Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene

Journal of Neurotrauma

Volumn 24, Issue 4, 2007, Pages 703-712

  Nakajima, Hideaki ^a,b   Uchida, Kenzo ^a   Kobayashi, Shigeru ^a   Inukai, Tomoo ^a   Horiuchi, Yukiko ^a   Yayama, Takafumi ^a   Sato, Ryuichiro ^a   Baba, Hisatoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

Axonal transport; Growth factor; Regeneration; Spinal cord injury; Therapeutic approaches for the treatment of CNS injury; Traumatic spinal cord injury

Indexed keywords

ACETYLCHOLINESTERASE; ADENOVIRUS VECTOR; BETA GALACTOSIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE ACETYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HORN CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; GENE TARGETING; GENETIC TRANSFECTION; MALE; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; RAT; RETROGRADE TRANSFECTION; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; STERNOCLEIDOMASTOID MUSCLE; ADENOVIRUS; ANIMAL; BIOSYNTHESIS; ENZYME IMMUNOASSAY; GENE THERAPY; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LACTOSE OPERON; METABOLISM; MOTONEURON; MOTOR NEURON DISEASE; NERVE CELL; PHYSIOLOGY;

ACETYLCHOLINESTERASE; ADENOVIRIDAE; ANIMALS; ANTERIOR HORN CELLS; BETA-GALACTOSIDASE; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CHOLINE O-ACETYLTRANSFERASE; GENE THERAPY; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; LAC OPERON; MALE; MOTOR NEURON DISEASE; MOTOR NEURONS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TRANSFECTION;

EID: 34249862830     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.0004     Document Type: Article

References (42)

1. BABA, H., MAEZAWA, Y., IMURA, S., KAWAHARA, N., NAKAHASHI, K., and TOMITA, K. (1996). Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse. J. Neurol. 243, 109-116.
2. BABA, H., MAEZAWA, Y., UCHIDA, K., et al. (1997). Three-dimensional topographic analysis of spinal accessory motoneurons under chronic mechanical compression: an experimental study in the mouse. J. Neurol. 244, 222-229.
3. BLACK, P., MARKOWITZ, R.S., COOPER, V., et al. (1986). Models of spinal cord injury: Part 1. Static load technique. Neurosurgery 19, 752-762.
4. BLESCH, A., LU, P., and TUSZYNSKI, M.H. (2002). Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res. Bull. 57, 83-88.
5. BLITS, B., OUDEGA, M., BOER, G.J., BARTLETT BUNGE, M., and VERHAAGEN, J. (2003). Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function. Neuroscience 118, 271-281.
6. BOULIS, N.M., TURNER, D.E., IMPERIALE, M.J., and FELDMAN, E.L. (2002). Neuronal survival following remote adenovirus gene delivery. J. Neurosurg. (Spine) 96, 212-219.
7. BOULIS, N.M., WILLMARTH, N.E., SONG, D.K., and FELDMAN, E.L. (2003). Intraneural colchicines inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery. Neurosurgery 52, 381-387.
8. CAI, D., SHEN, Y., DE BELLARD, M., TANG, S., and FILBIN, M.T. (1999). Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 22, 89-101.
9. COLLAZOS, J.E., SOTO, V.M., GUTIERREZ-DAVILA, M., and NIETO-SAMPEDRO, M. (2005). Motoneuron loss associated with chronic locomotion impairments after spinal cord contusion in the rat. J Neurotrauma 22, 544-558.
10. DOUGHERTY, K.D., DREYFUS, C.F., and BLACK, I.B. (2000). Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiology Dis. 7, 574-585.
11. EMBORG, M.E., and KORDOWER, J.H. (2001). Delivery of therapeutic molecules into the CNS. Prog. Brain Res. 128, 323-332.
12. GIEHL, K.M., ROHRIG, S., BONATZ, H., et al. (2001). Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J. Neurosci. 21, 3492-3502.
13. HAASE, G., PETTMANN, B., VIGNE, E., CASTELNAU-PTAKHINE, L., SCHMALBRUCH, H., and KAHN, A. (1998). Adenovirus-mediated transfer of the neurotrophin-3 gene into skeletal muscle of pmn mice: therapeutic effects and mechanisms of action. J. Neurol. Sci. 160, S97-S105.
14. HEDREEN, J.C., BACON, S.J., and PRICE, D.L. (1985). A modified histochemical technique to visualize acetylcholinesterase-containing axons. J. Histochem. Cytochem. 33, 134-140.
15. HERMENS, W.T., and VERHAAGEN, J. (1998). Viral vectors, tools for gene transfer in the nervous system. Prog. Neurobiol. 55, 399-432.
16. HENDRIKS, W.T., RUITENBERG, M.J., BLITS, B., BOER, G.J., and VERHAAGEN, J. (2004). Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Prog. Brain Res. 146, 451-476.
17. KASPAR, B.K., ERICKSON, D., SCHAFFER, D., HINH, L., GAGE, F.H., and PETERSON, D.A. (2002). Targeted retrograde gene delivery for neuronal protection. Mol. Ther. 5, 50-56.
18. KEIR, S.D., MITCHELL, W.J., FELDMAN, L.T., and MARTIN, J.R. (1995). Targeting gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector. J. Neuro. Virol. 1, 259-267.
19. KISHINO, A., ISHIGE, Y., TATSUNO, T., NAKAYAMA, C., and NOGUCHI, H. (1997). BDNF prevent and reverses adult rat motor neuron degeneration and induces axonal outgrowth. Exp. Neurol. 144, 273-286.
20. KISHINO, A., and NAKAYAMA, C. (2003). Enhancement of BDNF and activate-ERK immunoreactivity in spinal motor neuron after peripheral administration of BDNF. Brain Res. 964, 56-66.
21. KITAMURA, S., and SAKAI, A. (1982). A study on the localization of the sternocleidomastoid and trapezius motoneurons in the rat by means of the HRP method. Anat. Rec. 202, 527-536.
22. KODA, M., HASHIMOTO, M., MURAKAMI, M., et al. (2004). Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. J. Neurotrauma 21, 329-337.
23. KUO, H., INGRAM, D.K., CRYSTAL, R.G., and MASTRANGELI, A. (1995). Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies. Brain Res. 705, 31-38.
24. LIUDMILA, N., NOVIKOVA, L.N., and KELLERTH, J.O. (2002). Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats. J. Comp. Neurol. 452, 255-263.
25. MANNES, A.J., CAUDLE, R.M., O'CONNELL, B.C., and IADAROLA, M.J. (1998). Adenoviral gene transfer to spinal-cord neurons: intrathecal vs. intraparenchymal administration. Brain Res. 793, 1-6.
26. MCDONALD, J.W., LIU, X.Z., QU, Y., et al. (1999). Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med. 4, 291-297.
27. MIYAKE, S., MAKIMURA, M., KANEGAE, Y., et al. (1996). Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full- length virus genome. Proc. Natl. Acad. Sci. USA. 93, 1320-1324.
28. NAKAHARA, S., YONE, K., SAKOU, T., et al. (1999). Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. J Neuropathol Exp Neurol. 58, 442-450.
29. NAKAJIMA, H., UCHIDA, K., KOBAYASHI, S., et al. (2005). Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector. Neurosci. Lett. 385, 30-35.
30. NAKAMURA, M., and BREGMAN, B.S. (2001). Differences in neurotrophic factor gene expression profiles between neonate and adult rat spinal cord after injury. Exp. Neurol. 169, 407-415.
31. NAKAMURA, M., FUJIMURA, Y., YATO, Y., WATANABE, M., and YABE, Y. (1996). Changes in choline acetyltransferase activity and distribution following incomplete cervical spinal cord injury in the rat. Neuroscience 75, 481-494.
32. NAMIKI, J., KOJIMA, A., and TATOR, C.H. (2000) Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats. J. Neurotrauma 17, 1219-31.
33. NOVIKOVA, L.N., NOVIKOV, L.N., and KELLERTH, J.O. (1996). Brain-derived neurotrophic factor reduces necrotic zone and supports neuronal survival after spinal cord hemisection in adult rats. Neurosci. Lett. 220, 203-206.
34. OGAWA, Y., SAWAMOTO, K., MIYATA, T., et al. (2002). Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rat. J. Neurosci. Res. 69, 925-933.
35. PITTENGER, M.F., MACKAY, A.M., BECK, S.C., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147.
36. RUITENBERG, M.J., EGGERS, R., BOER, G.J., and VERHAAGEN, J. (2002). Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system. Methods 28, 182-194.
37. THOMAS, C.E., BIRKETT, D., ANOZIE, I., CASTRO, M.G., and LOWENSTEIN, P.R. (2001). Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. Mol. Ther. 3, 36-46.
38. UCHIDA, K., BABA, H., MAEZAWA, Y., FURUKAWA, S., FURUSAWA, N., and IMURA, S. (1998). Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors. J. Neurol. 245, 781-793.
39. UCHIDA, K., BABA, H., MAEZAWA, Y., et al. (2003). Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy). Acta Neuropathol. 106, 29-36.
40. UCHIDA, K., BABA, H., MAEZAWA, Y., and KUBOTA, C. (2002). Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical spinal cord compression in spinal hyperostotic mice. Spine 27, 480-486.
41. XU, K., UCHIDA, K., NAKAJIMA, H., KOBAYASHI, S., and BABA, H. (2006). Targeted retrograde adenovirus vector carrying brain-derived neurotrophic factor gene transfection prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression. Spine 31, 1867-1874.
42. YANG, Y., NUNES, F.A., BERENCSI, K., FURTH, E.E., GONCZOL, E., and WILSON, J.M. (1994). Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA. 91, 4407-4411.