Synthesis and in vitro evaluation of the anticancer activity of novel fluorinated thiazolo[4,5-d]pyrimidines

Archiv der Pharmazie

Volumn 336, Issue 4-5, 2003, Pages 216-225

  Fahmy, Hesham T Y ^a   Rostom, Sherif A F ^b   Saudi, Manal N ^b   Zjawiony, Jordan K ^b   Robins, David J ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b NONE

Author keywords

Anticancer activity; Fluorinated; Thaizole; Thiazolo 4,5 d pyrimidines

Indexed keywords

3 (4 FLUOROPHENYL) 2 (2,4 DIFLUOROBENZYLIDENE)THIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 2 (2,4 DIFLUOROBENZYLIDENEHYDRAZONO)THIAZOLO[4,5 D]PYRIMIDINE 7(6H) THIONE; 3 (4 FLUOROPHENYL) 2 (4 FLUOROBENZYLIDINE)THIAZOLO[4,5 D]PYRIMIDINE 3(3H) THIONE; 3 (4 FLUOROPHENYL) 2 HYDRAZONOTHIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (4 FLUOROPHENYL) 5 METHYLTHIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 6 (2,4 DIFLUOROBENZYL)THIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 6 (2,4 DIFLUOROPHENYL) THIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 6 (4 FLUOROBENZYL)THIAZOLO[4,5 D]PYRIMIDINE 3(3H) THIONE; 3 (4 FLUOROPHENYL) 7 (2,4 DIFLUOROBENZYL) 5 METHYLTHIAZOLO[4,5 D]PYRIMIDINE; 3 (4 FLUOROPHENYL) 7 (2,4 DIFLUOROBENZYL)MERCAPTOTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 7 (2,4 DIFLUOROBENZYLIDENEHYDRAZINO) 5 METHYLTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 7 (4 FLUOROBENZYL) 5 METHYLTHIAZOLO[4,5 D]PYRIMIDINE; 3 (4 FLUOROPHENYL) 7 (4 FLUOROBENZYL)MERCAPTOTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 7 (4 FLUOROPHENYLAMINO) 5 METHYLTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 7 HYDRAZINO 5 METHYLTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) 7 MERCAPTOTHIAZOLO[4,5 D]PYRIMIDINE 2(3H) THIONE; 3 (4 FLUOROPHENYL) THIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE 2(3H) THIONE; 3,6 BIS(4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE 2(3H) THIONE; 4 AMINO 3 (4 FLUOROPHENYL) 6 (2,4 DIFLUOROBENZYLIDENEHYDRAZINOCARBONYL)THIAZOLE 2(3H) THIONE; 4 AMINO 3 (4 FLUOROPHENYL)(2,4 FLUOROPHENYLAMINOCARBONYLTHIAZOLO) 2(3H) THIONE; 4 AMINO 3 (4 FLUOROPHENYL)(4 FLUOROPHENYLTHIAZOLO) 2(3H) THIONE; 6 (2,4 DIFLUOROBENZYLIDENEAMINO) 3 (4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE 2(3H) THIONE; 7 CHLORO 3 (4 FLUOROPHENYL) 5 METHYLTHIAZOLO[4,5]PYRIMIDINE 2(3H) THIONE; PYRIMIDINE DERIVATIVE; THIAZOLO[4,5 D]PYRIMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0041734725     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300734     Document Type: Article

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