1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Bioisosteric replacement of the carboxylic acid and carboxamide moiety

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2883-2891

  Hess, Mark ^a   Schulze Elfringhoff, Alwine ^a   Lehr, Matthias ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Bioisosteric replacement; Cytosolic phospholipase A2 inhibitors; Indol 1 ylpropan 2 ones

Indexed keywords

1 (4 OCTYLPHENOXY) 3 [5 (1H TETRAZOL 5 YL)INDOL 1 YL]PROPAN 2 ONE; 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 SULFONAMIDE; 1 [5 (3 BENZYL 1,2,4 OXADIAZOL 5 YL)INDOL 1 YL] 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 [5 (3 ETHYL 1,2,4 OXADIAZOL 5 YL)INDOL 1 YL] 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 1 [5 (MORPHOLINE 4 CARBONYL)INDOL 1 YL] 3 (4 OCTYLPHENOXY)PROPAN 2 ONE; 3 [1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOL 5 YL] 4,5 DIHYDRO 1,2,4 OXADIAZOL 5 ONE; 4 [3 (4 DECYLOXYPHENOXY) 2 OXOPROPOXY]BENZOIC ACID; 5 [1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOL 5 YLMETHYLIDENE]THIAZOLIDINE 2,4 DIONE; AMIDE; AR C70484XX; BENZOIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; INDOLE DERIVATIVE; N METHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXAMIDE; N METHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 SULFONAMIDE; N,N DIMETHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXAMIDE; N,N DIMETHYL 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 SULFONAMIDE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOSOL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50;

BLOOD PLATELETS; CARBOXYLIC ACIDS; CYTOSOL; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPASES A; PROPANE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947111963     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.016     Document Type: Article

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