Comparative QSAR as a cheminformatics tool in the design of dihydro-pyranone based HIV-1 protease inhibitors

Current Computer-Aided Drug Design

Volumn 4, Issue 4, 2008, Pages 283-310

  Bhhatarai, Barun ^a   Garg, Rajni ^b,c  

^a CLARKSON UNIVERSITY   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

AIDS; Cheminformatics; Dihydropyranone; Drug resisant mutant HIV 1 protease; HIV 1 protease inhibitors; QSAR; Tipranavir

Indexed keywords

COMPUTATIONAL CHEMISTRY; DRUG INTERACTIONS; ENZYMES; LIFE CYCLE; MOLECULAR GRAPHICS; SCAFFOLDS;

AIDS; CHEMINFORMATICS; DIHYDROPYRANONES; DRUG-RESISANT MUTANT HIV-1 PROTEASE; HIV-1 PROTEASE; HIV-1 PROTEASE INHIBITORS; INFECTED PATIENTS; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; SURVIVAL RATE; TIPRANAVIR;

BIOACTIVITY;

4 HYDROXY 5,6 DIHYDROPYRANONE; 6 PHENYL 6 PHENETHYL DIHYDROPYRANONE; 6 [2 (4 AMINOPHENYL)ETHYL] 3 (2 TERT BUTYL 4 HYDROXY 5 METHYLPHENYLTHIO) 5,6 DIHYDRO 4 HYDROXY 6 ISOPROPYL 2 PYRANONE; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ANTIVIRUS AGENT; ATAZANAVIR; DARUNAVIR; FURAN DERIVATIVE; IMIDAZOLE; INDINAVIR; INDOLE DERIVATIVE; LOPINAVIR; MOZENAVIR; NELFINAVIR; PHENPROCOUMON; PROTEINASE; PROTEINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRONE DERIVATIVE; RITONAVIR; RITONAVIR PLUS TIPRANAVIR; RNA DIRECTED DNA POLYMERASE; RO 318959; SAQUINAVIR; THIOPHENE DERIVATIVE; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

ALLOSTERISM; ANTIVIRAL ACTIVITY; BIOINFORMATICS; CLINICAL TRIAL; DIARRHEA; DRUG BINDING SITE; DRUG DESIGN; DRUG INDUCED HEADACHE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYDROPHOBICITY; IC 50; INFORMATION RETRIEVAL; NAUSEA; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SURVIVAL RATE;

EID: 65649119338     PISSN: 15734099     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340908786786029     Document Type: Review

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