Structure-based design of HIV protease inhibitors: 5,6-dihydro-4- hydroxy-2-pyrones as effective, nonpeptidic inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4630-4642

  Thaisrivongs, Suvit ^a   Romero, Donna L ^a   Tommasi, Ruben A ^a   Janakiraman, Musiri N ^a   Strohbach, Joseph W ^a   Turner, Steve R ^a   Biles, Carolyn ^a   Morge, Raymond R ^a   Johnson, Paul D ^a   Aristoff, Paul A ^a   Tomich, Paul K ^a   Lynn, Janet C ^a   Horng, Miao Miao ^a   Chong, Kong Teck ^a   Hinshaw, Roger R ^a   Howe, W Jeffrey ^b   Finzel, Barry C ^a   Watenpaugh, Keith D ^a  

^a PFIZER INC   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (ALPHA CYCLOPROPYLPHENYLMETHYL) 5,6 DIHYDRO 6,6 DIPROPYL 4 HYDROXY 2H PYRAN 2 ONE; 4 HYDROXY 6 (1 ETHYL 2 PHENYLETHYL) 3 (1 PHENYLPROPYL) 2 PYRONE; 5,6 DIHYDRO 4 HYDROXY 2 PYRONE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; VIRUS INHIBITION;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PYRONES; SPECTROPHOTOMETRY, INFRARED;

EID: 10544246488     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960228q     Document Type: Article

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