BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 1, 2001, Pages 376-385

  Burke, James R ^b   Davern, Lynda B ^a   Stanley, Paul L ^a   Gregor, Kurt R ^b   Banville, Jacques ^b   Remillard, Roger ^b   Russell, John W ^b   Brassil, Patrick J ^b   Witmer, Mark R ^b   Johnson, Graham ^b   Tredup, Jeffrey A ^b   Tramposch, Kenneth M ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 [2 [2 [BIS(4 CHLOROPHENYL)METHOXY]ETHYLSULFONYL]ETHOXY]PHENYL] 1,1,1 TRIFLUORO 2 BUTANONE; ANTIINFLAMMATORY AGENT; ARACHIDIC ACID; ARACHIDONIC ACID; BMS 229724; LEUKOTRIENE; LIPID; PHORBOL ESTER; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PHOSPHOLIPID; PROSTAGLANDIN; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; EDEMA; ENZYME INHIBITION; ERYTHEMA; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; MALE; MAST CELL; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; RAT; SKIN INFLAMMATION; THROMBOCYTE; TREATMENT OUTCOME; ULTRAVIOLET B RADIATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARCINOGENS; CHLOROBENZENES; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHEMA; FEMALE; GUINEA PIGS; HUMANS; INFLAMMATION; LEUKOTRIENE B4; MALE; MICE; NEUTROPHILS; PHORBOL ESTERS; PHOSPHOLIPASES A; PHOSPHOLIPIDS; PLATELET ACTIVATING FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SULFONES;

EID: 0034978804     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

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