Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint

Journal of Biological Chemistry

Volumn 284, Issue 14, 2009, Pages 9475-9488

  Varmeh, Shohreh ^a   Manfredi, James J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; APOPTOSIS; CANCER DEVELOPMENT; CATALYTIC ACTIVITY; CELL-CYCLE ARREST; CELL-CYCLE PROGRESSION; CELLULAR PROLIFERATIONS; CYCLIN-DEPENDENT KINASE; DNA CONTENT; IN-CELL; MULTI-STEP; ONCOGENIC ACTIVITIES; S-PHASE; TUMORIGENESIS;

CELL DEATH; CELL PROLIFERATION; CHEMICAL ACTIVATION; NITROGEN COMPOUNDS; NUCLEIC ACIDS; SECURITY OF DATA;

CELL MEMBRANES;

APHIDICOLIN; ATM PROTEIN; ATR PROTEIN; CAFFEINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; DUAL SPECIFICITY PHOSPHATASE; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; PHOSPHOTYROSINE; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA CONTENT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; CELL CYCLE; CELL LINE; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CAFFEINE; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE 2; ENZYME ACTIVATION; HUMANS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 66149137996     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900037200     Document Type: Article

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