Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice

American Journal of Pathology

Volumn 170, Issue 2, 2007, Pages 439-446

  Ranaivo, Hantamalala Ralay ^a,b   Carusio, Nunzia ^a,c   Wangensteen, Rosemary ^a   Ohlmann, Patrick ^a   Loichot, Cecile ^a   Tesse, Angela ^a,c   Chalupsky, Karel ^a   Lobysheva, Irina ^d   Haiech, Jacques ^b   Watterson, D Martin ^a   Andriantsitohaina, Ramaroson ^a,c,e  

^a CNRS   (France)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Universite d'Angers   (France)

^d SEMENOV INSTITUTE OF CHEMICAL PHYSICS   (Russian Federation)

^e UNIVERSITÉ D'ANGERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MYOSIN LIGHT CHAIN KINASE; NITROGEN OXIDE; VASOCONSTRICTOR AGENT; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CECUM; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; GENE DELETION; LIGATION; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUNCTURE; SEPTIC SHOCK; SURVIVAL RATE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENETICS; HEART MUSCLE; LIVER; LUNG; METABOLISM; MOUSE MUTANT; PATHOLOGY; VASOCONSTRICTION;

ANIMALS; AORTA; GENE DELETION; LIPOPOLYSACCHARIDES; LIVER; LUNG; MICE; MICE, KNOCKOUT; MYOCARDIUM; MYOSIN-LIGHT-CHAIN KINASE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; SHOCK, SEPTIC; UP-REGULATION; VASOCONSTRICTION;

EID: 33947508111     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060219     Document Type: Article

References (37)

1. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150
2. Parrillo JE: Pathogenetic mechanisms of septic shock. N Engl J Med 1993, 328:1471-1478
3. Court O, Kumar A, Parrillo JE, Kumar A: Clinical review: myocardial depression in sepsis and septic shock. Crit Care 2002, 6:500-508
4. Dudek SM, Garcia JG: Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001, 91:1487-1500
5. Yuan SY, Wu MH, Ustinova EE, Guo M, Tinsley JH, De Lanerolle P, Xu W: Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage. Circ Res 2002, 90:1214-1221
6. Sedgwick JB, Menon I, Gern JE, Busse WW: Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration. J Allergy Clin Immunol 2002, 110:752-756
7. Das UN: Current advances in sepsis and septic shock with particular emphasis on the role of insulin. Med Sci Monit 2003, 9:RA181-RA192
8. Orfanos SE, Mavrommati I, Korovesi I, Roussos C: Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 2004, 30:1702-1714
9. Peters K, Unger RE, Brunner J, Kirkpatrick CJ: Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res 2003, 60:49-57
10. Julou-Schaeffer G, Gray GA, Fleming I, Schott C, Parratt JR, Stoclet JC: Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am J Physiol 1990, 259:H1038-H1043
11. Stoclet JC, Muller B, Andriantsitohaina R, Kleschyov A: Overproduction of nitric oxide in pathophysiology of blood vessels. Biochemistry (Mosc) 1998, 63:826-832
12. Stoclet JC, Martinez MC, Ohlmann P, Chasserot S, Schott C, Kleschyov AL, Schneider F, Andriantsitohaina R: Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock. Circulation 1999, 100:107-112
13. Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR: Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest 2005, 115:2702-2715
14. Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, Van Eldik LJ, Watterson DM: Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci USA 2003, 100:6233-6238
15. Tinsley JH, De Lanerolle P, Wilson E, Ma W, Yuan SY: Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability. Am J Physiol 2000, 279:C1285-C1289
16. Tinsley JH, Teasdale NR, Yuan SY: Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns. Am J Physiol 2004, 286:L841-L847
17. Garcia JG, Verin AD, Herenyiova M, English D: Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration. J Appl Physiol 1998, 84:1817-1821
18. Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG: Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol 2001, 280:L1168-L1178
19. Watterson DM, Collinge M, Lukas TJ, Van Eldik LJ, Birukov KG, Stepanova OV, Shirinsky VP: Multiple gene products are produced from a novel protein kinase transcription region. FEBS Lett 1995, 373:217-220
20. Garcia JG, Lazar V, Gilbert-McClain LI, Gallagher PJ, Verin AD: Myosin light chain kinase in endothelium: molecular cloning and regulation. Am J Respir Cell Mol Biol 1997, 16:489-494
21. Kudryashov DS, Stepanova OV, Vilitkevich EL, Nikonenko TA, Nadezhdina ES, Shanina NA, Lukas TJ, Van Eldik LJ, Watterson DM, Shirinsky VP: Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Exp Cell Res 2004, 298:407-417
22. Bouchon A, Facchetti F, Weigand MA, Colonna M: TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001, 410:1103-1107
23. Chalupsky K, Lobysheva I, Nepveu F, Gadea I, Beranova P, Entlicher G, Stoclet JC, Muller B: Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle. Biochem Pharmacol 2004, 67:1203-1214
24. Miller FJ, Jr., Gutterman DD, Rios CD, Heistad DD, Davidson BL: Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 1998, 82:1298-1305
25. Ohlmann P, Tesse A, Loichot C, Ralay Ranaivo H, Roul G, Philippe C, Watterson DM, Haiech J, Andriantsitohaina R: Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function. Am J Physiol 2005, 289:H2342-H2349
26. Laubach VE, Shesely EG, Smithies O, Sherman PA: Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci USA 1995, 92:10688-10692
27. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ: Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997, 94:8093-8098
28. Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, de la Rubia G, Stoclet JC, de Murcia G: Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 1999, 18:4446-4454
29. Hattori Y, Nakanishi N, Kasai K, Shimoda SI, Gross SS: Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle. Eur J Pharmacol 1996, 296:107-112
30. Lin P, Luby-Phelps K, Stull JT: Properties of filament-bound myosin light chain kinase. J Biol Chem 1999, 274:5987-5994
31. Smith L, Parizi-Robinson M, Zhu MS, Zhi G, Fukui R, Kamm KE, Stull JT: Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J Biol Chem 2002, 277:35597-35604
32. Wadgaonkar R, Linz-McGillem L, Zaiman AL, Garcia JG: Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity. J Cell Biochem 2005, 94:351-364
33. Eutamene H, Theodorou V, Schmidlin F, Tondereau V, Garcia-Villar R, Salvador-Cartier C, Chovet M, Bertrand C, Bueno L: LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK. Eur Respir J 2005, 25:789-796
34. Moriez R, Salvador-Cartier C, Theodorou V, Fioramonti J, Eutamene H, Bueno L: Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats. Am J Pathol 2005, 167:1071-1079
35. Wadgaonkar R, Dudek SM, Zaiman AL, Linz-McGillem L, Verin AD, Nurmukhambetova S, Romer LH, Garcia JG: Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. J Cell Biochem 2005, 95:849-858
36. Schneider F, Bucher B, Schott C, Andre A, Julou-Schaeffer G, Stoclet JC: Effect of lypopolysaccharide on function of rat femoral arteries. Am J Physiol 1994, 266:H191-H198
37. Martínez MC, Muller B, Stoclet JC, Andriantsitohaina R: Alteration by lypopolysaccharide of the relationship between intracellular calcium level and contraction in rat mesenteric artery. Br J Pharmacol 1996, 118:1218-1222