Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library

Combinatorial Chemistry and High Throughput Screening

Volumn 9, Issue 8, 2006, Pages 599-611

  Hu, Jialiang ^a   Dubois, Véronique ^a   Chaltin, Patrick ^a   Fiten, Pierre ^a   Dillen, Christiane ^a   Van Den Steen, Philippe E ^a   Opdenakker, Ghislain ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Endotoxin; Inflammation; Lipopolysaccharide; Matrix metalloproteinase; Neutrophil; Sepsis

Indexed keywords

AMINO ACID; GELATINASE B; METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PEPTIDE LIBRARY; PYRIDINE DERIVATIVE; PYRIDYLALANINE; UNCLASSIFIED DRUG; ZINC ION;

AMINO ACID SEQUENCE; ARTICLE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; DRUG EFFECT; HUMAN; IN VITRO STUDY; IN VIVO CULTURE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SEPTIC SHOCK;

ADAM PROTEINS; ALANINE; ANIMALS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MICE; NEUTROPHILS; PEPTIDE LIBRARY; PEPTIDES; SHOCK, SEPTIC; ZINC;

EID: 33748267056     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620706778249758     Document Type: Article

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