Thyroid Hormone and Estrogen Receptor Expression in Normal Pituitary and Nonfunctioning Tumors of the Anterior Pituitary

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1960-1967

  Gittoes, Neil J L ^a,b   Mccabe, Christopher J ^a   Verhaeg, Julie ^a   Sheppard, Michael C ^a   Franklyn, Jayne A ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; HYPOPHYSIS HORMONE; MESSENGER RNA; THYROID HORMONE RECEPTOR;

ADENOHYPOPHYSIS; ARTICLE; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HYPOPHYSIS; HYPOPHYSIS TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; REFERENCE VALUE;

FEMALE; HUMANS; MALE; MIDDLE AGED; PITUITARY GLAND; PITUITARY GLAND, ANTERIOR; PITUITARY HORMONES; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RECEPTORS, THYROID HORMONE; REFERENCE VALUES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0031156815     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.6.1960     Document Type: Article

References (48)

1. Arafah BM. 1986 Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab. 62:1173-1179.
2. Snyder PJ, Bigdeli H, Gardner DF, et al. 1979 Gonadal function in fifty men with untreated pituitary adenomas. J Clin Endocrinol Metab. 48:309-314.
3. Snyder PJ, Bashey HM, Kim SU, Chappel SC. 1984 Secretion of uncombined subunits of luteinizing hormone by gonadotroph cell adenomas. J Clin Endocrinol Metab. 59:1169-1175.
4. Snyder PJ. 1985 Gonadotroph cell adenomas of the pituitary [Review]. Endocr Rev. 6:552-563.
5. Landolt AM, Heitz PU. 1986 Alpha-subunit-producing pituitary adenomas. Immunocytochemical and ultrastructural studies. Virchows Arch A [Pathol Anat Histopathol]. 409:417-431.
6. Jameson JL, Klibanski A, Black PM, et al. 1987 Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest. 80:1472-1478.
7. Klibanski A. 1987 Nonsecreting pituitary tumors [Review]. Endocrinol Metab Clin North Am. 16:793-804.
8. Black PM, Hsu DW, Klibanski A, et al. 1987 Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurg. 66:244-250.
9. Warnet A, Porsova-Dutoit I, Lahlou N, et al. 1994 Glycoprotein hormone alpha-subunit secretion in prolactinomas and in non-functioning adenomas: relation with the tumour size. Clin Endocrinol (Oxf). 41:177-184.
10. Oppenheim DS, Kana AR, Sangha JS, Klibanski A. 1990 Prevalence of alpha-subunit hypersecretion in patients with pituitary tumors: clinically nonfunctioning and somatotroph adenomas. J Clin Endocrinol Metab. 70:859-864.
11. Asa SL, Cheng Z, Ramyar L, et al. 1992 Human pituitary null cell adenomas and oncocytomas in vitro: effects of adenohypophysiotropic hormones and gonadal steroids on hormone secretion and tumor cell morphology. J Clin Endocrinol Metab. 74:1128-1134.
12. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A. 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest. 86:336-340.
13. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S. 1990 Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 71:1427-1433.
14. Spada A, Arosio M, Bochicchio D, et al. 1990 Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab. 71:1421-146.
15. Lyons J, Landis CA, Harsh G, et al. 1990 Two G protein oncogenes in human endocrine tumors. Science. 249:655-659.
16. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN. 1993 Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. J Clin Invest. 91:2815-2821.
17. Boggild MD, Jenkinson S, Pistorello M, et al. 1994 Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab. 78:387-392.
18. Cook CB, Kakucska I, Lechan RM, Koenig RJ. 1992 Expression of thyroid hormone receptor beta 2 in rat hypothalamus. Endocrinology. 130:1077-11179.
19. Schwartz HL, Lazar MA, Oppenheimer JH. 1994 Widespread distribution of immunoreactive, thyroid hormone beta 2 receptor (TR beta 2) in the nuclei of extrapituitary rat tissues. J Biol Chem. 269:24777-24782.
20. Miksicek RJ. 1994 Steroid receptor variants and their potential role in cancer [Review]. Semin Cancer Biol. 5:369-379.
21. Friend KE, Ang LW, Shupnik MA. 1995 Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc Natl Acad Sci USA. 92:4367-4371.
22. Pink JJ, Wu SQ, Wolf DM, Bilimoria MM, Jordan VC. 1996 A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7. Nucleic Acids Res. 24:962-969.
23. Pfeffer U. 1996 Estrogen receptor mRNA variants. Do they have a physiological role? [Review]. Ann NY Acad Sci 784:304-313.
24. Chamba A, Neuberger J, Strain A, Hopkins J, Sheppard MC, Franklyn JA. 1996 Expression and function of thyroid hormone receptor variants in normal and chronically diseased human liver. J Clin Endocrinol Metab. 81:360-367.
25. 1 cells. J Clin Invest. 54:853-865.
26. Laemmli UK. 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
27. Chomczynski P, Sacchi N. 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156-159.
28. Noonan KE, Beck C, Holzmayer TA, et al. 1990 Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA. 87:7160-7164.
29. Salomon RN, Underwood R, Doyle MV, Wang A, Libby P. 1992 Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma. Proc Natl Acad Sci USA. 89:2814-2818.
30. Nakayama H, Yokoi H, Fujita J. 1992 Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system. Nucleic Acids Res. 20:4939.
31. Zafar M, Ezzat S, Ramyar L, Pan N, Smyth HS, Asa SL. 1995 Cell-specific expression of estrogen receptor in the human pituitary, and its adenomas. J Clin Endocrinol Metab. 80:3621-3627.
32. Alexander JM, Swearingen B, Tindall GT, Klibanski A. 1995 Human pituitary adenomas express endogenous inhibin subunit and follistatin messenger ribonucleic acids. J Clin Endocrinol Metab. 80:147-152.
33. Yamada S, Takahashi M, Hara M, et al. 1996 Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method. Clin Endocrinol (Oxf). 45:263-272.
34. Stefaneanu L, Kovacs K. 1988 Immunocytochemical approach to demonstrate the estrogen receptor in human adenohypopheses, and pituitary adenomas with monoclonal antibodies. Med Sci Res. 16:449-450.
35. Friend KE, Chiou YK, Lopes MB, Laws Jr E, Hughes KM, Shupnik MA. 1994 Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. J Clin Endocrinol Metab. 78:1497-1504.
36. Robertson JF. 1996 Oestrogen receptor: a stable phenotype in breast cancer [Review]. Br J Cancer. 73:5-12.
37. Villa E, Camellini L, Dugani A, et al. 1995 Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma. Cancer Res. 55:498-500.
38. Brandon DD, Erickson TE, Keenan EJ, et al. 1995 Estrogen receptor gene expression in human uterine leiomyomata. J Clin Endocrinol Metab. 80:1876-1881.
39. Chaidarun S, Alexander J. Novel tumour-specific expression of estrogen receptor mRNA spliced variants in human pituitary adenomas. Proc of the 10th Int Congr of Endocrinol. 1996; 723.
40. Lane JT, Godbole M, Strait KA, Schwartz HL, Oppenheimer JH. 1991 Prolonged fasting reduces rat hepatic beta 1 thyroid hormone receptor protein without changing the level of its messenger ribonucleic acid. Endocrinology. 129:2881-2885.
41. Strait KA, Schwartz HL, Perez-Castillo A, Oppenheimer JH. 1990 Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. J Biol Chem. 265:10514-10521.
42. Wang CJ, Howng SL, Lin KH. 1995 Expression of thyroid hormone receptors in human pituitary tumor cells. Cancer Lett. 91:79-83.
43. Ridgway EC, Kieffer JD, Ross DS, Downing M, Mover H, Chin WW. 1983 Mouse pituitary tumor line secreting only the alpha-subunit of the glycoprotein hormones: development from a thyrotropic tumor. Endocrinology. 113:1587-1591.
44. Sarapura VD, Bright TM, Wood WM, Haugen BR, Gordon DF, Ridgway EC. Abnormal expression of T3 receptor isoforms in a non-T3 responsive thyrotropic tumor. Proc of the 11th Int Thyroid Congr. 1995; S191.
45. 1 thyroid receptor variants. J Endocrinol. 148(Suppl):OC29.
46. 2) in negative regulation by thyroid hormone. Proc of the 10th Int Congr of Endocrinol. 1996; 122.
47. 3-receptor mRNA levels and growth of thyrotropic tumors. Mol Cell Endocrinol. 91:75-81.
48. Bronnegard M, Torring O, Boos J, Sylven C, Marcus C, Wallin G. 1994 Expression of thyrotropin receptor and thyroid hormone receptor messenger ribonucleic acid in normal, hyperplastic, and neoplastic human thyroid tissue. J Clin Endocrinol Metab. 79:384-389.