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Important and highly interesting study illuminating the mechanism of action and binding of the salinosporamides to the 20S proteasome.
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Groll M., Huber R., and Potts B.C. Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc 128 (2006) 5136-5141. Important and highly interesting study illuminating the mechanism of action and binding of the salinosporamides to the 20S proteasome.
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(2006)
J Am Chem Soc
, vol.128
, pp. 5136-5141
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Groll, M.1
Huber, R.2
Potts, B.C.3
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47
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33947422815
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Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome
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Reed K.A., Manam R.R., Mitchell S.S., Xu J., Teisan S., Chao T.-H., Deyanat-Yazdi G., Neuteboom S.T., Lam K.S., and Potts B.C. Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. J Nat Prod 70 (2007) 269-276
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(2007)
J Nat Prod
, vol.70
, pp. 269-276
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Reed, K.A.1
Manam, R.R.2
Mitchell, S.S.3
Xu, J.4
Teisan, S.5
Chao, T.-H.6
Deyanat-Yazdi, G.7
Neuteboom, S.T.8
Lam, K.S.9
Potts, B.C.10
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48
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20044397059
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Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
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Macherla V.R., Mitchell S.S., Manam R.R., Reed K.A., Chao T.-H., Nicholson B., Deyanat-Yazdi G., Mai B., Jensen P.R., Fenical W.F., et al. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J Med Chem 48 (2005) 3684-3687
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(2005)
J Med Chem
, vol.48
, pp. 3684-3687
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Macherla, V.R.1
Mitchell, S.S.2
Manam, R.R.3
Reed, K.A.4
Chao, T.-H.5
Nicholson, B.6
Deyanat-Yazdi, G.7
Mai, B.8
Jensen, P.R.9
Fenical, W.F.10
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49
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45749125659
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Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
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This report describes the first genetic engineering of a new salinosporamide analog, which is the most active 'reversible' proteasome inhibitor of this structure class known to date.
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Eustáquio A.S., and Moore B.S. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed 47 (2008) 3936-3938. This report describes the first genetic engineering of a new salinosporamide analog, which is the most active 'reversible' proteasome inhibitor of this structure class known to date.
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(2008)
Angew Chem Int Ed
, vol.47
, pp. 3936-3938
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Eustáquio, A.S.1
Moore, B.S.2
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50
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45749102516
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Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
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McGlinchey R.P., Nett M., Eustáquio A.S., Asolkar R.N., Fenical W., and Moore B.S. Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130 (2008) 7822-7823
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(2008)
J Am Chem Soc
, vol.130
, pp. 7822-7823
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McGlinchey, R.P.1
Nett, M.2
Eustáquio, A.S.3
Asolkar, R.N.4
Fenical, W.5
Moore, B.S.6
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51
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21244463812
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An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition
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Reddy L.R., Fournier J.-F., Reddy B.V.S., and Corey E.J. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. J Am Chem Soc 127 (2005) 8974-8976
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(2005)
J Am Chem Soc
, vol.127
, pp. 8974-8976
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Reddy, L.R.1
Fournier, J.-F.2
Reddy, B.V.S.3
Corey, E.J.4
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52
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34447558011
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Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster
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This paper describes the cloning of the first vanadium-dependent chloroperoxidase from a marine bacterium involved in the biosynthesis of a natural product.
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Winter J.M., Moffit M.C., Zazopoulos E., McAlpine J.B., Dorrestein P.C., and Moore B.S. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem 282 (2007) 16362-16368. This paper describes the cloning of the first vanadium-dependent chloroperoxidase from a marine bacterium involved in the biosynthesis of a natural product.
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(2007)
J Biol Chem
, vol.282
, pp. 16362-16368
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Winter, J.M.1
Moffit, M.C.2
Zazopoulos, E.3
McAlpine, J.B.4
Dorrestein, P.C.5
Moore, B.S.6
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53
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36048994564
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GNAT-like strategy for polyketide chain initiation
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Gu L., Geders T.W., Wang B., Gerwick W.H., Hakansson K., Smith J.L., and Sherman D.H. GNAT-like strategy for polyketide chain initiation. Science 318 (2007) 970-974
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(2007)
Science
, vol.318
, pp. 970-974
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Gu, L.1
Geders, T.W.2
Wang, B.3
Gerwick, W.H.4
Hakansson, K.5
Smith, J.L.6
Sherman, D.H.7
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54
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56749085548
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Extending the biosynthetic repertoire in ribosomal peptide assembly
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Moore B.S. Extending the biosynthetic repertoire in ribosomal peptide assembly. Angew Chem Int Ed 47 (2008) 9386-9388
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(2008)
Angew Chem Int Ed
, vol.47
, pp. 9386-9388
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Moore, B.S.1
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55
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34548089959
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Enzymatic total synthesis of enterocin polyketides
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An impressive first example of a total biosynthesis of a marine microbial polyketide.
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Cheng Q., Xiang L., Izumikawa M., Meluzzi D., and Moore B.S. Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol 3 (2007) 557-558. An impressive first example of a total biosynthesis of a marine microbial polyketide.
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(2007)
Nat Chem Biol
, vol.3
, pp. 557-558
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Cheng, Q.1
Xiang, L.2
Izumikawa, M.3
Meluzzi, D.4
Moore, B.S.5
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56
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54349091335
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Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin
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Werneburg M., and Hertweck C. Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin. ChemBioChem 9 (2008) 2064-2066
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(2008)
ChemBioChem
, vol.9
, pp. 2064-2066
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Werneburg, M.1
Hertweck, C.2
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