Preventing injury from within, using selective cPLA2 inhibitors

Nature Immunology

Volumn 1, Issue 1, 2000, Pages 13-15

  Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PHOSPHOLIPASE A;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IMMUNOLOGY; LEUKOCYTE ACTIVATION; NEUTROPHIL; NOTE; SIGNAL TRANSDUCTION;

ADULT; ENZYME INHIBITORS; HUMANS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHOLIPASES A; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION;

EID: 0034232061     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/76865     Document Type: Short Survey

References (15)

1. 2. Nature Immunol. 1, 42-46 (2000)
2. Cotran, R.S., Kumar, V. & Collins, T. Robbins Pathologic Basis of Disease (W.B. Saunders Co., Philadelphia, 1999).
3. Samuelsson, B. in Les Prix Nobel: Nobel Prizes, Presentations, Biographies and Lectures 153-174 (Almqvist & Wiksell, Stockholm, 1982).
4. Bigby, T.D., Levy, B.D. & Serhan, C.N. in Five-Lipoxygenase Products in Asthma (eds Drazen, J.M., Dahlén, S.-E. & Lee, T.H.) 125-173 (Marcel Dekker, New York, 1998).
5. Pang, L., Pitt, A., Petkova, D. & Knox, A.J. The COX-1/COX-2 balance in asthma. Clin. Exp. Allergy 28, 1050-1058 (1998).
6. 2. J. Cell Biol. 145, 1219-1232 (1999).
7. 2 in eicosanoid generation. Am. J. Respir. Crit. Care Med. 161, S32-S35 (2000).
8. 2 activity during zebrafish embryogenesis. J. Biol. Chem. 274, 19338-19346 (1999).
9. 2. Nature 390, 622-625 (1997).
10. 2 reveals a novel topology and catalytic mechanism. Cell 97, 349-360 (1999).
11. Ohara, M. et al. Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: Selective cyclooxygenase-2 blockade reduces interleukin-6 production. Anesthesiology 88, 1014-1022 (1998).
12. Surette, M.E., Palmantier, R., Gosselin, J. & Borgeat, P. Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen. J. Exp. Med. 17B, 1347-1355 (1993).
13. Muzio, M., Polentarutti, N., Bosisio, D., Prahladan, M.K.P. & Mantovani, A. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J. Leukoc. Biol. 67, 450-456 (2000).
14. 4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J. Clin. Invest. 104, 309-316 (1999).
15. Qiu, F.-H., Wada, K., Stahl, G.L. & Serhan, C.N. IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment. Proc. Natl. Acad. Sci. USA 97, 4267-4272 (2000).