, N.M., Wood, P.L. and Iyengar, S., Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands, Brain Res., 561 (1991) 43-50.
35. Schoepp, D.D. and Conn, J.P., Metabotropic glutamate receptors in brain function and pathology, Trends Pharmacol. Sci., 14 (1993) 13-19.
36. 2+, and γ-aminobutyrate type A channels, Proc. Natl. Acad. Sci. USA, 85 (1988) 6192-6196.
37. 3H]arachidonic acid release from rat neonatal cerebellar granule cells in culture, J. Neurochem., 63 (1994) 1311-1318.
38. Strosberg, A.D., Structure/function relationships of proteins belonging to the family of receptors coupled to GTP-binding proteins, Eur. J. Biochem., 196 (1991) 1-10.
39. Tallarida, R.J. and Murray, R.B., Procedure #42. Chi-square test. In Manual of Pharmacologic Calculations with Computer Programs, 2nd edn., Springer, New York, 1986, pp. 140-142.
40. Watkins, J. and Collingridge, G., Phenylglycine derivatives as antagonists of metabotropic glutamate receptors, Trends Pharmacol. Sci., 15 (1994) 333-342.
41. Yamamoto, H., Yamamoto, T., Sagi, N., Klenerova, V., Goji, K., Kawai, N., Baba, A., Takamori, E. and Moroji, T., Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via σ site, J. Neurosci., 15 (1995) 731-736.