Ikaros isoforms in human pituitary tumors: Distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter

American Journal of Pathology

Volumn 163, Issue 3, 2003, Pages 1177-1184

  Ezzat, Shereen ^a   Yu, Shunjiang ^a   Asa, Sylvia L ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 4; HISTONE; IKAROS TRANSCRIPTION FACTOR; ISOPROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ACETYLATION; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HETEROCHROMATIN; HUMAN; HUMAN TISSUE; HYPOPHYSIS TUMOR; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZINC FINGER MOTIF;

EID: 0041924034     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63477-3     Document Type: Article

References (28)

1. Asa SL, Ezzat S: The pathogenesis of pituitary tumours. Nat Rev Cancer 2002, 2:836-849
2. Ezzat S, Smyth HS, Ramyar L, Asa SL: Heterogeneous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas. J Clin Endocrinol Metab 1995, 80:878-884
3. Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL: Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis J Clin Invest 2002, 109:69-78
4. Yu S, Asa SL, Ezzat S: Fibroblast growth factor receptor 4 is a target for the zinc-finger transcription factor Ikaros in the pituitary. Mol Endocrinol 2002, 16:1069-1078
5. Molnar A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K: The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 1996, 156:585-592
6. Georgopoulos K, Winandy S, Avitahl N: The role of the Ikaros gene in lymphocyte development and homeostasis, Annu Rev Immunol 1997, 15:155-176
7. Georgopoulos K: Haematopoietic cell-fate decisions, chromatin regulation and Ikaros. Nat Rev Immunol 2002, 2:162-174
8. Sun L, Liu A, Georgopoulos K: Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J 1996, 15:5358-5369
9. Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST: The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol Cell Biol 1994, 14:7111-7123
10. Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev 1998, 12:782-796
11. Winandy S, Wu P, Georgopoulos K: A dominant mutation in the lkaros gene leads to rapid development of leukemia and lymphoma. Cell 1995, 83:289-299
12. Molnar A, Georgopoulos K: The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 1994, 14:8292-8303
13. Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A, Sensel M, Reaman GH, Uckun FM: Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1999, 96: 680-685
14. Cortes M, Wong E, Koipally J, Georgopoulos K: Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol 1999, 11:167-171
15. Winandy S, Wu L, Wang JH, Georgopoulos K: Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med 1999, 190:1039-1048
16. Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K: Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996, 5:537-549
17. Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K: Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 1999, 10:333-343
18. Asa SL, Ramyar L, Murphy PR, Li AW, Ezzat S: The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Mol Endocrinol 2001, 15:589-599
19. Asa SL, Coschigano KT, Bellush L, Kopchick JJ, Ezzat S: Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-transgenic mice and GH receptor-deficient mice. Am J Pathol 2000, 156:1009-1015
20. Koipally J, Kim J, Jones B, Jackson A, Avitahl N, Winandy S, Trevisan M, Nichogiannopoulou A, Kelley C, Georgopoulos K: Ikaros chromatin remodeling complexes in the control of differentiation of the hemolymphoid system. Cold Spring Harbor Symp Quant Biol 1999, 64: 79-86
21. Wargnier A, Lafaurie C, Legros-Maida S, Bourge JF, Sigaux F, Sasportes M, Paul P: Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. J Biol Chem 1998, 273:35326-35331
22. Christopherson I, Piechoki M, Liu G, Ratner S, Galy A: Regulation of L-selectin expression by a dominant negative Ikaros protein J Leukoc Biol 2001, 69:675-683
23. Koipally J, Renold A, Kim J, Georgopoulos K: Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 1999, 18:3090-3100
24. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K: Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 1999, 10:345-355
25. Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N: Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J 2001, 20:2812-2822
26. Koipally J, Heller EJ, Seavitt JR, Georgopoulos K: Unconventional potentiation of gene expression by Ikaros J Biol Chem 2002, 277: 13007-13015
27. Koritschoner NP, Bartunek P, Knespel S, Blendinger G, Zenke M: The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation. Oncogene 1999, 18:5904-5914
28. Yu SJ, Asa SL, Weigel RJ, Ezzat S: Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J Biol Chem 2003; 278:19597-19602