메뉴 건너뛰기




Volumn 44, Issue 3, 2009, Pages 231-241

Controlling arachidonic acid metabolic network: From single-to multi-target inhibitors of key enzymes

Author keywords

Arachidonic acid metabolic network; Key enzymes; Multi target inhibitors; Single target inhibitors

Indexed keywords

6 METHOXY 2 NAPHTHYLACETIC ACID; ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CELECOXIB; DICLOFENAC; IBUPROFEN; INDOMETACIN; LICOFELONE; MELOXICAM; METHYLTESTOSTERONE; NAPROXEN; NIMESULIDE; PARACETAMOL; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; ROFECOXIB;

EID: 67249163020     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (64)
  • 1
    • 56049122716 scopus 로고    scopus 로고
    • From dual binding site acetylcholinesterase inbibitors to multi-target-directed ligands (MTDLs): A step forward in the treatment of Alzheimer's disease [J]
    • Bolognesi M, Minarini A, Rosini M, et al. From dual binding site acetylcholinesterase inbibitors to multi-target-directed ligands (MTDLs): A step forward in the treatment of Alzheimer's disease [J]. Mini Rev Med Chem, 2008, 8: 960-967.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 960-967
    • Bolognesi, M.1    Minarini, A.2    Rosini, M.3
  • 2
    • 34948904272 scopus 로고    scopus 로고
    • Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease [J]
    • Bolognesi ML, Banal R, Bartolini M, et al. Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease [J]. J Med Chem, 2007, 50: 4882-4897.
    • (2007) J Med Chem , vol.50 , pp. 4882-4897
    • Bolognesi, M.L.1    Banal, R.2    Bartolini, M.3
  • 3
    • 45849104166 scopus 로고    scopus 로고
    • Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer [J]
    • Chen CH, Liu DZ, Fang HW, et al. Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer [J]. Biosci Biotechnol Biocheni, 2008, 72: 1586-1594.
    • (2008) Biosci Biotechnol Biocheni , vol.72 , pp. 1586-1594
    • Chen, C.H.1    Liu, D.Z.2    Fang, H.W.3
  • 4
    • 41549108420 scopus 로고    scopus 로고
    • From single-to multi-target drugs in cancer therapy: When aspecificity becomes an advantage [J]
    • Petrelli A, Giordano S. From single-to multi-target drugs in cancer therapy: When aspecificity becomes an advantage [J]. Curr Med Chem, 2008, 15: 422-432.
    • (2008) Curr Med Chem , vol.15 , pp. 422-432
    • Petrelli, A.1    Giordano, S.2
  • 5
    • 38049040370 scopus 로고    scopus 로고
    • Multi- and single-target agents for major psychiatric diseases: Therapeutic opportunities and challenges [J]
    • Wong EH, Nikam SS, Shahid M. Multi- and single-target agents for major psychiatric diseases: Therapeutic opportunities and challenges [J]. Curr Opin Investig Drugs, 2008,9: 28-36.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 28-36
    • Wong, E.H.1    Nikam, S.S.2    Shahid, M.3
  • 7
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multi- target drugs: The network approach might help drug design [J]
    • Csermely P, Agoston V, Pongor S. The efficiency of multi- target drugs: The network approach might help drug design [J]. Trends Pharmacol Sci, 2005, 26: 178-182.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 8
    • 33846574259 scopus 로고    scopus 로고
    • Fragments, network biology and designing multiple ligands [J]
    • Morphy R, Rankovic Z. Fragments, network biology and designing multiple ligands [J]. Drug Discov Today, 2007, 12: 156-160.
    • (2007) Drug Discov Today , vol.12 , pp. 156-160
    • Morphy, R.1    Rankovic, Z.2
  • 9
    • 16244389350 scopus 로고    scopus 로고
    • Phospholipase A(2) inhibitors as potential anti-inflammatory agents [J]
    • Meyer MC, Rastogi P. Beckett CS, et al. Phospholipase A(2) inhibitors as potential anti-inflammatory agents [J]. Curr Pharm Des, 2005, 11: 1301-1312.
    • (2005) Curr Pharm Des , vol.11 , pp. 1301-1312
    • Meyer, M.C.1    Rastogi, P.2    Beckett, C.S.3
  • 10
    • 0034232061 scopus 로고    scopus 로고
    • 2 inhibitors [J]
    • 2 inhibitors [J]. Nat Immunol, 2000, 1: 13-15.
    • (2000) Nat Immunol , vol.1 , pp. 13-15
    • Serhan, C.N.1
  • 11
    • 0018829886 scopus 로고
    • Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit [J]
    • Vadas P, Hay JB. Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit [J]. Int Arch Allergy Appl Immunol, 1980, 62: 142-151.
    • (1980) Int Arch Allergy Appl Immunol , vol.62 , pp. 142-151
    • Vadas, P.1    Hay, J.B.2
  • 12
    • 0027314633 scopus 로고
    • Slow-binding and tight- binding inhibitors of the 85-kDa human phospholipase-A2 [J]
    • Street IP, Lin HK, Laliberte F, et al. Slow-binding and tight- binding inhibitors of the 85-kDa human phospholipase-A2 [J]. Biochemistry, 1993, 32: 5935-5940.
    • (1993) Biochemistry , vol.32 , pp. 5935-5940
    • Street, I.P.1    Lin, H.K.2    Laliberte, F.3
  • 13
    • 0034978804 scopus 로고    scopus 로고
    • BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models [JJ
    • Burke JR, Davern LB, Stanley PL, et al. BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models [JJ. J Pharmacol Exp Ther, 2001, 298: 376-385.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 376-385
    • Burke, J.R.1    Davern, L.B.2    Stanley, P.L.3
  • 14
    • 0030858926 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and structure- activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2 [J]
    • Lehr M. Synthesis, biological evaluation, and structure- activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2 [J]. J Med Chem, 1997, 40: 2694-2705.
    • (1997) J Med Chem , vol.40 , pp. 2694-2705
    • Lehr, M.1
  • 15
    • 0035829137 scopus 로고    scopus 로고
    • Novel 3-dodecanoylin- dole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2) [J]
    • Lehr M, Klimt M, Elfringhoff AS. Novel 3-dodecanoylin- dole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2) [J]. Bioorg Med Chem Lett, 2001, 11: 2569-2572.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 2569-2572
    • Lehr, M.1    Klimt, M.2    Elfringhoff, A.S.3
  • 16
    • 0036460991 scopus 로고    scopus 로고
    • Structure- activity relationship studies of 1-substituted 3-dodecanoylin- dole-2-carboxylic acids as inhibitors of cytosolic phospholipase A(2)-mediated arachidonic acid release in intact platelets [J]
    • Griessbach K, Klimt M, Elfringhoff AS, et al. Structure- activity relationship studies of 1-substituted 3-dodecanoylin- dole-2-carboxylic acids as inhibitors of cytosolic phospholipase A(2)-mediated arachidonic acid release in intact platelets [J]. Arch Pharm, 2003, 335: 547-555.
    • (2003) Arch Pharm , vol.335 , pp. 547-555
    • Griessbach, K.1    Klimt, M.2    Elfringhoff, A.S.3
  • 17
    • 33646146486 scopus 로고    scopus 로고
    • Design and synthesis of 1-indol-l-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A(2)alpha [J]
    • Ludwig J, Bovens S. Brauch C, et al. Design and synthesis of 1-indol-l-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A(2)alpha [J]. J Med Chem, 2006, 49: 2611-2620.
    • (2006) J Med Chem , vol.49 , pp. 2611-2620
    • Ludwig, J.1    Bovens, S.2    Brauch, C.3
  • 18
    • 33947111963 scopus 로고    scopus 로고
    • l-(5-Carboxy-and 5-car-bamoylindol-l-yl) propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: Bioisosteric replacement of the carboxylic acid and carboxaniide moiety [J]
    • Hess M, Elfringhoff AS, Lehr M. l-(5-Carboxy-and 5-car-bamoylindol-l-yl) propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: Bioisosteric replacement of the carboxylic acid and carboxaniide moiety [J]. Bioorg Med Chem, 2007, 15: 2883-2891.
    • (2007) Bioorg Med Chem , vol.15 , pp. 2883-2891
    • Hess, M.1    Elfringhoff, A.S.2    Lehr, M.3
  • 19
    • 45749141743 scopus 로고    scopus 로고
    • Indole cytosolic phospholipase A2 alpha inhibitors: Discovery and in vitro and in viva characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichloroben zyl) sulfonyl] amino} ethyl)-1 -(diphenylmethyl)-1H-indol-3-yl] propyl}benzoic acid, efipladib [J]
    • McKew JC, Lee KL, Shen MW, et al. Indole cytosolic phospholipase A2 alpha inhibitors: Discovery and in vitro and in viva characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichloroben zyl) sulfonyl] amino} ethyl)-1 -(diphenylmethyl)-1H-indol-3-yl] propyl}benzoic acid, efipladib [J]. J Med Chem, 2008, 51: 3388-3413.
    • (2008) J Med Chem , vol.51 , pp. 3388-3413
    • McKew, J.C.1    Lee, K.L.2    Shen, M.W.3
  • 20
    • 0036566182 scopus 로고    scopus 로고
    • Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone [J]
    • Ono T, Yamada K, Chikazawa Y, et al. Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone [J]. BiochemJ, 2002, 363: 727-735.
    • (2002) BiochemJ , vol.363 , pp. 727-735
    • Ono, T.1    Yamada, K.2    Chikazawa, Y.3
  • 21
    • 0028344912 scopus 로고
    • Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2 [J]
    • Beaton HG, Bennion C, Connolly S, et al. Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2 [J]. J Med Chem, 1994, 37: 557-559.
    • (1994) J Med Chem , vol.37 , pp. 557-559
    • Beaton, H.G.1    Bennion, C.2    Connolly, S.3
  • 22
    • 0029662266 scopus 로고    scopus 로고
    • High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67O47XX) [J]
    • Cha SS, Lee D, Adams J, et al. High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67O47XX) [J]. J Med Chem, 1996, 39: 3878-3881.
    • (1996) J Med Chem , vol.39 , pp. 3878-3881
    • Cha, S.S.1    Lee, D.2    Adams, J.3
  • 23
    • 0032535313 scopus 로고    scopus 로고
    • Iwama S, Segawa M, Fujii 5, et al. Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog [J]. Bioorg Med Chem Lett, 1998, 8: 3495-3498.
    • Iwama S, Segawa M, Fujii 5, et al. Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog [J]. Bioorg Med Chem Lett, 1998, 8: 3495-3498.
  • 24
    • 0027359607 scopus 로고
    • N-(carboxymethyl)n-[3, 5-bis(decyloxy)-phenyl]glycine (RO-23-9358) -a potent inhibitor of secretory phospholipases-A2 with antiinflammatory activity [J]
    • Lemahieu RA, Carson M, Han RJ, et al. N-(carboxymethyl)n-[3, 5-bis(decyloxy)-phenyl]glycine (RO-23-9358) -a potent inhibitor of secretory phospholipases-A2 with antiinflammatory activity [J]. J Med Chem, 1993, 36: 3029-3031.
    • (1993) J Med Chem , vol.36 , pp. 3029-3031
    • Lemahieu, R.A.1    Carson, M.2    Han, R.J.3
  • 25
    • 0027102398 scopus 로고
    • Novel inhibitor of phospholipase-A2 with topical anti-inflammatory activity
    • Traxnposch KM, Steiner SA, Stanley PL, et al. Novel inhibitor of phospholipase-A2 with topical anti-inflammatory activity [J). Biochem Biophys Res Commun, 1992, 189: 272-279.
    • (1992) J). Biochem Biophys Res Commun , vol.189 , pp. 272-279
    • Traxnposch, K.M.1    Steiner, S.A.2    Stanley, P.L.3
  • 26
    • 0028997717 scopus 로고
    • Structure-based design of the first potent and selective inhibitor of human nonpancreatic secretory phospholipase A2 [J]
    • Schevitz RW, Bach NJ, Carlson DG et al. Structure-based design of the first potent and selective inhibitor of human nonpancreatic secretory phospholipase A2 [J]. Nat Struct Biol, 1995, 2: 458-465.
    • (1995) Nat Struct Biol , vol.2 , pp. 458-465
    • Schevitz, R.W.1    Bach, N.J.2    Carlson, D.G.3
  • 27
    • 45749116608 scopus 로고    scopus 로고
    • Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis indole derivatives [J]
    • Zhou L, Fang C, Wei P, et al Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis indole derivatives [J]. J Med Chem, 2008, 51: 3360-3366.
    • (2008) J Med Chem , vol.51 , pp. 3360-3366
    • Zhou, L.1    Fang, C.2    Wei, P.3
  • 28
    • 34748817976 scopus 로고    scopus 로고
    • Membrane prostaglandin E synthase-1: A novel therapeutic target [J]
    • Samuelsson B, Morgenstern R, Jakobsson PJ. Membrane prostaglandin E synthase-1: A novel therapeutic target [J]. Pharmacol Rev, 2007, 59: 207-224.
    • (2007) Pharmacol Rev , vol.59 , pp. 207-224
    • Samuelsson, B.1    Morgenstern, R.2    Jakobsson, P.J.3
  • 29
    • 0035053038 scopus 로고    scopus 로고
    • COX-2 as a multifunctional neuronal modulator [J]
    • Bazan. NG COX-2 as a multifunctional neuronal modulator [J]. NatMed, 2001,7: 414-415.
    • (2001) NatMed , vol.7 , pp. 414-415
    • Bazan, N.G.1
  • 30
    • 0033755897 scopus 로고    scopus 로고
    • Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C-4 [J]
    • Thoren S, Jakobsson PJ. Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C-4 [J]. Eur J Biochem, 2000, 267: 6428-6434.
    • (2000) Eur J Biochem , vol.267 , pp. 6428-6434
    • Thoren, S.1    Jakobsson, P.J.2
  • 31
    • 20644467057 scopus 로고    scopus 로고
    • Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-l) derived from MK-886 Ii)
    • Riendeau D, Aspiotis R, Ethier D, et al. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-l) derived from MK-886 Ii). Bioorg Med Chem Lett, 2005, 15: 3352-3355.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 3352-3355
    • Riendeau, D.1    Aspiotis, R.2    Ethier, D.3
  • 32
    • 53849098967 scopus 로고    scopus 로고
    • MF63 [2-(6-chloro-1H- phenanthro [9, 10-d] imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation [J]
    • Xu DG Rowland SE, Clark P, et al. MF63 [2-(6-chloro-1H- phenanthro [9, 10-d] imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation [J]. J Pharmacol Exp Ther, 2008, 326: 754-763.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 754-763
    • Xu, D.G.1    Rowland, S.E.2    Clark, P.3
  • 33
    • 34548709664 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E-2-independent mechanisms [J]
    • Deasy BM, O'Sullivan-Coyne G, O'Donovan TR. et al. Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E-2-independent mechanisms [J]. Cancer Lett, 2007, 256: 246-258.
    • (2007) Cancer Lett , vol.256 , pp. 246-258
    • Deasy, B.M.1    O'Sullivan-Coyne, G.2    O'Donovan, T.R.3
  • 34
    • 0033526928 scopus 로고    scopus 로고
    • The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)- furanone], an orally active cyclooxygenase-2 inhibitor [J]
    • Prasit P, Wang Z, Brideau C, et al. The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)- furanone], an orally active cyclooxygenase-2 inhibitor [J]. Bioorg Med Chem Lett, 1999, 9: 1773-1778.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1773-1778
    • Prasit, P.1    Wang, Z.2    Brideau, C.3
  • 35
    • 1542613874 scopus 로고    scopus 로고
    • A prodrug approach to COX-2 inhibitors with methylsulfone [J]
    • Moh JH, Choi YH, Lim KM, et al. A prodrug approach to COX-2 inhibitors with methylsulfone [J]. Bioorg Med Chem Lett, 2004, 14: 1757-1760.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 1757-1760
    • Moh, J.H.1    Choi, Y.H.2    Lim, K.M.3
  • 36
    • 67249121666 scopus 로고    scopus 로고
    • Singh SK, Vobbalareddy 5, Kalleda SR, et al. Identification of 2-hydroxymethyl-4-15-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl] -N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration [C]. 225th National Meeting of the American-Chemical-Society, New Orleans, 2003: 8626-8634.
    • Singh SK, Vobbalareddy 5, Kalleda SR, et al. Identification of 2-hydroxymethyl-4-15-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl] -N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration [C]. 225th National Meeting of the American-Chemical-Society, New Orleans, 2003: 8626-8634.
  • 37
    • 27744468904 scopus 로고    scopus 로고
    • COX-2 controversy: Where are we and where do we go from here? [J]
    • Khanna D, Khanna PP, Furst DE. COX-2 controversy: Where are we and where do we go from here? [J]. Inflammopharmacology, 2005, 13: 395-402.
    • (2005) Inflammopharmacology , vol.13 , pp. 395-402
    • Khanna, D.1    Khanna, P.P.2    Furst, D.E.3
  • 38
    • 0010008102 scopus 로고
    • Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic-acid [J]
    • Shimizu T, Radmark 0, Samuelsson B. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic-acid [J]. Proc Natl Acad Sci USA, 1984, 81: 689-693.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 689-693
    • Shimizu, T.1    Radmark 02    Samuelsson, B.3
  • 40
    • 0026651822 scopus 로고
    • Methoxytet rahydropyrans -a new series of selective and orally potent 5-lipoxygenase inhibitors [J]
    • Crawley GC, Dowell RI, Edwards PN, et al. Methoxytet rahydropyrans -a new series of selective and orally potent 5-lipoxygenase inhibitors [J]. J Med Chem, 1992, 35: 2600-2609.
    • (1992) J Med Chem , vol.35 , pp. 2600-2609
    • Crawley, G.C.1    Dowell, R.I.2    Edwards, P.N.3
  • 41
    • 10144260637 scopus 로고    scopus 로고
    • Dioxalbicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: Structure-activity relationship study directed toward the improvement of metabolic stability [J]
    • Delorme D, Ducharme Y, Brideau C, et al. Dioxalbicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: Structure-activity relationship study directed toward the improvement of metabolic stability [J]. J Med Chem, 1996, 39: 3951-3970.
    • (1996) J Med Chem , vol.39 , pp. 3951-3970
    • Delorme, D.1    Ducharme, Y.2    Brideau, C.3
  • 42
    • 0030035655 scopus 로고    scopus 로고
    • Zileuton: The first 5-lipoxygenase inhibitor for the treatment of asthma [J]
    • Wenzel SE, Kamada AK. Zileuton: The first 5-lipoxygenase inhibitor for the treatment of asthma [J]. Ann Pharmacother, 1996, 30: 858-864.
    • (1996) Ann Pharmacother , vol.30 , pp. 858-864
    • Wenzel, S.E.1    Kamada, A.K.2
  • 43
    • 0031925949 scopus 로고    scopus 로고
    • Effects of a 5-lipoxygenase inhibitor, ABT-761, on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients [J]
    • Lehnigk B, Rabe KF, Dent G et al. Effects of a 5-lipoxygenase inhibitor, ABT-761, on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients [J]. Eur Respir J, 1998, 11: 617-623.
    • (1998) Eur Respir J , vol.11 , pp. 617-623
    • Lehnigk, B.1    Rabe, K.F.2    Dent, G.3
  • 44
    • 0025021789 scopus 로고
    • Identification and isolation of a membrane-protein necessary for leukotriene production [J]
    • Miller DK, Gillard JW, Vickers PJ, et al. Identification and isolation of a membrane-protein necessary for leukotriene production [J]. Nature, 1990, 343: 278-281.
    • (1990) Nature , vol.343 , pp. 278-281
    • Miller, D.K.1    Gillard, J.W.2    Vickers, P.J.3
  • 45
    • 0032509197 scopus 로고    scopus 로고
    • Involvement of leukotriene B4 in arthritis models [J]
    • Tsuji F, Old K, Fujisawa K, et al. Involvement of leukotriene B4 in arthritis models [J]. Life Sci, 1998, 64: 151-156.
    • (1998) Life Sci , vol.64 , pp. 151-156
    • Tsuji, F.1    Old, K.2    Fujisawa, K.3
  • 46
    • 0034744491 scopus 로고    scopus 로고
    • Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents [J]
    • Penning TD. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents [J]. Curr Pharm Des, 2001, 7: 163-179.
    • (2001) Curr Pharm Des , vol.7 , pp. 163-179
    • Penning, T.D.1
  • 47
    • 0037463772 scopus 로고    scopus 로고
    • Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase [J]
    • Penning TD, Chandrakumar NS, Desai BN, et al. Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase [J]. Bioorg Med Chem Lett, 2003, 13: 1137-1139.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1137-1139
    • Penning, T.D.1    Chandrakumar, N.S.2    Desai, B.N.3
  • 48
    • 47749128453 scopus 로고    scopus 로고
    • Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity [J]
    • Grice CA, Tays KL, Savall BM, et al. Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity [J]. J Med Chem, 2008, 51: 4150-4169.
    • (2008) J Med Chem , vol.51 , pp. 4150-4169
    • Grice, C.A.1    Tays, K.L.2    Savall, B.M.3
  • 49
    • 47149108683 scopus 로고    scopus 로고
    • Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase [J]
    • Ye B, Bauman J, Chen M, et al. Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase [J]. Bioorg Med Chem Lett, 2008, 18: 3891-3894.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 3891-3894
    • Ye, B.1    Bauman, J.2    Chen, M.3
  • 50
    • 10944253095 scopus 로고    scopus 로고
    • A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis [J]. 3
    • Haeggstrom JZ. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis [J]. 3 Biol Chem, 2004, 279: 50639-50642.
    • (2004) Biol Chem , vol.279 , pp. 50639-50642
    • Leukotriene, H.J.Z.1
  • 51
    • 0036778551 scopus 로고    scopus 로고
    • Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors [J]
    • Thunnissen MM, Andersson B, Samuelsson B, et al. Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors [J]. FASEB J, 2002, 16: 1648-1650.
    • (2002) FASEB J , vol.16 , pp. 1648-1650
    • Thunnissen, M.M.1    Andersson, B.2    Samuelsson, B.3
  • 52
    • 47349124275 scopus 로고    scopus 로고
    • What does systems biology mean for drug development? [J]
    • Schrattenholz A, Soskic V. What does systems biology mean for drug development? [J]. Curr Med Chem, 2008, 15: 1520-1528.
    • (2008) Curr Med Chem , vol.15 , pp. 1520-1528
    • Schrattenholz, A.1    Soskic, V.2
  • 53
    • 55549101279 scopus 로고    scopus 로고
    • Finding multiple target optimal intervention in disease-related molecular network [J]
    • Yang K, Bai HJ, Ouyang Q, et al. Finding multiple target optimal intervention in disease-related molecular network [J]. Mol Syst Biol, 2008, 4: 228.
    • (2008) Mol Syst Biol , vol.4 , pp. 228
    • Yang, K.1    Bai, H.J.2    Ouyang, Q.3
  • 54
    • 3242743000 scopus 로고    scopus 로고
    • Csermely R Strong links are important, but weak links stabilize them [J]. Trends Biochem Sci, 2004, 29: 331-334.
    • Csermely R Strong links are important, but weak links stabilize them [J]. Trends Biochem Sci, 2004, 29: 331-334.
  • 55
    • 38949164506 scopus 로고    scopus 로고
    • Genes and (common) pathways underlying drug addiction [J]
    • Li CY, Mao XZ, Wei ER Genes and (common) pathways underlying drug addiction [J]. PLoS Comput Biol, 2008, 4: 28-34.
    • (2008) PLoS Comput Biol , vol.4 , pp. 28-34
    • Li, C.Y.1    Mao, X.Z.2    Wei, E.R.3
  • 56
    • 0038399865 scopus 로고    scopus 로고
    • Prevention of thrombosis and vascular inflammation: Benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors [J]
    • de Gaetano G Donati MB, Cerletti C. Prevention of thrombosis and vascular inflammation: Benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors [J]. Trends Pharmacol Sci, 2003, 24: 245-252.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 245-252
    • de Gaetano, G.1    Donati, M.B.2    Cerletti, C.3
  • 57
    • 1042276537 scopus 로고    scopus 로고
    • Is licofelone, a dual inbibitor of cyclo-ozygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy 7 [J]
    • Bannwarth B. Is licofelone, a dual inbibitor of cyclo-ozygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy 7 [J]. Fundam Clin Pharmacol, 2004, 18: 125-130.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 125-130
    • Bannwarth, B.1
  • 58
    • 0031041096 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors [J]
    • Kolasa T, Brooks CD, Rodriques KE, et al. Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors [J]. J Med Chem, 1997, 40: 819-824.
    • (1997) J Med Chem , vol.40 , pp. 819-824
    • Kolasa, T.1    Brooks, C.D.2    Rodriques, K.E.3
  • 59
    • 0030979206 scopus 로고    scopus 로고
    • N-(5-substituted) thio phene-2-alkylsulfonamides as potent inhibitors of 5-lipozy-genase [J]
    • Beers SA, Malloy BA, Wu W, et al. N-(5-substituted) thio phene-2-alkylsulfonamides as potent inhibitors of 5-lipozy-genase [J]. Bioorg Med Chem, 1997, 5: 779-786.
    • (1997) Bioorg Med Chem , vol.5 , pp. 779-786
    • Beers, S.A.1    Malloy, B.A.2    Wu, W.3
  • 60
    • 0036264626 scopus 로고    scopus 로고
    • de Leval X, Julemont F, Delarge 3, et al. New trends in dual 5-LOX/COX inhibition [J]. Cun Med Chem, 2002, 9: 941-962.
    • de Leval X, Julemont F, Delarge 3, et al. New trends in dual 5-LOX/COX inhibition [J]. Cun Med Chem, 2002, 9: 941-962.
  • 61
    • 0036952707 scopus 로고    scopus 로고
    • Cyclooxygenase-1/2 (COX-l/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6, 7-diary1-2, 3-1H- dihydropyrrolizine type [J]
    • Ulbrich H, Fiebich B, Dannhardt G. Cyclooxygenase-1/2 (COX-l/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6, 7-diary1-2, 3-1H- dihydropyrrolizine type [J]. Eur J Med Chem, 2002, 37: 953-959.
    • (2002) Eur J Med Chem , vol.37 , pp. 953-959
    • Ulbrich, H.1    Fiebich, B.2    Dannhardt, G.3
  • 62
    • 34047216368 scopus 로고    scopus 로고
    • Dynamic simulations on the arachidonic acid metabolic network [J]
    • Yang K, Ma WZ, Liang HH, et al. Dynamic simulations on the arachidonic acid metabolic network [J]. PLoS Comput Biol, 2007, 3: 523-530.
    • (2007) PLoS Comput Biol , vol.3 , pp. 523-530
    • Yang, K.1    Ma, W.Z.2    Liang, H.H.3
  • 63
    • 33845727607 scopus 로고    scopus 로고
    • J Cbem Inf Model
    • 3, Lai LH. Pocket v, Further developments on receptor-based pharmacophore modeling [J, 46: 2684-2691
    • Chen 3, Lai LH. Pocket v.2: Further developments on receptor-based pharmacophore modeling [J]. J Cbem Inf Model, 2006,46: 2684-2691.
    • (2006) , vol.2
    • Chen1
  • 64
    • 58149088865 scopus 로고    scopus 로고
    • Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching [J]
    • Wei DG Hang XL, Zhou L, et al. Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching [J]. J Med Chem, 2008, 51: 7882-7888.
    • (2008) J Med Chem , vol.51 , pp. 7882-7888
    • Wei, D.G.1    Hang, X.L.2    Zhou, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.