JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-κB activation and the JAK/STAT pathway

Experimental Cell Research

Volumn 315, Issue 12, 2009, Pages 2064-2071

  Lv, Na ^a   Kim, Eun Kyung ^a   Song, Mi Young ^a   Choi, Ha Na ^a   Moon, Woo Sung ^a   Park, Sung Joo ^b   Park, Jin Woo ^a   Kwon, Kang Beom ^b   Park, Byung Hyun ^a  

^a Diabetes Research Center   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Cytokine; JAK; JANEX 1; NF B; SOCS; STAT; cells

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; JANUS KINASE; JANUS KINASE 3 INHIBITOR; NITRIC OXIDE; NITRITE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ARTICLE; CELL DAMAGE; CELL ISOLATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; INSULIN RELEASE; MALE; MOLECULAR MECHANICS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; WESTERN BLOTTING;

MUS;

EID: 67349091264     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.04.021     Document Type: Article

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