The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility

Molecular Endocrinology

Volumn 19, Issue 4, 2005, Pages 1004-1011

  Ezzat, Shereen ^a,c   Yu, Shunjiang ^a,c   Asa, Sylvia L ^b,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HISTONE DEACETYLASE INHIBITOR; IKAROS TRANSCRIPTION FACTOR; PROLACTIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REGULATORY MECHANISM; WESTERN BLOTTING; ZINC FINGER MOTIF;

ACETYLATION; ANIMALS; CELLS, CULTURED; CHROMATIN; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GROWTH HORMONE; HISTONE DEACETYLASES; HISTONES; HYDROXAMIC ACIDS; IKAROS TRANSCRIPTION FACTOR; MICE; PITUITARY GLAND; PROLACTIN; PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER; TRANSCRIPTION FACTOR PIT-1; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 15444368750     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0432     Document Type: Article

References (28)

1. Asa SL, Ezzat S 1998 The cytogenesis and pathogenesis of pituitary adenomas. Endocr Rev 19:798-827
2. Asa SL, Ezzat S 1999 Molecular determinants of pituitary cytodifferentiation. Pituitary 1:159-168
3. Molnar A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K 1996 The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 156:585-592
4. Georgopoulos K, Winandy S, Avitahl N 1997 The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol 15:155-176
5. Yu S, Asa SL, Ezzat S 2002 Fibroblast growth factor receptor 4 is a target for the zinc-finger transcription factor Ikaros in the pituitary. Mol Endocrinol 16: 1069-1078
6. Ezzat S, Yu S, Asa SL 2003 Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter. Am J Pathol 163:1177-1184
7. Yu S, Asa SL, Weigel RJ, Ezzat S 2003 Pituitary tumor AP-2α recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J Biol Chem 278: 19597-19602
8. Georgopoulos K 2002 Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2:162-174
9. Molnar A, Georgopoulos K 1994 The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 14:8292-8303
10. Sun L, Liu A, Georgopoulos K1996 Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J 15: 5358-5369
11. Koipally J, Renold A, Kim J, Georgopoulos K 1999 Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 18:3090-3100
12. Wargnier A, Lafaurie C, Legros-Maida S, Bourge JF, Sigaux F, Sasportes M, Paul P 1998 Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. J Biol Chem 273:35326-35331
13. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K 1999 Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10:345-355
14. Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N 2001 Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J 20: 2812-2822
15. Bodner M, Castrillo J-L, Theill LE, Deerinck T, Ellisman M, Karin M 1988 The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 55: 505-518
16. Ingraham HA, Albert VR, Chen R, Crenshaw III EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN, Rosenfeld MG 1990 A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Annu Rev Physiol 52:773-791
17. Rosenfeld MG 1991 POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev 5:897-907
18. Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW 1990 Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev 4:695-711
19. Theill LE, Hattori K, Lazzaro D, Castrillo J-L, Karin M 1992 Differential splicing of the GHF-1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J 11:2261-2269
20. Morris AE, Kloss B, McChesney RE, Bancroft C, Chasin LA 1992 An alternatively spliced Pit-1 isoform altered in its ability to trans-activate. Nucleic Acids Res 20: 1355-1361
21. Haugen BR, Wood WM, Gordon DF, Ridgway EC 1993 A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin B promoter. J Biol Chem 268:818-824
22. Haugen BR, Gordon DF, Nelson AR, Wood WM, Ridgway EC 1994 The combination of Pit-1 and Pit-1T have a synergistic stimulatory effect on the thyrotropin β-subunit promoter but not the growth hormone or prolactin promoters. Mol Endocrinol 8:1574-1582
23. Diamond SE, Gutierrez-Hartmann A 2000 The Pit-1β domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. J Biol Chem 275:30977-30986
24. Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carriere C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG 2000 Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290:1127-1131
25. Dorshkind K, Horseman ND 2000 The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev 21:292-312
26. Perdomo J, Holmes M, Chong B, Crossley M 2000 Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J Biol Chem 275:38347-38354
27. Asa SL, Ramyar L, Murphy PR, Li AW, Ezzat S 2001 The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Mol Endocrinol 15:589-599
28. Ezzat S, Zheng L, Asa SL 2004 Pituitary tumor-derived fibroblast growth factor receptor 4 isoform disrupts neural cell-adhesion molecule/N-cadherin signaling to diminish cell adhesiveness: a mechanism underlying pituitary neoplasia. Mol Endocrinol 18:2543-2552