Advances in secondary spinal cord injury: Role of apoptosis

Spine

Volumn 25, Issue 14, 2000, Pages 1859-1866

  Lu, Jike ^a   Ashwell, Ken W S ^a   Waite, Phil ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Apoptosis; Cytokines; Excitotoxicity; Free radicals; Secondary spinal cord injury

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; EXCITOTOXIN; FREE RADICAL; SCAVENGER;

APOPTOSIS; CELL DEATH; GLIA CELL; INFLAMMATION; NERVE CELL; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; CLINICAL TRIALS; CYTOKINES; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACIDS; FREE RADICALS; HUMANS; NECROSIS; NEUROGLIA; NEURONS; SPINAL CORD; SPINAL CORD INJURIES; WOUNDS AND INJURIES;

EID: 0034662011     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200007150-00022     Document Type: Review

References (56)

1. Agrawal SK, Fehlings MG. Mechanisms of secondary injury to spinal cord axons in vitro: Role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger. J Neurosci 1996;16:545-52.
2. Amar AP, Levy ML. Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 1999;44: 1027-40.
3. Anderson DK, Hall ED, Braughler JM, McCall JM, Means ED. Effect of delayed administration of U74006F (tirilazad mesylate) on recovery of locomotor function after experimental spinal cord injury. J Neurotrauma 1991;8:187-92.
4. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990;322:1405-11.
5. Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up: Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 1998;89:699-706.
6. Buki A, Okonkwo DO, Povlishock JT. Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury. J Neurotrauma 1999;16:511-21.
7. Cohen JJ. Apoptosis. Immunol Today 1993;14:126-30.
8. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3:73-6.
9. Dalkara T, Moskowitz MA. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol 1994;4:49-57.
10. Dawson TM, Dawson VL, Snyder SH. Molecular mechanisms of nitric oxide actions in the brain. Ann N Y Acad Sci 1994;738:76-85.
11. Dawson TM, Hung K, Dawson VL, Steiner JP, Snyder SH. Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase. Ann Neurol 1995;37:115-8.
12. Emery E, Aldana P, Bunge MB, et al. Apoptosis after traumatic human spinal cord injury. J Neurosurg 1998;89:911-20.
13. Faden AI, Demediuk P, Panter SS, Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989;244:798-800.
14. Furukawa K, Estus S, Fu W, Mark RJ, Mattson MP. Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways. J Cell Biol 1997;136:1137-49.
15. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
16. Geisler FH, Dorsey FC, Coleman WP. Past and current clinical studies with GM-1 ganglioside in acute spinal cord injury. Ann Emerg Med 1993;22:1041-7.
17. Geisler FH, Dorsey FC, Coleman WP. Recovery of motor function after spinal-cord injury - a randomized, placebo-controlled trial with GM-1 ganglioside. N Engl J Med 1991;324:1829-38.
18. Guth L, Zhang Z, DiProspero NA, Joubin K, Fitch MT. Spinal cord injury in the rat: Treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function. Exp Neurol 1994;126:76-87.
19. Hall ED, Braughler JM. Free radicals in CNS injury. Res Publ Assoc Res Nerv Ment Dis 1993;71:81-105.
20. Hamada Y, Ikata T, Katoh S, et al. Roles of nitric oxide in compression injury of rat spinal cord. Free Radic Biol Med 1996;20:1-9.
21. Hochman A, Sternin H, Gorodin S, et al. Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J of Neurochemistry 1998; 71:741-8.
22. Hollmann M, Hartley M, Heinemann S. Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 1991;252:851-3.
23. Hu S, Peterson PK, Chao CC. Cytokine-mediated neuronal apoptosis. Neurochem Int 1997;30:427-31.
24. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994;265:1883-5.
25. Jacobs TP, Shohami E, Baze W, et al. Thromboxane and 5-HETE increase after experimental spinal cord injury in rabbits. Cent Nerv Syst Trauma 1987;4: 95-118.
26. Kato H, Kanellopoulos GK, Matsuo S, et al. Neuronal apoptosis and necrosis following spinal cord ischemia in the rat. Exp Neurol 1997;148:464-74.
27. Katoh K, Ikata T, Katoh S, et al. Induction and its spread of apoptosis in rat spinal cord after mechanical trauma. Neurosci Lett 1996;216:9-12.
28. Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci. USA 1996;93:2317-21.
29. Kew JNC, Gill R, Lorez HP, et al. NMDA receptor NR2B subtype selective antagonists as neuroprotective agents in brain ischaemia (abstract). Fifth IBRO World Congress of Neuroscience 1999;5:31.
30. Lazarov-Spiegler O, Rapalino O, Agranov G, Schwartz M. Restricted inflammatory reaction in the CNS: A key impediment to axonal regeneration? Mol Med Today 1998;4:337-42.
31. Li GL, Brodin G, Farooque M, et al. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord. J Neuropathol Exp Neurol 1996;55: 280-9.
32. Liu XZ, Xu XM, Hu R, et al. Neuronal and glial apoptosis after traumaticspinal cord injury. J Neurosci 1997;17:5395-406.
33. Lu J, Waite P. Spine update: Advances in spinal cord regeneration. Spine 1999;24:926-30.
34. Maroney AC, Glicksman MA, Basma AN, et al. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998;18:104-11.
35. Martinou JC, Dubois-Dauphin M, Staple JK, et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994;13:1017-30.
36. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 1993;151:2132-41.
37. Newton K, Strasser A. The Bcl-2 family and cell death regulation. Curr Opin Genet Dev 1998;8:68-75.
38. Nishisho T, Tonai T, Tamura Y, Ikata T. Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. Neurosurgery 1996; 39:950-7.
39. Ogata T, Nakamura Y, Tsuji K, Shibata T, Kataoka K. Steroid hormones protect spinal cord neurons from glutamate toxicity. Neuroscience 1993;55: 445-9.
40. Raff M. Cell suicide for beginners. Nature 1998;396:119-22.
41. Resnick DK, Graham SH, Dixon CE, Marion DW. Role of cyclooxygenase 2 in acute spinal cord injury. J Neurotrauma 1998;15:1005-13.
42. Rosenberg LJ, Teng YD, Wrathall JR. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion. J Neurosci 1999;19:464-75.
43. Rosenberg LJ, Teng YD, Wrathall JR. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. J Neurosci 1999;19:6122-33.
44. Sharma HS, Westman J, Olsson Y, Aim P. Involvement of nitric oxide in acute spinal cord injury: An immunocytochemical study using light and electron microscopy in the rat. Neurosci Res 1996;24:373-84.
45. Stys PK. Anoxic and ischemic injury of myelinated axons in CNS white matter: From mechanistic concepts to therapeutics. J Cereb Blood Flow Metab 1998;18:2-25.
46. Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, et al. Exacerbation of damage and altered NF-kB activation in mice lacking tumor necrosis factor receptor after traumatic brain injury. J Neurosci 1999;19:6248-56.
47. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vase Surg 1993;17:357-70.
48. Takahashi K, Schwarz E, Ljubetic C, Murray M, Tessler A, Saavedra RA. DNA plasmid that codes for human Bcl-2 gene preserves axotomized Clarke's nucleus neurons and reduces atrophy after spinal cord hemisection in adult rats. J Comp Neurol 1999;404:159-71.
49. Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 1995;268:251-5.
50. Taoka Y, Okajima K, Uchiba M. Role of neutrophils in spinal cord injury in the rat. Neuroscience 1997;79:1177-82.
51. Tator CH, Koyanagi I. Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 1997;86:483-92.
52. Villa PG, Henzel WJ, Sensenbrenner M, Henderson CE, Pettmann B. Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J Cell Sci 1998;111:713-22.
53. Wada S, Yone K, Ishidou Y, et al. Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist. J Neurosurg 1999;91:98-104.
54. Wrathall JR, Choiniere D, Teng YD. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J Neurosci 1994;14:6598-607.
55. Yanase M, Sakou T, Fukuda T. Role of N-methyl-D-aspartate receptor in acute spinal cord injury. J Neurosurg 1995;83:884-8.
56. Yong C, Arnold PM, Zoubine MN, et al. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury. J Neurotrauma 1998; 15:459-72.