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Volumn 2, Issue 12, 1996, Pages 1316-1321

Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb(+/-) mice

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ANTIMITOTIC AGENT;

EID: 0029802927     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1296-1316     Document Type: Article
Times cited : (73)

References (49)
  • 1
    • 0024234852 scopus 로고
    • Suppression of the neoplastic pnenotype by replacement of the RB gene in human cancer cells
    • Huang, H.-J.S. et al. Suppression of the neoplastic pnenotype by replacement of the RB gene in human cancer cells. Science 242, 1563-1566 (1988).
    • (1988) Science , vol.242 , pp. 1563-1566
    • Huang, H.-J.S.1
  • 2
    • 0028170806 scopus 로고
    • The retinoblastoma protein: More than a tumor suppressor
    • Riley, D.J., Lee, E.Y.-H.P. & Lee, W.-H. The retinoblastoma protein: More than a tumor suppressor. Annu. Rev. Cell Biol. 10, 1-29 (1994).
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 1-29
    • Riley, D.J.1    Lee, E.Y.-H.P.2    Lee, W.-H.3
  • 3
    • 0025068887 scopus 로고
    • Suppression of the tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
    • Bookstein, R., Shew, J.-Y., Chen, P.-L., Scully, P. & Lee, W.-H. Suppression of the tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247, 712-715 (1990).
    • (1990) Science , vol.247 , pp. 712-715
    • Bookstein, R.1    Shew, J.-Y.2    Chen, P.-L.3    Scully, P.4    Lee, W.-H.5
  • 4
    • 0026355171 scopus 로고
    • Intraocular tumor suppression of retinoblastoma gene reconstituted retinoblastoma cells
    • Madreperla, S.A., Whittum-Hudson, J.A., Prendergast, R.A., Chen, P.-L. & Lee, W.-H. Intraocular tumor suppression of retinoblastoma gene reconstituted retinoblastoma cells. Cancer Res. 61, 6381-6384 (1990).
    • (1990) Cancer Res. , vol.61 , pp. 6381-6384
    • Madreperla, S.A.1    Whittum-Hudson, J.A.2    Prendergast, R.A.3    Chen, P.-L.4    Lee, W.-H.5
  • 5
    • 0027260523 scopus 로고
    • Reconstitution of the retinoblastoma gene suppresses the growth of small cell lung carcinoma cells carrying multiple genetic alterations
    • Ookawa, K. et al. Reconstitution of the retinoblastoma gene suppresses the growth of small cell lung carcinoma cells carrying multiple genetic alterations. Oncogene 8, 2175-2181 (1991)
    • (1991) Oncogene , vol.8 , pp. 2175-2181
    • Ookawa, K.1
  • 6
    • 0026653706 scopus 로고
    • Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation
    • Goodrich, D.W., Chen, Y., Scully, P. & Lee W.-H. Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation. Cancer Res. 52, 1968-1973 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 1968-1973
    • Goodrich, D.W.1    Chen, Y.2    Scully, P.3    Lee, W.-H.4
  • 7
    • 0027398585 scopus 로고
    • Tumor suppressor activity of RB and p53 genes in human breast cancer cells
    • Wang, N.P., To, H., Lee, W.-H. & Lee, E.Y.-H.P. Tumor suppressor activity of RB and p53 genes in human breast cancer cells. Oncogene 8, 279-288 (1993).
    • (1993) Oncogene , vol.8 , pp. 279-288
    • Wang, N.P.1    To, H.2    Lee, W.-H.3    Lee, E.Y.-H.P.4
  • 8
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee, E.Y.-H.P. et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-294 (1992).
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.-H.P.1
  • 9
    • 0026702996 scopus 로고
    • Effects of an Rb mutation in the mouse
    • Jacks, T. et al. Effects of an Rb mutation in the mouse. Nature 359, 295-300 (1992).
    • (1992) Nature , vol.359 , pp. 295-300
    • Jacks, T.1
  • 10
    • 0026760426 scopus 로고
    • Requirement for a functional Rb-1 gene in murine development
    • Clarke, A.R. et al. Requirement for a functional Rb-1 gene in murine development. Nature 359, 328-330 (1992).
    • (1992) Nature , vol.359 , pp. 328-330
    • Clarke, A.R.1
  • 11
    • 0028174064 scopus 로고
    • A20,+ mice are predisposed to tumors of the pituitary gland with nearly complete penetrance
    • A20,+ mice are predisposed to tumors of the pituitary gland with nearly complete penetrance. Oncogene 9, 1021-1029 (1994).
    • (1994) Oncogene , vol.9 , pp. 1021-1029
    • Hu, N.1
  • 12
    • 0028136594 scopus 로고
    • Cooperative tumorigenic effects of germline mutations in Rb and p53
    • Williams, B.O. et al. Cooperative tumorigenic effects of germline mutations in Rb and p53. Nature Genet. 7, 480-484 (1994).
    • (1994) Nature Genet. , vol.7 , pp. 480-484
    • Williams, B.O.1
  • 13
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathologic consequences
    • Williams, B.O. et al. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathologic consequences. EMBO J. 13, 4251-4259 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4251-4259
    • Williams, B.O.1
  • 16
    • 0028902753 scopus 로고
    • Cytostatic therapy for vascular proliferate disorders with a constitutively active form of the retinoblastoma gene product
    • Chang, M.W. et al. Cytostatic therapy for vascular proliferate disorders with a constitutively active form of the retinoblastoma gene product. Science 267, 518-522 (1995).
    • (1995) Science , vol.267 , pp. 518-522
    • Chang, M.W.1
  • 17
    • 0027182579 scopus 로고
    • Expression of a retinoblastoma transgene results in dwarf mice
    • Bignon, Y.-J. et al. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 7, 1654-1662 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 1654-1662
    • Bignon, Y.-J.1
  • 18
    • 0027755976 scopus 로고
    • Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis
    • Chang, C.-Y., Riley, D.J., Lee, E.Y.-H.P. & Lee, W.-H. Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis. Cell Growth Differ. 4, 1057-1064 (1993).
    • (1993) Cell Growth Differ. , vol.4 , pp. 1057-1064
    • Chang, C.-Y.1    Riley, D.J.2    Lee, E.Y.-H.P.3    Lee, W.-H.4
  • 19
    • 0027595949 scopus 로고
    • The basic science of gene therapy
    • Mulligan, R.C. The basic science of gene therapy. Science 260, 926-932 (1993).
    • (1993) Science , vol.260 , pp. 926-932
    • Mulligan, R.C.1
  • 20
    • 0026058874 scopus 로고
    • The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
    • Goodrich, D.W., Wang, N.P., Qian, Y.-W., Lee, E.Y.-H.P. & Lee, W.-H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67, 293-302 (1991).
    • (1991) Cell , vol.67 , pp. 293-302
    • Goodrich, D.W.1    Wang, N.P.2    Qian, Y.-W.3    Lee, E.Y.-H.P.4    Lee, W.-H.5
  • 21
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma functions by ectopic expression of human cyclins
    • Hinds, P.W. et al. Regulation of retinoblastoma functions by ectopic expression of human cyclins. Cell 70, 993-1006 (1992).
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1
  • 22
    • 0028131540 scopus 로고
    • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
    • Lee, E.Y.-H.P. et al. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8, 2008-2021 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2008-2021
    • Lee, E.Y.-H.P.1
  • 23
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S phase entry, activation of E2F-responsive genes, and apoptosis
    • Almasan, A. et al. Deficiency of retinoblastoma protein leads to inappropriate S phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA 92, 5436-5440 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5436-5440
    • Almasan, A.1
  • 24
    • 0028861428 scopus 로고
    • Inhibition of apoptosis by the retinoblastoma gene product
    • Hass-Kogan, D.A. et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J. 14, 461-472 (1995).
    • (1995) EMBO J. , vol.14 , pp. 461-472
    • Hass-Kogan, D.A.1
  • 25
    • 0028914946 scopus 로고
    • Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins
    • Slark, R.S. et al. Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. J. Cell Biol. 129, 779-788 (1995).
    • (1995) J. Cell Biol. , vol.129 , pp. 779-788
    • Slark, R.S.1
  • 26
    • 0029915968 scopus 로고    scopus 로고
    • Retinoblastoma protein inhibits IFN-γ induced apoptosis
    • Berry, D.E. et al. Retinoblastoma protein inhibits IFN-γ induced apoptosis. Oncogene 12, 1809-1819 (1996).
    • (1996) Oncogene , vol.12 , pp. 1809-1819
    • Berry, D.E.1
  • 27
    • 0000008685 scopus 로고
    • Transauricular hypophysectomy in rats and mice
    • Falconi, G. & Rossi, G.L. Transauricular hypophysectomy in rats and mice. Endocrinology 74, 301-304 (1964).
    • (1964) Endocrinology , vol.74 , pp. 301-304
    • Falconi, G.1    Rossi, G.L.2
  • 28
    • 9044252959 scopus 로고
    • Tyrosine hydroxylase: The initial step in norepinehrine biosynthesis
    • Nagatsu, T., Levitt, M. & Udenfriend, S. Tyrosine hydroxylase: The initial step in norepinehrine biosynthesis. J. Biol. Chem. 239, 2910-2916 (1964).
    • (1964) J. Biol. Chem. , vol.239 , pp. 2910-2916
    • Nagatsu, T.1    Levitt, M.2    Udenfriend, S.3
  • 29
    • 0022391791 scopus 로고
    • r 38,000 characteristic of presynaptic vesicles
    • r 38,000 characteristic of presynaptic vesicles. Cell 41, 1017-1028 (1985).
    • (1985) Cell , vol.41 , pp. 1017-1028
    • Weidenmann, B.1    Francke, W.W.2
  • 30
    • 0023032310 scopus 로고
    • Protein p38: An integral membrane protein specific for small vesicles of neurons and neuroendocrine cells
    • Navone, F. et al. Protein p38: An integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J. Cell Biol. 103, 2511-2527 (1986).
    • (1986) J. Cell Biol. , vol.103 , pp. 2511-2527
    • Navone, F.1
  • 31
    • 0025355694 scopus 로고
    • Two new monoclonal antibodies provide immunohistochemical evidence for the unique biochemical similarity of the mouse globus pallidus, entopeduncular nucleus, and substantia nigra pars reticulata
    • Sousa, R., Hrinya Tannery, N. & Lafer, E.M. Two new monoclonal antibodies provide immunohistochemical evidence for the unique biochemical similarity of the mouse globus pallidus, entopeduncular nucleus, and substantia nigra pars reticulata. Neuroscience 34, 403-410 (1990).
    • (1990) Neuroscience , vol.34 , pp. 403-410
    • Sousa, R.1    Hrinya Tannery, N.2    Lafer, E.M.3
  • 32
    • 0026637449 scopus 로고
    • Characterization of a novel synapse protein. I. Developmental expression and cellular localization of the F1-20 protein and mRNA
    • Sousa R., Hrinya Tannery, N., Zhou, S. & Lafer, E.M. Characterization of a novel synapse protein. I. Developmental expression and cellular localization of the F1-20 protein and mRNA. J. Neurosci. 12, 2130-2143 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 2130-2143
    • Sousa, R.1    Hrinya Tannery, N.2    Zhou, S.3    Lafer, E.M.4
  • 33
    • 0002598664 scopus 로고
    • Life span and aging patterns
    • (ed. Green, E.L.) McGraw-Hill, New York
    • Russell, E.S. Life span and aging patterns, in Biology of the Laboratory Mouse, 2nd edn. (ed. Green, E.L.) 511-519 (McGraw-Hill, New York, 1966).
    • (1966) Biology of the Laboratory Mouse, 2nd Edn. , pp. 511-519
    • Russell, E.S.1
  • 34
    • 13344286312 scopus 로고    scopus 로고
    • Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis
    • Zabner, J. et al. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97, 1504-1511 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 1504-1511
    • Zabner, J.1
  • 35
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • Roth, J.A. et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2, 985-991 (1996).
    • (1996) Nature Med. , vol.2 , pp. 985-991
    • Roth, J.A.1
  • 36
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemia cells that is inhibited by interleukin-6
    • Yonish-Rouach, E. et al. Wild-type p53 induces apoptosis of myeloid leukaemia cells that is inhibited by interleukin-6. Nature 352, 345-347 (1991).
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1
  • 37
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D.P. p53, guardian of the genome. Nature 358, 15-16 (1992).
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 38
    • 0025934488 scopus 로고
    • Molecular genetics of the retinoblastoma suppressor gene
    • Bookstein, R. & Lee, W.-H. Molecular genetics of the retinoblastoma suppressor gene. Crit. Rev. Oncogen. 2, 211-227 (1991).
    • (1991) Crit. Rev. Oncogen. , vol.2 , pp. 211-227
    • Bookstein, R.1    Lee, W.-H.2
  • 39
    • 0023686773 scopus 로고
    • Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
    • Harbour, J.W. et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241, 353-357 (1988).
    • (1988) Science , vol.241 , pp. 353-357
    • Harbour, J.W.1
  • 40
    • 0025311341 scopus 로고
    • Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer
    • Hensel, C.H. et al. Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res. 50, 3067-3072 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 3067-3072
    • Hensel, C.H.1
  • 41
    • 0028070540 scopus 로고
    • RB protein status and clinical correlation for 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma
    • Shizmu, E. et al. RB protein status and clinical correlation for 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9, 2441-2448 (1994).
    • (1994) Oncogene , vol.9 , pp. 2441-2448
    • Shizmu, E.1
  • 42
  • 43
    • 0027737463 scopus 로고
    • Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis
    • Rich, D.P. et al. Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Hum. Gene Ther. 4, 461-476 (1993).
    • (1993) Hum. Gene Ther. , vol.4 , pp. 461-476
    • Rich, D.P.1
  • 44
    • 0018581742 scopus 로고
    • Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
    • Jones, N. & Shenck, T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 17, 683-689 (1979).
    • (1979) Cell , vol.17 , pp. 683-689
    • Jones, N.1    Shenck, T.2
  • 45
    • 0344487371 scopus 로고
    • Structure of the human retinoblastoma gene
    • Hong, F.D. et al. Structure of the human retinoblastoma gene. Proc. Natl. Acad. Sci. USA 86, 5502-5506 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5502-5506
    • Hong, F.D.1
  • 46
    • 0027251721 scopus 로고
    • The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
    • Durfee, T. et al. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 555-569
    • Durfee, T.1
  • 47
    • 0027377867 scopus 로고
    • Application of LacZ fusions to post implantation development
    • Bonnerot, C. & Nicolas, J.-F. Application of LacZ fusions to post implantation development. Methods Enzymol. 225, 451-469 (1993).
    • (1993) Methods Enzymol. , vol.225 , pp. 451-469
    • Bonnerot, C.1    Nicolas, J.-F.2
  • 48
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-507 (1992).
    • (1992) J. Cell Biol. , vol.119 , pp. 493-507
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 49
    • 0025340056 scopus 로고
    • Two distinct and frequently mutated regions of the retinoblastoma protein are required for binding to SV40 T antigen
    • Huang, S., Wang, N.P., Tseng, B.Y., Lee, W.-H. & Lee, E.Y.-H.P. Two distinct and frequently mutated regions of the retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9, 1815-1822 (1990).
    • (1990) EMBO J. , vol.9 , pp. 1815-1822
    • Huang, S.1    Wang, N.P.2    Tseng, B.Y.3    Lee, W.-H.4    Lee, E.Y.-H.P.5


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