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Volumn 4, Issue , 2009, Pages 97-126

The pathogenesis of pituitary tumors

Author keywords

Differentiation; Epigenetics; Oncogenes; Proliferation; Tumor suppressors

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; ADENOVIRUS VECTOR; AROMATIC HYDROCARBON RECEPTOR; CORTICOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLINE; DOPAMINE 2 RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FOLLITROPIN; GLUCOCORTICOID RECEPTOR; GONADORELIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH HORMONE; METHIONINE; PEGVISOMANT; PROTIRELIN; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRANSCRIPTION FACTOR GATA 2; TRANSFORMING GROWTH FACTOR BETA;

EID: 66149120642     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev.pathol.4.110807.092259     Document Type: Review
Times cited : (224)

References (150)
  • 2
    • 0002854560 scopus 로고    scopus 로고
    • Tumors of the pituitary gland
    • fascicle 22.Washington, D.C.: Armed Forces Inst. Pathol.
    • Asa SL. 1998.Tumors of the pituitary gland. In Atlas of Tumor Pathology, 3rd ser., fascicle 22.Washington, D.C.: Armed Forces Inst. Pathol.
    • (1998) Atlas of Tumor Pathology, 3rd Ser.
    • Asa, S.L.1
  • 3
    • 0021305505 scopus 로고
    • Functional morphology of the human fetal pituitary
    • Asa SL, Kovacs K. 1984. Functional morphology of the human fetal pituitary. Pathol. Annu. 19(Pt. 1):275-315
    • (1984) Pathol. Annu. , vol.19 , Issue.PART 1 , pp. 275-315
    • Asa, S.L.1    Kovacs, K.2
  • 4
    • 0037155604 scopus 로고    scopus 로고
    • Pituitary development: Regulatory codes in mammalian organogenesis
    • DOI 10.1126/science.1062736
    • Scully KM, Rosenfeld MG. 2002. Pituitary development: regulatory codes in mammalian organogenesis. Science 295:2231-2235 (Pubitemid 34258830)
    • (2002) Science , vol.295 , Issue.5563 , pp. 2231-2235
    • Scully, K.M.1    Rosenfeld, M.G.2
  • 5
    • 0032246451 scopus 로고    scopus 로고
    • The cytogenesis and pathogenesis of pituitary adenomas
    • Asa SL, Ezzat S. 1998. The cytogenesis and pathogenesis of pituitary adenomas. Endocr. Rev. 19:798-827
    • (1998) Endocr. Rev. , vol.19 , pp. 798-827
    • Asa, S.L.1    Ezzat, S.2
  • 6
    • 0027367422 scopus 로고
    • Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas
    • DOI 10.1210/jc.77.5.1275
    • Asa SL, Puy LA, Lew AM, Sundmark VC, Elsholtz HP. 1993. Cell type-specific expression of the pituitary transcription activator Pit-1 in the human pituitary and pituitary adenomas. J. Clin. Endocrinol. Metab. 77:1275-1280 (Pubitemid 23345482)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.77 , Issue.5 , pp. 1275-1280
    • Asa, S.L.1    Puy, L.A.2    Lew, A.M.3    Sundmark, V.C.4    Elsholtz, H.P.5
  • 8
    • 0025671979 scopus 로고
    • Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene
    • Day RN, Koike S, Sakai M, Muramatsu M, Maurer RA. 1990. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol. Endocrinol. 4:1964-1971
    • (1990) Mol. Endocrinol. , vol.4 , pp. 1964-1971
    • Day, R.N.1    Koike, S.2    Sakai, M.3    Muramatsu, M.4    Maurer, R.A.5
  • 9
    • 0026091281 scopus 로고
    • TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    • Drolet DW, Scully KM, Simmons DM, Wegner M, Chu K, et al. 1991. TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 5:1739-1753 (Pubitemid 21905871)
    • (1991) Genes and Development , vol.5 , Issue.10 , pp. 1739-1753
    • Drolet, D.W.1    Scully, K.M.2    Simmons, D.M.3    Wegner, M.4    Chu, K.5    Swanson, L.W.6    Rosenfeld, M.G.7
  • 11
    • 0035937414 scopus 로고    scopus 로고
    • A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins
    • DOI 10.1016/S0092-8674(01)00282-3
    • Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, et al. 2001. A pituitary cell-restricted T box factor, Tpit, activatesPOMCtranscription in cooperation with Pitx homeoproteins. Cell 104:849-859 (Pubitemid 32289278)
    • (2001) Cell , vol.104 , Issue.6 , pp. 849-859
    • Lamolet, B.1    Pulichino, A.-M.2    Lamonerie, T.3    Gauthier, Y.4    Brue, T.5    Enjalbert, A.6    Drouin, J.7
  • 13
    • 0030013893 scopus 로고    scopus 로고
    • The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
    • DOI 10.1210/jc.81.6.2165
    • Asa SL, Bamberger A-M, Cao B, Wong M, Parker KL, Ezzat S. 1996. The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph. J. Clin. Endocrinol. Metab. 81:2165-2170 (Pubitemid 26176708)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , Issue.6 , pp. 2165-2170
    • Asa, S.L.1    Bamberger, A.-M.2    Cao, B.3    Wong, M.4    Parker, K.L.5    Ezzat, S.6
  • 14
    • 0020662692 scopus 로고
    • The pars tuberalis of the human pituitary. a histologic, immunohistochemical, ultrastructural and immunoelectron microscopic analysis
    • Asa SL, Kovacs K, Bilbao JM. 1983. The pars tuberalis of the human pituitary. A histologic, immunohistochemical, ultrastructural and immunoelectron microscopic analysis. Virchows Arch. [A] 399:49-59 (Pubitemid 13185601)
    • (1983) Virchows Archiv a Pathological Anatomy and Histology , vol.399 , Issue.1 , pp. 49-59
    • Asa, S.L.1    Kovacs, K.2    Bilbao, J.M.3
  • 15
    • 0018408599 scopus 로고
    • Pituitary-brain vascular relations: A new paradigm
    • Bergland RM, Page RB. 1979. Pituitary-brain vascular relations: a new paradigm. Science 204:18-24
    • (1979) Science , vol.204 , pp. 18-24
    • Bergland, R.M.1    Page, R.B.2
  • 20
    • 0034792558 scopus 로고    scopus 로고
    • Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma
    • DOI 10.1046/j.1365-2265.2001.01322.x
    • Zahedi A, Booth GL, Smyth HS, Farrell WE, Clayton RN, et al. 2001. Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma. Clin. Endocrinol. (Oxf.) 55:549-556 (Pubitemid 32955495)
    • (2001) Clinical Endocrinology , vol.55 , Issue.4 , pp. 549-556
    • Zahedi, A.1    Booth, G.L.2    Smyth, H.S.3    Farrell, W.E.4    Clayton, R.N.5    Asa, S.L.6    Ezzat, S.7
  • 21
    • 0036831826 scopus 로고    scopus 로고
    • The pathogenesis of pituitary tumours
    • Asa SL, Ezzat S. 2002. The pathogenesis of pituitary tumours. Nat. Rev. Cancer 2:836-849
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 836-849
    • Asa, S.L.1    Ezzat, S.2
  • 22
    • 33646545708 scopus 로고    scopus 로고
    • Mechanisms of disease: The pathogenesis of pituitary tumors
    • Ezzat S, Asa SL. 2006. Mechanisms of disease: The pathogenesis of pituitary tumors. Nat. Clin. Pract. Endocrinol. Metab. 2:220-230
    • (2006) Nat. Clin. Pract. Endocrinol. Metab. , vol.2 , pp. 220-230
    • Ezzat, S.1    Asa, S.L.2
  • 23
    • 0036144332 scopus 로고    scopus 로고
    • Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
    • DOI 10.1172/JCI200214036
    • Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL. 2002. Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J. Clin. Invest. 109:69-78 (Pubitemid 34052543)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.1 , pp. 69-78
    • Ezzat, S.1    Zheng, L.2    Zhu, X.-F.3    Wu, G.E.4    Asa, S.L.5
  • 24
    • 0037490204 scopus 로고    scopus 로고
    • Pituitary tumor AP-2α recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4
    • DOI 10.1074/jbc.M212432200
    • Yu S, Asa SL,Weigel RJ, Ezzat S. 2003. Pituitary tumor AP-2α recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J. Biol. Chem. 278:19597-19602 (Pubitemid 36799142)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19597-19602
    • Yu, S.1    Asa, S.L.2    Weigel, R.J.3    Ezzat, S.4
  • 25
    • 0041924034 scopus 로고    scopus 로고
    • Ikaros isoforms in human pituitary tumors: Distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter
    • Ezzat S, Yu S, Asa SL. 2003. Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter. Am. J. Pathol. 163:1177-1184 (Pubitemid 37040153)
    • (2003) American Journal of Pathology , vol.163 , Issue.3 , pp. 1177-1184
    • Ezzat, S.1    Yu, S.2    Asa, S.L.3
  • 26
    • 5044219637 scopus 로고    scopus 로고
    • Pituitary tumor-derived fibroblast growth factor receptor 4 isoform disrupts neural cell-adhesion molecule/N-cadherin signaling to diminish cell adhesiveness: A mechanism underlying pituitary neoplasia
    • DOI 10.1210/me.2004-0182
    • Ezzat S, Zheng L, Asa SL. 2004. Pituitary tumor-derived fibroblast growth factor receptor 4 isoform disrupts neural cell-adhesion molecule/N-cadherin signaling to diminish cell adhesiveness: a mechanism underlying pituitary neoplasia. Mol. Endocrinol. 18:2543-2552 (Pubitemid 39335987)
    • (2004) Molecular Endocrinology , vol.18 , Issue.10 , pp. 2543-2552
    • Ezzat, S.1    Zheng, L.2    Asa, S.L.3
  • 31
    • 38749106141 scopus 로고    scopus 로고
    • Pituitary-specific knockout of the carney complex gene Prkar1a leads to pituitary tumorigenesis
    • DOI 10.1210/me.2006-0428
    • Yin Z, Williams-Simons L, Parlow AF, Asa S, Kirschner LS. 2008. Pituitary-specific knockout of the Carney complex gene prkar1a leads to pituitary tumorigenesis. Mol. Endocrinol. 22:380-387 (Pubitemid 351185937)
    • (2008) Molecular Endocrinology , vol.22 , Issue.2 , pp. 380-387
    • Yin, Z.1    Williams-Simons, L.2    Parlow, A.F.3    Asa, S.4    Kirschner, L.S.5
  • 33
    • 35348826087 scopus 로고    scopus 로고
    • AIP mutations are not identified in patients with sporadic pituitary adenomas
    • DOI 10.1007/s12022-007-0010-z
    • DiGiovanni R, Serra S, Ezzat S, Asa SL. 2007. AIP mutations are not identified in patients with sporadic pituitary adenomas. Endocr. Pathol. 18:76-78 (Pubitemid 47574990)
    • (2007) Endocrine Pathology , vol.18 , Issue.2 , pp. 76-78
    • Digiovanni, R.1    Serra, S.2    Ezzat, S.3    Asa, S.L.4
  • 35
    • 0027265595 scopus 로고
    • GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    • DOI 10.1038/ng0793-227
    • Godfrey P, Rahal J, Beamer W, Copeland N, Jenkins N, Mayo K. 1993. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat. Genet 4:227-232 (Pubitemid 23205169)
    • (1993) Nature Genetics , vol.4 , Issue.3 , pp. 227-232
    • Godfrey, P.1    Rahal, J.O.2    Beamer, W.G.3    Copeland, N.G.4    Jenkins, N.A.5    Mayo, K.E.6
  • 36
    • 0024464381 scopus 로고
    • Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: A histological, immunocytochemical, and electron microscopic investigation
    • Stefaneanu L, Kovacs K, Horvath E, Asa SL, Losinski NE, et al. 1989. Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation. Endocrinology 125:2710-2718 (Pubitemid 19279463)
    • (1989) Endocrinology , vol.125 , Issue.5 , pp. 2710-2718
    • Stefaneanu, L.1    Kovacs, K.2    Horvath, E.3    Asa, S.L.4    Losinski, N.E.5    Billestrup, N.6    Price, J.7    Vale, W.8
  • 37
    • 0020419989 scopus 로고
    • Somatotroph hyperplasia: Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone- Releasing factor
    • Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, et al. 1982. Somatotroph hyperplasia: successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone- releasing factor. J. Clin. Invest. 70:965-977
    • (1982) J. Clin. Invest. , vol.70 , pp. 965-977
    • Thorner, M.O.1    Perryman, R.L.2    Cronin, M.J.3    Rogol, A.D.4    Draznin, M.5
  • 38
    • 0024065111 scopus 로고
    • Growth hormone-releasing hormone-producing tumors: Clinical, biochemical, and morphological manifestations
    • Sano T, Asa SL, Kovacs K. 1988. Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr. Rev. 9:357-373
    • (1988) Endocr. Rev. , vol.9 , pp. 357-373
    • Sano, T.1    Asa, S.L.2    Kovacs, K.3
  • 39
    • 0026763324 scopus 로고
    • Growth hormone-releasing hormone transcripts in human pituitary adenomas
    • Levy A, Lightman SL. 1992. Growth hormone-releasing hormone transcripts in human pituitary adenomas. J. Clin. Endocrinol. Metab. 74:1474-1476
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 1474-1476
    • Levy, A.1    Lightman, S.L.2
  • 44
    • 0028849727 scopus 로고
    • Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas
    • Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, et al. 1995. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J. Clin. Endocrinol. Metab. 80:2933-2939
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 2933-2939
    • Hashimoto, K.1    Koga, M.2    Motomura, T.3    Kasayama, S.4    Kouhara, H.5
  • 51
    • 0023522307 scopus 로고
    • Altered G(s) and adenylate cyclase activity in human GH-secreting pituitary adenomas
    • DOI 10.1038/330566a0
    • Vallar L, Spada A, Giannattasio G. 1987. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330:566-568 (Pubitemid 17164352)
    • (1987) Nature , vol.330 , Issue.6148 , pp. 566-568
    • Vallar, L.1    Spada, A.2    Giannattasio, G.3
  • 52
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the α chain of G(s) and stimulate adenylyl cyclase in human pituitary tumours
    • DOI 10.1038/340692a0
    • Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. 1989. GTPase inhibiting mutations activate the α-chain of Gs and stimulate adenylate cyclase in human pituitary tumors. Nature 340:692-696 (Pubitemid 19214389)
    • (1989) Nature , vol.340 , Issue.6236 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 54
    • 0025695763 scopus 로고
    • Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase
    • Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, et al. 1990. Clinical, biochemical and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J. Clin. Endocrinol. Metab. 71:1421-1426 (Pubitemid 120032754)
    • (1990) Journal of Clinical Endocrinology and Metabolism , vol.71 , Issue.6 , pp. 1421-1426
    • Spada, A.1    Arosio, M.2    Bochicchio, D.3    Bazzoni, N.4    Vallar, L.5    Bassetti, M.6    Faglia, G.7
  • 57
    • 27544470454 scopus 로고    scopus 로고
    • The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    • DOI 10.1210/jc.2005-0998
    • Bhayana S, Booth GL, Asa SL, Kovacs K, Ezzat S. 2005. The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly. J. Clin. Endocrinol. Metab. 90:6290-6295 (Pubitemid 41606558)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.11 , pp. 6290-6295
    • Bhayana, S.1    Booth, G.L.2    Asa, S.L.3    Kovacs, K.4    Ezzat, S.5
  • 58
    • 0033899871 scopus 로고    scopus 로고
    • Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-Transgenic mice and GH receptor-deficient mice
    • Asa SL, Coschigano KT, Bellush L, Kopchick JJ, Ezzat S. 2000. Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-transgenic mice and GH receptor-deficient mice. Am. J. Pathol. 156:1009-1015 (Pubitemid 30626958)
    • (2000) American Journal of Pathology , vol.156 , Issue.3 , pp. 1009-1015
    • Asa, S.L.1    Coschigano, K.T.2    Bellush, L.3    Kopchick, J.J.4    Ezzat, S.5
  • 60
    • 0034898543 scopus 로고    scopus 로고
    • Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro
    • DOI 10.1159/000054675
    • Lohrer P, Gloddek J, Hopfner U, Losa M, Uhl E, et al. 2001. Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro. Neuroendocrinology 74: 95-105 (Pubitemid 32727576)
    • (2001) Neuroendocrinology , vol.74 , Issue.2 , pp. 95-105
    • Lohrer, P.1    Gloddek, J.2    Hopfner, U.3    Losa, M.4    Uhl, E.5    Pagotto, U.6    Stalla, G.K.7    Renner, U.8
  • 61
    • 0036153636 scopus 로고    scopus 로고
    • Functional role of estrogen in pituitary tumor pathogenesis
    • DOI 10.1172/JCI200214264
    • Heaney AP, Fernando M, Melmed S. 2002. Functional role of estrogen in pituitary tumor pathogenesis. J. Clin. Invest. 109:277-283 (Pubitemid 34083748)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.2 , pp. 277-283
    • Heaney, A.P.1    Fernando, M.2    Melmed, S.3
  • 62
    • 0033280666 scopus 로고    scopus 로고
    • Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner
    • DOI 10.1210/en.140.6.2628
    • Shen ES, Hardenburg JL, Meade EH, Arey BJ, Merchenthaler I, Lopez FJ. 1999. Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor α-dependent manner. Endocrinology 140:2628-2631 (Pubitemid 32248700)
    • (1999) Endocrinology , vol.140 , Issue.6 , pp. 2628-2631
    • Shen, E.S.1    Hardenburg, J.L.2    Meade, E.H.3    Arey, B.J.4    Merchenthaler, I.5    Lopez, F.J.6
  • 63
    • 0035716822 scopus 로고    scopus 로고
    • Adenovirus-directed expression of dominant negative estrogen receptor induces apoptosis in breast cancer cells and regression of tumors in nude mice
    • Lee EJ, Jakacka M, Duan WR, Chien PY, Martinson F, et al. 2001. Adenovirus-directed expression of dominant negative estrogen receptor induces apoptosis in breast cancer cells and regression of tumors in nude mice. Mol. Med. 7:773-782 (Pubitemid 34175299)
    • (2001) Molecular Medicine , vol.7 , Issue.11 , pp. 773-782
    • Eun, J.L.1    Jakacka, M.2    Duan, W.R.3    Pei, Y.C.4    Martinson, F.5    Gehm, B.D.6    Jameson, J.L.7
  • 65
    • 0141519699 scopus 로고    scopus 로고
    • Pituitary tumors and pregnancy
    • Molitch ME. 2003. Pituitary tumors and pregnancy. Growth Horm. IGF Res. 13(Suppl. A):S38-44
    • (2003) Growth Horm. IGF Res. , vol.13 , Issue.SUPPL. A
    • Molitch, M.E.1
  • 66
    • 0028290461 scopus 로고
    • Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration: A morphologic study
    • Kovacs K, Stefaneanu L, Ezzat S, Smyth HS. 1994. Prolactin-producing pituitary adenoma in amale-tofemale transsexual patient with protracted estrogen administration. A morphologic study. Arch. Pathol. Lab. Med. 118:562-565 (Pubitemid 24176837)
    • (1994) Archives of Pathology and Laboratory Medicine , vol.118 , Issue.5 , pp. 562-565
    • Kovacs, K.1    Stefaneanu, L.2    Ezzat, S.3    Smyth, H.S.4
  • 70
    • 0033303537 scopus 로고    scopus 로고
    • Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice
    • Asa SL, Kelly MA, Grandy DK, Low MJ. 1999. Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice. Endocrinology 140:5348-5355 (Pubitemid 30687146)
    • (1999) Endocrinology , vol.140 , Issue.11 , pp. 5348-5355
    • Asa, S.L.1    Kelly, M.A.2    Grandy, D.K.3    Low, M.J.4
  • 72
    • 0032745221 scopus 로고    scopus 로고
    • Autoregulation of the rat prolactin gene in lactotrophs
    • Devost D, Boutin JM. 1999. Autoregulation of the rat prolactin gene in lactotrophs. Mol. Cell Endocrinol. 158:99-109
    • (1999) Mol. Cell Endocrinol. , vol.158 , pp. 99-109
    • Devost, D.1    Boutin, J.M.2
  • 73
    • 0035066958 scopus 로고    scopus 로고
    • Implications of multiple phenotypes observed in prolactin receptor knockout mice
    • DOI 10.1006/frne.2001.0212
    • Kelly PA, Binart N, Lucas B, Bouchard B, Goffin V. 2001. Implications of multiple phenotypes observed in prolactin receptor knockout mice. Front. Neuroendocrinol. 22:140-145 (Pubitemid 32281580)
    • (2001) Frontiers in Neuroendocrinology , vol.22 , Issue.2 , pp. 140-145
    • Kelly, P.A.1    Binart, N.2    Lucas, B.3    Bouchard, B.4    Goffin, V.5
  • 74
    • 0036792502 scopus 로고    scopus 로고
    • Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms
    • Schuff KG, Hentges ST, Kelly MA, Binart N, Kelly PA, et al. 2002. Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. J. Clin. Invest. 110:973-981
    • (2002) J. Clin. Invest. , vol.110 , pp. 973-981
    • Schuff, K.G.1    Hentges, S.T.2    Kelly, M.A.3    Binart, N.4    Kelly, P.A.5
  • 76
    • 0027327234 scopus 로고
    • Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: Cloning and functional expression of the human thyrotropin-releasing hormone receptor gene
    • DOI 10.1006/bbrc.1993.2107
    • Yamada M, Monden T, Satoh T, Sato N, Murakami M, et al. 1993. Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. Biochem. Biophys. Res. Commun. 195:737-745 (Pubitemid 23280478)
    • (1993) Biochemical and Biophysical Research Communications , vol.195 , Issue.2 , pp. 737-745
    • Yamada, M.1    Monden, T.2    Satoh, T.3    Satoh, N.4    Murakami, M.5    Iriuchijima, T.6    Kakekgawa, T.7    Mori, M.8
  • 78
    • 0034837089 scopus 로고    scopus 로고
    • Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance
    • DOI 10.1210/me.15.9.1529
    • Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, et al. 2001. Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Mol. Endocrinol. 15:1529-1538 (Pubitemid 32826405)
    • (2001) Molecular Endocrinology , vol.15 , Issue.9 , pp. 1529-1538
    • Ando, S.1    Sarlis, N.J.2    Krishnan, J.3    Feng, X.4    Refetoff, S.5    Zhang, M.Q.6    Oldfield, E.H.7    Yen, P.M.8
  • 79
    • 0032720491 scopus 로고    scopus 로고
    • Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
    • Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, et al. 1999. Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system. J. Clin. Invest. 104:291-300
    • (1999) J. Clin. Invest. , vol.104 , pp. 291-300
    • Abel, E.D.1    Boers, M.E.2    Pazos-Moura, C.3    Moura, E.4    Kaulbach, H.5
  • 80
    • 18044383754 scopus 로고    scopus 로고
    • Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2
    • BrinkmeierML,Stahl JH, Gordon DF, Ross BD, Sarapura VD, et al. 2001. Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. Mol. Endocrinol. 15:2129-2136
    • (2001) Mol. Endocrinol. , vol.15 , pp. 2129-2136
    • Brinkmeier, M.L.1    Stahl, J.H.2    Gordon, D.F.3    Ross, B.D.4    Sarapura, V.D.5
  • 81
    • 0021268811 scopus 로고
    • Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. a clinical, morphologic, and biochemical study
    • Carey RM, Varma SK, Drake CR Jr, Thorner MO, Kovacs K, et al. 1984. Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. A clinical, morphologic, and biochemical study. N. Engl. J. Med. 311:13-20
    • (1984) N. Engl. J. Med. , vol.311 , pp. 13-20
    • Carey, R.M.1    Varma, S.K.2    Drake Jr., C.R.3    Thorner, M.O.4    Kovacs, K.5
  • 83
    • 0020554048 scopus 로고
    • The pituitary gland in untreated Addison's disease. a histologic and immunocytologic study of 18 adenohypophyses
    • Scheithauer BW, Kovacs K, Randall RV. 1983. The pituitary gland in untreated Addison's disease. A histologic and immunocytologic study of 18 adenohypophyses. Arch. Pathol. Lab. Med. 107:484-487
    • (1983) Arch. Pathol. Lab. Med. , vol.107 , pp. 484-487
    • Scheithauer, B.W.1    Kovacs, K.2    Randall, R.V.3
  • 84
    • 0030026713 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
    • Bamberger CM, Schulte HM, Chrousos GP. 1996. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr. Rev. 17:245-261
    • (1996) Endocr. Rev. , vol.17 , pp. 245-261
    • Bamberger, C.M.1    Schulte, H.M.2    Chrousos, G.P.3
  • 85
    • 0026026319 scopus 로고
    • Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
    • Hurley DM, Accili D, Stratakis CA, Karl M, Vamvakopoulos N, et al. 1991. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J. Clin. Invest. 87:680-686
    • (1991) J. Clin. Invest. , vol.87 , pp. 680-686
    • Hurley, D.M.1    Accili, D.2    Stratakis, C.A.3    Karl, M.4    Vamvakopoulos, N.5
  • 86
    • 0030179298 scopus 로고    scopus 로고
    • Cushing's disease preceded by generalized glucocorticoid resistance: Clinical consequences of a novel dominant-negative glucocorticoid receptor mutation
    • Karl M, Lamberts SWJ, Koper JW, Katz DA, Huizenga NE, et al. 1996. Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel dominant-negative glucocorticoid receptor mutation. Proc. Assoc. Am. Phys. 108:296-307
    • (1996) Proc. Assoc. Am. Phys. , vol.108 , pp. 296-307
    • Karl, M.1    Lamberts, S.W.J.2    Koper, J.W.3    Katz, D.A.4    Huizenga, N.E.5
  • 87
    • 9044238065 scopus 로고    scopus 로고
    • Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene
    • Karl M, von Wichert G, Kempter E, Katz DA, Reincke M, et al. 1996. Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene. J. Clin. Endocrinol. Metab. 81:124-129
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 124-129
    • Karl, M.1    Von Wichert, G.2    Kempter, E.3    Katz, D.A.4    Reincke, M.5
  • 88
    • 0018907113 scopus 로고
    • Gonadotroph cell adenoma of the pituitary in a woman with long-standing hypogonadism
    • Kovacs K, Horvath E, Rewcastle NB, Ezrin C. 1980. Gonadotroph cell adenoma of the pituitary in a woman with long-standing hypogonadism. Arch. Gynecol. 229:57-65 (Pubitemid 10137099)
    • (1980) Archives of Gynecology , vol.229 , Issue.1 , pp. 57-65
    • Kovacs, K.1    Horvath, E.2    Rewcastle, N.B.3    Ezrin, C.4
  • 93
    • 0034534149 scopus 로고    scopus 로고
    • Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling
    • Zhou Y, Sun H, Danila DC, Johnson SR, Sigai DP, et al. 2000. Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling. Mol. Endocrinol. 14:2066-2075
    • (2000) Mol. Endocrinol. , vol.14 , pp. 2066-2075
    • Zhou, Y.1    Sun, H.2    Danila, D.C.3    Johnson, S.R.4    Sigai, D.P.5
  • 96
    • 0033575347 scopus 로고    scopus 로고
    • Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
    • DOI 10.1126/science.285.5426.418
    • Zou H, McGarry TJ, Bernal T, Kirschner MW. 1999. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285:418-422 (Pubitemid 29343966)
    • (1999) Science , vol.285 , Issue.5426 , pp. 418-421
    • Zou, H.1    McGarry, T.J.2    Bernal, T.3    Kirschner, M.W.4
  • 97
    • 0030910680 scopus 로고    scopus 로고
    • Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    • DOI 10.1210/me.11.4.433
    • Pei L, Melmed S. 1997. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol. Endocrinol. 11:433-441 (Pubitemid 27147011)
    • (1997) Molecular Endocrinology , vol.11 , Issue.4 , pp. 433-441
    • Pei, L.1    Melmed, S.2
  • 101
    • 0023473125 scopus 로고
    • Characterization of murine monoclonal antibodies directed against basic fibroblast growth factor
    • DOI 10.1002/jcp.1041320316
    • Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. 1987. Structural characterization and biological functions of fibroblast growth factor. Endocr. Rev. 8:95-114 (Pubitemid 18005478)
    • (1987) Journal of Cellular Physiology , vol.132 , Issue.3 , pp. 531-537
    • Massoglia, S.L.1    Kenney, J.S.2    Gospodarowicz, D.J.3
  • 102
    • 0023548399 scopus 로고
    • Isolation and characterization of acidic and basic fibroblast growth factor
    • Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. 1987. Pituitary follicular cells produce basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA 84:5773-5777 (Pubitemid 18013014)
    • (1987) Methods in Enzymology , vol.147 , pp. 106-119
    • Gospodarowicz, D.1
  • 103
    • 0032536823 scopus 로고    scopus 로고
    • Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
    • DOI 10.1093/emboj/17.6.1642
    • Celli G, LaRochelle WJ, Mackem S, Sharp R, Merlino G. 1998. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J. 17:1642-1655 (Pubitemid 28119118)
    • (1998) EMBO Journal , vol.17 , Issue.6 , pp. 1642-1655
    • Celli, G.1    Larochelle, W.J.2    Mackem, S.3    Sharp, R.4    Merlino, G.5
  • 104
    • 0028912517 scopus 로고
    • Heterogeneous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas
    • Ezzat S, Smyth HS, Ramyar L, Asa SL. 1995. Heterogeneous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas. J. Clin. Endocrinol. Metab. 80:878-884
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 878-884
    • Ezzat, S.1    Smyth, H.S.2    Ramyar, L.3    Asa, S.L.4
  • 105
    • 0026621645 scopus 로고
    • Identification and characterization of high molecular weight forms of basic fibroblast growth factor in human pituitary adenomas
    • DOI 10.1210/jc.75.6.1436
    • Li Y, Koga M, Kasayama S, Matsumoto K, Arita N, et al. 1992. Identification and characterization of high molecular weight forms of basic fibroblast growth factor in human pituitary adenomas. J. Clin. Endocrinol. Metab. 75:1436-1441 (Pubitemid 23001398)
    • (1992) Journal of Clinical Endocrinology and Metabolism , vol.75 , Issue.6 , pp. 1436-1441
    • Li, Y.1    Koga, M.2    Kasayama, S.3    Matsumoto, K.4    Arita, N.5    Hayakawa, T.6    Sato, B.7
  • 107
    • 0035058293 scopus 로고    scopus 로고
    • The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production
    • DOI 10.1210/me.15.4.589
    • Asa SL, Ramyar L, Murphy PR, Li AW, Ezzat S. 2001. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Mol. Endocrinol. 15: 589-599 (Pubitemid 32324440)
    • (2001) Molecular Endocrinology , vol.15 , Issue.4 , pp. 589-599
    • Asa, S.L.1    Ramyar, L.2    Murphy, P.R.3    Li, A.W.4    Ezzat, S.5
  • 108
    • 0032742157 scopus 로고    scopus 로고
    • Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis
    • DOI 10.1038/15275
    • Heaney AP, Horwitz GA,Wang Z, Singson R, Melmed S. 1999. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat. Med. 5:1317-1321 (Pubitemid 29535612)
    • (1999) Nature Medicine , vol.5 , Issue.11 , pp. 1317-1321
    • Heaney, A.P.1    Horwitz, G.A.2    Wang, Z.3    Singson, R.4    Melmed, S.5
  • 109
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • DOI 10.1016/j.tig.2004.08.007, PII S0168952504002410
    • Itoh N, Ornitz DM. 2004. Evolution of the Fgf and Fgfr gene families. Trends Genet. 20:563-569 (Pubitemid 39314564)
    • (2004) Trends in Genetics , vol.20 , Issue.11 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 110
    • 0033961133 scopus 로고    scopus 로고
    • An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    • De Moerlooze L, Spencer-Dene B, Revest J, Hajihosseini M, Rosewell I, Dickson C. 2000. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127:483-492 (Pubitemid 30093396)
    • (2000) Development , vol.127 , Issue.3 , pp. 483-492
    • De Moerlooze, L.1    Spencer-Dene, B.2    Revest, J.-M.3    Hajihosseini, M.4    Rosewell, I.5    Dickson, C.6
  • 111
    • 0030904029 scopus 로고    scopus 로고
    • Altered expression of fibroblast growth factor receptors in human pituitary adenomas
    • DOI 10.1210/jc.82.4.1160
    • Abbass SAA, Asa SL, Ezzat S. 1997. Altered expression of fibroblast growth factor receptors in human pituitary adenomas. J. Clin. Endocrinol. Metab. 82:1160-1166 (Pubitemid 27166658)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.4 , pp. 1160-1166
    • Abbass, S.A.A.1    Asa, S.L.2    Ezzat, S.3
  • 112
    • 34250809655 scopus 로고    scopus 로고
    • Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells
    • DOI 10.2353/ajpath.2007.061111
    • Zhu X, Lee K, Asa SL, Ezzat S. 2007. Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells. Am. J. Pathol. 170:1618-1628 (Pubitemid 47339306)
    • (2007) American Journal of Pathology , vol.170 , Issue.5 , pp. 1618-1628
    • Zhu, X.1    Lee, K.2    Asa, S.L.3    Ezzat, S.4
  • 113
    • 42249103085 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia
    • DOI 10.1158/1078-0432.CCR-07-2003
    • Zhu X, Asa SL, Ezzat S. 2008. FGFR2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia. Clin. Cancer Res. 14:1984-1996 (Pubitemid 351551107)
    • (2008) Clinical Cancer Research , vol.14 , Issue.7 , pp. 1984-1996
    • Zhu, X.1    Asa, S.L.2    Ezzat, S.3
  • 114
    • 0033958517 scopus 로고    scopus 로고
    • Polysialylated-neural cell adhesion molecule expression in rat pituitary transplantable tumors (spontaneous mammotropic transplantable tumor in Wistar-Furth rats) is related to growth rate and malignancy
    • Daniel L, Trouillas J, Renaud W, Chevallier P, Gouvernet J, et al. 2000. Polysialylated-neural cell adhesion molecule expression in rat pituitary transplantable tumors (spontaneous mammotropic transplantable tumor inWistar-Furth rats) is related to growth rate and malignancy. Cancer Res. 60:80-85 (Pubitemid 30058735)
    • (2000) Cancer Research , vol.60 , Issue.1 , pp. 80-85
    • Daniel, L.1    Trouillas, J.2    Renaud, W.3    Chevallier, P.4    Gouvernet, J.5    Rougon, G.6    Figarella-Branger, D.7
  • 117
    • 0028961786 scopus 로고
    • Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: Evidence for a chromosome 13 tumor suppressor gene other than RB
    • Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D. 1995. Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res. 55:1613-1616
    • (1995) Cancer Res. , vol.55 , pp. 1613-1616
    • Pei, L.1    Melmed, S.2    Scheithauer, B.3    Kovacs, K.4    Benedict, W.F.5    Prager, D.6
  • 118
    • 0030057813 scopus 로고    scopus 로고
    • Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors
    • DOI 10.1002/(SICI)1097-0215(19960703)67:1<16::AID-IJC4>3.0.CO;2-2
    • Woloschak M, Yu A, Xiao J, Post KD. 1996. Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors. Int. J. Cancer 67:16-19 (Pubitemid 26236062)
    • (1996) International Journal of Cancer , vol.67 , Issue.1 , pp. 16-19
    • Woloschak, M.1    Yu, A.2    Xiao, J.3    Post, K.D.4
  • 119
    • 0031037481 scopus 로고    scopus 로고
    • Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker
    • Bates AS, Farrell WE, Bicknell EJ, McNicol AM, Talbot AJ, et al. 1997. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J. Clin. Endocrinol. Metab. 82:818-824
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 818-824
    • Bates, A.S.1    Farrell, W.E.2    Bicknell, E.J.3    McNicol, A.M.4    Talbot, A.J.5
  • 121
    • 17644387182 scopus 로고    scopus 로고
    • Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    • DOI 10.1128/MCB.25.9.3563-3574.2005
    • Lasorella A, Rothschild G, Yokota Y, Russell RG, Iavarone A. 2005. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol. Cell Biol. 25:3563-3574 (Pubitemid 40559563)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.9 , pp. 3563-3574
    • Lasorella, A.1    Rothschild, G.2    Yokota, Y.3    Russell, R.G.4    Iavarone, A.5
  • 123
    • 0027415702 scopus 로고
    • Immunohistochemical expression of protein kinase C Type III in human pituitary adenomas
    • Sumi T, Stefaneanu L, Kovacs K, Asa SL, Rindi G. 1993. Immunohistochemical study of p53 protein in human and animal pituitary tumors. Endocr. Pathol. 4:95-99 (Pubitemid 23099531)
    • (1993) Neurosurgery , vol.32 , Issue.4 , pp. 635-642
    • Todo, T.1    Buchfelder, M.2    Thierauf, P.3    Fahlbusch, R.4    Kovacs, K.5
  • 124
    • 0029917618 scopus 로고    scopus 로고
    • P53 Expression in pituitary adenomas and carcinomas: Correlation with invasiveness and tumor growth fractions
    • Thapar K, Scheithauer BW, Kovacs K, Pernicone PJ, Laws ER Jr. 1996. p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions. Neurosurgery 38:765-771 (Pubitemid 26087884)
    • (1996) Neurosurgery , vol.38 , Issue.4 , pp. 765-771
    • Thapar, K.1    Scheithauer, B.W.2    Kovacs, K.3    Pernicone, P.J.4    Laws Jr., E.R.5
  • 126
    • 0033171011 scopus 로고    scopus 로고
    • Invasive pituitary adenomas: Significance of proliferation parameters
    • Amar AP, Hinton DR, Krieger MD, Weiss MH. 1999. Invasive pituitary adenomas: significance of proliferation parameters. Pituitary 2:117-122
    • (1999) Pituitary , vol.2 , pp. 117-122
    • Amar, A.P.1    Hinton, D.R.2    Krieger, M.D.3    Weiss, M.H.4
  • 127
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9: 1149-1163
    • (1995) Genes Dev. , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 128
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • DOI 10.1016/S0092-8674(00)81237-4
    • Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, et al. 1996. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707-720 (Pubitemid 26181050)
    • (1996) Cell , vol.85 , Issue.5 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6    Horii, I.7    Loh, D.Y.8    Nakayama, K.-I.9
  • 134
    • 0036793767 scopus 로고    scopus 로고
    • Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells
    • Liu W, Asa SL, Ezzat S. 2002. Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells. Brain Pathol. 12: 412-419 (Pubitemid 35154928)
    • (2002) Brain Pathology , vol.12 , Issue.4 , pp. 412-419
    • Liu, W.1    Asa, S.L.2    Ezzat, S.3
  • 136
    • 0030801289 scopus 로고    scopus 로고
    • Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation
    • DOI 10.1002/(SICI)1098-2744(199708)19:4<221::AID-MC1>3.0.CO;2-F
    • Woloschak M, Yu A, Post KD. 1997. Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol. Carcinog. 19:221-224 (Pubitemid 27391999)
    • (1997) Molecular Carcinogenesis , vol.19 , Issue.4 , pp. 221-224
    • Woloschak, M.1    Yu, A.2    Post, K.D.3
  • 137
    • 0033304571 scopus 로고    scopus 로고
    • Transfection of an inducible p16/CDKN2A construct mediates reversible growth inhibition and G1 arrest in the AtT20 pituitary tumor cell line
    • Frost SJ, Simpson DJ, Clayton RN, Farrell WE. 1999. Transfection of an inducible p16/CDKN2A construct mediates reversible growth inhibition and G1 arrest in the AtT20 pituitary tumor cell line. Mol. Endocrinol. 13:1801-1810
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1801-1810
    • Frost, S.J.1    Simpson, D.J.2    Clayton, R.N.3    Farrell, W.E.4
  • 139
    • 1342322685 scopus 로고    scopus 로고
    • Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation
    • DOI 10.1038/sj.onc.1207193
    • Bahar A, Bicknell JE, Simpson DJ, Clayton RN, Farrell WE. 2004. Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation. Oncogene 23:936-944 (Pubitemid 38250939)
    • (2004) Oncogene , vol.23 , Issue.4 , pp. 936-944
    • Bahar, A.1    Bicknell, J.E.2    Simpson, D.J.3    Clayton, R.N.4    Farrell, W.E.5
  • 140
    • 17844397712 scopus 로고    scopus 로고
    • Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors
    • DOI 10.1210/jc.2004-1848
    • Zhao J, Dahle D, Zhou Y, Zhang X, Klibanski A. 2005. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. J. Clin. Endocrinol. Metab. 90:2179-2186 (Pubitemid 40586259)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.4 , pp. 2179-2186
    • Zhao, J.1    Dahle, D.2    Zhou, Y.3    Zhang, X.4    Klibanski, A.5
  • 142
    • 0030933151 scopus 로고    scopus 로고
    • The role of the Ikaros gene in lymphocyte development and homeostasis
    • DOI 10.1146/annurev.immunol.15.1.155
    • Georgopoulos K,Winandy S, Avitahl N. 1997. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu. Rev. Immunol. 15:155-176 (Pubitemid 27169278)
    • (1997) Annual Review of Immunology , vol.15 , pp. 155-176
    • Georgopoulos, K.1    Winandy, S.2    Avitahl, N.3
  • 145
    • 15444368750 scopus 로고    scopus 로고
    • The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility
    • DOI 10.1210/me.2004-0432
    • Ezzat S, Yu S, Asa SL. 2005. The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. Mol. Endocrinol. 19:1004-1011 (Pubitemid 40397064)
    • (2005) Molecular Endocrinology , vol.19 , Issue.4 , pp. 1004-1011
    • Ezzat, S.1    Yu, S.2    Asa, S.L.3
  • 146
    • 33751520959 scopus 로고    scopus 로고
    • Tumor-derived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells
    • DOI 10.1210/me.2006-0265
    • Ezzat S, Zhu X, Loeper S, Fischer S, Asa SL. 2006. Tumor-derived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells. Mol. Endocrinol. 20:2976-2986 (Pubitemid 44833549)
    • (2006) Molecular Endocrinology , vol.20 , Issue.11 , pp. 2976-2986
    • Ezzat, S.1    Zhu, X.2    Loeper, S.3    Fischer, S.4    Asa, S.L.5
  • 147
    • 45549101308 scopus 로고    scopus 로고
    • Ikaros modulates cholesterol uptake: A link between tumor suppression and differentiation
    • Loeper S, Asa SL, Ezzat S. 2008. Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res. 68:3715-3723
    • (2008) Cancer Res. , vol.68 , pp. 3715-3723
    • Loeper, S.1    Asa, S.L.2    Ezzat, S.3
  • 150
    • 33751526944 scopus 로고    scopus 로고
    • Targeting N-cadherin through fibroblast growth factor receptor-4: Distinct pathogenetic and therapeutic implications
    • DOI 10.1210/me.2006-0223
    • Ezzat S, Zheng L, Winer D, Asa SL. 2006. Targeting N-cadherin through fibroblast growth factor receptor - 4: distinct pathogenetic and therapeutic implications. Mol. Endocrinol. 20:2965-2975 (Pubitemid 44833547)
    • (2006) Molecular Endocrinology , vol.20 , Issue.11 , pp. 2965-2975
    • Ezzat, S.1    Zheng, L.2    Winer, D.3    Asa, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.