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Volumn 47, Issue 3, 2009, Pages 161-168

Examining requirement for formation of functional presenilin proteins and their processing events in vivo

Author keywords

secretase; Drosophila; Notch; Presenilin; Presenilinase mediated endoproteolysis

Indexed keywords

GAMMA SECRETASE; PRESENILIN; PRESENILINASE; PROTEINASE; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; SECRETASE;

EID: 67049136597     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20475     Document Type: Article
Times cited : (2)

References (47)
  • 2
    • 0029990348 scopus 로고    scopus 로고
    • Notch and Wingless signals collide
    • Blair SS. 1996. Notch and Wingless signals collide. Science 271:1822-1823.
    • (1996) Science , vol.271 , pp. 1822-1823
    • Blair, S.S.1
  • 4
    • 0037795653 scopus 로고    scopus 로고
    • Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase
    • Campbell WA, Reed ML, Strahle J, Wolfe MS, Xia W. 2003. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem 85:1563-1574.
    • (2003) J Neurochem , vol.85 , pp. 1563-1574
    • Campbell, W.A.1    Reed, M.L.2    Strahle, J.3    Wolfe, M.S.4    Xia, W.5
  • 5
    • 1542438695 scopus 로고    scopus 로고
    • Presenilin-interacting proteins
    • Chen Q, Schubert D. 2002. Presenilin-interacting proteins. Expert Rev Mol Med 4:1-18.
    • (2002) Expert Rev Mol Med , vol.4 , pp. 1-18
    • Chen, Q.1    Schubert, D.2
  • 6
    • 0035204206 scopus 로고    scopus 로고
    • Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila
    • Chung HM, Struhl G. 2001. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat Cell Biol 3:1129-1132.
    • (2001) Nat Cell Biol , vol.3 , pp. 1129-1132
    • Chung, H.M.1    Struhl, G.2
  • 7
    • 33645578379 scopus 로고    scopus 로고
    • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology
    • Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. 2006. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci 26:3845-3854.
    • (2006) J Neurosci , vol.26 , pp. 3845-3854
    • Deng, Y.1    Tarassishin, L.2    Kallhoff, V.3    Peethumnongsin, E.4    Wu, L.5    Li, Y.M.6    Zheng, H.7
  • 8
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
    • De Strooper B. 2003. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38:9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 10
    • 42149109088 scopus 로고    scopus 로고
    • Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease
    • Dries DR, Yu G. 2008. Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease. Curr Alzheimer Res 5:132-146.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 132-146
    • Dries, D.R.1    Yu, G.2
  • 11
    • 34249854658 scopus 로고    scopus 로고
    • p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity
    • Dunys J, Kawarai T, Sevalle J, Dolcini V, George-Hyslop PS, Da Costa CA, Checler F. 2007. p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity. J Biol Chem 282:10516-10525.
    • (2007) J Biol Chem , vol.282 , pp. 10516-10525
    • Dunys, J.1    Kawarai, T.2    Sevalle, J.3    Dolcini, V.4    George-Hyslop, P.S.5    Da Costa, C.A.6    Checler, F.7
  • 12
    • 0345826185 scopus 로고    scopus 로고
    • Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis
    • Fluhrer R, Friedlein A, Haass C, Walter J. 2004. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J Biol Chem 279:1585-1593.
    • (2004) J Biol Chem , vol.279 , pp. 1585-1593
    • Fluhrer, R.1    Friedlein, A.2    Haass, C.3    Walter, J.4
  • 14
    • 0033756708 scopus 로고    scopus 로고
    • Physical and genetic interaction of filamin with presenilin in Drosophila
    • Guo Y, Zhang SX, Sokol N, Cooley L, Boulianne GL. 2000. Physical and genetic interaction of filamin with presenilin in Drosophila. J Cell Sci 113 (Pt 19):3499-3508.
    • (2000) J Cell Sci , vol.113 , Issue.PART 19 , pp. 3499-3508
    • Guo, Y.1    Zhang, S.X.2    Sokol, N.3    Cooley, L.4    Boulianne, G.L.5
  • 15
    • 0034080403 scopus 로고    scopus 로고
    • aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
    • Goutte C, Hepler W, Mickey KM, Priess JR. 2000. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-2492.
    • (2000) Development , vol.127 , pp. 2481-2492
    • Goutte, C.1    Hepler, W.2    Mickey, K.M.3    Priess, J.R.4
  • 16
    • 0037154158 scopus 로고    scopus 로고
    • APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
    • Goutte C, Tsunozaki M, Hale VA, Priess JR. 2002. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 99:775-779.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 775-779
    • Goutte, C.1    Tsunozaki, M.2    Hale, V.A.3    Priess, J.R.4
  • 18
    • 0038360879 scopus 로고    scopus 로고
    • Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex
    • Hu Y, Fortini ME. 2003. Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol 161:685-690.
    • (2003) J Cell Biol , vol.161 , pp. 685-690
    • Hu, Y.1    Fortini, M.E.2
  • 19
    • 0036007117 scopus 로고    scopus 로고
    • Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
    • Hu Y, Ye Y, Fortini ME. 2002. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell 2:69-78.
    • (2002) Dev Cell , vol.2 , pp. 69-78
    • Hu, Y.1    Ye, Y.2    Fortini, M.E.3
  • 20
    • 2942604376 scopus 로고    scopus 로고
    • The gamma-secretase complex: Machinery for intramembrane proteolysis
    • Iwatsubo T. 2004. The gamma-secretase complex: Machinery for intramembrane proteolysis. Curr Opin Neurobiol 14:379-383.
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 379-383
    • Iwatsubo, T.1
  • 21
    • 0030868903 scopus 로고    scopus 로고
    • Alternativ cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    • Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. 1997. Alternativ cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277:373-376.
    • (1997) Science , vol.277 , pp. 373-376
    • Kim, T.W.1    Pettingell, W.H.2    Jung, Y.K.3    Kovacs, D.M.4    Tanzi, R.E.5
  • 23
    • 0035834145 scopus 로고    scopus 로고
    • PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling
    • Levitan D, Lee J, Song L, Manning R, Wong G, Parker E, Zhang L. 2001. PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling. Proc Natl Acad Sci USA 98:12186-12190.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12186-12190
    • Levitan, D.1    Lee, J.2    Song, L.3    Manning, R.4    Wong, G.5    Parker, E.6    Zhang, L.7
  • 25
    • 0030918403 scopus 로고    scopus 로고
    • The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    • Micchelli CA, Rulifson EJ, Blair SS. 1997. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124:1485-1495.
    • (1997) Development , vol.124 , pp. 1485-1495
    • Micchelli, C.A.1    Rulifson, E.J.2    Blair, S.S.3
  • 27
    • 33847021476 scopus 로고    scopus 로고
    • Presenilin diversifies its portfolio
    • Parks AL, Curtis D. 2007. Presenilin diversifies its portfolio. Trends Genet 23:140-150.
    • (2007) Trends Genet , vol.23 , pp. 140-150
    • Parks, A.L.1    Curtis, D.2
  • 29
    • 1242265691 scopus 로고    scopus 로고
    • Notch signaling activity
    • Schweisguth F. 2004. Notch signaling activity. Curr Biol 14:R129-R138.
    • (2004) Curr Biol , vol.14
    • Schweisguth, F.1
  • 31
    • 35348860241 scopus 로고    scopus 로고
    • Presenilin: Running with scissors in the membrane
    • Selkoe DJ, Wolfe MS. 2007. Presenilin: Running with scissors in the membrane. Cell 131:215-221.
    • (2007) Cell , vol.131 , pp. 215-221
    • Selkoe, D.J.1    Wolfe, M.S.2
  • 33
    • 0033639117 scopus 로고    scopus 로고
    • Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    • Struhl G, Adachi A. 2000. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol Cell 6:625-636.
    • (2000) Mol Cell , vol.6 , pp. 625-636
    • Struhl, G.1    Adachi, A.2
  • 34
    • 0033515530 scopus 로고    scopus 로고
    • Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071
    • Stahl B, Diehlmann A, Sudhof TC. 1999. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J Biol Chem 274:9141-9148.
    • (1999) J Biol Chem , vol.274 , pp. 9141-9148
    • Stahl, B.1    Diehlmann, A.2    Sudhof, T.C.3
  • 35
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G, Greenwald I. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-525.
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 36
    • 0035793082 scopus 로고    scopus 로고
    • Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
    • Struhl G, Greenwald I. 2001. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci USA 98:229-234.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 229-234
    • Struhl, G.1    Greenwald, I.2
  • 39
    • 84871967410 scopus 로고    scopus 로고
    • SVM-based prediction of caspase substrate cleavage sites
    • Wee LJ, Tan TW, Ranganathan S. 2006. SVM-based prediction of caspase substrate cleavage sites. BMC Bioinformatics 7(Suppl 5):S14.
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 5
    • Wee, L.J.1    Tan, T.W.2    Ranganathan, S.3
  • 40
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. 1999. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398:513-517.
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 41
    • 0037933495 scopus 로고    scopus 로고
    • Relationship between presenilinase and gamma-secretase
    • Xia W. 2003. Relationship between presenilinase and gamma-secretase. Drug News Perspect 16:69-74.
    • (2003) Drug News Perspect , vol.16 , pp. 69-74
    • Xia, W.1
  • 43
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu T, Rubin GM. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223-1237.
    • (1993) Development , vol.117 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 44
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    • Ye Y, Lukinova N, Fortini ME. 1999. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398:525-529.
    • (1999) Nature , vol.398 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3
  • 46
    • 17344372115 scopus 로고    scopus 로고
    • Interaction of presenilins with the filamin family of actin-binding proteins
    • Zhang W, Han SW, McKeel DW, Goate A, Wu JY. 1998. Interaction of presenilins with the filamin family of actin-binding proteins. J Neurosci 18:914-922.
    • (1998) J Neurosci , vol.18 , pp. 914-922
    • Zhang, W.1    Han, S.W.2    McKeel, D.W.3    Goate, A.4    Wu, J.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.