Structure-based design of HIV protease inhibitors: Sulfonamide- containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 22, 1996, Pages 4349-4353

  Thaisrivongs, S ^a   Skulnick, H I ^a   Turner, S R ^a   Strohbach, J W ^a   Tommasi, R A ^a   Johnson, P D ^a   Aristoff, P A ^a   Judge, T M ^a   Gammill, R B ^a   Morris, J K ^a   Romines, K R ^a   Chrusciel, R A ^a   Hinshaw, R R ^a   Chong, K T ^a   Tarpley, W G ^a   Poppe, S M ^a   Slade, D E ^a   Lynn, J C ^a   Horng, M M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 6 (1 ETHYL 2 PHENYLETHYL) 3 (1 PHENYLPROPYL) 2 PYRONE; 5,6 DIHYDRO 4 HYDROXY 2 PYRONE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEINASE INHIBITOR; PYRONE DERIVATIVE; SULFONAMIDE; TIPRANAVIR; U 103017; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV PROTEASE INHIBITORS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRONES; STEREOISOMERISM; SULFONAMIDES;

EID: 0029909674     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960541s     Document Type: Article

References (0)