Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

Biochemical Pharmacology

Volumn 70, Issue 4, 2005, Pages 535-544

  Hu, Jialiang ^a   Van Den Steen, Philippe E ^a   Dillen, Chris ^a   Opdenakker, Ghislain ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Endotoxin; Inflammation; Lipopolysaccharide; Matrix metalloproteinase; Neutrophil; Sepsis

Indexed keywords

COLLAGENASE 3; GELATINASE B; GELATINASE INHIBITOR; INTERSTITIAL COLLAGENASE; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; NEUTROPHIL COLLAGENASE; REGASEPIN 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLASMA HALF LIFE; PRIORITY JOURNAL; SEPTIC SHOCK;

ANIMALS; ENDOTOXINS; HALF-LIFE; HUMANS; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MICE; MOLECULAR MIMICRY; OLIGOPEPTIDES; PROTEASE INHIBITORS;

EID: 22144471934     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.047     Document Type: Article

References (32)

1. R.C. Bone The pathogenesis of sepsis Ann Intern Med 115 1991 457 469
2. J.E. Parrillo Mechanisms of disease: pathogenetic mechanisms of septic shock N Engl J Med 328 1993 1471 1477
3. B. Beutler Toll-like receptors: how they work and what they do Curr Opin Hematol 9 2002 2 10
4. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C.V. Huffel, and X. Du Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
5. S.T. Qureshi, L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, and P. Gros Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med 189 1999 615 625
6. K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, and Y. Takeda Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J Immunol 162 1999 3749 3752
7. J. Rothe, W. Lesslauer, H. Lotscher, Y. Lang, P. Koebel, and F. Kontgen Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes Nature 364 1993 798 802
8. K. Pfeffer, T. Matsuyama, T.M. Kundig, A. Wakeham, K. Kishihara, and A. Shahinian Mice deficient for the 55 kDa tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection Cell 73 1993 457 467
9. B.D. Car, V.M. Eng, B. Schnyder, L. Ozmen, S. Huang, and P. Gallay Interferon gamma receptor deficient mice are resistant to endotoxic shock J Exp Med 179 1994 1437 1444
10. B. Dubois, S. Starckx, A. Pagenstecher, J. van den Oord, B. Arnold, and G. Opdenakker Gelatinase B deficiency protects against endotoxin shock Eur J Immunol 32 2002 2163 2171
11. A. Nakamura, Y. Mori, K. Hagiwara, T. Suzuki, T. Sakakibara, and T. Kikuchi Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice J Exp Med 197 2003 669 674
12. N.C. Riedemann, R.F. Guo, K.D. Bernacki, J.S. Reuben, I.J. Laudes, and T.A. Neff Regulation by C5a of neutrophil activation during sepsis Immunity 19 2003 193 202
13. E. Abraham, M.R. Gyetko, K. Kuhn, J. Arcaroli, D. Strassheim, and J.S. Park Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation J Immunol 170 2003 5644 5651
14. S.J. Weiss Tissue destruction by neutrophils N Engl J Med 320 1989 365 376
15. L. Paemen, P.M. Jansen, P. Proost, J. Van Damme, G. Opdenakker, and E. Hack Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia Cytokine 9 1997 412 415
16. J. Pugin, M.C. Widmer, S. Kossodo, C.M. Liang, H.L. Preas, and A.F. Suffredini Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators Am J Respir Cell Mol Biol 20 1999 458 464
17. A. Pagenstecher, A.K. Stalder, C.L. Kincaid, B. Volk, and I.L. Campbell Regulation of matrix metalloproteinases and their inhibitor genes in lipopolysaccharide-induced endotoxemia in mice Am J Pathol 157 2000 197 210
18. P.E. Van den Steen, P. Proost, A. Wuyts, J. Van Damme, and G. Opdenakker Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact Blood 96 2000 2673 2681
19. C.G. Knight, F. Willenbrock, and G. Murphy A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases FEBS Lett 296 1992 263 266
20. P.E. Van den Steen, P. Proost, D.D. Brand, A.H. Kang, J. Van Damme, and G. Opdenakker Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B Biochemistry 43 2004 10809 10816
21. T. Rabilloud Mechanisms of protein silver staining in polyacrylaminde gels: a 10-year synthesis Electrophoresis 11 1990 785 794
22. M.J. Castillo, K. Nakajima, M. Zimmerman, and J. Powers Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases Anal Biochem 99 1979 53 64
23. P.E. Van den Steen, P. Proost, B. Grillet, D.D. Brand, A.H. Kang, and J. Van Damme Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis FASEB J 12 2002 379 389
24. G. Opdenakker, P.E. Van den Steen, and J. Van Damme Gelatinase B: a tuner and amplifier of immune functions Trends Immunol 22 2001 571 579
25. W. Kafienah, D.J. Buttle, D. Burnett, and A.P. Hollander Cleavage of native type I collagen by human neutrophil elastase Biochem J 330 1998 897 902
26. A. Belaaouaj, R. McCarthy, M. Baumann, Z. Gao, T.J. Ley, and S.N. Abraham Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis Nat Med 4 1998 615 618
27. C.E. Hack, M. Hart, R.J. Van Schijndel, A.J. Eerenberg, J.H. Nuijens, and L.G. Thijs Interleukin-8 in sepsis: relation to shock and inflammatory mediators Infect Immun 60 1992 2835 2842
28. S. Endo, K. Inada, M. Ceska, T. Takakuwa, Y. Yamada, and H. Nakae Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock J Inflamm 45 1995 136 142
29. K.J. Van Zee, L.E. DeForge, E. Fischer, M.A. Marano, J.S. Kenney, and D.G. Remick IL-8 in septic shock, endotoxemia, and after IL-1 administration J Immunol 146 1991 3478 3482
30. S. Masure, P. Proost, J. Van Damme, and G. Opdenakker Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8 Eur J Biochem 198 1991 391 398
31. L. Paemen, E. Martens, K. Norga, S. Masure, E. Roets, and J. Hoogmartens The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors Biochem Pharmacol 52 1996 105 111
32. C.C. Solorzano, R. Ksontini, J.H. Pruitt, T. Auffenberg, C. Tannahill, and R.E. Galardy A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality Shock 7 1997 427 431