Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type

European Journal of Medicinal Chemistry

Volumn 37, Issue 12, 2002, Pages 953-959

  Ulbrich, Holger ^a,b   Fiebich, Bernd ^c   Dannhardt, Gerd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

COX 1, COX 2 and 5 LOX inhibition; Diarylpyrrolizines; Non steroidal anti inflammatory drugs; Structure activity relationship

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FUNCTIONAL GROUP; LIPOPOLYSACCHARIDE; LIPOXYGENASE INHIBITOR; PYRROLIZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CATTLE; CELL STIMULATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BLOOD PLATELETS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MONOCYTES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; RADIOIMMUNOASSAY;

EID: 0036952707     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01418-6     Document Type: Article

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