Differential effects between marimastat, a TNF-α converting enzyme inhibitor, and anti-TNF-α antibody on murine models for sepsis and arthritis

Cytokine

Volumn 17, Issue 6, 2002, Pages 294-300

  Tsuji, Fumio ^a   Oki, Kenji ^a   Okahara, Akihiko ^a   Suhara, Hiroshi ^a   Yamanouchi, Takashi ^a   Sasano, Minoru ^a   Mita, Shiro ^a   Horiuchi, Masato ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anti TNF ; Antibody; Arthritis; Human TNF transgenic mouse; Marimastat; Sepsis

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MARIMASTAT; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ADAM PROTEIN; ANTIBODY; ENZYME INHIBITOR; HYDROXAMIC ACID; METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL MODEL; ARTHRITIS; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; HISTOPATHOLOGY; LETHALITY; MALE; MORBIDITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEPTIC SHOCK; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG ANTAGONISM; GENETICS; HUMAN; IMMUNOLOGY; PATHOLOGY; SEPSIS;

MURINAE; MUS MUSCULUS;

ADAM PROTEINS; ANIMALS; ANTIBODIES; ARTHRITIS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; LIPOPOLYSACCHARIDES; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035985372     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2002.1015     Document Type: Article

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