The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 24633-24641

  Varmeh Ziaie, Shohreh ^a,b   Manfredi, James J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECTOPIC EXPRESSION; HUMAN TUMORS; PHOSPHATASES;

ENZYME INHIBITION; GENE EXPRESSION; MAMMALS; PHOSPHORYLATION; PROTEINS; TUMORS;

CATALYST ACTIVITY;

AMINO ACID; CD25B ENZYME; CDC25C ENZYME; CYCLIN B; PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CARCINOGENESIS; CATALYSIS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOSIS; MUTATIONAL ANALYSIS; PHOSPHORYLATION; PLASMID; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

CATALYTIC DOMAIN; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 2; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 34548314534     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703105200     Document Type: Article

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