σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion

Stroke

Volumn 31, Issue 4, 2000, Pages 976-982

  Harukuni, Izumi ^a   Bhardwaj, Anish ^a   Shaivitz, Amanda B ^a   DeVries, A Courtney ^a   London, Edythe D ^b   Hurn, Patricia D ^a   Traystman, Richard J ^a   Kirsch, Jeffrey R ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cerebral infarction; Cerebral ischemia, focal; Excitotoxicity; Ligands; Rats

Indexed keywords

4 PHENYL 1 (4 PHENYLBUTYL) PIPERIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PIPERIDINE DERIVATIVE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; LASER DOPPLER FLOWMETRY; LOCOMOTION; MALE; MAZE TEST; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; REPERFUSION; STAINING;

EID: 0034077903     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.31.4.976     Document Type: Article

References (37)

1. Yamamoto H, Yamamoto T, Sagi N, Klenerova V, Goji K, Kawai N, Baba A, Takamori E, Moroji T. Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site. J Neurosci. 1995;15:731-736.
2. Maurice T, Lockhart BP. Neuroprotective and anti-amnesic potentials of sigma receptor ligands. Prog Neuropsychopharmacol Biol Psychiatr. 1997;21:69-102.
3. Lobner D, Lipton P. σ-Ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia. Neurosci Lett. 1990; 117:169-174.
4. Carter C, Benavides J, Legendre P, Vincent JD, Noel F, Thuret F, Lloyd KG, Arbilla S, Zivkovic B, MacKenzie ET. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents, II: evidence for N-methyl-D-aspartate receptor antagonist properties. J Pharmacol Exp Ther. 1988;247: 1222-1232.
5. Lesage AS, De Loore KL, Peeters L, Leysen JE. Neuroprotective sigma ligands interfere with the glutamate-activated NOS pathway in hippocampal cell culture. Synapse. 1995;20:156-164.
6. 3H]dopamine release from rat striatal slices by a receptor ligands. J Pharmacol Exp Ther. 1994;271:212-219.
7. Willette RN, Lysko PG, Sauermelch CF. A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression. Brain Res. 1994; 648:347-351.
8. 1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo. Stroke. 1998;29:2404-2411.
9. Takahashi H, Kirsch JR, Hashimoto K, London ED, Koehler RC, Traystman RJ. PPBP [4-phenyl-1-(4-phenylbutyl)peperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27: 2120-2123.
10. Takahashi H, Kirsch JR, Hashimoto K, London ED, Koehler RC, Traystman RJ. PPBP [4-phenyl-1-(4-phenylbuty))peperidine], a potent (σ-receptor ligand, decreases brain injury after transient focal ischemia in cats. Stroke. 1995;26:1676-1682.
11. Harukuni I, Bhardwaj A, Traystman RJ, Grain B, London ED, Kirsch JR. Neuroprotection from focal ischemia by 4-phenyl-1-(4-phenylbutyl) peperidine (PPBP) is dependent on treatment duration in rats. Anesth Analg. 1998;87:1299-1305.
12. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem. 1984;42:1-11.
13. Obey JW, Labuyere J, Price MT. Pathological changes induced by phencyclidine and related drugs. Science. 1989;244:1360-1362.
14. Grotta JC, Pettigrew LC, Reid C, Rosenbaum D, McCandless D, Rhoades H. Studies on the efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia. Stroke. 1988;19:447-454.
15. Grotta JC, Picone CM, Ostrow PT, Strong RA, Earls RM, Yao LP, Rhoades HM, Dedman JR. GCS 19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol. 1990;27:612-619.
16. Dixon CA, Cliffton GL, Lighthall JW, Yaghmai AA, Hayes RL. A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods. 1991;39:253-262.
17. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke. 1998;29: 159-166.
18. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20: 84-91.
19. Du C, Hu R, Csemansky CA, Hsu CY, Choi DW. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis. J Cereb Blood Flow Metab. 1996;16:195-201.
20. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 1993; 24:117-121.
21. 3H]4-phenyl-1-(4-phenylbutyl)peperidine. Synapse. 1995;20:85-90.
22. Lysko PG, Yue TL, Gu JL, Feuerstein G. Neuroprotective effects of (+) SKF 10,047 in vitro and in gerbil global brain ischemia. Stroke. 1992; 23:1319-1323.
23. Chen H, Chopp M, Welch KMA. Effect of mild hyperthermia on ischemic infarct volume after middle cerebral artery occlusion in the rat. Neurology. 1991;41:1133-1135.
24. Morikawa E, Ginsberg MD, Dietrich WD, Duncan RC, Kraydieh S, Globus MY, Busto R. The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab. 1992;12:380-389.
25. Busto R, Dietrich WD, Globus M Y-T, Valdes I, Scheinberg P, Ginsperg MD. Small differences in intraischemic temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab. 1987;7:729-738.
26. Dietrich WD, Busto R, Valdes I, Loor Y. Effects of normothermic versus mild hyperthermic forebrain ischemia in rats. Stroke. 1990;21: 1318-1325.
27. Moyer DJ, Welsh FA, Zager EL. Spontaneous cerebral hypothermia diminishes focal infarction in rat brain. Stroke. 1992;23:1812-1816.
28. Takahashi H, Traystman RJ, Hashimoto K, London ED, Kirsch JR. Postischemic brain injury is affected stereospecifically by pentazocine in rats. Anesth Analg. 1997;85:353-357.
29. Montkowski A, Landgraf R, Yassouridis A, Holsboer F, Schobitz B. Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats. Pharmacol Biochem Behav. 1997;1997:58:329-336.
30. Dunn AJ, Swiergiel AH. The role of cytokines in infection-related behavior. Ann NY Acad Sci. 1998;840:577-585.
31. De Renzi E, Barbieri C. The incidence of the grasp reflex following hemispheric lesion and its relation to frontal damage. Brain. 1992;115: 293-313.
32. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartowski H. Rat middle artery occlusion: evaluation of model and development of neurological examination. Stroke. 1986;17:472-476.
33. Aronowski J, Samways E, Strong R, Rhoades HM, Grotta JC. An alternative method of the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: analysis of behavioral deficit. J Cereb Blood Flow Metab. 1996;16:705-713.
34. Johansson BB, Ohlsson AL. Environment, social interaction, and physical activity as determinants of functional outcome after cerebral infarction in the rat. Exp Neurol. 1996;139:322-327.
35. Ohlsson AL, Johansson BB. Environment influences functional outcome of cerebral infarction in rats. Stroke. 1995;1995:26:644-649.
36. van der Staay FJ, Augstein KH, Horvath E. Sensorimotor impairments in rats with cerebral infarction, induced by unilateral occlusion of the left middle cerebral artery: strain differences and effects of the occlusion site. Brain Res. 1996;735:271-284.
37. Wahl F, Allix M, Plotkine M, Boulu RG. Neurological and behavioral outcomes of focal cerebral ischemia in rats. Stroke. 1992;1992:23: 267-272.