Anaplastic lymphoma kinase: Role in cancer pathogenesis and small-molecule inhibitor development for therapy

Expert Review of Anticancer Therapy

Volumn 9, Issue 3, 2009, Pages 331-356

  Webb, Thomas R ^a   Slavish, Jake ^a   George, Rani E ^b   Look, A Thomas ^b   Xue, Liquan ^a   Jiang, Qin ^a   Cui, Xiaoli ^a   Rentrop, Walter B ^a   Morris, Stephan W ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anaplastic large cell lymphoma; Anaplastic lymphoma kinase; Esophageal squamous cell carcinoma; Glioblastoma; Inflammatory myofibroblastic tumor; Midkine; Neuroblastoma; Non small cell lung carcinoma; Pleiotrophin; Targeted cancer therapy; Tyrosine kinase inhibitor

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 7 HYDROXYSTAUROSPORINE; ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE SMALL MOLECULE INHIBITOR; ANTINEOPLASTIC AGENT; CRL 151104A; DASATINIB; ENZYME INHIBITOR; ERLOTINIB; GEFITINIB; GEMCITABINE; GENOMIC DNA; HYBRID PROTEIN; IMATINIB; NVP TAE 684; PH 2341066; PLACEBO; PLEIOTROPHIN; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDONE 14; PYRIDONE 15; PYRIDOPYRAZINE 21; STAUROSPORINE; UNCLASSIFIED DRUG; WZ 5 126;

ANTINEOPLASTIC ACTIVITY; B CELL LYMPHOMA; CARCINOGENESIS; CELLULAR DISTRIBUTION; CHROMOSOME REARRANGEMENT; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; DRUG APPROVAL; DRUG DETERMINATION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE ACTIVATION; GENE AMPLIFICATION; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; HISTIOCYTOSIS; HUMAN; IC 50; IMMUNOREACTIVITY; LARGE CELL LYMPHOMA; LUNG NON SMALL CELL CANCER; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PLASMA CELL GRANULOMA; POINT MUTATION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; CYTOKINES; ENZYME INHIBITORS; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PROTEIN-TYROSINE KINASES;

EID: 65749083100     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.9.3.331     Document Type: Review

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