High-resolution Xray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX)

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 3878-3881

  Cha, Sun Shin ^b   Lee, Dennis ^a   Adams, Jerry ^a   Kurdyla, Jeffrey T ^a   Jones, Christopher S ^a   Marshall, Lisa A ^a   Bolognese, Brian ^a   Abdel Meguid, Sherin S ^a   Oh, Byung Ha ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; FPL 67047XX; LEUKOTRIENE; LYSOPHOSPHOLIPID; PHOSPHOLIPASE A2; PHOSPHOLIPASE INHIBITOR; PROSTAGLANDIN; THROMBOCYTE ACTIVATING FACTOR; THROMBOXANE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; BENZHYDRYL DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPASE A;

AMINO ACID SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; PHOSPHOLIPID SYNTHESIS; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; HUMAN; HYDROGEN BOND; METABOLISM; MOUSE; OTITIS; PHYSICAL CHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZHYDRYL COMPOUNDS; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; OTITIS; PHOSPHOLIPASES A;

EID: 0029662266     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960502g     Document Type: Article

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