Neuroprotective effect of σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

Stroke

Volumn 32, Issue 7, 2001, Pages 1613-1620

  Goyagi, Toru ^a   Goto, Shozo ^a   Bhardwaj, Anish ^a,b   Dawson, Valina L ^a   Hurn, Patricia D ^a   Kirsch, Jeffrey R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cerebral ischemia, focal; Excitotoxicity; Infarction; Nitric oxide; Receptors; Reperfusion; Sigma

Indexed keywords

4 PHENYL 1 (4 PHENYLBUTYL)PIPERIDINE; 7 NITROINDAZOLE; NITRIC OXIDE SYNTHASE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

EID: 0034930737     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.7.1613     Document Type: Article

References (45)

1. BMY-14802 protects against ischemia-induced neuronal damage in the gerbil
2. 3H]dopamine release from rat striatal slices by σ receptor ligands
3. 1-Receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine affords neuroprotection from focal ischemia with prolonged reperfusion
4. σ-Ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia
5. Neuroprotective effects of (+)SKF 10,047 in vitro and in gerbil global brain ischemia
6. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent σ-receptor ligand, decreases brain injury after transient focal ischemia in cats
7. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats
8. Neuroprotection from focal ischemia by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is dependent on treatment duration in rats
9. Distinct neuroprotective profiles for σ-ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies
10. σ Receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures
11. Role of calcium in sigma-mediated neuroprotection in rat primary cortical cultures
12. 1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo
13. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents, II: Evidence for N-methyl-D-aspartate receptor antagonist properties
14. Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site
15. A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression
16. Neuroprotective sigma ligands interfere with the glutamate-activated NOS pathway in hippocampal cell culture
17. Neurobiology of ischemic stroke: An integrated view
18. Bright and dark sides of nitric oxide in ischemic brain injury
19. Nitric oxide synthase in models of focal ischemia
20. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
21. 7-Nitroindazole reduces nitric oxide concentration in rat hippocampus after transient forebrain ischemia
22. The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats
23. Gender-linked brain injury in experimental stroke
24. Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats
25. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
26. Stroke in estrogen receptor-alpha-deficient mice
27. Estrogen receptor antagonist, ICI182,780. Exacerbates ischemic injury in female mouse
28. Adenosine modulates N-methyl-D-aspartate-stimulated hippocampal nitric oxide production in vivo
29. Characterization of ionotropic glutamate receptor-mediated nitric oxide production in vivo in rats
30. Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo
31. Localization of nitric oxide synthase indicating a neural role for nitric oxide
32. Reversible middle cerebral artery occlusion without craniectomy in rats
33. Targeted disruption of the neuronal nitric oxide synthase gene
34. 3H]4-phenyl-1-(4-phenylbutyl) piperidine
35. 1-binding site
36. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons
37. Activation of metabotropic glutamate receptors in hippocampus increases cyclic AMP accumulation
38. Selective neuronal NOS inhibitor decreases infarct volume after transient focal cerebral ischemia in rats
39. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
40. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia
41. Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion
42. Model studies for brain dialysis
43. Glutamate: A neurotransmitter in mammalian brain
44. Extracellular cGMP in the hippocampus of freely moving rats as an index of nitric oxide (NO) synthase activity