Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling

Journal of Medicinal Chemistry

Volumn 49, Issue 19, 2006, Pages 5759-5768

  Gunby, Rosalind H ^a   Ahmed, Shaheen ^b   Sottocornola, Roberta ^a   Gasser, Marc ^b   Redaelli, Sara ^a   Mologni, Luca ^a   Tartari, Carmen J ^a,c   Belloni, Valentina ^a   Gambacorti Passerini, Carlo ^a,d   Scapozza, Leonardo ^b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 ANILINO 3 QUINOLINECARBONITRILE; 4 PHENYLAMINOQUINOLINE DERIVATIVE; 6 (2,6 DICHLOROPHENYL) 8 METHYL 2 (3 METHYLTHIOANILINO) 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ANAPLASTIC LYMPHOMA KINASE; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; BOSUTINIB; DOCKING PROTEIN; HYBRID PROTEIN; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; PYRIDO[2,3 D]PYRIMIDINE INHIBITOR; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANILINE COMPOUNDS; BINDING SITES; CATALYTIC DOMAIN; CELLS, CULTURED; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NITRILES; PIPERAZINES; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIDONES; PYRIMIDINES; QUINOLINES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33748861075     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060380k     Document Type: Article

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