Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 51, Issue 6, 2008, Pages 1764-1770

  Cosimelli, Barbara ^a   Greco, Giovanni ^a   Ehlardo, Marina ^a   Novellino, Ettore ^a   Da Settimo, Federico ^b   Taliani, Sabrina ^b   La Motta, Concettina ^b   Bellandi, Marusca ^b   Tuccinardi, Tiziano ^b   Martinelli, Adriano ^b   Ciampi, Osele ^b   Trincavelli, Maria Letizia ^b   Martini, Claudia ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 HYDROXY 2 MERCAPTOPYRIMIDINE DERIVATE; ADENOSINE A3 RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 41149167187     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701159t     Document Type: Article

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