Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome

Journal of Natural Products

Volumn 70, Issue 2, 2007, Pages 269-276

  Reed, Katherine A ^a   Manam, Rama Rao ^a   Mitchell, Scott S ^a   Xu, Jianlin ^a   Teisan, Sy ^a   Chao, Ta Hsiang ^a   Deyanat Yazdi, Gordafaried ^a   Neuteboom, Saskia T C ^a   Lam, Kin S ^a   Potts, Barbara C M ^a  

^a Nereus Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOSALINOSPORAMIDE; CHYMOTRYPSIN; LACTACYSTIN; LACTACYSTIN BETA LACTONE; NATURAL PRODUCT; NPI 0052; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; SALINOSPORAMIDE B; SALINOSPORAMIDE D; SALINOSPORAMIDE E; SALINOSPORAMIDE F; SALINOSPORAMIDE G; SALINOSPORAMIDE H; SALINOSPORAMIDE I; SALINOSPORAMIDE J; THIOESTER; THIOESTER 15; THIOESTER 16; THIOESTER 17; THIOESTER 18; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG ISOLATION; IC 50; MARINE BACTERIUM; MULTIPLE MYELOMA; NONHUMAN; SALINISPORA TROPICA; STRUCTURE ACTIVITY RELATION;

ACTINOBACTERIA; BAHAMAS; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; LACTONES; MARINE BIOLOGY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRROLES;

ORYCTOLAGUS CUNICULUS; SALINISPORA TROPICA;

EID: 33947422815     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np0603471     Document Type: Article

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