Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock

Clinical Microbiology Reviews

Volumn 22, Issue 2, 2009, Pages 224-239

  Vanlaere, Ineke ^b   Libert, Claude ^a  

^a GHENT UNIVERSITY   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; BB 1101; CORTICOSTEROID; DOXYCYCLINE; ILOMASTAT; INCYCLINIDE; MARIMASTAT; MATRIX METALLOPROTEINASE; TETRACYCLINE; TOLL LIKE RECEPTOR 4;

CHLAMYDIA; DISEASE MODEL; DRUG INHIBITION; DRUG TARGETING; ENDOTOXEMIA; ESCHERICHIA; GRAM NEGATIVE BACTERIUM; HELICOBACTER; INFECTION; INFLAMMATION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PSEUDOMONAS; REVIEW; SALMONELLA; SEPTIC SHOCK;

ANIMALS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MATRIX METALLOPROTEINASES; MICE; SHOCK, SEPTIC;

NEGIBACTERIA;

EID: 66449132072     PISSN: 08938512     EISSN: 10986618     Source Type: Journal    
DOI: 10.1128/CMR.00047-08     Document Type: Review

References (161)

1. Acharya, M. R., J. Venitz, W. D. Figg, and A. Sparreboom. 2004. Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist. Update 7:195-208. (Pubitemid 39024520)
2. Albert, J., A. Radomski, A. Soop, A. Sollevi, C. Frostell, and M. W. Radomski. 2003. Differential release of matrix metalloproteinase-9 and nitric oxide following infusion of endotoxin to human volunteers. Acta Anaesthesiol. Scand. 47:407-410.
3. Angus, D. C., W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:1303-1310.
4. Annane, D. 2001. Corticosteroids for septic shock. Crit. Care Med. 29: S117-S120.
5. Barton, G. M., and R. Medzhitov. 2003. Toll-like receptor signaling pathways. Science 300:1524-1525. (Pubitemid 36682871)
6. Becker, C. E., and L. A. O'Neill. 2007. Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin. Immunopathol. 29:239-248.
7. Bergin, P. J., S. Raghavan, H. Svensson, S. Starckx, I. Van Aelst, I. Gjertsson, G. Opdenakker, and M. Quiding-Jarbrink. 2008. Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis. FEMS Immunol. Med. Microbiol. 52:88-98.
8. Betsuyaku, T., J. M. Shipley, Z. Liu, and R. M. Senior. 1999. Neutrophil emigration in the lungs, peritoneum, and skin does not require gelatinase B. Am. J. Respir. Cell Mol. Biol. 20:1303-1309.
9. Beutler, B., and E. T. Rietschel. 2003. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol. 3:169-176.
10. Bianchi, M. E. 2007. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81:1-5.
11. Bodger, K., S. Ahmed, L. Pazmany, D. M. Pritchard, A. Micheal, A. L. Khan, R. Dimaline, G. J. Dockray, and A. Varro. 2008. Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection. J. Clinical Pathol. 61:72-78.
12. Brunn, G. J., M. K. Bungum, G. B. Johnson, and J. L. Platt. 2005. Conditional signaling by Toll-like receptor 4. FASEB J. 19:872-874. (Pubitemid 40617413)
13. Buras, J. A., B. Holzmann, and M. Sitkovsky. 2005. Animal models of sepsis: setting the stage. Nat. Rev. Drug Discov. 4:854-865.
14. Busiek, D. F., V. Baragi, L. C. Nehring, W. C. Parks, and H. G. Welgus. 1995. Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J. Immunol. 154:6484-6491.
15. Calandra, T., and J. Cohen. 2005. The International Sepsis Forum consensus conference on definitions of infection in the intensive care unit. Crit. Care Med. 33:1538-1548.
16. Castaneda, F. E., B. Walia, M. Vijay-Kumar, N. R. Patel, S. Roser, V. L. Kolachala, M. Rojas, L. Wang, G. Oprea, P. Garg, A. T. Gewirtz, J. Roman, D. Merlin, and S. V. Sitaraman. 2005. Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology 129:1991-2008. (Pubitemid 41772976)
17. Cauwe, B., P. E. Van den Steen, and G. Opdenakker. 2007. The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Crit. Rev. Biochem. Mol. Biol. 42:113-185.
18. Cavaillon, J. M., M. Adib-Conquy, C. Fitting, C. Adrie, and D. Payen. 2003. Cytokine cascade in sepsis. Scand. J. Infect. Dis. 35:535-544.
19. Chatterjee, S., S. Premachandran, J. Shukla, and T. B. Poduval. 2007. Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock. J. Surg. Res. 140:99-108.
20. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature 420:885-891. (Pubitemid 36019643)
21. Cohen, J. 2001. Mechanisms of tissue injury in sepsis: contrasts between gram positive and gram negative infection. J. Chemother. 13(Spec. No. 1):153-158. (Pubitemid 34183610)
22. Corbel, M., V. Lagente, N. Theret, N. Germain, B. Clement, and E. Boichot. 1999. Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm. Pharmacol. Ther. 12:165-171.
23. Cunningham, C., D. C. Wilcockson, S. Campion, K. Lunnon, and V. H. Perry. 2005. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 25:9275-9284. (Pubitemid 41500836)
24. Dean, R. A., J. H. Cox, C. L. Bellac, A. Doucet, A. E. Starr, and C. M. Overall. 2008. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood 112:3455-3464.
25. de Bentzmann, S., M. Polette, J. M. Zahm, J. Hinnrasky, C. Kileztky, O. Bajolet, J. M. Klossek, A. Filloux, A. Lazdunski, and E. Puchelle. 2000. Pseudomonas aeruginosa virulence factors delay airway epithelial wound repair by altering the actin cytoskeleton and inducing overactivation of epithelial matrix metalloproteinase-2. Lab. Investig. 80:209-219.
26. Deitch, E. A. 1998. Animal models of sepsis and shock: a review and lessons learned. Shock 9:1-11. (Pubitemid 128463868)
27. Delany, A. M., and C. E. Brinckerhoff. 1992. Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. J. Cell Biochem. 50:400-410. (Pubitemid 23005807)
28. Demeule, M., M. Brossard, M. Page, D. Gingras, and R. Beliveau. 2000. Matrix metalloproteinase inhibition by green tea catechins. Biochim. Biophys. Acta 1478:51-60.
29. Dubois, B., S. Starckx, A. Pagenstecher, J. Oord, B. Arnold, and G. Opdenakker. 2002. Gelatinase B deficiency protects against endotoxin shock. Eur. J. Immunol. 32:2163-2171.
30. Eipel, C., E. Kidess, K. Abshagen, K. Leminh, M. D. Menger, H. Burkhardt, and B. Vollmar. 2007. Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine- sensitized mice to lipopolysaccharide. Br. J. Pharmacol. 151:406-413.
31. Elkington, P. T., C. M. O'Kane, and J. S. Friedland. 2005. The paradox of matrix metalloproteinases in infectious disease. Clin. Exp. Immunol. 142: 12-20.
32. French, K., J. J. Yerbury, and M. R. Wilson. 2008. Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity. Biochemistry 47:1176-1185.
33. Freudenberg, M. A., S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler, and C. Galanos. 2008. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity. Immunobiology 213:193-203.
34. Gearing, A. J., P. Beckett, M. Christodoulou, M. Churchill, J. Clements, A. H. Davidson, A. H. Drummond, W. A. Galloway, R. Gilbert, J. L. Gordon, et al. 1994. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature 370:555-557. (Pubitemid 24264920)
35. Gibbs, D. F., T. P. Shanley, R. L. Warner, H. S. Murphy, J. Varani, and K. J. Johnson. 1999. Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases. Am. J. Respir. Cell Mol. Biol. 20:1145-1154.
36. Gibson, R. L., J. L. Burns, and B. W. Ramsey. 2003. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am. J. Respir. Crit. Care Med. 168:918-951.
37. Gottschall, P. E., X. Yu, and B. Bing. 1995. Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture. J. Neurosci. Res. 42:335-342.
38. Gurney, K. J., E. Y. Estrada, and G. A. Rosenberg. 2006. Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Neurobiol. Dis. 23:87-96.
39. Halter, J. M., L. A. Pavone, J. M. Steinberg, L. A. Gatto, J. DiRocco, S. Landas, and G. F. Nieman. 2006. Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture. Shock 26:587-591. (Pubitemid 44789633)
40. Handley, S. A., and V. L. Miller. 2007. General and specific host responses to bacterial infection in Peyer's patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infection. Mol. Microbiol. 64:94-110.
41. Haro, H., H. C. Crawford, B. Fingleton, K. Shinomiya, D. M. Spengler, and L. M. Matrisian. 2000. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J. Clin. Investig. 105:143-150.
42. Hartzell, W., and S. D. Shapiro. 1999. Macrophage elastase prevents Gemella morbillorum infection and improves outcome following murine bone marrow transplantation. Chest 116:31S-32S. (Pubitemid 29340194)
43. Hastbacka, J., M. Hynninen, E. Kolho, V. Pettila, T. Tervahartiala, T. Sorsa, and A. Lauhio. 2007. Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. Shock 27:145-150. (Pubitemid 46105830)
44. Hoffmann, U., T. Bertsch, E. Dvortsak, C. Liebetrau, S. Lang, V. Liebe, G. Huhle, M. Borggrefe, and M. Brueckmann. 2006. Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis. Scand. J. Infect. Dis. 38:867-872.
45. Holmbeck, K., P. Bianco, S. Yamada, and H. Birkedal-Hansen. 2004. MT1-MMP: a tethered collagenase. J. Cell Physiol. 200:11-19. (Pubitemid 38720617)
46. Hu, J., V. Dubois, P. Chaltin, P. Fiten, C. Dillen, P. E. Van den Steen, and G. Opdenakker. 2006. Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library. Comb. Chem. High Throughput Screen. 9:599-611.
47. Hu, J., P. E. Van den Steen, C. Dillen, and G. Opdenakker. 2005. Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock. Biochem. Pharmacol. 70:535-544.
48. Hu, J., P. E. Van den Steen, Q. X. Sang, and G. Opdenakker. 2007. Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat. Rev. Drug Discov. 6:480-498.
49. Imtiaz, M. T., J. T. Distelhorst, J. H. Schripsema, I. M. Sigar, J. N. Kasimos, S. R. Lacy, and K. H. Ramsey. 2007. A role for matrix metalloproteinase-9 in pathogenesis of urogenital Chlamydia muridarum infection in mice. Microbes Infect. 9:1561-1566. (Pubitemid 350217080)
50. Imtiaz, M. T., J. H. Schripsema, I. M. Sigar, J. N. Kasimos, and K. H. Ramsey. 2006. Inhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from urogenital Chlamydia muridarum infection. Infect. Immun. 74:5513-5521.
51. Ito, A., A. Mukaiyama, Y. Itoh, H. Nagase, I. B. Thogersen, J. J. Enghild, Y. Sasaguri, and Y. Mori. 1996. Degradation of interleukin 1beta by matrix metalloproteinases. J. Biol. Chem. 271:14657-14660.
52. Janeway, C. A., Jr., and R. Medzhitov. 1998. The role of innate immunity in the adaptive immune response. Semin. Immunol. 10:349-350.
53. Johnson, G. B., G. J. Brunn, Y. Kodaira, and J. L. Platt. 2002. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168:5233-5239. (Pubitemid 34495991)
54. Johnson, G. B., G. J. Brunn, and J. L. Platt. 2004. Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)- like reactions through Toll-like receptor 4. J. Immunol. 172:20-24. (Pubitemid 38020450)
55. Josephs, M. D., F. R. Bahjat, K. Fukuzuka, R. Ksontini, C. C. Solorzano, C. K. Edwards III, C. L. Tannahill, S. L. MacKay, E. M. Copeland III, and L. L. Moldawer. 2000. Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:R1196-R1201.
56. Kaplan, M. L., and L. Kaplan. 1933. The Gram stain and differential staining. J. Bacteriol. 25:309-321.
57. Kassim, S. Y., S. A. Gharib, B. H. Mecham, T. P. Birkland, W. C. Parks, and J. K. McGuire. 2007. Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect. Immun. 75:5640-5650. (Pubitemid 350207800)
58. Kim, H., and G. Koh. 2000. Lipopolysaccharide activates matrix metalloproteinase-2 in endothelial cells through an NF-κB-dependent pathway. Biochem. Biophys. Res. Commun. 269:401-405.
59. Kim, J. H., S. Y. Lee, S. M. Bak, I. B. Suh, S. Y. Lee, C. Shin, J. J. Shim, K. H. In, K. H. Kang, and S. H. Yoo. 2004. Effects of matrix metalloproteinase inhibitor on LPS-induced goblet cell metaplasia. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L127-L133.
60. Kim, K. C., and C. H. Lee. 2005. MAP kinase activation is required for the MMP-9 induction by TNF-stimulation. Arch. Pharm. Res. 28:1257-1262.
61. Kol, A., G. K. Sukhova, A. H. Lichtman, and P. Libby. 1998. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98:300-307. (Pubitemid 28348051)
62. Kundu, P., A. K. Mukhopadhyay, R. Patra, A. Banerjee, D. E. Berg, and S. Swarnakar. 2006. Cag pathogenicity island-independent up-regulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by Helicobacter pylori infection. J. Biol. Chem. 281:34651-34662.
63. Kwan, J. A., C. J. Schulze, W. Wang, H. Leon, M. Sariahmetoglu, M. Sung, J. Sawicka, D. E. Sims, G. Sawicki, and R. Schulz. 2004. Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J. 18:690-692.
64. Lai, W. C., M. Zhou, U. Shankavaram, G. Peng, and L. M. Wahl. 2003. Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Immunol. 170:6244-6249. (Pubitemid 36682609)
65. Lalu, M. M., J. Cena, R. Chowdhury, A. Lam, and R. Schulz. 2006. Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction. Br. J. Pharmacol. 149:31-42.
66. Lalu, M. M., T. Csont, and R. Schulz. 2004. Matrix metalloproteinase activities are altered in the heart and plasma during endotoxemia. Crit. Care Med. 32:1332-1337.
67. Lalu, M. M., C. Q. Gao, and R. Schulz. 2003. Matrix metalloproteinase inhibitors attenuate endotoxemia induced cardiac dysfunction: a potential role for MMP-9. Mol. Cell Biochem. 251:61-66.
68. Lambert, E., E. Dasse, B. Haye, and E. Petitfrere. 2004. TIMPs as multifacial proteins. Crit. Rev. Oncol. Hematol. 49:187-198.
69. Le, N. T., M. Xue, L. A. Castelnoble, and C. J. Jackson. 2007. The dual personalities of matrix metalloproteinases in inflammation. Front. Biosci. 12:1475-1487.
70. Lee, M. M., B. J. Yoon, K. Osiewicz, M. Preston, B. Bundy, A. M. van Heeckeren, Z. Werb, and P. D. Soloway. 2005. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect. Immun. 73:661-665.
71. Li, C. K., S. L. Pender, K. M. Pickard, V. Chance, J. A. Holloway, A. Huett, N. S. Goncalves, J. S. Mudgett, G. Dougan, G. Frankel, and T. T. MacDonald. 2004. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J. Immunol. 173:5171-5179. (Pubitemid 39387800)
72. Lin, M., P. Jackson, A. M. Tester, E. Diaconu, C. M. Overall, J. E. Blalock, and E. Pearlman. 2008. Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am. J. Pathol. 173: 144-153.
73. Lohi, J., C. L. Wilson, J. D. Roby, and W. C. Parks. 2001. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J. Biol. Chem. 276:10134-10144.
74. Lois, M., L. A. Brown, I. M. Moss, J. Roman, and D. M. Guidot. 1999. Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia. Am. J. Respir. Crit. Care Med. 160:1354-1360.
75. Lopez-Boado, Y. S., C. L. Wilson, L. V. Hooper, J. I. Gordon, S. J. Hultgren, and W. C. Parks. 2000. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J. Cell Biol. 148:1305-1315.
76. Lopez-Boado, Y. S., C. L. Wilson, and W. C. Parks. 2001. Regulation of matrilysin expression in airway epithelial cells by Pseudomonas aeruginosa flagellin. J. Biol. Chem. 276:41417-41423.
77. Madigan, M. M., J. Martinko, and J. Parker. 2003. Brock biology of microorganisms, 10th ed., p. 727-753. Pearson Education, Inc., Upper Saddle River, NJ.
78. Maier, S., T. Traeger, M. Entleutner, A. Westerholt, B. Kleist, N. Huser, B. Holzmann, A. Stier, K. Pfeffer, and C. D. Heidecke. 2004. Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 21:505-511.
79. Maitra, S. R., S. Bhaduri, P. D. Valane, T. Tervahartiala, T. Sorsa, and N. Ramamurthy. 2003. Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis. Shock 20:280-285.
80. Malemud, C. J. 2006. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front. Biosci. 11:1696-1701.
81. Malik, M., C. S. Bakshi, K. McCabe, S. V. Catlett, A. Shah, R. Singh, P. L. Jackson, A. Gaggar, D. W. Metzger, J. A. Melendez, J. E. Blalock, and T. J. Sellati. 2007. Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis. J. Immunol. 178:1013-1020. (Pubitemid 46095174)
82. Manicone, A. M., and J. K. McGuire. 2008. Matrix metalloproteinases as modulators of inflammation. Semin. Cell Dev. Biol. 19:34-41.
83. Marshall, J. C., E. Deitch, L. L. Moldawer, S. Opal, H. Redl, and T. van der Poll. 2005. Preclinical models of shock and sepsis: what can they tell us? Shock 24(Suppl. 1):1-6.
84. Martin, E. L., L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. Veldhuizen. 2005. Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 289:L244-L251.
85. Martin, E. L., B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. Veldhuizen. 2003. Negative impact of tissue inhibitor of metalloproteinase- 3 null mutation on lung structure and function in response to sepsis. Am. J. Physiol. Lung Cell Mol. Physiol. 285:L1222-L1232.
86. McCaig, C., C. Duval, E. Hemers, I. Steele, D. M. Pritchard, S. Przemeck, R. Dimaline, S. Ahmed, K. Bodger, D. D. Kerrigan, T. C. Wang, G. J. Dockray, and A. Varro. 2006. The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology 130:1754-1763. (Pubitemid 43668841)
87. McClellan, S. A., X. Huang, R. P. Barrett, S. Lighvani, Y. Zhang, D. Richiert, and L. D. Hazlett. 2006. Matrix metalloproteinase-9 amplifies the immune response to Pseudomonas aeruginosa corneal infection. Investig. Ophthalmol. Vis. Sci. 47:256-264.
88. Mignon, A., N. Rouquet, M. Fabre, S. Martin, J. C. Pages, J. F. Dhainaut, A. Kahn, P. Briand, and V. Joulin. 1999. LPS challenge in D-galactosamine- sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am. J. Respir. Crit. Care Med. 159:1308-1315.
89. Milano, S., F. Arcoleo, P. D'Agostino, and E. Cillari. 1997. Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood. Antimicrob. Agents Chemother. 41:117-121.
90. Mohan, M. J., T. Seaton, J. Mitchell, A. Howe, K. Blackburn, W. Burkhart, M. Moyer, I. Patel, G. M. Waitt, J. D. Becherer, M. L. Moss, and M. E. Milla. 2002. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry 41:9462-9469. (Pubitemid 34810022)
91. Moore, T. A., H. Y. Lau, A. L. Cogen, C. L. Monteleon, and T. J. Standiford. 2003. Anti-tumor necrosis factor-alpha therapy during murine Klebsiella pneumoniae bacteremia: increased mortality in the absence of liver injury. Shock 20:309-315.
92. Mulvey, M. A., Y. S. Lopez-Boado, C. L. Wilson, R. Roth, W. C. Parks, J. Heuser, and S. J. Hultgren. 1998. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 282:1494-1497. (Pubitemid 28538612)
93. Mun-Bryce, S., A. Lukes, J. Wallace, M. Lukes-Marx, and G. A. Rosenberg. 2002. Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation. Brain Res. 933:42-49. (Pubitemid 34258533)
94. Mun-Bryce, S., and G. A. Rosenberg. 1998. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am. J. Physiol. 274:R1203-R1211.
95. Muzio, M., N. Polentarutti, D. Bosisio, P. P. Manoj Kumar, and A. Mantovani. 2000. Toll-like receptor family and signalling pathway. Biochem. Soc. Trans. 28:563-566.
96. Nakamura, T., I. Ebihara, N. Shimada, H. Shoji, and H. Koide. 1998. Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment. Am. J. Med. Sci. 316:355-360.
97. Natividad, A., G. Cooke, M. J. Holland, M. J. Burton, H. M. Joof, K. Rockett, D. P. Kwiatkowski, D. C. Mabey, and R. L. Bailey. 2006. A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. BMC Med. Genet. 7:40.
98. Nenan, S., E. Boichot, J. M. Planquois, P. Berna, S. Hitier, T. Benard, V. Lagente, and C. P. Bertrand. 2008. Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways. Eur. J. Pharmacol. 579:374-381.
99. Nenan, S., V. Lagente, J. M. Planquois, S. Hitier, P. Berna, C. P. Bertrand, and E. Boichot. 2007. Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur. J. Pharmacol. 559:75-81.
100. Netea, M. G., B. J. Kullberg, L. A. Joosten, T. Sprong, I. Verschueren, O. C. Boerman, F. Amiot, W. B. van den Berg, and J. W. Van der Meer. 2001. Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways. Eur. J. Immunol. 31:2529-2538.
101. Nguyen, H. B., and D. Smith. 2007. Sepsis in the 21st century: recent definitions and therapeutic advances. Am. J. Emerg. Med. 25:564-571.
102. Ogden, S. R., L. E. Wroblewski, C. Weydig, J. Romero-Gallo, D. P. O'Brien, D. A. Israel, U. S. Krishna, B. Fingleton, A. B. Reynolds, S. Wessler, and R. M. Peek, Jr. 2008. p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell 19:4110-4121.
103. Oh, J., R. Takahashi, S. Kondo, A. Mizoguchi, E. Adachi, R. M. Sasahara, S. Nishimura, Y. Imamura, H. Kitayama, D. B. Alexander, C. Ide, T. P. Horan, T. Arakawa, H. Yoshida, S. Nishikawa, Y. Itoh, M. Seiki, S. Itohara, C. Takahashi, and M. Noda. 2001. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107:789-800. (Pubitemid 34033671)
104. Okamoto, T., T. Akaike, M. Suga, S. Tanase, H. Horie, S. Miyajima, M. Ando, Y. Ichinose, and H. Maeda. 1997. Activation of human matrix metalloproteinases by various bacterial proteinases. J. Biol. Chem. 272:6059-6066.
105. Okamura, Y., M. Watari, E. S. Jerud, D. W. Young, S. T. Ishizaka, J. Rose, J. C. Chow, and J. F. Strauss III. 2001. The extra domain A of fibronectin activates Toll-like receptor 4. J. Biol. Chem. 276:10229-10233.
106. Oku, N., M. Matsukawa, S. Yamakawa, T. Asai, S. Yahara, F. Hashimoto, and T. Akizawa. 2003. Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. Biol. Pharm. Bull. 26:1235-1238.
107. Opal, S. M. 2007. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int. J. Med. Microbiol. 297:365-377.
108. Osiewicz, K., M. McGarry, and P. D. Soloway. 1999. Hyper-resistance to infection in TIMP-1-deficient mice is neutrophil dependent but not immune cell autonomous. Ann. N. Y. Acad. Sci. 878:494-496.
109. Overall, C. M., J. L. Wrana, and J. Sodek. 1991. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J. Biol. Chem. 266:14064-14071.
110. Owen, C. A., Z. Hu, C. Lopez-Otin, and S. D. Shapiro. 2004. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J. Immunol. 172:7791-7803. (Pubitemid 38747647)
111. Ozato, K., H. Tsujimura, and T. Tamura. 2002. Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. BioTechniques Suppl. 66-68, 70, 72. (Pubitemid 35168044)
112. Page-McCaw, A., A. J. Ewald, and Z. Werb. 2007. Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 8:221-233.
113. Pagenstecher, A., A. K. Stalder, C. L. Kincaid, B. Volk, and I. L. Campbell. 2000. Regulation of matrix metalloproteinases and their inhibitor genes in lipopolysaccharide-induced endotoxemia in mice. Am. J. Pathol. 157:197-210.
114. Pal, S., A. P. Schmidt, E. M. Peterson, C. L. Wilson, and L. M. de la Maza. 2006. Role of matrix metalloproteinase-7 in the modulation of a Chlamydia trachomatis infection. Immunology 117:213-219.
115. Parks, W. C., C. L. Wilson, and Y. S. Lopez-Boado. 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat. Rev. Immunol. 4:617-629.
116. Pei, D., and S. J. Weiss. 1995. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature 375:244-247.
117. Puente, X. S., A. M. Pendas, E. Llano, G. Velasco, and C. Lopez-Otin. 1996. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56:944-949. (Pubitemid 26065382)
118. Pugin, J., M. C. Widmer, S. Kossodo, C. M. Liang, H. L. n. Preas, and A. F. Suffredini. 1999. Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am. J. Respir. Cell Mol. Biol. 20:458-464.
119. Ra, H. J., and W. C. Parks. 2007. Control of matrix metalloproteinase catalytic activity. Matrix Biol. 26:587-596. (Pubitemid 350180394)
120. Ralay Ranaivo, H., N. Carusio, R. Wangensteen, P. Ohlmann, C. Loichot, A. Tesse, K. Chalupsky, I. Lobysheva, J. Haiech, D. M. Watterson, and R. Andriantsitohaina. 2007. Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice. Am. J. Pathol. 170:439-446.
121. Ramsey, K. H., I. M. Sigar, J. H. Schripsema, N. Shaba, and K. P. Cohoon. 2005. Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice. Infect. Immun. 73:6962-6973.
122. Rather, L. J. 1971. Disturbance of function (functio laesa): the legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus. Bull. N. Y. Acad. Med. 47:303-322.
123. Remick, D. G., D. E. Newcomb, G. L. Bolgos, and D. R. Call. 2000. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock 13:110-116.
124. Renckens, R., J. J. Roelofs, S. Florquin, A. F. de Vos, H. R. Lijnen, C. van't Veer, and T. van der Poll. 2006. Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J. Immunol. 176:3735-3741.
125. Rhee, J. W., K. W. Lee, D. Kim, Y. Lee, O. H. Jeon, H. J. Kwon, and D. S. Kim. 2007. NF-κB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7. J. Biochem. Mol. Biol. 40:88-94.
126. Rosenberg, G. A., E. Y. Estrada, and S. Mobashery. 2007. Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced bloodbrain barrier opening in rodents: differences in response based on strains and solvents. Brain Res. 1133:186-192. (Pubitemid 46123248)
127. Rossa, C., Jr., M. Liu, P. Bronson, and K. L. Kirkwood. 2007. Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase. J. Endotoxin Res. 13:85-93. (Pubitemid 47471324)
128. Schaefer, L., A. Babelova, E. Kiss, H. J. Hausser, M. Baliova, M. Krzyzankova, G. Marsche, M. F. Young, D. Mihalik, M. Gotte, E. Malle, R. M. Schaefer, and H. J. Grone. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J. Clin. Investig. 115:2223-2233.
129. Schonbeck, U., F. Mach, and P. Libby. 1998. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J. Immunol. 161:3340-3346. (Pubitemid 128470627)
130. Schroen, D. J., and C. E. Brinckerhoff. 1996. Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. Gene Expr. 6:197-207.
131. Schultz, M. J., and T. van der Poll. 2002. Animal and human models for sepsis. Ann. Med. 34:573-581.
132. Sempowski, G. D., D. M. Lee, R. M. Scearce, D. D. Patel, and B. F. Haynes. 1999. Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. J. Exp. Med. 189:1011-1016.
133. Senft, A. P., T. R. Korfhagen, J. A. Whitsett, S. D. Shapiro, and A. M. LeVine. 2005. Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12. J. Immunol. 174:4953-4959. (Pubitemid 40514461)
134. Shapira, L., W. A. Soskolne, Y. Houri, V. Barak, A. Halabi, and A. Stabholz. 1996. Protection against endotoxic shock and lipopolysaccharide- induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect. Immun. 64:825-828.
135. Sharma, V. K., and R. P. Dellinger. 2006. Treatment options for severe sepsis and septic shock. Expert Rev. Anti Infect. Ther. 4:395-403.
136. Shi, J., S. Aono, W. Lu, A. J. Ouellette, X. Hu, Y. Ji, L. Wang, S. Lenz, F. W. van Ginkel, M. Liles, C. Dykstra, E. E. Morrison, and C. O. Elson. 2007. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J. Immunol. 179:1245-1253.
137. Smiley, S. T., J. A. King, and W. W. Hancock. 2001. Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J. Immunol. 167:2887-2894. (Pubitemid 32768923)
138. Smookler, D. S., F. F. Mohammed, Z. Kassiri, G. S. Duncan, T. W. Mak, and R. Khokha. 2006. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J. Immunol. 176:721-725. (Pubitemid 43099666)
139. Solorzano, C. C., R. Ksontini, J. H. Pruitt, T. Auffenberg, C. Tannahill, R. E. Galardy, G. P. Schultz, S. L. MacKay, E. M. Copeland III, and L. L. Moldawer. 1997. A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality. Shock 7:427-431. (Pubitemid 127726465)
140. Speidl, W. S., W. G. Toller, C. Kaun, T. W. Weiss, S. Pfaffenberger, S. P. Kastl, A. Furnkranz, G. Maurer, K. Huber, H. Metzler, and J. Wojta. 2004. Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937: possible implications for peri-operative plaque instability. FASEB J. 18:603-605.
141. Stamenkovic, I. 2003. Extracellular matrix remodelling: the role of matrix metalloproteinases. J. Pathol. 200:448-464. (Pubitemid 36818245)
142. Steinberg, J., J. Halter, H. J. Schiller, M. Dasilva, S. Landas, L. A. Gatto, P. Maisi, T. Sorsa, M. Rajamaki, H. M. Lee, and G. F. Nieman. 2003. Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J. Surg. Res. 111:185-195.
143. Takeda, M., K. Imada, T. Sato, and A. Ito. 2000. Activation of human progelatinase A/promatrix metalloproteinase 2 by Escherichia coli-derived serine proteinase. Biochem. Biophys. Res. Commun. 268:128-132.
144. Tanaka, A., Y. Yamane, and H. Matsuda. 2001. Mast cell MMP-9 production enhanced by bacterial lipopolysaccharide. J. Vet. Med. Sci. 63:811-813.
145. Termeer, C., F. Benedix, J. Sleeman, C. Fieber, U. Voith, T. Ahrens, K. Miyake, M. Freudenberg, C. Galanos, and J. C. Simon. 2002. Oligosaccharides of Hyaluronan activate dendritic cells via Toll-like receptor 4. J. Exp. Med. 195:99-111.
146. Tester, A. M., J. H. Cox, A. R. Connor, A. E. Starr, R. A. Dean, X. S. Puente, C. Lopez-Otin, and C. M. Overall. 2007. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One 2:e312.
147. Triantafilou, M., and K. Triantafilou. 2005. The dynamics of LPS recognition: complex orchestration of multiple receptors. J. Endotoxin Res. 11:5-11. (Pubitemid 40533073)
148. Tsuji, F., K. Oki, A. Okahara, H. Suhara, T. Yamanouchi, M. Sasano, S.
149. Vabulas, R. M., P. Ahmad-Nejad, S. Ghose, C. J. Kirschning, R. D. Issels, and H. Wagner. 2002. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J. Biol. Chem. 277:15107-15112.
150. Van den Steen, P. E., S. J. Husson, P. Proost, J. Van Damme, and G. Opdenakker. 2003. Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. Biochem. Biophys. Res. Commun. 310:889-896.
151. Van Lint, P., and C. Libert. 2007. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J. Leukoc. Biol. 82:1375-1381.
152. Van Lint, P., B. Wielockx, L. Puimege, A. Noel, C. Lopez-Otin, and C. Libert. 2005. Resistance of collagenase-2 (matrix metalloproteinase-8)-de- ficient mice to TNF-induced lethal hepatitis. J. Immunol. 175:7642-7649. (Pubitemid 41713464)
153. Vincent, J. L. 2007. Drotrecogin alfa (activated) in the treatment of severe sepsis. Curr. Drug Saf. 2:227-231.
154. Vincent, J. L., Y. Sakr, C. L. Sprung, V. M. Ranieri, K. Reinhart, H. Gerlach, R. Moreno, J. Carlet, J. R. Le Gall, and D. Payen. 2006. Sepsis in European intensive care units: results of the SOAP study. Crit. Care Med. 34:344-353.
155. Wang, W., A. Mitra, B. Poole, S. Falk, M. S. Lucia, S. Tayal, and R. Schrier. 2004. Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure. Am. J. Physiol. Renal Physiol. 287:F1044-F1048.
156. Warner, R. L., N. Bhagavathula, K. C. Nerusu, H. Lateef, E. Younkin, K. J. Johnson, and J. Varani. 2004. Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro. Exp. Mol. Pathol. 76:189-195.
157. Wilson, C. L., A. J. Ouellette, D. P. Satchell, T. Ayabe, Y. S. Lopez-Boado, J. L. Stratman, S. J. Hultgren, L. M. Matrisian, and W. C. Parks. 1999. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286:113-117. (Pubitemid 29484488)
158. Wroblewski, L. E., P. J. Noble, A. Pagliocca, D. M. Pritchard, C. A. Hart, F. Campbell, A. R. Dodson, G. J. Dockray, and A. Varro. 2003. Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J. Cell Sci. 116:3017-3026. (Pubitemid 36926990)
159. Xu, J., J. Qu, L. Cao, Y. Sai, C. Chen, L. He, and L. Yu. 2008. Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J. Pathol. 214:472-481.
160. Xu, T., B. Zeng, and X. Li. 2004. The role of neutrophil collagenase in endotoxic acute lung injury. J. Huazhong Univ. Sci. Technol. Med. Sci. 24:196-198.
161. Yassen, K. A., H. F. Galley, and N. R. Webster. 2001. Matrix metalloproteinase-9 concentrations in critically ill patients. Anaesthesia 56:729-732. (Pubitemid 32755137)