-
1
-
-
33644832749
-
Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene
-
Aoki M., Kato S., Nagai M., and Itoyama Y. Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene. Neuropathology 25 (2005) 365-370
-
(2005)
Neuropathology
, vol.25
, pp. 365-370
-
-
Aoki, M.1
Kato, S.2
Nagai, M.3
Itoyama, Y.4
-
2
-
-
0036787365
-
Survival-promoting activity of nimodipine and nifedipine in rat motoneurons: implications of an intrinsic calcium toxicity in motoneurons
-
Arakawa Y., Nishijima C., Shimizu N., and Urushidani T. Survival-promoting activity of nimodipine and nifedipine in rat motoneurons: implications of an intrinsic calcium toxicity in motoneurons. J. Neurochem. 83 (2002) 150-156
-
(2002)
J. Neurochem.
, vol.83
, pp. 150-156
-
-
Arakawa, Y.1
Nishijima, C.2
Shimizu, N.3
Urushidani, T.4
-
3
-
-
0025514410
-
Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines
-
Arakawa Y., Sendtner M., and Thoenen H. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci. 10 (1990) 3507-3515
-
(1990)
J. Neurosci.
, vol.10
, pp. 3507-3515
-
-
Arakawa, Y.1
Sendtner, M.2
Thoenen, H.3
-
4
-
-
0344076149
-
A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)
-
BDNF-Group
-
BDNF-Group. A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III). Neurology 52 (1999) 1427-1433
-
(1999)
Neurology
, vol.52
, pp. 1427-1433
-
-
-
5
-
-
0028097839
-
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
-
Bensimon G., Lacomblez L., and Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med 330 (1994) 585-591
-
(1994)
N Engl J Med
, vol.330
, pp. 585-591
-
-
Bensimon, G.1
Lacomblez, L.2
Meininger, V.3
-
6
-
-
0031722582
-
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
-
Borasio G.D., Robberecht W., Leigh P.N., Emile J., Guiloff R.J., Jerusalem F., Silani V., Vos P.E., Wokke J.H., and Dobbins T. A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group. Neurology 51 (1998) 583-586
-
(1998)
Neurology
, vol.51
, pp. 583-586
-
-
Borasio, G.D.1
Robberecht, W.2
Leigh, P.N.3
Emile, J.4
Guiloff, R.J.5
Jerusalem, F.6
Silani, V.7
Vos, P.E.8
Wokke, J.H.9
Dobbins, T.10
-
7
-
-
2442646665
-
A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group
-
CNTF-Group. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46 (1996) 1244-1249
-
(1996)
Neurology
, vol.46
, pp. 1244-1249
-
-
CNTF-Group1
-
8
-
-
33644835931
-
Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen
-
Cordey M., and Pike C.J. Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. J. Neurochem. 96 (2006) 204-217
-
(2006)
J. Neurochem.
, vol.96
, pp. 204-217
-
-
Cordey, M.1
Pike, C.J.2
-
9
-
-
0027478471
-
Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures
-
Felipo V., Minana M.D., and Grisolia S. Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res. 604 (1993) 192-196
-
(1993)
Brain Res.
, vol.604
, pp. 192-196
-
-
Felipo, V.1
Minana, M.D.2
Grisolia, S.3
-
10
-
-
36148960127
-
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
-
Gordon P.H., Moore D.H., Miller R.G., Florence J.M., Verheijde J.L., Doorish C., Hilton J.F., Spitalny G.M., MacArthur R.B., Mitsumoto H., Neville H.E., Boylan K., Mozaffar T., Belsh J.M., Ravits J., Bedlack R.S., Graves M.C., McCluskey L.F., Barohn R.J., and Tandan R. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol. 6 (2007) 1045-1053
-
(2007)
Lancet Neurol.
, vol.6
, pp. 1045-1053
-
-
Gordon, P.H.1
Moore, D.H.2
Miller, R.G.3
Florence, J.M.4
Verheijde, J.L.5
Doorish, C.6
Hilton, J.F.7
Spitalny, G.M.8
MacArthur, R.B.9
Mitsumoto, H.10
Neville, H.E.11
Boylan, K.12
Mozaffar, T.13
Belsh, J.M.14
Ravits, J.15
Bedlack, R.S.16
Graves, M.C.17
McCluskey, L.F.18
Barohn, R.J.19
Tandan, R.20
more..
-
11
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., Chen W., Zhai P., Sufit R.L., and Siddique T. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264 (1994) 1772-1775
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.X.10
Chen, W.11
Zhai, P.12
Sufit, R.L.13
Siddique, T.14
-
12
-
-
1942472491
-
Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C
-
Han Y.S., Zheng W.H., Bastianetto S., Chabot J.G., and Quirion R. Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br. J. Pharmacol. 141 (2004) 997-1005
-
(2004)
Br. J. Pharmacol.
, vol.141
, pp. 997-1005
-
-
Han, Y.S.1
Zheng, W.H.2
Bastianetto, S.3
Chabot, J.G.4
Quirion, R.5
-
13
-
-
0345184327
-
Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord
-
Hu J.H., Zhang H., Wagey R., Krieger C., and Pelech S.L. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. J. Neurochem. 85 (2003) 432-442
-
(2003)
J. Neurochem.
, vol.85
, pp. 432-442
-
-
Hu, J.H.1
Zhang, H.2
Wagey, R.3
Krieger, C.4
Pelech, S.L.5
-
14
-
-
0030959304
-
Bcl-2 phosphorylation required for anti-apoptosis function
-
Ito T., Deng X., Carr B., and May W.S. Bcl-2 phosphorylation required for anti-apoptosis function. J. Biol. Chem. 272 (1997) 11671-11673
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11671-11673
-
-
Ito, T.1
Deng, X.2
Carr, B.3
May, W.S.4
-
15
-
-
20044393676
-
Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons
-
Jung Y.S., Lee B.K., Park H.S., Shim J.K., Kim S.U., Lee S.H., Baik E.J., and Moon C.H. Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons. Neuroreport 16 (2005) 741-744
-
(2005)
Neuroreport
, vol.16
, pp. 741-744
-
-
Jung, Y.S.1
Lee, B.K.2
Park, H.S.3
Shim, J.K.4
Kim, S.U.5
Lee, S.H.6
Baik, E.J.7
Moon, C.H.8
-
16
-
-
0141918835
-
Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis
-
Krieger C., Hu J.H., and Pelech S. Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis. Trends Pharmacol. Sci. 24 (2003) 535-541
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 535-541
-
-
Krieger, C.1
Hu, J.H.2
Pelech, S.3
-
17
-
-
15044346521
-
Deficient RNA editing of GluR2 and neuronal death in amyotrophic lateral sclerosis
-
Kwak S., and Kawahara Y. Deficient RNA editing of GluR2 and neuronal death in amyotrophic lateral sclerosis. J. Mol. Med. 83 (2005) 110-120
-
(2005)
J. Mol. Med.
, vol.83
, pp. 110-120
-
-
Kwak, S.1
Kawahara, Y.2
-
18
-
-
0029977337
-
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/Riluzole Study Group II
-
Lacomblez L., Bensimon G., Leigh P.N., Guillet P., and Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/Riluzole Study Group II. Lancet 347 (1996) 1425-1431
-
(1996)
Lancet
, vol.347
, pp. 1425-1431
-
-
Lacomblez, L.1
Bensimon, G.2
Leigh, P.N.3
Guillet, P.4
Meininger, V.5
-
19
-
-
0029731655
-
A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II
-
Lacomblez L., Bensimon G., Leigh P.N., Guillet P., Powe L., Durrleman S., Delumeau J.C., and Meininger V. A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II. Neurology 47 (1996) S242-S250
-
(1996)
Neurology
, vol.47
-
-
Lacomblez, L.1
Bensimon, G.2
Leigh, P.N.3
Guillet, P.4
Powe, L.5
Durrleman, S.6
Delumeau, J.C.7
Meininger, V.8
-
20
-
-
6844266272
-
Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group
-
Lai E.C., Felice K.J., Festoff B.W., Gawel M.J., Gelinas D.F., Kratz R., Murphy M.F., Natter H.M., Norris F.H., and Rudnicki S.A. Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 49 (1997) 1621-1630
-
(1997)
Neurology
, vol.49
, pp. 1621-1630
-
-
Lai, E.C.1
Felice, K.J.2
Festoff, B.W.3
Gawel, M.J.4
Gelinas, D.F.5
Kratz, R.6
Murphy, M.F.7
Natter, H.M.8
Norris, F.H.9
Rudnicki, S.A.10
-
21
-
-
27644472331
-
Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons
-
Lallemend F., Hadjab S., Hans G., Moonen G., Lefebvre P.P., and Malgrange B. Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons. J. Cell Sci. 118 (2005) 4511-4525
-
(2005)
J. Cell Sci.
, vol.118
, pp. 4511-4525
-
-
Lallemend, F.1
Hadjab, S.2
Hans, G.3
Moonen, G.4
Lefebvre, P.P.5
Malgrange, B.6
-
22
-
-
10244237798
-
Recombinant human insulin-like growth factor-I in ALS: description of a double-blind, placebo-controlled study. North American ALS/IGF-I Study Group
-
discussion S94-S95
-
Lange D.J., Felice K.J., Festoff B.W., Gawel M.J., Gelinas D.F., Kratz R., Lai E.C., Murphy M.F., Natter H.M., Norris F.H., and Rudnicki S. Recombinant human insulin-like growth factor-I in ALS: description of a double-blind, placebo-controlled study. North American ALS/IGF-I Study Group. Neurology 47 (1996) S93-S94 discussion S94-S95
-
(1996)
Neurology
, vol.47
-
-
Lange, D.J.1
Felice, K.J.2
Festoff, B.W.3
Gawel, M.J.4
Gelinas, D.F.5
Kratz, R.6
Lai, E.C.7
Murphy, M.F.8
Natter, H.M.9
Norris, F.H.10
Rudnicki, S.11
-
23
-
-
0032032013
-
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
-
Lin C.L., Bristol L.A., Jin L., Dykes-Hoberg M., Crawford T., Clawson L., and Rothstein J.D. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 20 (1998) 589-602
-
(1998)
Neuron
, vol.20
, pp. 589-602
-
-
Lin, C.L.1
Bristol, L.A.2
Jin, L.3
Dykes-Hoberg, M.4
Crawford, T.5
Clawson, L.6
Rothstein, J.D.7
-
24
-
-
0030825472
-
Therapeutic advances in amyotrophic lateral sclerosis
-
Louvel E., Hugon J., and Doble A. Therapeutic advances in amyotrophic lateral sclerosis. Trends Pharmacol. Sci. 18 (1997) 196-203
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 196-203
-
-
Louvel, E.1
Hugon, J.2
Doble, A.3
-
25
-
-
0032104245
-
The extended protein kinase C superfamily
-
Mellor H., and Parker P.J. The extended protein kinase C superfamily. Biochem. J. 332 Pt 2 (1998) 281-292
-
(1998)
Biochem. J.
, vol.332
, Issue.PART 2
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
26
-
-
9044219848
-
A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group
-
Miller R.G., Petajan J.H., Bryan W.W., Armon C., Barohn R.J., Goodpasture J.C., Hoagland R.J., Parry G.J., Ross M.A., and Stromatt S.C. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann. Neurol. 39 (1996) 256-260
-
(1996)
Ann. Neurol.
, vol.39
, pp. 256-260
-
-
Miller, R.G.1
Petajan, J.H.2
Bryan, W.W.3
Armon, C.4
Barohn, R.J.5
Goodpasture, J.C.6
Hoagland, R.J.7
Parry, G.J.8
Ross, M.A.9
Stromatt, S.C.10
-
27
-
-
0029923440
-
Controlled trial of nimodipine in amyotrophic lateral sclerosis
-
Miller R.G., Shepherd R., Dao H., Khramstov A., Mendoza M., Graves J., and Smith S. Controlled trial of nimodipine in amyotrophic lateral sclerosis. Neuromuscul. Disord. 6 (1996) 101-104
-
(1996)
Neuromuscul. Disord.
, vol.6
, pp. 101-104
-
-
Miller, R.G.1
Shepherd, R.2
Dao, H.3
Khramstov, A.4
Mendoza, M.5
Graves, J.6
Smith, S.7
-
28
-
-
0031833159
-
Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis
-
Nagao M., Kato S., Oda M., and Hirai S. Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol. (Berl.) 96 (1998) 52-56
-
(1998)
Acta Neuropathol. (Berl.)
, vol.96
, pp. 52-56
-
-
Nagao, M.1
Kato, S.2
Oda, M.3
Hirai, S.4
-
29
-
-
0035142007
-
Survival activity of troglitazone in rat motoneurons
-
Nishijima C., Kimoto K., and Arakawa Y. Survival activity of troglitazone in rat motoneurons. J. Neurochem. 76 (2001) 383-390
-
(2001)
J. Neurochem.
, vol.76
, pp. 383-390
-
-
Nishijima, C.1
Kimoto, K.2
Arakawa, Y.3
-
30
-
-
0032566717
-
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
-
Ruvolo P.P., Deng X., Carr B.K., and May W.S. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 273 (1998) 25436-25442
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25436-25442
-
-
Ruvolo, P.P.1
Deng, X.2
Carr, B.K.3
May, W.S.4
-
31
-
-
33846678063
-
How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?
-
Shaw B.F., and Valentine J.S. How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?. Trends Biochem. Sci. 32 (2007) 78-85
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 78-85
-
-
Shaw, B.F.1
Valentine, J.S.2
-
32
-
-
0035070937
-
Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
-
Shibata N. Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. Neuropathology 21 (2001) 82-92
-
(2001)
Neuropathology
, vol.21
, pp. 82-92
-
-
Shibata, N.1
-
33
-
-
0033520937
-
p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway
-
Tan Y., Ruan H., Demeter M.R., and Comb M.J. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J. Biol. Chem. 274 (1999) 34859-34867
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34859-34867
-
-
Tan, Y.1
Ruan, H.2
Demeter, M.R.3
Comb, M.J.4
-
34
-
-
33746849034
-
Neuroprotective agents for clinical trials in ALS: a systematic assessment
-
Traynor B.J., Bruijn L., Conwit R., Beal F., O'Neill G., Fagan S.C., and Cudkowicz M.E. Neuroprotective agents for clinical trials in ALS: a systematic assessment. Neurology 67 (2006) 20-27
-
(2006)
Neurology
, vol.67
, pp. 20-27
-
-
Traynor, B.J.1
Bruijn, L.2
Conwit, R.3
Beal, F.4
O'Neill, G.5
Fagan, S.C.6
Cudkowicz, M.E.7
-
35
-
-
0034889654
-
Modulation of NMDA-mediated excitotoxicity by protein kinase C
-
Wagey R., Hu J., Pelech S.L., Raymond L.A., and Krieger C. Modulation of NMDA-mediated excitotoxicity by protein kinase C. J. Neurochem. 78 (2001) 715-726
-
(2001)
J. Neurochem.
, vol.78
, pp. 715-726
-
-
Wagey, R.1
Hu, J.2
Pelech, S.L.3
Raymond, L.A.4
Krieger, C.5
-
36
-
-
0031672857
-
The genetic and molecular mechanisms of motor neuron disease
-
Wong P.C., Rothstein J.D., and Price D.L. The genetic and molecular mechanisms of motor neuron disease. Curr. Opin. Neurobiol. 8 (1998) 791-799
-
(1998)
Curr. Opin. Neurobiol.
, vol.8
, pp. 791-799
-
-
Wong, P.C.1
Rothstein, J.D.2
Price, D.L.3
|