메뉴 건너뛰기




Volumn 60, Issue 3, 2006, Pages 216-226

Kinase inhibitors in the treatment of renal cell carcinoma

Author keywords

Kinase inhibition; Metastatic; Renal cell carcinoma; Systemic therapy; Targeted drugs

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; AG 013736; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CETUXIMAB; ERLOTINIB; GEFITINIB; IMATINIB; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MEDROXYPROGESTERONE ACETATE; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SEMAXANIB; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 33750711391     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2006.06.008     Document Type: Review
Times cited : (32)

References (95)
  • 1
    • 0033006836 scopus 로고    scopus 로고
    • Cancer statistics, 1999
    • 1
    • Landis S.H., et al. Cancer statistics, 1999. CA Cancer J Clin 49 1 (1999) 8-31 1
    • (1999) CA Cancer J Clin , vol.49 , Issue.1 , pp. 8-31
    • Landis, S.H.1
  • 3
    • 23844480769 scopus 로고    scopus 로고
    • Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma
    • Ficarra V., et al. Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma. Cancer 104 5 (2005) 968-974
    • (2005) Cancer , vol.104 , Issue.5 , pp. 968-974
    • Ficarra, V.1
  • 4
    • 0037407573 scopus 로고    scopus 로고
    • Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma
    • Cheville J.C., et al. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 27 5 (2003) 612-624
    • (2003) Am J Surg Pathol , vol.27 , Issue.5 , pp. 612-624
    • Cheville, J.C.1
  • 5
    • 2142853538 scopus 로고    scopus 로고
    • Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma
    • Beck S.D., et al. Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma. Ann Surg Oncol 11 1 (2004) 71-77
    • (2004) Ann Surg Oncol , vol.11 , Issue.1 , pp. 71-77
    • Beck, S.D.1
  • 6
    • 0036569472 scopus 로고    scopus 로고
    • Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology.
    • Motzer R.J., et al. Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology. J Clin Oncol 20 9 (2002) 2376-2381
    • (2002) J Clin Oncol , vol.20 , Issue.9 , pp. 2376-2381
    • Motzer, R.J.1
  • 7
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • Latif F., et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260 5112 (1993) 1317-1320
    • (1993) Science , vol.260 , Issue.5112 , pp. 1317-1320
    • Latif, F.1
  • 8
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim W.Y., and Kaelin W.G. Role of VHL gene mutation in human cancer. J Clin Oncol 22 24 (2004) 4991-5004
    • (2004) J Clin Oncol , vol.22 , Issue.24 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 9
    • 16744366213 scopus 로고    scopus 로고
    • VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation
    • Brauch H., et al. VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. Cancer Res 60 7 (2000) 1942-1948
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 1942-1948
    • Brauch, H.1
  • 10
    • 18344396226 scopus 로고    scopus 로고
    • Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters
    • Kondo K., et al. Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters. Genes Chromosomes Cancer 34 1 (2002) 58-68
    • (2002) Genes Chromosomes Cancer , vol.34 , Issue.1 , pp. 58-68
    • Kondo, K.1
  • 11
    • 0037120977 scopus 로고    scopus 로고
    • VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma.
    • Yao M., et al. VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst 94 20 (2002) 1569-1575
    • (2002) J Natl Cancer Inst , vol.94 , Issue.20 , pp. 1569-1575
    • Yao, M.1
  • 12
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
    • Herman J.G., et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91 21 (1994) 9700-9704
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.21 , pp. 9700-9704
    • Herman, J.G.1
  • 13
    • 3042538398 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of kidney cancer
    • Dulaimi E., et al. Promoter hypermethylation profile of kidney cancer. Clin Cancer Res 10 12 Pt 1 (2004) 3972-3979
    • (2004) Clin Cancer Res , vol.10 , Issue.12 PART 1 , pp. 3972-3979
    • Dulaimi, E.1
  • 14
    • 0031776704 scopus 로고    scopus 로고
    • Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis
    • Clifford S.C., et al. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosomes Cancer 22 3 (1998) 200-209
    • (1998) Genes Chromosomes Cancer , vol.22 , Issue.3 , pp. 200-209
    • Clifford, S.C.1
  • 15
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M., et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2 7 (2000) 423-427
    • (2000) Nat Cell Biol , vol.2 , Issue.7 , pp. 423-427
    • Ohh, M.1
  • 16
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349 5 (2003) 427-434
    • (2003) N Engl J Med , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1
  • 17
    • 30944452354 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
    • Hainsworth J.D., et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 23 31 (2005) 7889-7896
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 7889-7896
    • Hainsworth, J.D.1
  • 18
    • 0037093238 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation
    • Turner K.J., et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 62 10 (2002) 2957-2961
    • (2002) Cancer Res , vol.62 , Issue.10 , pp. 2957-2961
    • Turner, K.J.1
  • 19
    • 0020517980 scopus 로고
    • Stratification of risk factors in renal cell carcinoma
    • Selli C., et al. Stratification of risk factors in renal cell carcinoma. Cancer 52 5 (1983) 899-903
    • (1983) Cancer , vol.52 , Issue.5 , pp. 899-903
    • Selli, C.1
  • 20
    • 0033514050 scopus 로고    scopus 로고
    • Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial
    • Medical Research Council Renal Cancer Collaborators
    • Medical Research Council Renal Cancer Collaborators. Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial. Lancet 353 9146 (1999) 14-17
    • (1999) Lancet , vol.353 , Issue.9146 , pp. 14-17
  • 21
    • 4644354183 scopus 로고    scopus 로고
    • Prognostic factors for survival of patients with stage IV renal cell carcinoma: memorial sloan-kettering cancer center experience
    • Motzer R.J., Bacik J., and Mazumdar M. Prognostic factors for survival of patients with stage IV renal cell carcinoma: memorial sloan-kettering cancer center experience. Clin Cancer Res 10 18 Pt 2 (2004) 6302S-6303S
    • (2004) Clin Cancer Res , vol.10 , Issue.18 PART 2
    • Motzer, R.J.1    Bacik, J.2    Mazumdar, M.3
  • 22
    • 1442290393 scopus 로고    scopus 로고
    • Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma
    • Motzer R.J., et al. Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22 3 (2004) 454-463
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 454-463
    • Motzer, R.J.1
  • 23
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial
    • Mickisch G.H., et al. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet 358 9286 (2001) 966-970
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 966-970
    • Mickisch, G.H.1
  • 24
    • 0035818877 scopus 로고    scopus 로고
    • Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer
    • Flanigan R.C., et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med 345 23 (2001) 1655-1659
    • (2001) N Engl J Med , vol.345 , Issue.23 , pp. 1655-1659
    • Flanigan, R.C.1
  • 25
    • 0024310179 scopus 로고
    • Failure of cytotoxic chemotherapy, 1983-1998, and the emerging role of monoclonal antibodies for renal cancer
    • Yagoda A., and Bander N.H. Failure of cytotoxic chemotherapy, 1983-1998, and the emerging role of monoclonal antibodies for renal cancer. Urol Int 44 6 (1989) 338-345
    • (1989) Urol Int , vol.44 , Issue.6 , pp. 338-345
    • Yagoda, A.1    Bander, N.H.2
  • 26
    • 0021013543 scopus 로고
    • Hormonal therapy and chemotherapy of renal-cell carcinoma
    • Harris D.T. Hormonal therapy and chemotherapy of renal-cell carcinoma. Semin Oncol 10 4 (1983) 422-430
    • (1983) Semin Oncol , vol.10 , Issue.4 , pp. 422-430
    • Harris, D.T.1
  • 27
    • 0024467415 scopus 로고
    • An assessment of the current use of human interferons in therapy of urological cancers
    • Horoszewicz J.S., and Murphy G.P. An assessment of the current use of human interferons in therapy of urological cancers. J Urol 142 5 (1989) 1173-1180
    • (1989) J Urol , vol.142 , Issue.5 , pp. 1173-1180
    • Horoszewicz, J.S.1    Murphy, G.P.2
  • 28
    • 2442737061 scopus 로고    scopus 로고
    • Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
    • Pyrhonen S., et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol 17 9 (1999) 2859-2867
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2859-2867
    • Pyrhonen, S.1
  • 29
    • 18944385751 scopus 로고    scopus 로고
    • Immunotherapy for advanced renal cell cancer
    • Coppin C., et al. Immunotherapy for advanced renal cell cancer. Cochrane Database Syst Rev 1 (2005) CD001425
    • (2005) Cochrane Database Syst Rev , vol.1
    • Coppin, C.1
  • 30
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
    • Negrier S., et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 338 18 (1998) 1272-1278
    • (1998) N Engl J Med , vol.338 , Issue.18 , pp. 1272-1278
    • Negrier, S.1
  • 31
    • 0032471712 scopus 로고    scopus 로고
    • Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response
    • Rosenberg S.A., et al. Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann Surg 228 3 (1998) 307-319
    • (1998) Ann Surg , vol.228 , Issue.3 , pp. 307-319
    • Rosenberg, S.A.1
  • 32
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott D.F., et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23 1 (2005) 133-141
    • (2005) J Clin Oncol , vol.23 , Issue.1 , pp. 133-141
    • McDermott, D.F.1
  • 33
    • 21044442672 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer
    • Atkins M., et al. Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res 11 10 (2005) 3714-3721
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3714-3721
    • Atkins, M.1
  • 34
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 2 (2000) 211-225
    • (2000) Cell , vol.103 , Issue.2 , pp. 211-225
    • Schlessinger, J.1
  • 35
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W., et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101 36 (2004) 13306-13311
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1
  • 36
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R., et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305 5687 (2004) 1163-1167
    • (2004) Science , vol.305 , Issue.5687 , pp. 1163-1167
    • Sordella, R.1
  • 37
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 6 (2003) 669-676
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 38
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N., et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3 5 (2004) 391-400
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.5 , pp. 391-400
    • Ferrara, N.1
  • 39
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker B.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344 14 (2001) 1031-1037
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1
  • 40
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study
    • van Oosterom A.T., et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 358 9291 (2001) 1421-1423
    • (2001) Lancet , vol.358 , Issue.9291 , pp. 1421-1423
    • van Oosterom, A.T.1
  • 41
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2
    • Herbst R.S., et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol 22 5 (2004) 785-794
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 785-794
    • Herbst, R.S.1
  • 42
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1
    • Giaccone G., et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 22 5 (2004) 777-784
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 777-784
    • Giaccone, G.1
  • 43
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    • Kris M.G., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290 16 (2003) 2149-2158
    • (2003) JAMA , vol.290 , Issue.16 , pp. 2149-2158
    • Kris, M.G.1
  • 44
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd F.A., et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353 2 (2005) 123-132
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1
  • 45
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304 5676 (2004) 1497-1500
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1
  • 46
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 21 (2004) 2129-2139
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1
  • 47
    • 0029146750 scopus 로고
    • Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: correlation with metastatic behavior and prognosis
    • Uhlman D.L., et al. Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: correlation with metastatic behavior and prognosis. Clin Cancer Res 1 8 (1995) 913-920
    • (1995) Clin Cancer Res , vol.1 , Issue.8 , pp. 913-920
    • Uhlman, D.L.1
  • 48
    • 12444251187 scopus 로고    scopus 로고
    • Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
    • Motzer R.J., et al. Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest New Drugs 21 1 (2003) 99-101
    • (2003) Invest New Drugs , vol.21 , Issue.1 , pp. 99-101
    • Motzer, R.J.1
  • 49
    • 9744240281 scopus 로고    scopus 로고
    • A phase II trial of gefitinib (Iressa ZD1839) in stage IV and recurrent renal cell carcinoma
    • Dawson N.A., et al. A phase II trial of gefitinib (Iressa ZD1839) in stage IV and recurrent renal cell carcinoma. Clin Cancer Res 10 23 (2004) 7812-7819
    • (2004) Clin Cancer Res , vol.10 , Issue.23 , pp. 7812-7819
    • Dawson, N.A.1
  • 50
    • 0345714775 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
    • Drucker B., et al. Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 21 3 (2003) 341-345
    • (2003) Invest New Drugs , vol.21 , Issue.3 , pp. 341-345
    • Drucker, B.1
  • 51
    • 27144437981 scopus 로고    scopus 로고
    • A phase II, open-label study of gefitinib (IRESSA) in patients with locally advanced, metastatic, or relapsed renal-cell carcinoma
    • Jermann M., et al. A phase II, open-label study of gefitinib (IRESSA) in patients with locally advanced, metastatic, or relapsed renal-cell carcinoma. Cancer Chemother Pharmacol (2005) 1-7
    • (2005) Cancer Chemother Pharmacol , pp. 1-7
    • Jermann, M.1
  • 52
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92 3 (2000) 205-216
    • (2000) J Natl Cancer Inst , vol.92 , Issue.3 , pp. 205-216
    • Therasse, P.1
  • 53
    • 0038327794 scopus 로고    scopus 로고
    • Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
    • Kuenen B.C., et al. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin Cancer Res 9 5 (2003) 1648-1655
    • (2003) Clin Cancer Res , vol.9 , Issue.5 , pp. 1648-1655
    • Kuenen, B.C.1
  • 54
    • 10744225601 scopus 로고    scopus 로고
    • SU5416 plus interferon alpha in advanced renal cell carcinoma: a phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition
    • Lara Jr. P.N., et al. SU5416 plus interferon alpha in advanced renal cell carcinoma: a phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition. Clin Cancer Res 9 13 (2003) 4772-4781
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4772-4781
    • Lara Jr., P.N.1
  • 55
    • 19944428106 scopus 로고    scopus 로고
    • Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668
    • Davis D.W., et al. Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. Clin Cancer Res 11 2 Pt 1 (2005) 678-689
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 1 , pp. 678-689
    • Davis, D.W.1
  • 56
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 1 (2003) 327-337
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1
  • 57
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell A.M., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101 9 (2003) 3597-3605
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell, A.M.1
  • 58
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S., et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24 1 (2006) 25-35
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1
  • 59
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24 1 (2006) 16-24
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 16-24
    • Motzer, R.J.1
  • 60
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results
    • Rugo H.S., et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 23 24 (2005) 5474-5483
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1
  • 61
    • 0031041171 scopus 로고    scopus 로고
    • Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
    • Marais R., et al. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem 272 7 (1997) 4378-4383
    • (1997) J Biol Chem , vol.272 , Issue.7 , pp. 4378-4383
    • Marais, R.1
  • 62
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar S.S., Hedley D., and Siu L.L. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 4 4 (2005) 677-685
    • (2005) Mol Cancer Ther , vol.4 , Issue.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 63
    • 0023767118 scopus 로고
    • Activated H-ras oncogenes in human kidney tumors
    • Fujita J., et al. Activated H-ras oncogenes in human kidney tumors. Cancer Res 48 18 (1988) 5251-5255
    • (1988) Cancer Res , vol.48 , Issue.18 , pp. 5251-5255
    • Fujita, J.1
  • 64
    • 0029080247 scopus 로고
    • Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma
    • Oka H., et al. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res 55 18 (1995) 4182-4187
    • (1995) Cancer Res , vol.55 , Issue.18 , pp. 4182-4187
    • Oka, H.1
  • 65
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H., et al. Mutations of the BRAF gene in human cancer. Nature 417 6892 (2002) 949-954
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1
  • 66
    • 0042839707 scopus 로고    scopus 로고
    • Frequent allelic changes at chromosome 7q34 but lack of mutation of the BRAF in papillary renal cell tumors
    • Nagy A., Balint I., and Kovacs G. Frequent allelic changes at chromosome 7q34 but lack of mutation of the BRAF in papillary renal cell tumors. Int J Cancer 106 6 (2003) 980-981
    • (2003) Int J Cancer , vol.106 , Issue.6 , pp. 980-981
    • Nagy, A.1    Balint, I.2    Kovacs, G.3
  • 67
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64 19 (2004) 7099-7109
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1
  • 68
    • 20344362911 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
    • Awada A., et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 92 10 (2005) 1855-1861
    • (2005) Br J Cancer , vol.92 , Issue.10 , pp. 1855-1861
    • Awada, A.1
  • 69
    • 27144527372 scopus 로고    scopus 로고
    • Hirte HW, et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol; 2005.
  • 70
    • 0141634089 scopus 로고    scopus 로고
    • Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors
    • Strumberg D., et al. Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors. Int J Clin Pharmacol Ther 40 12 (2002) 580-581
    • (2002) Int J Clin Pharmacol Ther , vol.40 , Issue.12 , pp. 580-581
    • Strumberg, D.1
  • 71
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D., et al. Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 23 5 (2005) 965-972
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 965-972
    • Strumberg, D.1
  • 72
    • 0037112181 scopus 로고    scopus 로고
    • Randomized discontinuation design: application to cytostatic antineoplastic agents
    • Rosner G.L., Stadler W., and Ratain M.J. Randomized discontinuation design: application to cytostatic antineoplastic agents. J Clin Oncol 20 22 (2002) 4478-4484
    • (2002) J Clin Oncol , vol.20 , Issue.22 , pp. 4478-4484
    • Rosner, G.L.1    Stadler, W.2    Ratain, M.J.3
  • 73
    • 20544432488 scopus 로고    scopus 로고
    • Successful implementation of the randomized discontinuation trial design: an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma-CALGB 69901
    • Stadler W.M., et al. Successful implementation of the randomized discontinuation trial design: an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma-CALGB 69901. J Clin Oncol 23 16 (2005) 3726-3732
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3726-3732
    • Stadler, W.M.1
  • 74
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • Hudson C.C., et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22 20 (2002) 7004-7014
    • (2002) Mol Cell Biol , vol.22 , Issue.20 , pp. 7004-7014
    • Hudson, C.C.1
  • 75
    • 0242330122 scopus 로고    scopus 로고
    • Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth
    • Shin Lee J., et al. Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth. J Surg Oncol 84 3 (2003) 166-172
    • (2003) J Surg Oncol , vol.84 , Issue.3 , pp. 166-172
    • Shin Lee, J.1
  • 76
    • 21344446791 scopus 로고    scopus 로고
    • Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor
    • Hara S., et al. Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Ann Oncol 16 6 (2005) 928-933
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 928-933
    • Hara, S.1
  • 77
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S., et al. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 16 4 (2005) 525-537
    • (2005) Ann Oncol , vol.16 , Issue.4 , pp. 525-537
    • Vignot, S.1
  • 78
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins M.B., et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22 5 (2004) 909-918
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 909-918
    • Atkins, M.B.1
  • 79
    • 0038721475 scopus 로고    scopus 로고
    • The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia
    • Wolff N.C., et al. The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. Blood 101 12 (2003) 5010-5013
    • (2003) Blood , vol.101 , Issue.12 , pp. 5010-5013
    • Wolff, N.C.1
  • 80
    • 1342330066 scopus 로고    scopus 로고
    • Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI-571)
    • Leis J.F., et al. Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI-571). Leuk Lymphoma 45 4 (2004) 695-698
    • (2004) Leuk Lymphoma , vol.45 , Issue.4 , pp. 695-698
    • Leis, J.F.1
  • 81
    • 0842301456 scopus 로고    scopus 로고
    • Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy
    • Bujassoum S., Rifkind J., and Lipton J.H. Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy. Leuk Lymphoma 45 2 (2004) 401-403
    • (2004) Leuk Lymphoma , vol.45 , Issue.2 , pp. 401-403
    • Bujassoum, S.1    Rifkind, J.2    Lipton, J.H.3
  • 82
    • 0036399992 scopus 로고    scopus 로고
    • Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid
    • Takayama N., et al. Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid. Br J Haematol 119 1 (2002) 106-118
    • (2002) Br J Haematol , vol.119 , Issue.1 , pp. 106-118
    • Takayama, N.1
  • 83
    • 12144290456 scopus 로고    scopus 로고
    • Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588
    • le Coutre P., et al. Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588. Cancer Chemother Pharmacol 53 4 (2004) 313-323
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.4 , pp. 313-323
    • le Coutre, P.1
  • 84
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
    • Dai H., et al. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 304 3 (2003) 1085-1192
    • (2003) J Pharmacol Exp Ther , vol.304 , Issue.3 , pp. 1085-1192
    • Dai, H.1
  • 85
    • 21644487878 scopus 로고    scopus 로고
    • The MRC randomised-controlled trial of interferon-alpha, interleukin-2 and 5-fluorouracil vs. interferon-alpha alone in patients with advanced renal cell carcinoma (RE04): rationale and progress
    • Larkin J.M., and Gore M.E. The MRC randomised-controlled trial of interferon-alpha, interleukin-2 and 5-fluorouracil vs. interferon-alpha alone in patients with advanced renal cell carcinoma (RE04): rationale and progress. Clin Oncol (R Coll Radiol) 17 5 (2005) 319-321
    • (2005) Clin Oncol (R Coll Radiol) , vol.17 , Issue.5 , pp. 319-321
    • Larkin, J.M.1    Gore, M.E.2
  • 86
    • 22344432541 scopus 로고    scopus 로고
    • Clear cell renal cell carcinoma: gene expression analyses identify a potential signature for tumor aggressiveness
    • Kosari F., et al. Clear cell renal cell carcinoma: gene expression analyses identify a potential signature for tumor aggressiveness. Clin Cancer Res 11 14 (2005) 5128-5139
    • (2005) Clin Cancer Res , vol.11 , Issue.14 , pp. 5128-5139
    • Kosari, F.1
  • 87
    • 21344446106 scopus 로고    scopus 로고
    • A molecular classification of papillary renal cell carcinoma
    • Yang X.J., et al. A molecular classification of papillary renal cell carcinoma. Cancer Res 65 13 (2005) 5628-5637
    • (2005) Cancer Res , vol.65 , Issue.13 , pp. 5628-5637
    • Yang, X.J.1
  • 88
    • 23644452642 scopus 로고    scopus 로고
    • Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg
    • Zalcberg J.R., et al. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer 41 12 (2005) 1751-1757
    • (2005) Eur J Cancer , vol.41 , Issue.12 , pp. 1751-1757
    • Zalcberg, J.R.1
  • 89
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich M.C., et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21 23 (2003) 4342-4349
    • (2003) J Clin Oncol , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1
  • 90
    • 0041411517 scopus 로고    scopus 로고
    • Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working group randomized trial
    • Clark J.I., et al. Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working group randomized trial. J Clin Oncol 21 16 (2003) 3133-3140
    • (2003) J Clin Oncol , vol.21 , Issue.16 , pp. 3133-3140
    • Clark, J.I.1
  • 91
    • 0038514165 scopus 로고    scopus 로고
    • Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oncology Group/Intergroup trial
    • Messing E.M., et al. Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oncology Group/Intergroup trial. J Clin Oncol 21 7 (2003) 1214-1222
    • (2003) J Clin Oncol , vol.21 , Issue.7 , pp. 1214-1222
    • Messing, E.M.1
  • 92
    • 0035863285 scopus 로고    scopus 로고
    • Interferon adjuvant to radical nephrectomy in Robson stages II and III renal cell carcinoma: a multicentric randomized study
    • Pizzocaro G., et al. Interferon adjuvant to radical nephrectomy in Robson stages II and III renal cell carcinoma: a multicentric randomized study. J Clin Oncol 19 2 (2001) 425-431
    • (2001) J Clin Oncol , vol.19 , Issue.2 , pp. 425-431
    • Pizzocaro, G.1
  • 93
    • 20144388609 scopus 로고    scopus 로고
    • Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)
    • Atzpodien J., et al. Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). Br J Cancer 92 5 (2005) 843-846
    • (2005) Br J Cancer , vol.92 , Issue.5 , pp. 843-846
    • Atzpodien, J.1
  • 94
    • 0032887665 scopus 로고    scopus 로고
    • Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer
    • Chang J., et al. Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. J Clin Oncol 17 10 (1999) 3058-3063
    • (1999) J Clin Oncol , vol.17 , Issue.10 , pp. 3058-3063
    • Chang, J.1
  • 95
    • 4644318882 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in renal cell carcinoma
    • Potti A., and George D.J. Tyrosine kinase inhibitors in renal cell carcinoma. Clin Cancer Res 10 18 Pt 2 (2004) 6371S-6376S
    • (2004) Clin Cancer Res , vol.10 , Issue.18 PART 2
    • Potti, A.1    George, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.