The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 9648-9655

  Zhou, Jun ^a,e   Vos, Chantal Chanel ^b   Gjyrezi, Ada ^b   Yoshida, Minoru ^c   Khuri, Fadlo R ^a   Tamanoi, Fuyuhiko ^d   Giannakakou, Paraskevi ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c RIKEN   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE EFFECT; C TERMINUS; CANCER CHEMOTHERAPY; CANCER PATIENTS; CELL MIGRATION; CELLULAR PATHWAY; DEACETYLASE; FARNESYLATION; FARNESYLTRANSFERASE; IN-VITRO; IN-VIVO; MICROTUBULE; MICROTUBULE STABILITY; MICROTUBULES; PARENTAL CELLS; PROTEIN COMPLEXES; PROTEIN FARNESYLTRANSFERASE; PROTEIN TARGETS; SINGLE-AGENT; UPSTREAM REGULATION;

CHEMOTHERAPY; CYTOLOGY;

PROTEIN FOLDING;

COLCHICINE; HISTONE DEACETYLASE 6; LONAFARNIB; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PACLITAXEL; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB; TRICHOSTATIN A; TUBULIN; VINBLASTINE; ANTINEOPLASTIC AGENT; HDAC6 PROTEIN, HUMAN; HISTONE DEACETYLASE; P21(RAS) FARNESYL PROTEIN TRANSFERASE; P21(RAS) FARNESYL-PROTEIN TRANSFERASE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; TRANSFERASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL PROLIFERATION; CELL STRESS; CHEMOSENSITIVITY; CONTROLLED STUDY; DEACETYLATION; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MICROTUBULE; NUCLEOTIDE SEQUENCE; PATIENT SELECTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; BIOLOGICAL MODEL; CELL LINE; CYTOPLASM; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; TIME; TUMOR CELL LINE;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; MICROTUBULES; MODELS, BIOLOGICAL; PACLITAXEL; PIPERIDINES; PYRIDINES; TIME FACTORS;

EID: 65649130809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808708200     Document Type: Article

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