Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-γ to mediate its mitogenicity

Molecular and Cellular Biology

Volumn 18, Issue 12, 1998, Pages 6951-6961

  Bai, Ren Yuan ^a   Dieter, Peter ^b   Peschel, Christian ^a   Morris, Stephan W ^c   Duyster, Justus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD30 ANTIGEN; INOSITOL PHOSPHATE; NUCLEOPHOSMIN; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE;

ANAPLASTIC CARCINOMA; ANIMAL CELL; ARTICLE; CHROMOSOME TRANSLOCATION; ENZYME ACTIVATION; GENE TARGETING; IMMUNOBLOTTING; LARGE CELL LYMPHOMA; MITOGENICITY; MOUSE; NONHODGKIN LYMPHOMA; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALIA; IPS;

EID: 0031755958     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.12.6951     Document Type: Article

References (49)

1. Alimandi, M., M. A. Heidaran, J. S. Gutkind, J. Zhang, N. Ellmore, M. Valius, A. Kazlauskas, J. H. Pierce, and W. Li. 1997. PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene 15:585-593.
2. Atherton, E., and R. C. Sheppard. 1989. Solid phase peptide synthesis - a practical approach. IRL Press, Oxford, England.
3. Bartram, C. R., A. de Klein, A. Hagemeijer, T. van Agthoven, A. D. van Kessel, D. Bootsma, G. Grosveld, M. A. Ferguson-Smith, T. Davies, M. Stone, N. Heisterkamp, J. R. Stephenson, and J. Groffen. 1983. Translocation of c-Abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukemia. Nature 306:277-280.
4. Bischof, D., K. Pulford, D. Y. Mason, and S. W. Morris. 1997. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol. Cell. Biol. 17:2312-2325.
5. Borer, R. A., C. F. Lehner, H. M. Eppenberger, and E. A. Nigg. 1989. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56:379-390.
6. Chan, W. Y., Q. R. Liu, J. Borjigin, H. Busch, O. M. Rennert, L. A. Tease, and P. K. Chan. 1989. Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. Biochemistry 28:1033-1039.
7. Cortez, D., L. Kadlec, and A. M. Pendergast. 1995. Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Mol. Cell. Biol. 15:5531-5541.
8. Daly, R. J., G. M. Sanderson, P. W. Janes, and R. L. Sutherland. 1996. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J. Biol. Chem. 271:12502-12510.
9. Dieter, P., S. A. Schulze, and E. Fitzke. 1991. Activation of phospholipase C is not correlated to the formation of prostaglandins and superoxide in cultured rat liver macrophages. Cell. Signalling 3:65-71.
10. Dumbar, T. S., G. A. Gentry, and M. O. Olson. 1989. Interaction of nucleolar phosphoprotein B23 with nucleic acids. Biochemistry 28:9495-9501.
11. Duyster, J., R. Baskaran, and J. Y. J. Wang. 1995. Catalytic role for the SH2 domain of Abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 92:1555-1559.
12. Fujimoto, J., M. Shiota, T. Iwahara, N. Seki, H. Satoh, S. Mori, and T. Yamamoto. 1996. Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). Proc. Natl. Acad. Sci. USA 93:4181-4186.
13. Goga, A., J. McLaughlin, D. E. Afar, D. C. Saffran, and O. N. Witte. 1995. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell 82:981-988.
14. Hall, H., E. J. Williams, S. E. Moore, F. S. Walsh, A. Prochiantz, and P. Doherty. 1996. Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide. Curr. Biol. 6:580-587.
15. Heisterkamp, N., J. R. Stephenson, J. Groffen, P. F. Hansen, A. de Klein, C. R. Bartram, and G. Grosveld. 1983. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 315:758-761.
16. Iwahara, T., J. Fujimoto, D. Wen, R. Cupples, N. Bucay, T. Arakawa, S. Mori, B. Ratzkin, and T. Yamamoto. 1997. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14:439-449.
17. Kadin, M. E. 1994. Ki-1/CD30+ (anaplastic) large-cell lymphoma: maturation of a clinicopathologic entity with prospects of effective therapy. J. Clin. Oncol. 12:884-887.
18. Kashishian, A., and J. A. Cooper. 1993. Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1. Mol. Biol. Cell 4:49-57.
19. Katan, M. 1996. The control of inositol lipid hydrolysis. Cancer Surv. 27: 199-211.
20. Kim, H. K., J. W. Kim, A. Zilberstein, B. Margolis, J. G. Kim, J. Schlessinger, and S. G. Rhee. 1991. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell 65:435-441.
21. Koch, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668-674.
22. Kozutsumi, H., H. Toyoshima, K. Hagiwara, Y. Yazaki, and H. Hirai. 1994. Human Itk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. Oncogene 9:2991-2998.
23. Kuefer, M. U., A. T. Look, K. Pulford, F. G. Behm, P. K. Pattengale, D. Y. Mason, and S. W. Morris. 1997. Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood 90:2901-2910.
24. Mason, D. Y., C. Bastard. R. Rimokh, N. Dastugue, J. L. Huret, U. Kristoffersson, J. P. Magaud, C. Nezelof, H. Tilly, and J. P. Vannier. 1990. CD30-positive large-cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35. Br. J. Haematol. 74:161-168.
25. McWhirter, J. R., and J. Y. J. Wang. 1993. An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO J. 12:1533-1546.
26. Mes-Masson, A. M., J. McLaughlin, G. Q. Daley, M. Paskind, and O. N. Witte. 1986. Overlapping cDNA clones define the complete coding region for the p210 Bcr-Abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Proc. Natl. Acad. Sci. USA 83:9768-9772.
27. Morris, S. W., M. N. Kirstein, M. B. Valentine, K. G. Dittmer, D. N. Shapiro, D. L. Saltman, and A. T. Look. 1994. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263: 1281-1284.
28. Morris, S. W., C. Naeve, P. Mathew, P. L. James, M. N. Kirstein, X. Cui, and D. P. Witte. 1997. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14:2175-2188.
29. Noh, D. Y., S. H. Shin, and S. G. Rhee. 1995. Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim. Biophys. Acta 1242:99-113.
30. Obermeier, A., R. A. Bradshaw, K. Seedorf, A. Choidas, J. Schlessinger, and A. Ullrich. 1994. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J. 13:1585-1590.
31. Ohta, S., A. Matsui, Y. Nazawa, and Y. Kagawa. 1988. Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. FEBS Lett. 242:31-35.
32. Ooi, J., V. Yajnik, D. Immanuel, M. Gordon, J. J. Moskow, A. M. Buchberg, and B. Margolis. 1995. The cloning of Grb10 reveals a new family of SH2 domains proteins. Oncogene 10:1621-1630.
33. Palacios, R., and M. Steinmetz. 1985. IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727-734.
34. Pascal, S. M., A. U. Singer, G. Gish, T. Yamazaki, S. E. Shoelson, T. Pawson, L. E. Kay, and K. J. Forman. 1994. Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell 77:461-472.
35. Pawson, T. 1995. Protein modules and signalling networks. Nature 373:573-580.
36. Renshaw, M. W., J. R. McWhirter, and J. Y. J. Wang. 1995. The human leukemia oncogene bcr-abl abrogates the anchorage requirement hut not the growth factor requirement for proliferation. Mol. Cell. Biol. 15:1286-1293.
37. Rodrigues, G. A., and M. Park. 1994. Oncogenic activation of tyrosine kinases. Curr. Opin. Genet. Dev. 4:15-24.
38. Rotin, D., B. Margolis, M. Mohammadi, R. J. Daly, G. Daum, N. Li, E. H. Fischer, W. H. Burgess, A. Ullrich, and J. Schlessinger. 1992. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J. 11:559-567.
39. Sawyers, C. L., and C. T. Denny. 1994. Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about. Cell 77:171-173.
40. Sawyers, C. L., J. McLaughlin, and O. N. Witte. 1995. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J. Exp. Med. 181:307-313.
41. Schmidt, Z. M., and W. W. Franke. 1988. DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23. Chromosoma 96:417-426.
42. Shiota, M., J. Fujimoto, T. Semba, H. Satoh, T. Yamamoto, and S. Mori. 1994. Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line AMS3. Oncogene 9:1567-1574.
43. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptide expressed in Escherichia coli as fusions with glutathione-5-transferase. Gene 67:31-40.
44. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, B. G. Neel, R. B. Birge, J. E. Fajardo, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. Cantley. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767-778.
45. Stein, H., and F. Dallenbach. 1992. Neoplastic hematopathology, p. 675-714. Williams & Wilkins, Baltimore, Md.
46. Stein, H., H. Herbst, I. Anagnostopoulos, G. Niedobitek, F. Dallenbach, and H. C. Kratzsch. 1991. The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma. Ann. Oncol. 2:33-38.
47. Ueno, H., K. Sasaki, H. Kozutsumi, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai. 1996. Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. J. Biol. Chem. 271:27707-27714.
48. Ullrich, A., and J. Schlessinger. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
49. Valius, M., C. Bazenet, and A. Kazlauskas. 1993. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively. Mol. Cell. Biol. 13:133-143.