6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: Novel HIV protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 6, 1996, Pages 719-724

  Hamilton, Harriet W ^a   Tait, Bradley D ^a   Gajda, Christopher ^a   Hagen, Susan E ^a   Ferguson, Donna ^a   Lunney, Elizabeth A ^a   Pavlovsky, Alexander ^a   Tummino, Peter J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PROTEINASE INHIBITOR; PYRAN DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0029871029     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00099-6     Document Type: Article

References (9)

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2. b. Vara Prasad, J. V. N.; Lunney, E. A.; Ferguson, D.; Tummino, P. J.; Rubin, J. R.; Reyner, E. L.; Stewart, B. H.; Guttendorf, R. J.; Domagala, J. M.; Suvorov, L. I.; Gulnik, S. V.; Topol, I. A.; Bhat, T. N.; Erickson, J. W. J. Amer. Chem. Soc., 1995, 117, 11070.
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5. Poshkus, A. C.; Herweh, J. E.; Magnotta, F. A. J. Org. Chem. 1963, 28, 2766.
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7. Tummino, P. J.; Ferguson, D.; Hupe, L.; Hupe, D. Biochem. Biophys. Res. Commun. 1994 200, 1658.
8. Compound XIV in Roberts, N. A.; Martin, J. A.; Kinchington, D.; Broadhurst, A. V.; Craig, J. C.; Duncan, I. B.; Galpin, S. A.; Handa, B. K.; Kay, J.; Krohn, A.; Lambert, R. W.; Merrett, J. H.; Mills, J. S.; Parkes, K. E. B.; Redshaw, S.; Ritchie, A. J.; Taylor, D. L.; Thomas, G. J.; Machin, P. J. Science, 1990, 248, 358, is a close analog of Ro 31-8959 where the decahydro-3-isoquinolinecarbonyl has been replaced by piperidine-2-carbonyl.
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