Synthesis and anti-tumor activities of novel pyrazolo[1,5-a]pyrimidines

Archiv der Pharmazie

Volumn 339, Issue 11, 2006, Pages 593-597

  Li, Juan ^a   Zhao, Yan Fang ^a   Zhao, Xiang Lin ^a   Yuan, Xiao Ye ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor activities; Pyrazolo 1,5 a pyrimidines; Synthesis

Indexed keywords

3 AMINO 4 CYANO PYRAZOLE; 5 CHLOROMETHYL 3 CYANO 7 CHLOROPYRAZOLO[1,5 A]PYRIMIDINE; 5 CHLOROMETHYL 3 CYANO 7 HYDROXYPYRAZOLO[1,5 A]PYRIMIDINE; 7 (3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (4 METHYLPIPERAZIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (DIETHYLAMINO)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (DIMETHYLAMINO)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (PYRROLIDIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,4 DICHLOROPHENYLAMINO) 3 CYANO 5 ((2 (4 METHYLPIPERAZIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,4 DICHLOROPHENYLAMINO) 3 CYANO 5 ((2 (DIETHYLAMINO)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,4 DICHLOROPHENYLAMINO) 3 CYANO 5 ((2 (DIMETHYLAMINO)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,5 BIS(TRIFLUOROMETHYL)PHENYLAMINO)3 CYANO 5 ((2 (4 METHYLPIPERAZIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,5 BIS(TRIFLUOROMETHYL)PHENYLAMINO)3 CYANO 5 ((2 MORPHOLINOETHYL)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (3,5 BIS(TRIFLUOROMETHYL)PHENYLAMINO)3 CYANO 5 ((2 PIPERIDIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (4 BROMO 3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (2 PYRROLIDIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (4 BROMO 3 CHLOROPHENYLAMINO) 3 CYANO 5 ((2 (4 METHYLPIPERAZIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (BENZO[D][1,3]DIOXOL 5 YL AMINO) 3 CYANO 5 ((2 (2 METHYLPIPERAZIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; 7 (BENZO[D][1,3]DIOXOL 5 YL AMINO) 3 CYANO 5 ((2 (2 PYRROLIDIN 1 YL)ETHOXY)METHYL)PYRAZOLO[1,5 A]PYRIMIDINE; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33751506561     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600098     Document Type: Article

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