The MEN-1 gene is rarely down-regulated in pituitary adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 9, 1998, Pages 3210-3212

  Asa, Sylvia L ^a,b   Somers, Katia ^a   Ezzat, Shereen ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ARTICLE; CANCER GENETICS; CONTROLLED STUDY; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ADENOMA; ADULT; AGED; DNA, NEOPLASM; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; MUTATION; NEOPLASM PROTEINS; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA-DIRECTED DNA POLYMERASE;

EID: 0031797339     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.9.3210     Document Type: Article

References (17)

1. Asa SL, Ezzat S. The cytogenesis and pathogenesis of pituitary adenomas. Endocr Rev. In press.
2. Bystrom C, Larsson C, Blomberg C, Sandelin K, Falkmer E, 1990 Localization of the MEN-1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA. 87:1968-1972.
3. Herman V, Drazin NZ, Gonsky R, Melmed S. 1993 Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab. 77:50-55.
4. Boggild MD, Jenkinson S, Pistorello M, et al. 1994 Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab. 78:387-392.
5. Chandrasekharappa SC, Guru SC, Manickam P, et al. 1997 Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 276:404-407.
6. Zhuang Z, Ezzat S, Vortmeyer AO, et al. 1997 Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res. 57:5446-5451.
7. Zafar M, Ezzat S, Ramyar L, Pan N, Smyth HS, Asa SL. 1995 Cell-specific expression of estrogen receptor in the human pituitary and its adenomas. J Clin Endocrinol Metab. 80:3621-3627.
8. Asa SL, Bamberger A-M, Cao B, Wong M, Parker KL, Ezzat S. 1996 The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph. J Clin Endocrinol Metab. 81:2165-2170.
9. Abbass SAA, Asa SL, Ezzat S. 1997 Altered expression of fibroblast growth factor receptors in human pituitary adenomas. J Clin Endocrinol Metab. 82:1160-1166.
10. Horvath E, Kovacs K, Smyth HS, et al. 1988 A novel type of pituitary adenoma: morphological feature and clinical correlations. J Clin Endocrinol Metab. 66:1111-1118.
11. Agarwal SK, Kester MB, Debelenko LV, et al. 1997 Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet. 6:1169-1175.
12. Dong Q, Debelenko LV, Chandrasekharappa SC, et al. 1997 Loss of heterozygosty at 11p13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 82:1416-1420.
13. Zhuang Z, Vortmeyer AO, Pack S, et al. 1997 Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas Cancer Res. 57:4682-4686.
14. Debelenko LV, Zhuang Z, Emmert-Buck MR, et al. 1997 Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res. 57:2238-2243.
15. Toliat M, Berger W, Ropers HH, Neuhaus P, Wiedenmann B. 1997 Mutations in the MEN1 gene in sporadic neuroendocrine tumours of gastroenteropancreatic system. Lancet. 350:1223.
16. Heppner C, Kester MB, Agarwal SK, et al. 1997 Somatic mutation of the MEN1 gene in parathyroid tumours. Nat Genet. 16:375-378.
17. Vortmeyer AO, Böni R, Pak E, Pack S, Zhuang Z. 1998 Multiple endocrine neoplasia 1 gene alteration in MEN1-associated and sporadic lipomas. J Natl Cancer Inst. 90:398-399.