The Cytogenesis and Pathogenesis of Pituitary Adenomas

Endocrine Reviews

Volumn 19, Issue 6, 1998, Pages 798-827

  Asa, Sylvia L ^a,b   Ezzat, Shereen ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMA; ANIMAL; CELL CYCLE; CELL DIFFERENTIATION; HUMAN; HYPOPHYSIS TUMOR; PATHOLOGY; REVIEW;

ADENOMA; ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; HUMANS; PITUITARY NEOPLASMS;

EID: 0032246451     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.19.6.798     Document Type: Article

References (365)

1. Kovacs K, Horvath E, Asa SL, Stefaneanu L, Sano T 1989 Pituitary cells producing more than one hormone. Human pituitary adenomas. Trends Endocrinol Metab 1:104-107
2. Asa SL 1998 Tumors of the pituitary gland. In: Rosai J, Sobin LH (eds) Atlas of Tumor Pathology, Third Series. Fascicle 22. Armed Forces Institute of Pathology, Washington, D.C.
3. Coire CI, Horvath E, Kovacs K, Smyth HS, Ezzat S 1997 Cushing's syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical and ultrastructural study and review of the literature. Endocr Pathol 8:65-74
4. Costello RT 1936 Subclinical adenoma of the pituitary gland. Am J Pathol 12:205-215
5. Burrow GN, Wortzman G, Rewcastle NB, Holgate RC, Kovacs K 1981 Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 304:156-158
6. Elster AD 1993 Modern imaging of the pituitary. Radiology 187: 1-14
7. Kovacs K, Ryan N, Horvath E, Singer W, Ezrin C 1980 Pituitary adenomas in old age. J Gerontol 35:16-22
8. McComb DJ, Ryan N, Horvath E, Kovacs K 1983 Subclinical adenomas of the human pituitary. New light on old problems. Arch Pathol Lab Med 107:488-491
9. Kovacs K, Horvath E 1986 Tumors of the pituitary gland. In: Hartmann WH, Sobin LH (eds) Atlas of Tumor Pathology, Second Series, Fascicle 21. Armed Forces Institute of Pathology, Washington, D.C.
10. Scheithauer BW 1984 Surgical pathology of the pituitary: the adenomas. Part I. Pathol Annu 19:317-374
11. Gold EB 1981 Epidemiology of pituitary adenomas. Epidemiol Rev 3:163-183
12. Mindermann T, Wilson CB 1994 Age-related and gender-related occurrence of pituitary adenomas. Clin Endocrinol (Oxf) 41:359-364
13. Wilson CB, Dempsey LC 1978 Transsphenoidal microsurgical removal of 250 pituitary adenomas. J Neurosurg 48:13-22
14. Terada T, Kovacs K, Stefaneanu L, Horvath E 1995 Incidence, pathology, and recurrence of pituitary adenomas: study of 647 unselected surgical cases. Endocr Pathol 6:301-310
15. Klibanski A, Zervas NT 1991 Diagnosis and management of hormone-secreting pituitary adenomas. N Engl J Med 324:822-831
16. Kane LA, Leinung MC, Scheithauer BW, Bergstralh EJ, Laws Jr ER, Groover RV, Kovacs K, Horvath E, Zimmerman D 1994 Pituitary adenomas in childhood and adolescence. J Clin Endocrinol Metab 79:1135-1140
17. Mukai K, Seljeskog EL, Dehner LP 1986 Pituitary adenomas in patients under 20 years old. A clinicopathological study of 12 cases. J Neurooncol 4:79-89
18. Kontogeorgos G, Kovacs K, Horvath E, Scheithauer BW 1991 Multiple adenomas of the human pituitary. A retrospective autopsy study with clinical implications. J Neurosurg 74:243-247
19. Kontogeorgos G, Scheithauer BW, Horvath E, Kovacs K, Lloyd RV, Smyth HS, Rologis D 1992 Double adenomas of the pituitary: a clinicopathological study of 11 tumors. Neurosurgery 31:840-849
20. Apel RL, Wilson RJ, Asa SL 1994 A composite somatotroph-corticotroph pituitary adenoma. Endocr Pathol 5:240-246
21. Thodou E, Kontogeorgos G, Horvath E, Kovacs K, Smyth HS, Ezzat S 1995 Asynchronous pituitary adenomas with differing morphology. Arch Pathol Lab Med 119:748-750
22. Hardy J 1973 Transsphenoidal surgery of hypersecreting pituitary tumors. In: Kohler PO, Ross GT (eds) Diagnosis and Treatment of Pituitary Tumors. International Congress Series No. 303. Exerpta Medica, Amsterdam, pp 179-198
23. Scheithauer BW, Kovacs KT, Laws Jr ER, Randall RV 1986 Pathology of invasive pituitary tumors with special reference to functional classification. J Neurosurg 65:733-744
24. Selman WR, Laws Jr ER, Scheithauer BW, Carpenter SM 1986 The occurrence of dural invasion in pituitary adenomas. J Neurosurg 64:402-407
25. Sautner D, Saeger W 1991 Invasiveness of pituitary adenomas. Pathol Res Pract 187:632-636
26. van der Mey AG, van Seters AP, van Krieken JH, Vielvoye J, Van Dulken H, Hulshof JH 1989 Large pituitary adenomas with extension into the nasopharynx. Report of three cases with a review of the literature. Ann Otol Rhinol Laryngol 98:618-624
27. Wong K, Raisanen J, Taylor SL, McDermott MW, Wilson CB, Gutin PH 1995 Pituitary adenoma as an unsuspected clival tumor. Am J Surg Pathol 19:900-903
28. Horvath E, Kovacs K, Smyth HS, Killinger DW, Scheithauer BW, Randall R, Laws Jr ER, Singer W 1988 A novel type of pituitary adenoma: morphological feature and clinical correlations. J Clin Endocrinol Metab 66:1111-1118
29. Anniko M, Tribukait B, Wersäll J 1984 DNA ploidy and cell phase in human pituitary tumors. Cancer 53:1708-1713
30. Fitzgibbons PL, Appley AJ, Turner RR, Bishop PC, Parker JW, Breeze RF, Weiss MH, Apuzzo MLJ 1988 Flow cytometric analysis of pituitary tumors. Correlation of nuclear antigen p105 and DNA content with clinical behavior. Cancer 62:1556-1560
31. Landolt AM, Shibata T, Kleihues P 1987 Growth rate of human pituitary adenomas. J Neurosurg 67:803-806
32. Knosp E, Kitz K, Perneczky A 1989 Proliferation activity in pituitary adenomas: measurement by monoclonal antibody Ki-67. Neurosurgery 25:927-930
33. Thapar K, Kovacs K, Scheithauer BW, Stefaneanu L, Horvath E, Pernicone PJ, Murray D, Laws Jr ER 1996 Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody. Neurosurgery 38:99-107
34. Hsu DW, Hakim F, Biller BMK, De La Monte S, Zervas NT, Klibanski A, Hedley-Whyte ET 1993 Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence. J Neurosurg 78:753-761
35. Gandour-Edwards R, Kapadia SB, Janecka IP, Martinez AJ, Barnes L 1995 Biologic markers of invasive pituitary adenomas involving the sphenoid sinus. Mod Pathol 8:160-164
36. Sano T, Ohshima T, Yamada S 1991 Expression of glycoprotein hormones and intracytoplasmic distribution of cytokeratin in growth hormone-producing pituitary adenomas. Pathol Res Pract 187:530-533
37. Kovacs K, Horvath E, Ryan N, Ezrin C 1980 Null cell adenoma of the human pituitary. Virchows Arch [Pathol Anat ] 387:165-174
38. Asa SL, Bamberger A-M, Cao B, Wong M, Parker KL, Ezzat S 1996 The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph. J Clin Endocrinol Metab 81:2165-2170
39. Kumar TR, Graham KE, Asa SL, Low MJ 1998 Simian virus 40 T antigen-induced gonadotroph adenomas: a model of human null cell adenomas. Endocrinology 139:3342-3351
40. Asa SL, Kovacs K 1984 Functional morphology of the human fetal pituitary. Pathol Annu 19:275-315
41. Asa SL, Kovacs K, Laszlo FA, Domokos I, Ezrin C 1986 Human fetal adenohypophysis. Histologic and immunocytochemical analysis. Neuroendocrinology 43:308-316
42. Asa SL, Kovacs K, Horvath E, Losinski NE, Laszlo FA, Domokos I, Halliday WC 1988 Human fetal adenohypophysis. Electron microscopic and ultrastructural immunocytochemical analysis. Neuroendocrinology 48:423-431
43. Asa SL, Kovacs K, Singer W 1991 Human fetal adenohypophysis: morphologic and functional analysis in vitro. Neuroendocrinology 53:562-572
44. Lamonerie T, Tremblay JJ, Lanctot C, Themen M, Gauthier Y, Drouin J 1996 Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev 10:1284-1295
45. Crawford MJ, Lanctot C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B, Drouin J 1997 Human and murine PTX1/ Ptx1 gene maps to the region for Treacher Collins syndrome. Mamm Genome 8:841-845
46. Tremblay JJ, Lanctot C, Drouin J 1998 The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1) acts in synergy with SF-1 and Pit-1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol Endocrinol 12:428-441
47. Gage PJ, Camper SA 1997 Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. Hum Mol Genet 6:457-464
48. Sheng HZ, Moriyama K, Yamashita T, Li H, Potter SS, Mahon KA, Westphal H 1997 Multistep control of pituitary organogenesis. Science 278:1809-1812
49. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG 1995 P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci USA 92:2720-2724
50. Hermesz E, Machem S, Mahon KA 1996 Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development 122:41-52
51. Gage PJ, Brinkmeier ML, Scarlett LM, Knapp LT, Camper SA, Mahon KA 1996 The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation. Mol Endocrinol 10: 1570-1581
52. Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carriere C, Ryan AK, Miller AP, Zuo L, Glieberman AS, Andersen B, Beamer WG, Rosenfeld MG 1996 Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384:327-333
53. Wu W, Cogan JD, Pfäffle RW, Dasen JS, Frisch H, O'Connell SM, Flynn SE, Brown MR, Mullis PE, Parks JS, Phillips JAI, Rosenfeld MG 1998 Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat Genet 18:147-149
54. Fofanova O, Takmura N, Kinoshita E, Parks JS, Brown MR, Peterkova VA, Evgrafov OV, Goncharov NP, Bulatov AA, Dedov II, Yamashita S 1998 Compound heterozygous deletion of the prop-1 gene in children with combined pituitary hormone deficiency. J Clin Endocrinol Metab 83:2601-2604
55. Jackson SM, Barnhart KM, Mellon P, Gutierrez-Hartmann A, Hoeffler JP 1993 Helix-loop proteins are present and differentially expressed in different cell lines from the anterior pituitary. Mol Cell Endocrinol 96:167-176
56. Ingraham HA, Chen R, Mangalam HJ, Elsholtz HP, Flynn SE, Lin CR, Simmons DM, Swanson L, Rosenfeld MG 1988 A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55:519-529
57. Bodner M, Castrillo J-L, Theill LE, Deerinck T, Ellisman M, Karin M 1988 The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 55:505-518
58. Rosenfeld MG 1991 POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev 5:897-907
59. Ingraham HA, Albert VR, Chen R, Crenshaw III EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN, Rosenfeld MG 1990 A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Annu Rev Physiol 52:773-791
60. Castrillo J-L, Bodner M, Karin M 1989 Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. Science 243:814-817
61. Lefevre C, Imagawa M, Dana S, Grindlay J, Bodner M, Karin M 1987 Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J 6:971-981
62. Bodner M, Karin M 1987 A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell 50:267-275
63. Nelson C, Albert VR, Elsholtz HP, Lu LI-W, Rosenfeld MG 1988 Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science 239: 1400-1405
64. Theill LE, Castrillo J-L, Wu D, Karin M 1989 Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature 342:945-948
65. Mangalam HJ, Albert VR, Ingraham HA, Kapiloff M, Wilson L, Nelson C, Elsholtz HP, Rosenfeld MG 1989 A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev 3:946-958
66. Fox SR, Jong MTC, Casanova J, Ye Z-S, Stanley F, Samuels HH 1990 The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters. Mol Endocrinol 4:1069-1080
67. McCormick A, Wu D, Castrillo J-L, Dana S, Strobl J, Thompson EB, Karin M 1988 Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell 55:379-389
68. Dollé P, Castrillo J-L, Theill LE, Deerinck T, Ellisman M, Karin M 1990 Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell 60:809-820
69. Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW 1990 Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev 4:695-711
70. Crenshaw III EB, Kalla K, Simmons DM, Swanson LW, Rosenfeld MG 1989 Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements. Genes Dev 3:959-972
71. Steinfelder HJ, Radovick S, Wondisford FE 1992 Hormonal regulation of the thyrotropin β-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1. Proc Natl Acad Sci USA 89:5942-5945
72. Mason ME, Friend KE, Copper J, Shupnik MA 1993 Pit-1/GHF-1 binds to TRH-sensitive regions of the rat thyrotropin β gene. Biochemistry 32:8932-8938
73. Kim MK, McClaskey JH, Bodenner DL, Weintraub BD 1993 An AP-1-like factor and the pituitary-specific factor Pit-1 are both necessary to mediate hormonal induction of human thyrotropin β gene expression. J Biol Chem 268:23366-23375
74. Drolet DW, Scully KM, Simmons DM, Wegner M, Chu K, Swanson LW, Rosenfeld MG 1991 TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev 5:1739-1753
75. Lin S-C, Li S, Drolet DW, Rosenfeld MG 1994 Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development 120:515-522
76. Konzak KE, Moore DD 1992 Functional isoforms of Pit-1 generated by alternative messenger RNA splicing. Mol Endocrinol 6:241-247
77. Theill LE, Hattori K, Lazzaro D, Castrillo J-L, Karin M 1992 Differential splicing of the GHF-1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J 11:2261-2269
78. Morris AE, Kloss B, McChesney RE, Bancroft C, Chasin LA 1992 An alternatively spliced Pit-1 isoform altered in its ability to trans-activate. Nucleic Acids Res 20:1355-1361
79. Haugen BR, Wood WM, Gordon DF, Ridgway EC 1993 A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin B promoter. J Biol Chem 268:818-824
80. Haugen BR, Gordon DF, Nelson AR, Wood WM, Ridgway EC 1994 The combination of Pit-1 and Pit-1T have a synergistic stimulatory effect on the thyrotropin B-subunit promoter but not the growth hormone or prolactin promoters. Mol Endocrinol 8:1574-1582
81. Asa SL, Puy LA, Lew AM, Sundmark VC, Elsholtz HP 1993 Cell type-specific expression of the pituitary transcription activator Pit-1 in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab 77:1275-1280
82. Friend KE, Chiou Y-K, Laws Jr ER, Lopes MBS, Shupnik MA 1993 Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas. J Clin Endocrinol Metab 77:1281-1286
83. Pellegrini I, Barlier A, Gunz G, Figarella-Branger D, Enjalbert A, Grisoli F, Jaquet P 1994 Pit-1 gene expression in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab 79:189-196
84. Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, van der Nat H, van den Brande JL, Rosenfeld MG, Ingraham HA 1992 Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Science 257:1118-1121
85. Chen R, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG 1990 Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583-586
86. Puy LA, Asa SL 1996 The ontogeny of pit-1 expression in the human fetal pituitary gland. Neuroendocrinology 63:349-355
87. Li S, Crenshaw III EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG 1990 Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347:528-533
88. Tatsumi K, Miyai K, Notomi T, Kaibe K, Amino N, Mizuno Y, Kohno H 1992 Cretinism with combined hormone deficiency caused by a mutation in the Pit-1 gene. Nat Genet 1:56-58
89. Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE 1992 A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257:1115-1118
90. Castrillo J-L, Theill LE, Karin M 1991 Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science 253:197-199
91. Verrijzer CP, Kal AJ, van der Vliet PC 1990 The DNA binding domain (POU domain) of transcription factor Oct-1 suffices for stimulation of DNA replication. EMBO J 9:1883-1888
92. Mayo KE 1992 Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. Mol Endocrinol 6:1734-1744
93. Lin C, Lin S-C, Chang C-P, Rosenfeld MG 1992 Pit-1 dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360:765-768
94. Theill LE, Karin M 1993 Transcriptional control of GH expression and anterior pituitary development. Endocr Rev 14:670-689
95. McCormick A, Brady H, Theill LE, Karin M 1990 Regulation of the pituitary-specific homeobox gene GHF-1 by cell-autonomous and environmental cues. Nature 345:829-832
96. Delegeane AM, Ferland LH, Mellon P 1987 Tissue specific enhancer of the human glycoprotein hormone α subunit gene: dependence on cAMP inducible elements. Mol Cell Biol 7:3994-4002
97. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR 1991 Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624
98. Wiedemann E, Schwartz E, Frantz AG 1976 Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. J Clin Endocrinol Metab 42:942-951
99. Shupnik MA, Baxter LA, French LR, Gorski J 1979 In vivo effects of estrogen on ovine pituitaries: prolactin and growth hormone biosynthesis and messenger ribonucleic acid translation. Endocrinology 104:729-735
100. Vician L, Shupnik MA, Gorski J 1979 Effects of estrogen on primary ovine pituitary cell cultures: stimulation of prolactin secretion, synthesis, and preprolactin messenger ribonucleic acid activity. Endocrinology 104:736-743
101. Shull JD, Walent JH, Gorski J 1987 Estradiol stimulates prolactin gene transcription in primary cultures of rat anterior pituitary cells. J Steroid Biochem 26:451-456
102. Lieberman ME, Maurer RA, Gorski J 1978 Estrogen control of prolactin synthesis in vitro. Proc Natl Acad Sci USA 75:5946-5949
103. Lloyd RV, Cano M, Landefeld TD 1988 The effects of estrogens on tumor growth and on prolactin and growth hormone mRNA expression in rat pituitary tissues. Am J Pathol 133:397-406
104. Lloyd RV 1983 Estrogen-induced hyperplasia and neoplasia in the rat anterior pituitary gland. An immunohistochemical study. Am J Pathol 113:198-206
105. Maurer RA, Notides AC 1987 Identification of an estrogen-responsive element from the 5′-flanking region of the rat prolactin gene. Mol Cell Biol 7:4247-4254
106. Waterman ML, Adler S, Nelson C, Greene GL, Evans R, Rosenfeld MG 1988 A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene. Mol Endocrinol 2:14-21
107. Day RN, Koike S, Sakai M, Muramatsu M, Maurer RA 1990 Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol Endocrinol 4:1964-1971
108. Chaidarun SS, Eggo MC, Stewart PM, Barber PC, Sheppard MC 1994 Role of growth factors and estrogen as modulators of growth, differentiation, and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells. Endocrinology 134:935-944
109. Gharib SD, Wierman ME, Shupnik MA, Chin WW 1990 Molecular biology of the pituitary gonadotropins. Endocr Rev 11:177-198
110. Shupnik MA, Gharib SD, Chin WW 1989 Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments. Mol Endocrinol 3:474-480
111. Shupnik MA, Weinmann CM, Notides AC, Chin WW 1989 An upstream region of the rat luteinizing hormone β gene binds estrogen receptor and confers estrogen responsiveness. J Biol Chem 264:80-86
112. Stumpf WE, Sar M 1976 Autoradiographic localization of estrogen, androgen, progestin and glucocorticosteroid in target tissues and non-target tissues. In: Pasqualini JR (ed) Receptors and Mechanism of Action of Steroid hormone. Marcel Dekker, New York, pp. 41-84
113. 3H-estradiol uptake in immunocytochemically characterized pituitary cells. Cell Tissue Res 166:25-35
114. Stefaneanu L, Kovacs K 1988 Immunocytochemistry approach to demonstrate the estrogen receptor in human adenohypophyses and pituitary adenomas with monoclonal antibody. Med Sci Res 16:449-450
115. Zafar M, Ezzat S, Ramyar L, Pan N, Smyth HS, Asa SL 1995 Cell-specific expression of estrogen receptor in the human pituitary and its adenomas. J Clin Endocrinol Metab 80:3621-3627
116. Friend KE, Chiou YK, Lopes MBS, Laws Jr ER, Hughes KM, Shupnik MA 1994 Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. J Clin Endocrinol Metab 78:1497-1504
117. Losinski NE, Horvath E, Kovacs K, Asa SL 1991 Immunoelectron microscopic evidence of mammosomatotrophs in human adult and fetal adenohypophyses, rat adenohypophyses and human and rat pituitary adenomas. Anat Anz 172:11-16
118. Nakao H, Koga M, Arao M, Nakao M, Sato B, Kishimoto S, Saitoh Y, Arita N, Mori S 1989 Enzyme-immunoassay for estrogen receptors in human pituitary adenomas. Acta Endocrinol (Copenh) 120:233-238
119. Ironside JW, Dangerfield VJM, Timperley WR, Underwood JCE 1986 Steroid hormone receptors in pituitary adenomas: a biochemical, immunohistochemical and morphometric study on cryostat sections. Neuropathol Appl Neurobiol 12:539-546
120. Chaidarun SS, Klibanski A, Alexander JM 1997 Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas. J Clin Endocrinol Metab 82:1058-1065
121. Simard J, Hubert JF, Hosseinzadeh T, Labrie F 1986 Stimulation of growth hormone release and synthesis in rat anterior pituitary cells in culture. Endocrinology 119:2004-2011
122. Kontogeorgos G, Asa SL, Kovacs K, Smyth HS, Singer W 1993 Production of alpha-subunit of glycoprotein hormones by pituitary somatotroph adenomas in vitro. Acta Endocrinol (Copenh) 129: 565-572
123. Behringer RR, Mathews LS, Palmiter RD, Brinster RL 1988 Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev 2:453-461
124. Borrelli E, Heyman RA, Arias C, Sawchenko PE, Evans RM 1989 Transgenic mice with inducible dwarfism. Nature 339:538-541
125. Frawley LS, Boockfor FR, Hoeffler JP 1985 Identification by plaque assays of a pituitary cell type that secretes both growth hormone and prolactin. Endocrinology 116:734-737
126. Frawley LS 1989 Mammosomatotropes: current status and possible functions. Trends Endocrinol Metab 1:31-34
127. Stefaneanu L, Kovacs K, Lloyd RV, Scheithauer BW, Young Jr WF, Sano T, Jin L 1992 Pituitary lactotrophs and somatotrophs in pregnancy: a correlative in situ hybridization and immunocytochemical study. Virchows Arch [B] 62:291-296
128. Asa SL, Ezzat S 1997 Pituitary transcription factors and cytodifferentiation in the human fetus. Ann Endocrinol (Paris) 58:1S79 (Abstract)
129. Couse JF, Curtis SW, Washburn TF, Eddy EM, Schomberg DW, Korach KS 1995 Disruption of the mouse estrogen receptor gene: resulting phenotypes and experimental findings. Biochem Soc Trans 23:929-935
130. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11262-11166
131. Scully KM, Glieberman AS, Lindzey J, Lubahn DB, Korach KS, Rosenfeld MG 1997 Role of estrogen receptor-α in the anterior pituitary gland. Mol Endocrinol 11:674-681
132. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Speciker B, Williams TC, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061
133. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöd M, Gustafsson JA 1997 Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82:4258-4265
134. Asa SL, Penz G, Kovacs K, Ezrin C 1982 Prolactin cells in the human pituitary. A quantitative immunocytochemical analysis. Arch Pathol Lab Med 106:360-363
135. Scheithauer BW, Sano T, Kovacs KT, Young Jr WF, Ryan N, Randall RV 1990 The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases. Mayo Clin Proc 65:461-474
136. Blackwell RE 1985 Diagnosis and management of prolactinomas. Fertil Steril 43:5-16
137. Grossman A, Besser GM 1985 Prolactinomas. Br Med J 290:182-184
138. Kovacs K, Stefaneanu L, Ezzat S, Smyth HS 1994 Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. Arch Pathol Lab Med 118:562-565
139. Horvath E, Lloyd RV, Kovacs K 1990 Propylthiouracyl-induced hypothyroidism results in reversible transdifferentiation of somatotrophs into thyroidectomy cells. A morphologic study of the rat pituitary including immunoelectron microscopy. Lab Invest 63: 511-520
140. Lala DS, Rice DA, Parker KL 1992 Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6:1249-1258
141. Honda S-I, Morohashi K-I, Nomura M, Takeya H, Kitajima M, Omura T 1993 Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J Biol Chem 268:7494-7502
142. Morohashi K-I, Honda S-I, Inomata Y, Handa H, Omura T 1992 A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450 s. J Biol Chem 267:17913-17919
143. Morohashi K-I, Zanger UM, Honda S-I, Hara M, Waterman MR, Omura T 1993 Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Mol Endocrinol 7:1196-1204
144. Morohashi K-I, Iida H, Nomura M, Hatano O, Honda S-I, Tsukiyama T, Niwa O, Hara T, Takakusu A, Shibata Y, Omura T 1994 Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Mol Endocrinol 8:643-653
145. Ikeda Y, Lala DS, Luo X, Kim E, Moisan M-P, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
146. Ikeda Y, Shen W-H, Ingraham HA, Parker KL 1994 Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol 8:654-662
147. Shen W-H, Moore CCD, Ikeda Y, Parker KL, Ingraham HA 1994 Nuclear receptor steroidogenic factor 1 regulates the Müllerian inhibiting substance gene: a link to the sex determination cascade. Cell 77:651-661
148. Luo X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490
149. Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen W-H, Nachtigal MW, Abbud R, Nilson JH, Parker KL 1994 The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 8:2302-2312
150. Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL 1995 The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 9:478-486
151. Barnhart KM, Mellon PL 1994 The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes. Mol Endocrinol 8:878-885
152. Asa SL, Cheng Z, Ramyar L, Singer W, Kovacs K, Smyth HS, Muller P 1992 Human pituitary null cell adenomas and oncocytomas in vitro: effects of adenohypophysiotropic hormones and gonadal steroids on hormone secretion and tumor cell morphology. J Clin Endocrinol Metab 74:1128-1134
153. Therrien M, Drouin J 1993 Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Mol Cell Biol 13:2342-2353
154. Poulin G, Turgeon B, Drouin J 1997 NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol Cell Biol 17:6673-6682
155. Lipkin SM, Naar AM, Kalla KA, Sack RA, Rosenfeld MG 1993 Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes Dev 7:1674-1687
156. MacLeod K, LePrince D, Stehelin D 1992 The ets gene family. Trends Biochem Sci 17:251-256
157. Bradford AP, Conrad KE, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A 1995 Functional interaction of c-Ets-1 and GHF-1/ Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain. Mol Cell Biol 15:2849-2857
158. Bennani-Bäiti IM, Asa SL, Song D, Iratni R, Liebhaber SA, Cooke NE 1998 DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression. Proc Natl Acad Sci USA 95:10655-10660
159. Billestrup N, Swanson LW, Vale W 1986 Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 83:6854-6857
160. Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K 1982 Somatotroph hyperplasia: successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965-977
161. Sano T, Asa SL, Kovacs K 1988 Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev 9:357-373
162. Asa SL, Scheithauer BW, Bilbao JM, Horvath E, Ryan N, Kovacs K, Randall RV, Laws Jr ER, Singer W, Linfoot JA, Thorner MO, Vale W 1984 A case for hypothalamic acromegaly: a clinicopathoiogical study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58:796-803
163. Peillon F, Le Dafniel M, Garnier P, Feinstein MC, Donnadieu M, Barret A, Gautron JP, Brandi AM, Benlot C, Lagoguey A, Lefebvre P, Blumberg-Tick J, Joubert (Bression) D 1989 Neurohormones coming from the normal and tumoral human anterior pituitary. Secretion and regulation in vitro [Fre]. Pathol Biol 37:840-845
164. Joubert (Bression) D, Benlot C, Lagoguey A, Garnier P, Brandi AM, Gautron JP, LeGrand JC, Peillon F 1989 Normal and growth hormone (GH)-secreting adenomatous human pituitaries release somatostatin and GH-releasing hormone. J Clin Endocrinol Metab 68:572-577
165. Levy A, Lightman SL 1992 Growth hormone-releasing hormone transcripts in human pituitary adenomas. J Clin Endocrinol Metab 74:1474-1476
166. Thapar K, Kovacs K, Stefaneanu L, Scheithauer B, Killinger D, Lloyd RV, Smyth HS, Barr A, Thorner MO, Gaylinn B, Laws Jr ER 1997 Overexpression of the growth-hormone-releasing hormone gene in acromegaly-associated pituitary tumors. An event associated with neoplastic progression and aggressive behavior. Am J Pathol 151:769-784
167. Adams EF, Winslow CLJ, Mashiter K 1983 Pancreatic growth hormone releasing factor stimulates growth hormone secretion by pituitary cells. Lancet 1:1100-1101
168. Adams EF, Bhuttacharji SC, Halliwell CLJ, Loizou M, Birch G, Mashiter K 1984 Effect of pancreatic growth hormone releasing factors on GH secretion by human somatotrophic pituitary tumours in cell culture. Clin Endocrinol (Oxf) 21:709-718
169. Loras B, Li JY, Durand A, Trouillas J, Sassolas G, Girod C 1985 GRF et adénomes somatotropes humains. Corrélations in vivo et in vitro entre la libération de GH et les aspects morphologiques et immunocytochimiques. Ann Endocrinol (Paris) 46:373-382
170. Spada A, Elahi FR, Arosio M, Sartorio A, Guglielmo L, Vallar L, Faglia G 1987 Lack of desensitization of adenomatous somatotrophs to growth hormone-releasing hormone in acromegaly. J Clin Endocrinol Metab 64:585-591
171. Kawakita S, Asa SL, Kovacs K 1989 Effects of growth hormone-releasing hormone (GHRH) on densely granulated somatotroph adenomas and sparsely granulated somatotroph adenomas in vitro: a morphological and functional investigation. J Endocrinol Invest 12:443-448
172. White MC, Daniels M, Kendall-Taylor P, Turner SJ, Mathias D, Teasdale G 1985 Effects of growth hormone-releasing factor (1-44) on growth hormone release from human somatotrophinomas in vitro: interaction with somatostatin, dopamine, vasoactive intestinal peptide and cycloheximide. J Endocrinol 105:269-276
173. Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C, Vale W 1992 Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Endocrinology 131: 2083-2089
174. Lloyd RV, Jin L, Chang A, Kulig E, Camper SA, Ross BD, Downs TR, Frohman LA 1992 Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. Am J Pathol 141:895-906
175. Saeger W 1977 Die Morphologie der paraadenomatösen Adenohypophyse. Ein Beitrag zur Pathogenese der Hypophysenadenome. Virchows Arch [Pathol Anat ] 372:299-314
176. Ezzat S, Asa SL, Stefaneanu L, Whittom R, Smyth HS, Horvath E, Kovacs K, Frohman LA 1994 Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing hormone-producing bronchial carcinoid. J Clin Endocrinol Metab 78:555-560
177. Lin S, Lin C, Gukovsky I, Lusis A, Sawchenko P, Rosenfeld MG 1993 Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364:208-213
178. Godfrey P, Rahal J, Beamer W, Copeland N, Jenkins N, Mayo K 1993 GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4:227-232
179. Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B, Kishimoto T 1995 Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J Clin Endocrinol Metab 80:2933-2939
180. Krieger DT 1983 Physiopathology of Cushing's disease. Endocr Rev 4:22-43
181. Krieger DT 1979 Medical treatment of Cushing disease. In: Tolis G, Labrie F, Martin JB, Naftolin F (eds) Clinical Neuroendocrinology: A Pathophysiological Approach. Raven Press, New York, pp. 423-427
182. Carey RM, Varma SK, Drake Jr CR, Thorner MO, Kovacs K, Rivier J, Vale W 1984 Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. A clinical, morphologic, and biochemical study. N Engl J Med 311:13-20
183. Fjellestad-Paulsen A, Abrahamsson P-A, Bjartell A, Grino M, Grimelius L, Hedeland H, Falkmer S 1988 Carcinoma of the prostate with Cushing's syndrome. A case report with immunohistochemical and chemical demonstration of immunoreactive corticotropin-releasing hormone in plasma and tumor tissue. Acta Endocrinol (Copenh) 119:506-516
184. Asa SL, Kovacs K, Tindall GT, Barrow DL, Horvath E, Vecsei P 1984 Cushing's disease associated with an intrasellar gangliocytoma producing corticotrophin-releasing factor. Ann Intern Med 101:789-793
185. Gertz BJ, Contreras LN, McComb DJ, Kovacs K, Tyrrell JB, Dallman MF 1987 Chronic administration of corticotropin-releasing factor increases pituitary corticotroph number. Endocrinology 120: 381-388
186. McNicol AM, Kubba MAG, McTeague E 1988 The mitogenic effects of corticotrophin-releasing factor on the anterior pituitary gland of the rat. J Endocrinol 118:237-241
187. Asa SL, Kovacs K, Hammer GD, Liu B, Roos BA, Low MJ 1992 Pituitary corticotroph hyperplasia in rats implanted with a medullary thyroid carcinoma cell line transfected with a corticotropin-releasing hormone complementary deoxyribonucleic acid expression vector. Endocrinology 131:715-720
188. Suda T 1992 Corticotropin-releasing factor gene expression. Methods Neurosci 9:23-31
189. Suda T, Tozawa F, Yamada M, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Demura H, Shizume K 1988 Effects of corticotropin-releasing hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph adenoma cells in vitro. J Clin Invest 82:110-114
190. Suda T, Tozawa F, Dobasi I, Horiba N, Ohmori N, Yamakado M, Yamada M, Demura H 1993 Corticotropin-releasing hormone, proopiomelaninocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro. J Clin Invest 92:2790-2795
191. Sakai Y, Horiba N, Sakai K, Tozawa F, Kuwayama A, Demura H, Suda T 1997 Corticotropin-releasing factor up-regulates its own receptor gene expression in corticotropic adenoma cells in vitro. J Clin Endocrinol Metab 82:1229-1234
192. De Keyzer Y, Rene P, Lenne F, Auzan C, Clauser E, Bertagna X 1997 V3 vasopressin receptor and corticotropic phenotype in pituitary and nonpituitary tumors. Horm Res 47:259-262
193. Gesundheit N, Petrick PA, Nissim M, Dahlberg PA, Doppman JL, Emerson CH, Braverman LE, Oldfield EH, Weintraub BD 1989 Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity. Case reports and follow-up of nine patients. Ann Intern Med 111:827-835
194. Scheithauer BW, Kovacs K, Randall RV, Ryan N 1985 Pituitary gland in hypothyroidism. Histologic and immunocytologic study. Arch Pathol Lab Med 109:499-504
195. Horvath E, Kovacs K 1991 The adenohypophysis. In: Kovacs K, Asa SL (eds) Functional Endocrine Pathology. Blackwell Scientific Publications, Inc., Boston, pp. 245-281
196. Le Dafniet M, Lefebvre P, Barret A, Mechain C, Feinstein MC, Brandi AM, Peillon F 1990 Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. J Clin Endocrinol Metab 71:480-486
197. May V, Wilber JF, U'Prichard DC, Childs GV 1987 Persistence of immunoreactive TRH and GnRH in long-term primary anterior pituitary cultures. Peptides 8:543-558
198. Le Dafniet M, Blumberg-Tick J, Yuan Li J, Brandi AM, Bression D, Barret A, Feinstein MC, Peillon F 1988 Release of thyrotropin releasing hormone (TRH) from human prolactin-secreting pituitary adenoma cells. Modulation by dopamine [Fre]. C R Acad Sci III 306:129-134
199. Le Dafniet M, Blumberg-Tick J, Gozlan H, Barret A, Joubert Bression D, Peillon F 1989 Altered balance between thyrotropin-releasing hormone and dopamine in prolactinomas and other pituitary tumors compared to normal pituitaries. J Clin Endocrinol Metab 69:267-271
200. Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M 1993 Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. Biochem Biophys Res Commun 195:737-745
201. Le Dafniet M, Grouselle D, Li JY, Kujas M, Bression D, Barret A, Tixier-Vidal A, Peillon F 1987 Evidence of thyrotropin-releasing hormone (TRH) and TRH-binding sites in human nonsecreting pituitary adenomas. J Clin Endocrinol Metab 65:1014-1019
202. Yamada M, Hashimoto K, Satoh T, Shibusawa N, Kohga H, Ozawa Y, Yamada S, Mori M 1997 A novel transcript for the thyrotropin-releasing hormone receptor in human pituitary and pituitary tumors. J Clin Endocrinol Metab 82:4224-4228
203. Dong Q, Brucker-Davis F, Weintraub BD, Smallridge RC, Carr FE, Battey J, Spiegel AM, Shenker A 1996 Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the Gαq, G α11, Gαs, or thyrotropin-releasing hormone receptor genes. J Clin Endocrinol Metab 81:1134-1140
204. Ezzat S 1992 Hypophysiotropic regulation of anterior pituitary hormones: cellular and molecular mechanisms. In: Selman WR (ed) Neuroendocrinology. Williams & Wilkins, Baltimore, pp. 3-18
205. Snyder PJ 1985 Gonadotroph cell adenomas of the pituitary. Endoer Rev 6:552-563
206. Nicolis G, Shimshi TM, Allen C, Halmi NS, Kourides IA 1988 Gonadotropin-producing pituitary adenoma in a man with long-standing primary hypogonadism. J Clin Endocrinol Metab 66:237-241
207. Sanno N, Jin L, Qian X, Osamura RY, Scheithauer BW, Kovacs K, Lloyd RV 1997 Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor messenger ribonucleic acids expression in nontumorous and neoplastic pituitaries. J Clin Endocrinol Metab 82:1974-1982
208. Pagesy P, Yuan Li J, Berthet M, Peillon F 1991 Evidence of gonadotropin-releasing hormone mRNA in the rat anterior pituitary. Mol Endocrinol 6:523-528
209. Spada A, Lania A 1996 Hormone receptors in pituitary adenomas. In: Landolt AM, Vance ML, Reilly PL (eds) Pituitary Adenomas. Churchill Livingstone, New York, pp. 59-71
210. Miller GM, Alexander JM, Klibanski A 1996 Gonadotropin-releasing hormone messenger RNA expression in gonadotropin tumors and normal human pituitary. J Clin Endocrinol Metab 81: 80-83
211. Alexander JM, Klibanski A 1994 Gonadotropin-releasing hormone receptor mRNA expression by human pituitary tumors in vitro. J Clin Invest 93:2332-2339
212. Molitch ME 1987 Pathogenesis of pituitary tumors. Endocrinol Metab Clin North Am 16:503-527
213. Schechter J, Goldsmith P, Wilson C, Weiner R 1988 Morphological evidence for the presence of arteries in human prolactinomas. J Clin Endocrinol Metab 67:713-719
214. Senogles SE, Benovic JL, Amlaiky N, Unson C, Milligan G, Vinitsky R, Spiegel AM, Caron MG 1987 The D2 receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. J Biol Chem 262: 4860-4867
215. Wood DF, Johnston JM, Johnston DG 1991 Dopamine, the dopamine D2 receptor and pituitary tumours. Clin Endocrinol (Oxf) 35:455-466
216. Vallar L, Meldolesi J 1989 Mechanisms of signal transduction at the dopamine D2 receptor. Trends Pharmacol Sci 10:74-77
217. Koga M, Nakao H, Arao M, Sato B, Noma K, Morimoto Y, Kishimoto S, Mori S, Uozumi T 1987 Demonstration of specific dopamine receptors on human pituitary adenomas. Acta Endocrinol (Copenh) 114:595-602
218. Kelly MA, Rubinstein M, Asa SL, Zhang G, Saez C, Bunzow JR, Allen RG, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ 1997 Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19:103-113
219. Kelly MA, Rubinstein M, Asa SL, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ, Disruption of dopamine D2 receptors in the mouse. Proceedings of the 80th Annual Meeting of The Endocrine Society, New Orleans, LA, 1998 (Abstract)
220. Filetti S, Rapoport B, Aron DC, Greenspan FC, Wilson CB, Fraser W 1982 TSH and TSH-subunit production by human thyrotrophic tumour cells in monolayer culture. Acta Endocrinol (Copenh) 99: 224-231
221. Bevan JS, Burke CW, Esiri MM, Adams CBT, Ballabio M, Nissim M, Faglia G 1989 Studies of two thyrotrophin-secreting pituitary adenomas: evidence for dopamine receptor deficiency. Clin Endocrinol (Oxf) 31:59-70
222. Spada A, Bassetti M, Martino E, Giannattasio G, Beck-Peccoz P, Sartorio A, Vallar L, Baschieri L, Pinchera A, Faglia G 1985 In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine. J Endocrinol Invest 8:193-198
223. Trouillas J, Girod C, Loras B, Claustrat B, Sassolas G, Perrin G, Buonaguidi R 1988 The TSH secretion in the human pituitary adenomas. Pathol Res Pract 183:596-600
224. Friedman E, Adams EF, Hoog A, Gejman PV, Carson E, Larsson C, De Marco L, Werner S, Fahlbusch R, Nordenskjöld M 1994 Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors. J Clin Endocrinol Metab 78: 568-574
225. Kelijman M, Williams TC, Downs TR, Frohman LA 1988 Comparison of the sensitivity of growth hormone secretion to somatostatin in vivo and in vitro in acromegaly. J Clin Endocrinol Metab 67:958-963
226. Reubi JC, Landolt AM 1989 The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status. J Clin Endocrinol Metab 68:844-850
227. Bertherat J, Chanson P, Dewailly D, Dupuy M, Jaquet P, Peillon F, Epelbaum J 1993 Somatostatin receptors, adenylate cyclase activity, and growth hormone (GH) response to octreotide in GH-secreting adenomas. J Clin Endocrinol Metab 77:1577-1583
228. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A 1995 Somatostatin receptor subtype gene expression in pituitary adenomas. J Clin Endocrinol Metab 80:1386-1392
229. Levy L, Bourdais J, Mouhieddine B, Benlot C, Villares S, Cohen P, Peillon F, Joubert D 1993 Presence and characterization of the somatostatin precursor in normal human pituitaries and in growth hormone secreting adenomas. J Clin Endocrinol Metab 76:85-90
230. Peillon F, Liappi G, Garnier P, Brandi AM, Evain-Brion D, Dodeur M, Gautron JP, Donnadieu M, Michard M, Racadot J, Joubert (Bression) D 1988 In vitro secretion of somatostatin (SRIH) by human adenomatous somatotropic cells. Relation with somatotropic hormone (GH) release and modulation by thyroliberin (TRH) [Fre]. C R Acad Sci III 306:161-166
231. Scheithauer BW, Kovacs K, Randall RV 1983 The pituitary gland in untreated Addison's disease. A histologic and immunocytologic study of 18 adenohypophyses. Arch Pathol Lab Med 107:484-487
232. Lüdecke DK, Westphal M, Schabet M, Höllt V 1980 In vitro secretion of ACTH, β-endorphin and β-lipotropin in Cushing's disease and Nelson's syndrome. Horm Res 13:259-279
233. Horvath SE, Asa SL, Kovacs K, Adams LA, Singer W, Smyth HS 1990 Human pituitary corticotroph adenomas in vitro: morphologic and functional responses to corticotropin-releasing hormone and cortisol. Neuroendocrinology 51:241-248
234. Bamberger CM, Schulte HM, Chrousos GP 1996 Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17:245-261
235. Hurley DM, Accili D, Stratakis CA, Karl M, Vamvakopoulos N, Rorer E, Constatine K, Taylor SI, Chrousos GP 1991 Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest 87:680-686
236. Karl M, Lamberts SWJ, Koper JW, Katz DA, Huizenga NE, Kino T, Haddad BR, Hughes MR, Chrousos GP 1996 Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel dominant-negative glucocorticoid receptor mutation. Proc Assoc Am Physicians 108:296-307
237. Karl M, von Wichert G, Kempter E, Katz DA, Reincke M, Mönig H, Ali IU, Stratakis CA, Oldfield EH, Chrousos GP, Schulte HM 1996 Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene. J Clin Endocrinol Metab 81:124-129
238. Ray DW, Littlewood AC, Clark AJ, Davis JRE, White A 1994 Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function. J Clin Invest 93:1625-1630
239. Gittoes NJL, McCabe CJ, Verhaeg J, Sheppard MC, Franklyn JA 1997 Thyroid hormone and estrogen receptor expression in normal pituitary and nonfunctioning tumors of the anterior pituitary. J Clin Endocrinol Metab 82:1960-1967
240. Wang CJ, Howng SL, Lin KH 1995 Expression of thyroid hormone receptors in human pituitary tumor cells. Cancer Lett 91:79-83
241. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest 86:336-340
242. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S 1990 Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71:1427-1433
243. Gicquel C, LeBouc Y, Luton J-P, Girad F, Bertagna X 1992 Monoclonality of corticotroph macroadenomas in Cushing's disease. J Clin Endocrinol Metab 75:472-475
244. Schulte HM, Oldfield EH, Allolio B, Katz DA, Berkman RA, Ali IU 1991 Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis. J Clin Endocrinol Metab 73:1302-1308
245. Spada A, Vallar L, Faglia G 1992 G protein oncogenes in pituitary tumors. Trends Endocrinol Metab 3:355-360
246. Gilman AG 1987 G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649
247. Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Dun Q-Y, Clark OH, Kawasaki E, Bourne HR, McCormick F 1990 Two G protein oncogenes in human endocrine tumors. Science 249:655-659
248. s α-gene in nonfunctioning pituitary tumors. J Clin Endocrinol Metab 77:765-769
249. i2α mutations in clinically non-functioning pituitary tumours. Clin Endocrinol (Oxf) 41:815-820
250. Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE 1995 G-Protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. Eur J Clin Invest 25:128-131
251. s protein. J Clin Endocrinol Metab 71:1416-1420
252. Harris PE, Alexander JM, Bikkal HA, Hsu DW, Hedley-Whyte T, Klibanski A, Jameson JL 1992 Glycoprotein hormone α-subunit production in somatotroph adenomas with and without Gsα mutations. J Clin Endocrinol Metab 75:918-923
253. Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G 1990 Clinical, biochemical and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 71:1421-1426
254. Ezzat S, Kontogeorgos G, Redelmeier DA, Horvath E, Harris AG, Kovacs K 1995 In vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide. Eur J Endocrinol 133:686-690
255. Bertherat J, Chanson P, Montminy M 1995 The cyclic adenosine 3′5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol 9:777-783
256. Burton FH, Hasel KW, Bloom FE, Sutcliffe JG 1991 Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. Nature 350:74-77
257. Lewis MD, Webster J, Ham J, Davies JS, Scanlon MF 1996 AMP is a component of the low molecular weight mitogenic activity present in human pituitary tumours. J Clin Endocrinol Metab 81: 1296-1298
258. Hsieh KP, Martin TF 1992 Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phopholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11. Mol Endocrinol 6:1673-1681
259. Oyesiku NM, Evans C-O, Brown MR, Blevins LS, Tindall GT, Parks JS 1997 Pituitary adenomas: screening for Gαq mutations. J Clin Endocrinol Metab 82:4184-4188
260. Barbacid MA 1987 Ras genes. Annu Rev Biochem 56:779-827
261. Bos JL 1989 ras Oncogenes in human cancer: a review. Cancer Res 49:4682-4689
262. Ezzat S, Zheng L, Kolenda J, Safarian A, Freeman JL, Asa SL 1996 Prevalence of activating ras mutations in morphologically characterized thyroid nodules. Thyroid 6:409-416
263. Karga HJ, Alexander JM, Hedley-Whyte ET, Klibanski A, Jameson JL 1992 Ras mutations in human pituitary tumors. J Clin Endocrinol Metab 74:914-919
264. Herman V, Drazin NZ, Gonsky R, Melmed S 1993 Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab 77:50-55
265. Pei L, Melmed S, Scheithauer B, Kovacs K, Prager D 1994 H-ras mutations in human pituitary carcinoma metastases. J Clin Endocrinol Metab 78:842-846
266. Cai WY, Alexander JM, Hedley-Whyte ET, Scheithauer BW, Jameson JL, Zervas NT, Klibanski A 1994 Ras mutations in human prolactinomas and pituitary carcinomas. J Clin Endocrinol Metab 78:89-93
267. Stabel S, Parker PJ 1991 Protein kinase C. Pharmacol Ther 51:71-95
268. Alvaro V, Touraine Ph Raisman Vozari R, Bai-Grenier F, Birman P, Joubert(Bression) D 1992 Protein kinase C activity and expression in normal and adenomatous human pituitaries. Int J Cancer 50:724-730
269. Alvaro V, Lévy L, Dubray C, Roche A, Peillon F, Quérat B, Joubert D 1993 Invasive human pituitary tumors express a point-mutated a-protein kinase-C. J Clin Endocrinol Metab 77:1125-1129
270. Schiemann U, Assert R, Moskopp D, Gellner R, Hengst K, Gullotta F, Domschke W, Pfeiffer A 1997 Analysis of a protein kinase C-alpha mutation in human pituitary tumours. J Endocrinol 153: 131-137
271. erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA 90:1746-1750
272. Qian X, LeVea CM, Freeman JK, Dougall WC, Greene MI 1994 Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc Natl Acad Sci USA 91: 1500-1504
273. Dougall WC, Quan X, Peterson NC, Miller MJ, Samanta A, Greene MI 1994 The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies. Oncogene 9:2109-2123
274. Goldman R, Levy RB, Peles E, Yarden Y 1990 Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochem J 29:11024-11028
275. Ezzat S, Zheng L, Smyth HS, Asa SL 1997 The c-erbB-2/neu protooncogene in human pituitary tumours. Clin Endocrinol (Oxf) 46: 599-606
276. Pei L, Melmed S 1997 Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11:433-441
277. Marx SJ 1989 Familial multiple endocrine neoplasia type 1. Mutation of a tumor suppressor gene. Trends Endocrinol Metab 1:76-82
278. Byström C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B, Öberg K, Werner S, Nordenskjöld M 1990 Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA 87:1968-1972
279. Larsson C, Skogseid B, Öberg K, Nakamura Y, Nordenskjöld M 1988 Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 332:85-87
280. Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PT 1990 Localization of the gene encoding a type 1 protein phosphatase catalytic subunit to human chromosome band 11q13. Genomics 7:159-166
281. Bale SJ, Bale AE, Stewart K, Dachowski L, McBride OW, Glaser T, Green JI, Mulvihill JJ, Brandi M-L, Sakaguchi K 1989 Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11. Genomics 4:320-322
282. Bale AE, Norton JA, Wong EL, Fryburg JS, Maton PN, Oldfield EH, Streeten E, Aurbach GD, Brandi ML, Friedman E, Spiegel AM, Taggart RT, Marx SJ 1991 Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia Type 1. Cancer Res 51:1154-1157
283. Bystrom C, Larsson C, Blomberg C, Sandelin K, Falkmer E 1990 Localization of the MEN-1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA 87:1968-1972
284. Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan P, Perrett CW, Thakker RV, Clayton RN 1994 Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 78:387-392
285. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN 1993 Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. J Clin Invest 91:2815-2821
286. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ 1997 Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276:404-407
287. Zhuang Z, Ezzat S, Vortmeyer AO, Weil R, Oldfield EH, Park W-S, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL, Lubensky IA 1997 Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res 57:5446-5451
288. Asa SL, Somers K, Ezzat S 1998 The MEN-1 gene is rarely down-regulated in pituitary adenomas. J Clin Endocrin Metab 83:3210-3212
289. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA 1993 Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499-511
290. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA 1992 Effects of an Rb mutation in the mouse. Nature 359:295-300
291. delta/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9:1021-1027
292. Cryns VL, Alexander JM, Klibanski A, Arnold A 1993 The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab 77:644-646
293. Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG, Black PM 1994 Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab 78:922-927
294. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D 1995 Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 55:1613-1616
295. Sherr CJ, Roberts JM 1995 Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163
296. Hartwell L, Kastan M 1994 Cell cycle and cancer. Science 266: 1821-1828
297. INK4a gene product in human pituitary tumors. Cancer Res 56:2493-2496
298. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707-720
299. Kip1. Cell 85:721-732
300. Kip1-deficient mice. Cell 85:733-744
301. Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. J Clin Endocrinol Metab 82:3141-3147
302. Baker SJ, Markowitz S, Fearon ER, Wilson JK, Vogelstein B 1990 Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249:912-915
303. Levine AJ, Momand J, Finlay CA 1991 The p53 tumour suppressor gene. Nature 315:453-456
304. Yoshimoto K, Iwahana H, Fukuda A, Sano T, Saito S, Itakura M 1992 Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism. Cancer Res 52:5061-5064
305. Sumi T, Stefaneanu L, Kovacs K, Asa SL, Rindi G 1993 Immunohistochemical study of p53 protein in human and animal pituitary tumors. Endocr Pathol 4:95-99
306. Levy A, Hall L, Yeundall WA, Lightman SL 1994 p53 Gene mutations in pituitary adenomas: rare events. Clin Endocrinol (Oxf) 41:809-814
307. Buckley N, Bates AS, Broome JC, Strange RC, Perrett CW, Burke CW, Clayton RN 1994 p53 Protein accumulation in Cushings adenomas and invasive non-functional adenomas. J Clin Endocrinol Metab 79:1513-1516
308. Takino H, Herman V, Weiss M, Melmed S 1995 Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. J Clin Endocrinol Metab 80:1733-1738
309. Rizzino A 1991 Growth factors. In: Kovacs K, Asa SL (eds) Functional Endocrine Pathology. Blackwell Scientific Publications Inc., Boston, pp. 979-989
310. Ezzat S, Melmed S 1990 The role of growth factors in the pituitary. J Endocrinol Invest 13:691-698
311. Asa SL, Kovacs K, Melmed S 1995 The hypothalamic-pituitary axis. In: Melmed S (ed) The Pituitary. Blackwell Scientific Publication Inc., Boston, pp. 3-44
312. Webster J, Ham J, Bevan JS, Scanlon MF 1989 Growth factors and pituitary tumors. Trends Endocrinol Metab 1:95-98
313. Patterson J, Childs GV 1994 Nerve growth factor in the anterior pituitary: regulation of secretion. Endocrinology 135:1697-1704
314. Gospodarowicz D, Abraham JA, Schilling J 1989 Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86:7311-7315
315. Newman CB, Cosby H, Friesen HG, Feldman M, Cooper P, De Crescito V, Pilon M, Kleinberg DL 1987 Evidence for a nonprolactin, non-growth-hormone mammary mitogen in the human pituitary gland. Proc Natl Acad Sci USA 84:8110-8114
316. Samsoondar J, Kudlow JE 1987 Partial purification of an adrenal growth factor produced by normal bovine anterior pituitary cells in culture. Endocrinology 120:929-935
317. Jones KL, Villela JF, Lewis UJ 1986 The growth of cultured rabbit articular chondrocytes is stimulated by pituitary growth factors but not by purified human growth hormone or ovine prolactin. Endocrinology 118:2588-2593
318. Kasper S, Friesen HG 1986 Human pituitary tissue secretes a potent growth factor for chondrocyte proliferation. J Clin Endocrinol Metab 62:70-76
319. Webster J, Ham J, Bevan JS, ten Horn CD, Scanlon MF 1991 Preliminary characterization of growth factors secreted by human pituitary tumors. J Clin Endocrinol Metab 72:687-692
320. Ezzat S, Walpola IA, Ramyar L, Smyth HS, Asa SL 1995 Membrane-anchored expression of transforming growth factor-α in human pituitary adenoma cells. J Clin Endocrinol Metab 80:534-539
321. Fisher DA, Lakshmanan J 1990 Metabolism and effects of epidermal growth factor and related growth factors in mammals. Endocr Rev 11:418-442
322. Nelson KG, Takahashi T, Lee DC, Luetteke NC, Bossert NL, Ross K, Eitzman BE, McLachlan JA 1992 Transforming growth factor-α is a potential medicator of estrogen action in the mouse uterus. Endocrinology 131:1657-1664
323. McAndrew J, Paterson AJ, Asa SL, McCarthy KJ, Kudlow JE 1995 Targeting of transforming growth factor-α expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology 136:4479-4488
324. Beerli RR, Hynes NE 1996 Epidermal growth factor-related pep3 tides activate distinct subsets of ErbB receptors and differ in their biological activities. J Biol Chem 271:6071-6076
325. Marchionni MA, Goodearl ADJ, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M, Danehy F, Misumi D, Sudhalter J, Kobayashi K, Wroblewski D, Lynch C, Baldassare M, Hiles I, Davis JB, Hsuan JJ, Totty NF, Otsu M, McBurney RN, Waterfield MD, Stroobant P, Gwynne D 1993 Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362:312-318
326. LeRiche V, Asa SL, Ezzat S 1996 Epidermal growth factor and its receptor (EGF-R) in human pituitary adenomas: EGF-R correlates with tumor aggressiveness. J Clin Endocrinol Metab 81:656-662
327. White BA, Bancroft FC 1983 Epidermal growth factor and thyrotropin-releasing hormone interact synergistically with calcium to regulate prolactin mRNA levels. J Biol Chem 258:4618-4622
328. Murdoch GH, Potter E, Nicolaisen AK, Evans RM, Rosenfeld MG 1982 Epidermal growth factor rapidly stimulates prolactin gene transcription. Nature 300:192-194
329. Ramsdell JS, Tashjian AH 1985 Thyrotropin-releasing hormone and epidermal growth factor stimulate prolactin synthesis by a pathway(s) that differs from that used by phorbol esters: dissociation of actions by calcium dependency and additivity. Endocrinology 117:2050-2060
330. Polk DH, Ervin MG, Padbury JF, Lam RW, Reviczky AL, Fisher DA 1987 Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs. J Clin Invest 79:984-988
331. Childs GV, Rougeau D, Unabia G 1995 Corticotropin-releasing hormone and epidermal growth factor: mitogens for anterior pituitary corticotropes. Endocrinology 136:1595-1602
332. Ikeda H, Mitsuhashi T, Kubota K, Kuzuya N, Uchimura H 1984 Epidermal
333. Ying S-Y 1988 Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 9:267-293
334. Haddad G, Penabad JL, Bashey HM, Asa SL, Gennarelli TA, Cirullo R, Snyder PJ 1994 Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas. J Clin Endocrinol Metab 79:1399-1403
335. Alexander JM, Swearingen B, Tindall GT, Klibanski A 1995 Human pituitary adenomas express endogenous inhibin subunit and follistatin messenger ribonucleic acids. J Clin Endocrinol Metab 80:147-152
336. Alexander JM, Jameson JL, Bikkal HA, Schwall RH, Klibanski A 1991 The effects of activin on follicle-stimulating hormone secretion and biosynthesis in human glycoprotein hormone-producing pituitary adenomas. J Clin Endocrinol Metab 72:1261-1267
337. Penabad JL, Bashey HM, Asa SL, Haddad G, Davis KD, Herbst AB, Gennarelli TA, Kaiser UB, Chin WW, Snyder PJ 1996 Decreased follistatin gene expression in gonadotroph adenomas. J Clin Endocrinol Metab 81:3397-3403
338. Mason IJ 1994 The ins and outs of fibroblast growth factors. Cell 78:547-552
339. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G 1987 Structural characterization and biological functions of fibroblast growth factor. Endocr Rev 8:95-114
340. Baird A, Mormède P, Ying S-Y, Wehrenberg WB, Ueno N, Ling N, Guillemin R 1985 A nonmitogenic pituitary function of fibroblast growth factor: regulation of thyrotropin and prolactin secretion. Proc Natl Acad Sci USA 82:5545-5549
341. Larson GH, Koos RD, Sortino MA, Wise PM 1990 Acute effect of basic fibroblast growth factor on secretion of prolactin as assessed by the reverse hemolytic plaque assay. Endocrinology 126:927-932
342. Ezzat S, Smyth HS, Ramyar L, Asa SL 1995 Heterogenous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas. J Clin Endocrinol Metab 80:878-884
343. Li Y, Koga M, Kasayama S, Matsumoto K, Arita N, Hayakawa T, Sato B 1992 Identification and characterization of high molecular weight forms of basic fibroblast growth factor in human pituitary adenomas. J Clin Endocrinol Metab 75:1436-1441
344. Jin L, Chandler WF, Lloyd RV 1994 Localization of basic fibroblast growth factor (bFGF) protein and mRNA in human pituitaries: regulation of bFGF mRNA by gonadotropin-releasing hormone. Endocr Pathol 5:27-34
345. Prysor-Jones RA, Silverlight JJ, Jenkins JS 1989 Oestradiol, vasoactive intestinal peptide and fibroblast growth factor in the growth of human pituitary tumour cells in vitro. J Endocrinol 120: 171-177
346. Zimering MB, Katsumata N, Sato Y, Brandi ML, Aurbach GD, Marx SJ, Friesen HG 1993 Increased basic fibroblast growth factor in plasma from multiple endocine neoplasia type 1: relation to pituitary tumor. J Clin Endocrinol Metab 76:1182-1187
347. Gonsky R, Herman V, Melmed S, Fagin J 1991 Transforming DNA sequences present in human prolactin-secreting pituitary tumors. Mol Endocrinol 5:1687-1695
348. Shimon I, Hüttner A, Said J, Spirna OM, Melmed S 1996 Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription. J Clin Invest 97:187-195
349. Weiner RI, Windle J, Mellon P, Schechter J 1991 Role of FGF in tumorigenesis of the anterior pituitary. J Endocrinol Invest 14 [Suppl]:S13 (Abstract)
350. Givol D, Yayon A 1992 Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 6:3362-3369
351. Yan G, Wang F, Fukabori Y, Sussman D, Hou J, McKeehan WL 1992 Expression and transformation of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the exon at alternate 3′-acceptor site. Biochem Biophys Res Commun 183:423-430
352. Peters KG, Werner S, Chen G, Williams LT 1992 Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114:233-243
353. Hanneken A, Ying W, Ling N, Baird A 1994 Identification of soluble forms of the fibroblast growth factor receptor in blood. Proc Natl Acad Sci USA 91:9170-9174
354. Werner S, Weinberg W, Liao X, Peters KG, Blessing M, Yuspa SH, Weiner RL, Williams LT 1993 Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J 12:2635-2643
355. Gonzalez AM, Logan A, Ying W, Lappi DA, Berry M, Baird A 1994 Fibroblast growth factor in the hypothalamic-pituitary axis: differential expression of fibroblast growth factor-2 and a high affinity receptor. Endocrinology 134:2289-2297
356. Eisemman A, Ahn AJ, Graziani G, Tronick SR, Ron D 1991 Alternative splicing generates at least five different isoforms of the human bFGF receptor. Oncogene 6:1195-1202
357. Becker D, Lee PLP, Rodeck U, Herlyn M 1992 Inhibition of the fibroblast growth factor receptor 1 (FGFR-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation. Oncogene 7:2303-2313
358. Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL 1993 Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy Mol Cell Biol 13:4513-4522
359. Abbass SAA, Asa SL, Ezzat S 1997 Altered expression of fibroblast growth factor receptors in human pituitary adenomas. J Clin Endocrinol Metab 82:1160-1166
360. Abbass SAA, Zheng L, Asa SL, Ezzat S, Novel isoforms of fibroblast growth factor receptor 4 predict differential activity in normal and adenomatous human pituitary. Program of the 79th Annual Meeting of The Endocrine Society, Minneapolis, MN, 1997 (Abstract 358)
361. Ezzat S, Horvath E, Kovacs K, Smyth HS, Singer W, Asa SL 1995 Basic fibroblast growth factor expression by two prolactin and thyrotropin-producing pituitary adenomas. Endocr Pathol 6:125-134
362. Borrelli E, Sawchenko PE, Evans RM 1992 Pituitary hyperplasia induced by ectopic expression of nerve growth factor. Proc Natl Acad Sci USA 89:2764-2768
363. Missale C, Boroni F, Losa M, Giovanelli MA, Zanellato A, Dal Toso R, Balsari A, Spano P 1993 Nerve growth factor suppresses the transforming phenotype of human prolactinomas. Proc Natl Acad Sci USA 90:7961-7965
364. Missale C, Boroni F, Sigala S, Zanellato A, Dal Toso R, Balsari A, Spano P 1994 Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype. Endocrinology 135:290-298
365. Daniely M, Aviram A, Adams EF, Buchfelder M, Barkai G, Fahlbusch R, Goldman B, Friedman E 1998 Comparative genomic hybridization analysis of non functioning pituitary tumors. J Clin Endocrinol Metab 83:1801-1805