Benzimidazole condensed ring systems: New synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo[4,5]imidazo[1, 2-a]pyrimidine derivatives

Archives of Pharmacal Research

Volumn 30, Issue 6, 2007, Pages 678-684

  Abdel Hafez, Atef Abdel Monem ^a  

^a University of Assiut   (Egypt)

Author keywords

Anticancer; Azinazoles; Benzimidazole; Cytotoxicity; Methyl cinnamates; Pyrimido 1,2 a benzimidazole

Indexed keywords

EID: 34347375692     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02977627     Document Type: Article

References (13)

1. Abadi, A. H., El-Subbagh, H. I., and Al-Khamees, H. A., Synthesis, antitumor and antitubercular evaluation of certain new xanthenone and acridinone analogs. Arzneim-Forsch./ Drug Res., 49, 259-266 (1999).
2. Badawy, E. and Kappe, T., Benzimidazole condensed ring systems. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-a]benzimidazoles and related derivatives. Eur. J. Med. Chem., 30, 327-332 (1995).
3. Bousignore, L., Loy, G., and Secci, D. A., Convenient synthesis of new heterocycles from benzimidazoles and carbon suboxide. J. Heterocycl. Chem., 29, 1033-1034 (1992).
4. Elnagdi, M. and WamHoff, H., Heterocyclic β-enamino esters. 28. The reaction of heterocyclic b-enamino esters and nitriles with cyclic amidines. A simple route to azolopyrimidines. J. Heterocycl. Chem., 18, 1287-1292 (1981).
5. Filippatos, E., Papadaki-Valiraki, A., Todoulou, O., and Jacquemin-Sablon A., Synthesis of N-(9H-xanthen-9-yl)aminoalkanamide and N-(9H-thioxanthen-9-yl) aminoalkanamide derivatives and their in vitro evaluation as potential intercalators and antitumor drugs. Arch. Pharm., 327, 61-66 (1994).
6. Frolov, A. N., Photochemic synthesis of pyrimido[1,2-a]benzimidazole derivatives. Russian J. Gen.Chem., 74, 1949-1951 (2004).
7. Gray, G. D. and Wickstrom, E., Evaluation of anchorage-independent proliferation in tumorigenic cells using the redox dye alamarBlue. Biotechniques, 21, 780-782 (1996).
8. Kimura, M., Kato, A., and Okabayashi, I., Acridine derivatives. IV.Synthesis, molecular structure, and antitumor activity of the novel 9-anilino-2,3-methylenedioxyacridines. J. Heterocycl. Chem., 29, 73-80 (1992).
9. Kreutzberger, A. and Leger, M., Antiarrhythmika. I. 2,4-dialkylpyrimido[ 1,2-a]benzimidazole. J. Heterocycl. Chem., 15, 1587-1588 (1981).
10. Matelli, S., Dzieduszyacka, M., Stefanska, B., Bontemps-Gracz, M., and Borowski, E., Synthesis and antineoplastic evaluation of 1,4- bis(aminoalkanamido)-9,10-anthracenediones. J. Med. Chem., 31, 1956-1959 (1988).
11. Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vislica, D., Hose, C., Langley, J., Cronise, P., and Vaigro-Wolff, A., Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83, 757-766 (1991).
12. Palmer, B. D., Rewcastle, G. W., Atwell, G. J., Baguley, B. C., and Denny, W. A., Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides. J. Med. Chem., 31, 707-712 (1988).
13. Soliman, F. S. G., Reda, S. M., Badawy, E., and Kappe, T., Synthesis and substituted 3 hydroxy-1H,5H-pyrido[1,2-a] benzimidazol-2-ones as possible antimicrobial and antineoplastic agents. Arch. Pharm., 317, 951-958 (1984).