메뉴 건너뛰기




Volumn 155, Issue 1, 2008, Pages 104-113

Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock protein 70 levels are modulated in microglial cells

Author keywords

FK506; microglia; motoneuron; neuroprotection; organotypic culture; spinal cord injury

Indexed keywords

GELDANAMYCIN; GLUTAMIC ACID; HEAT SHOCK PROTEIN 70; TACROLIMUS;

EID: 47249145512     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.04.078     Document Type: Article
Times cited : (28)

References (76)
  • 2
    • 0025059371 scopus 로고
    • Histamine stimulation of cyclic AMP accumulation in astrocyte-enriched and neuronal primary cultures from rat brain
    • Agullo L., Picatoste F., and Garcia A. Histamine stimulation of cyclic AMP accumulation in astrocyte-enriched and neuronal primary cultures from rat brain. J Neurochem 55 (1990) 1592-1598
    • (1990) J Neurochem , vol.55 , pp. 1592-1598
    • Agullo, L.1    Picatoste, F.2    Garcia, A.3
  • 3
    • 0242570575 scopus 로고    scopus 로고
    • Spinal circuits formation: a study of developmentally regulated markers in organotypic cultures of embryonic mouse spinal cord
    • Avossa D., Rosato-Siri M.D., Mazzarol F., and Ballerini L. Spinal circuits formation: a study of developmentally regulated markers in organotypic cultures of embryonic mouse spinal cord. Neuroscience 122 (2003) 391-405
    • (2003) Neuroscience , vol.122 , pp. 391-405
    • Avossa, D.1    Rosato-Siri, M.D.2    Mazzarol, F.3    Ballerini, L.4
  • 4
    • 19444379962 scopus 로고    scopus 로고
    • Oxidative and heat stress gene changes in hypertrophic scar fibroblasts stimulated with interleukin-1beta
    • Barrow R.E., and Dasu M.R. Oxidative and heat stress gene changes in hypertrophic scar fibroblasts stimulated with interleukin-1beta. J Surg Res 126 (2005) 59-65
    • (2005) J Surg Res , vol.126 , pp. 59-65
    • Barrow, R.E.1    Dasu, M.R.2
  • 6
    • 0032816454 scopus 로고    scopus 로고
    • The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration
    • Bavetta S., Hamlyn P.J., Burnstock G., Lieberman A.R., and Anderson P.N. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. Exp Neurol 158 (1999) 382-393
    • (1999) Exp Neurol , vol.158 , pp. 382-393
    • Bavetta, S.1    Hamlyn, P.J.2    Burnstock, G.3    Lieberman, A.R.4    Anderson, P.N.5
  • 7
    • 0033963212 scopus 로고    scopus 로고
    • Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain
    • Bechtold D.A., Rush S.J., and Brown I.R. Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain. J Neurochem 74 (2000) 641-646
    • (2000) J Neurochem , vol.74 , pp. 641-646
    • Bechtold, D.A.1    Rush, S.J.2    Brown, I.R.3
  • 8
    • 0033550906 scopus 로고    scopus 로고
    • Cellular localization of the heat shock transcription factors HSF1 and HSF2 in the rat brain during postnatal development and following hyperthermia
    • Brown I.R., and Rush S.J. Cellular localization of the heat shock transcription factors HSF1 and HSF2 in the rat brain during postnatal development and following hyperthermia. Brain Res 821 (1999) 333-340
    • (1999) Brain Res , vol.821 , pp. 333-340
    • Brown, I.R.1    Rush, S.J.2
  • 9
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky O., Talpalar A.E., Ben-Yaakov K., and Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci 29 (2005) 381-393
    • (2005) Mol Cell Neurosci , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben-Yaakov, K.3    Schwartz, M.4
  • 10
    • 0032031661 scopus 로고    scopus 로고
    • Evident transsynaptic degeneration of motor neurons after spinal cord injury: a study of neuromuscular jitter by axonal microstimulation
    • Chang C.W. Evident transsynaptic degeneration of motor neurons after spinal cord injury: a study of neuromuscular jitter by axonal microstimulation. Am J Phys Med Rehabil 77 (1998) 118-121
    • (1998) Am J Phys Med Rehabil , vol.77 , pp. 118-121
    • Chang, C.W.1
  • 11
    • 0029097801 scopus 로고
    • Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin
    • Chang H.Y., Takei K., Sydor A.M., Born T., Rusnak F., and Jay D.G. Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 376 (1995) 686-690
    • (1995) Nature , vol.376 , pp. 686-690
    • Chang, H.Y.1    Takei, K.2    Sydor, A.M.3    Born, T.4    Rusnak, F.5    Jay, D.G.6
  • 12
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 13
    • 33745785027 scopus 로고    scopus 로고
    • Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia
    • Christensen R.N., Ha B.K., Sun F., Bresnahan J.C., and Beattie M.S. Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia. J Neurosci Res 84 (2006) 170-181
    • (2006) J Neurosci Res , vol.84 , pp. 170-181
    • Christensen, R.N.1    Ha, B.K.2    Sun, F.3    Bresnahan, J.C.4    Beattie, M.S.5
  • 14
    • 0003299278 scopus 로고
    • Organotypic spinal cord cultures and a model of chronic glutamate-mediated motor neuron degeneration
    • Ohnishi S.T., and Ohnishi T.E. (Eds), CRC Press, New York
    • Corse A.M., and Rothstein J.D. Organotypic spinal cord cultures and a model of chronic glutamate-mediated motor neuron degeneration. In: Ohnishi S.T., and Ohnishi T.E. (Eds). Central nervous system trauma research techniques (1995), CRC Press, New York 341-351
    • (1995) Central nervous system trauma research techniques , pp. 341-351
    • Corse, A.M.1    Rothstein, J.D.2
  • 16
    • 0027453536 scopus 로고
    • Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
    • Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., and Snyder S.H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci U S A 90 (1993) 9808-9812
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9808-9812
    • Dawson, T.M.1    Steiner, J.P.2    Dawson, V.L.3    Dinerman, J.L.4    Uhl, G.R.5    Snyder, S.H.6
  • 17
    • 0029914112 scopus 로고    scopus 로고
    • Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis
    • Farooque M., Hillered L., Holtz A., and Olsson Y. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J Neurotrauma 13 (1996) 537-548
    • (1996) J Neurotrauma , vol.13 , pp. 537-548
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 18
    • 0026033354 scopus 로고
    • Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines
    • Fincato G., Polentarutti N., Sica A., Mantovani A., and Colotta F. Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines. Blood 77 (1991) 579-586
    • (1991) Blood , vol.77 , pp. 579-586
    • Fincato, G.1    Polentarutti, N.2    Sica, A.3    Mantovani, A.4    Colotta, F.5
  • 19
    • 0032806939 scopus 로고    scopus 로고
    • A submersion method to induce hypoxic damage in organotypic hippocampal cultures
    • Frantseva M.V., Carlen P.L., and El-Beheiry H. A submersion method to induce hypoxic damage in organotypic hippocampal cultures. J Neurosci Methods 89 (1999) 25-31
    • (1999) J Neurosci Methods , vol.89 , pp. 25-31
    • Frantseva, M.V.1    Carlen, P.L.2    El-Beheiry, H.3
  • 20
    • 0019725433 scopus 로고
    • Organotypic monolayer cultures of nervous tissue
    • Gahwiler B.H. Organotypic monolayer cultures of nervous tissue. J Neurosci Methods 4 (1981) 329-342
    • (1981) J Neurosci Methods , vol.4 , pp. 329-342
    • Gahwiler, B.H.1
  • 22
    • 0034653555 scopus 로고    scopus 로고
    • Opposite changes in synaptic activity of organotypic rat spinal cord cultures after chronic block of AMPA/kainate or glycine and GABAA receptors
    • Galante M., Nistri A., and Ballerini L. Opposite changes in synaptic activity of organotypic rat spinal cord cultures after chronic block of AMPA/kainate or glycine and GABAA receptors. J Physiol 523 Pt 3 (2000) 639-651
    • (2000) J Physiol , vol.523 , Issue.PART 3 , pp. 639-651
    • Galante, M.1    Nistri, A.2    Ballerini, L.3
  • 23
    • 33747784580 scopus 로고    scopus 로고
    • Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries
    • García-Alias G., Valero-Cabré A., López-Vales R., Forés J., Verdú E., and Navarro X. Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries. Brain Res 1108 (2006) 195-204
    • (2006) Brain Res , vol.1108 , pp. 195-204
    • García-Alias, G.1    Valero-Cabré, A.2    López-Vales, R.3    Forés, J.4    Verdú, E.5    Navarro, X.6
  • 24
    • 0027333423 scopus 로고
    • Role of the major heat shock proteins as molecular chaperones
    • Georgopoulos C., and Welch W.J. Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Biol 9 (1993) 601-634
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 601-634
    • Georgopoulos, C.1    Welch, W.J.2
  • 25
    • 0025376090 scopus 로고
    • A stable double-stranded DNA-ethidium homodimer complex: application to picogram fluorescence detection of DNA in agarose gels
    • Glazer A.N., Peck K., and Mathies R.A. A stable double-stranded DNA-ethidium homodimer complex: application to picogram fluorescence detection of DNA in agarose gels. Proc Natl Acad Sci U S A 87 (1990) 3851-3855
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3851-3855
    • Glazer, A.N.1    Peck, K.2    Mathies, R.A.3
  • 26
    • 0033034203 scopus 로고    scopus 로고
    • Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
    • Gold B.G., Densmore V., Shou W., Matzuk M.M., and Gordon H.S. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther 289 (1999) 1202-1210
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1202-1210
    • Gold, B.G.1    Densmore, V.2    Shou, W.3    Matzuk, M.M.4    Gordon, H.S.5
  • 27
    • 0028783373 scopus 로고
    • The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve
    • Gold B.G., Katoh K., and Storm-Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J Neurosci 15 (1995) 7509-7516
    • (1995) J Neurosci , vol.15 , pp. 7509-7516
    • Gold, B.G.1    Katoh, K.2    Storm-Dickerson, T.3
  • 28
    • 2942565668 scopus 로고    scopus 로고
    • Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies
    • Gold B.G., Udina E., Bourdette D., and Navarro X. Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies. Neurol Res 26 (2004) 371-380
    • (2004) Neurol Res , vol.26 , pp. 371-380
    • Gold, B.G.1    Udina, E.2    Bourdette, D.3    Navarro, X.4
  • 29
    • 1842814246 scopus 로고    scopus 로고
    • The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy
    • Gold B.G., Voda J., Yu X., and Gordon H. The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy. Exp Neurol 187 (2004) 160-170
    • (2004) Exp Neurol , vol.187 , pp. 160-170
    • Gold, B.G.1    Voda, J.2    Yu, X.3    Gordon, H.4
  • 30
    • 0141595912 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds
    • Gold B.G., and Villafranca J.E. Neuroimmunophilin ligands: the development of novel neuroregenerative/neuroprotective compounds. Curr Top Med Chem 3 (2003) 1368-1375
    • (2003) Curr Top Med Chem , vol.3 , pp. 1368-1375
    • Gold, B.G.1    Villafranca, J.E.2
  • 31
    • 20444441180 scopus 로고    scopus 로고
    • Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures
    • Hailer N.P., Vogt C., Korf H.W., and Dehghani F. Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Eur J Neurosci 21 (2005) 2347-2360
    • (2005) Eur J Neurosci , vol.21 , pp. 2347-2360
    • Hailer, N.P.1    Vogt, C.2    Korf, H.W.3    Dehghani, F.4
  • 32
    • 18744390011 scopus 로고    scopus 로고
    • Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages
    • Hausler K.G., Prinz M., Nolte C., Weber J.R., Schumann R.R., Kettenmann H., and Hanisch U.K. Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci 16 (2002) 2113-2122
    • (2002) Eur J Neurosci , vol.16 , pp. 2113-2122
    • Hausler, K.G.1    Prinz, M.2    Nolte, C.3    Weber, J.R.4    Schumann, R.R.5    Kettenmann, H.6    Hanisch, U.K.7
  • 33
    • 33645979933 scopus 로고    scopus 로고
    • Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors
    • Hayashi Y., Ishibashi H., Hashimoto K., and Nakanishi H. Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors. Glia 53 (2006) 660-668
    • (2006) Glia , vol.53 , pp. 660-668
    • Hayashi, Y.1    Ishibashi, H.2    Hashimoto, K.3    Nakanishi, H.4
  • 34
    • 9144271238 scopus 로고    scopus 로고
    • Glial expression of the 90-kDa heat shock protein (HSP90) and the 94-kDa glucose-regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus
    • Jeon G.S., Park S.W., Kim D.W., Seo J.H., Cho J., Lim S.Y., Kim S.D., and Cho S.S. Glial expression of the 90-kDa heat shock protein (HSP90) and the 94-kDa glucose-regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus. Glia 48 (2004) 250-258
    • (2004) Glia , vol.48 , pp. 250-258
    • Jeon, G.S.1    Park, S.W.2    Kim, D.W.3    Seo, J.H.4    Cho, J.5    Lim, S.Y.6    Kim, S.D.7    Cho, S.S.8
  • 35
    • 3142705798 scopus 로고    scopus 로고
    • Molecular mechanisms of neuroprotective action of immunosuppressants-facts and hypotheses
    • Kaminska B., Gaweda-Walerych K., and Zawadzka M. Molecular mechanisms of neuroprotective action of immunosuppressants-facts and hypotheses. J Cell Mol Med 8 (2004) 45-58
    • (2004) J Cell Mol Med , vol.8 , pp. 45-58
    • Kaminska, B.1    Gaweda-Walerych, K.2    Zawadzka, M.3
  • 36
    • 0037352890 scopus 로고    scopus 로고
    • The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
    • Klettner A., and Herdegen T. The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br J Pharmacol 138 (2003) 1004-1012
    • (2003) Br J Pharmacol , vol.138 , pp. 1004-1012
    • Klettner, A.1    Herdegen, T.2
  • 38
    • 22244440491 scopus 로고    scopus 로고
    • Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity
    • Lai Y., Du L., Dunsmore K.E., Jenkins L.W., Wong H.R., and Clark R.S. Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity. J Neurochem 94 (2005) 360-366
    • (2005) J Neurochem , vol.94 , pp. 360-366
    • Lai, Y.1    Du, L.2    Dunsmore, K.E.3    Jenkins, L.W.4    Wong, H.R.5    Clark, R.S.6
  • 39
    • 0036128693 scopus 로고    scopus 로고
    • AFGF promotes axonal growth in rat spinal cord organotypic slice co-cultures
    • Lee Y.S., Baratta J., Yu J., Lin V.W., and Robertson R.T. AFGF promotes axonal growth in rat spinal cord organotypic slice co-cultures. J Neurotrauma 19 (2002) 357-367
    • (2002) J Neurotrauma , vol.19 , pp. 357-367
    • Lee, Y.S.1    Baratta, J.2    Yu, J.3    Lin, V.W.4    Robertson, R.T.5
  • 40
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S.A., and Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330 (1994) 613-622
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 41
    • 0025907224 scopus 로고
    • Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
    • Liu D., Thangnipon W., and McAdoo D.J. Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res 547 (1991) 344-348
    • (1991) Brain Res , vol.547 , pp. 344-348
    • Liu, D.1    Thangnipon, W.2    McAdoo, D.J.3
  • 42
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J., Farmer Jr. J.D., Lane W.S., Friedman J., Weissman I., and Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66 (1991) 807-815
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 43
    • 0032791163 scopus 로고    scopus 로고
    • Neurotoxicity of glutamate at the concentration released upon spinal cord injury
    • Liu D., Xu G.Y., Pan E., and McAdoo D.J. Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience 93 (1999) 1383-1389
    • (1999) Neuroscience , vol.93 , pp. 1383-1389
    • Liu, D.1    Xu, G.Y.2    Pan, E.3    McAdoo, D.J.4
  • 44
    • 33750824777 scopus 로고    scopus 로고
    • Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury
    • López-Vales R., Forés J., Navarro X., and Verdú E. Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury. Neurobiol Dis 24 (2006) 443-454
    • (2006) Neurobiol Dis , vol.24 , pp. 443-454
    • López-Vales, R.1    Forés, J.2    Navarro, X.3    Verdú, E.4
  • 46
    • 0026328490 scopus 로고
    • The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity
    • Lowenstein D.H., Chan P.H., and Miles M.F. The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Neuron 7 (1991) 1053-1060
    • (1991) Neuron , vol.7 , pp. 1053-1060
    • Lowenstein, D.H.1    Chan, P.H.2    Miles, M.F.3
  • 47
    • 0034662011 scopus 로고    scopus 로고
    • Advances in secondary spinal cord injury: role of apoptosis
    • Lu J., Ashwell K.W., and Waite P. Advances in secondary spinal cord injury: role of apoptosis. Spine 25 (2000) 1859-1866
    • (2000) Spine , vol.25 , pp. 1859-1866
    • Lu, J.1    Ashwell, K.W.2    Waite, P.3
  • 48
  • 49
    • 0026740369 scopus 로고
    • Expression of heat shock genes (hsp70) in the rabbit spinal cord: localization of constitutive and hyperthermia-inducible mRNA species
    • Manzerra P., and Brown I.R. Expression of heat shock genes (hsp70) in the rabbit spinal cord: localization of constitutive and hyperthermia-inducible mRNA species. J Neurosci Res 31 (1992) 606-615
    • (1992) J Neurosci Res , vol.31 , pp. 606-615
    • Manzerra, P.1    Brown, I.R.2
  • 50
    • 0034680965 scopus 로고    scopus 로고
    • Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat
    • Mautes A.E., and Noble L.J. Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat. Brain Res 883 (2000) 233-237
    • (2000) Brain Res , vol.883 , pp. 233-237
    • Mautes, A.E.1    Noble, L.J.2
  • 51
    • 0032848944 scopus 로고    scopus 로고
    • Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
    • McAdoo D.J., Xu G.Y., Robak G., and Hughes M.G. Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord. Exp Neurol 159 (1999) 538-544
    • (1999) Exp Neurol , vol.159 , pp. 538-544
    • McAdoo, D.J.1    Xu, G.Y.2    Robak, G.3    Hughes, M.G.4
  • 52
    • 0036303385 scopus 로고    scopus 로고
    • Stimulation of the weak ATPase activity of human hsp90 by a client protein
    • McLaughlin S.H., Smith H.W., and Jackson S.E. Stimulation of the weak ATPase activity of human hsp90 by a client protein. J Mol Biol 315 (2002) 787-798
    • (2002) J Mol Biol , vol.315 , pp. 787-798
    • McLaughlin, S.H.1    Smith, H.W.2    Jackson, S.E.3
  • 53
    • 0010387582 scopus 로고
    • A rapid, pH insensitive, two color fluorescence viability (cytotoxicity) assay
    • [Abstract No. 304]
    • Moore P.L., MacCoubrey I.C., and Haugland R.P. A rapid, pH insensitive, two color fluorescence viability (cytotoxicity) assay. J Cell Biol (1990) 111 [Abstract No. 304]
    • (1990) J Cell Biol , pp. 111
    • Moore, P.L.1    MacCoubrey, I.C.2    Haugland, R.P.3
  • 54
    • 0032535245 scopus 로고    scopus 로고
    • Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
    • Morimoto R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12 (1998) 3788-3796
    • (1998) Genes Dev , vol.12 , pp. 3788-3796
    • Morimoto, R.I.1
  • 55
    • 0038642590 scopus 로고    scopus 로고
    • Detailed in vitro pharmacological analysis of FK506-induced neuroprotection
    • Muramoto M., Yamazaki T., Nishimura S., and Kita Y. Detailed in vitro pharmacological analysis of FK506-induced neuroprotection. Neuropharmacology 45 (2003) 394-403
    • (2003) Neuropharmacology , vol.45 , pp. 394-403
    • Muramoto, M.1    Yamazaki, T.2    Nishimura, S.3    Kita, Y.4
  • 56
    • 0025162091 scopus 로고
    • Alteration in extracellular amino acids after traumatic spinal cord injury
    • Panter S.S., Yum S.W., and Faden A.I. Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27 (1990) 96-99
    • (1990) Ann Neurol , vol.27 , pp. 96-99
    • Panter, S.S.1    Yum, S.W.2    Faden, A.I.3
  • 57
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration
    • Park E., Velumian A.A., and Fehlings M.G. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 21 (2004) 754-774
    • (2004) J Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 58
    • 0032959590 scopus 로고    scopus 로고
    • Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
    • Roe S.M., Prodromou C., O'Brien R., Ladbury J.E., Piper P.W., and Pearl L.H. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 42 (1999) 260-266
    • (1999) J Med Chem , vol.42 , pp. 260-266
    • Roe, S.M.1    Prodromou, C.2    O'Brien, R.3    Ladbury, J.E.4    Piper, P.W.5    Pearl, L.H.6
  • 59
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein J.D., Jin L., Dykes-Hoberg M., and Kuncl R.W. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci U S A 90 (1993) 6591-6595
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 60
    • 2142715917 scopus 로고    scopus 로고
    • FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats
    • Sasaki T., Hamada J., Shibata M., Gotoh J., Araki N., and Fukuuchi Y. FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats. Brain Res 1009 (2004) 34-39
    • (2004) Brain Res , vol.1009 , pp. 34-39
    • Sasaki, T.1    Hamada, J.2    Shibata, M.3    Gotoh, J.4    Araki, N.5    Fukuuchi, Y.6
  • 61
    • 0037154968 scopus 로고    scopus 로고
    • A 72 kDa heat shock protein is protective against the selective vulnerability of CA1 neurons and is essential for the tolerance exhibited by CA3 neurons in the hippocampus
    • Sato K., and Matsuki N. A 72 kDa heat shock protein is protective against the selective vulnerability of CA1 neurons and is essential for the tolerance exhibited by CA3 neurons in the hippocampus. Neuroscience 109 (2002) 745-756
    • (2002) Neuroscience , vol.109 , pp. 745-756
    • Sato, K.1    Matsuki, N.2
  • 63
    • 14844309321 scopus 로고    scopus 로고
    • Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators
    • Shaked I., Tchoresh D., Gersner R., Meiri G., Mordechai S., Xiao X., Hart R.P., and Schwartz M. Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. J Neurochem 92 (2005) 997-1009
    • (2005) J Neurochem , vol.92 , pp. 997-1009
    • Shaked, I.1    Tchoresh, D.2    Gersner, R.3    Meiri, G.4    Mordechai, S.5    Xiao, X.6    Hart, R.P.7    Schwartz, M.8
  • 64
    • 0030975605 scopus 로고    scopus 로고
    • Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
    • Steiner J.P., Connolly M.A., Valentine H.L., Hamilton G.S., Dawson T.M., Hester L., and Snyder S.H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 3 (1997) 421-428
    • (1997) Nat Med , vol.3 , pp. 421-428
    • Steiner, J.P.1    Connolly, M.A.2    Valentine, H.L.3    Hamilton, G.S.4    Dawson, T.M.5    Hester, L.6    Snyder, S.H.7
  • 65
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L., Buchs P.A., and Muller D. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37 (1991) 173-182
    • (1991) J Neurosci Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 67
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator C.H., and Fehlings M.G. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75 (1991) 15-26
    • (1991) J Neurosurg , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 68
    • 0342657086 scopus 로고    scopus 로고
    • Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS
    • Tsang Y.M., Chiong F., Kuznetsov D., Kasarskis E., and Geula C. Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS. Brain Res 861 (2000) 45-58
    • (2000) Brain Res , vol.861 , pp. 45-58
    • Tsang, Y.M.1    Chiong, F.2    Kuznetsov, D.3    Kasarskis, E.4    Geula, C.5
  • 69
    • 0036730462 scopus 로고    scopus 로고
    • Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve
    • Udina E., Ceballos D., Verdú E., Gold B.G., and Navarro X. Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve. Muscle Nerve 26 (2002) 348-355
    • (2002) Muscle Nerve , vol.26 , pp. 348-355
    • Udina, E.1    Ceballos, D.2    Verdú, E.3    Gold, B.G.4    Navarro, X.5
  • 70
    • 3943051255 scopus 로고    scopus 로고
    • FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells
    • Udina E., Rodriguez F.J., Verdú E., Espejo M., Gold B.G., and Navarro X. FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells. Glia 47 (2004) 120-129
    • (2004) Glia , vol.47 , pp. 120-129
    • Udina, E.1    Rodriguez, F.J.2    Verdú, E.3    Espejo, M.4    Gold, B.G.5    Navarro, X.6
  • 71
    • 0033289087 scopus 로고    scopus 로고
    • FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft
    • Wang M.S., and Gold B.G. FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. J Spinal Cord Med 22 (1999) 287-296
    • (1999) J Spinal Cord Med , vol.22 , pp. 287-296
    • Wang, M.S.1    Gold, B.G.2
  • 72
    • 0030839896 scopus 로고    scopus 로고
    • Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve
    • Wang M.S., Zeleny-Pooley M., and Gold B.G. Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. J Pharmacol Exp Ther 282 (1997) 1084-1093
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1084-1093
    • Wang, M.S.1    Zeleny-Pooley, M.2    Gold, B.G.3
  • 73
    • 0033777909 scopus 로고    scopus 로고
    • Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro
    • Wilde G.J., Pringle A.K., Sundstrom L.E., Mann D.A., and Iannotti F. Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro. Eur J Neurosci 12 (2000) 3863-3870
    • (2000) Eur J Neurosci , vol.12 , pp. 3863-3870
    • Wilde, G.J.1    Pringle, A.K.2    Sundstrom, L.E.3    Mann, D.A.4    Iannotti, F.5
  • 74
    • 0031862204 scopus 로고    scopus 로고
    • Considerations in the determination by microdialysis of resting extracellular amino acid concentrations and release upon spinal cord injury
    • Xu G.Y., McAdoo D.J., Hughes M.G., Robak G., and de Castro Jr. R. Considerations in the determination by microdialysis of resting extracellular amino acid concentrations and release upon spinal cord injury. Neuroscience 86 (1998) 1011-1021
    • (1998) Neuroscience , vol.86 , pp. 1011-1021
    • Xu, G.Y.1    McAdoo, D.J.2    Hughes, M.G.3    Robak, G.4    de Castro Jr., R.5
  • 75
    • 0037302354 scopus 로고    scopus 로고
    • Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes
    • Zawadzka M., and Kaminska B. Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes. Mol Cell Neurosci 22 (2003) 202-209
    • (2003) Mol Cell Neurosci , vol.22 , pp. 202-209
    • Zawadzka, M.1    Kaminska, B.2
  • 76
    • 11144347830 scopus 로고    scopus 로고
    • A novel mechanism of FK506-mediated neuroprotection: downregulation of cytokine expression in glial cells
    • Zawadzka M., and Kaminska B. A novel mechanism of FK506-mediated neuroprotection: downregulation of cytokine expression in glial cells. Glia 49 (2005) 36-51
    • (2005) Glia , vol.49 , pp. 36-51
    • Zawadzka, M.1    Kaminska, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.