5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 843-858

  Boyer, Frederick E ^a   Vara Prasad, J V N ^a   Domagala, John M ^a   Ellsworth, Edmund L ^a   Gajda, Christopher ^a   Hagen, Susan E ^a   Markoski, Larry J ^a   Tait, Bradley D ^a   Lunney, Elizabeth A ^a   Palovsky, Alexander ^a   Ferguson, Donna ^a   Graham, Neil ^a   Holler, Tod ^a   Hupe, Donald ^a   Nouhan, Carolyn ^a   Tummino, Peter J ^a   Urumov, A ^a   Zeikus, Eric ^a   Zeikus, Greg ^a   Gracheck, Stephen J ^a   Sanders, James M ^a   VanderRoest, Steven ^a   Brodfuehrer, Joanne ^a   Iyer, Krishna ^a   Sinz, Michael ^a   Gulnik, Sergei V ^b   Erickson, John W ^b   more..

^a PFIZER INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; PROTEINASE INHIBITOR; PYRAN DERIVATIVE; SAQUINAVIR; SULFONE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ARYLSULFONATES; BIOLOGICAL AVAILABILITY; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LYMPHOCYTES; MICE; MODELS, MOLECULAR; PYRANS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0343415623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990281p     Document Type: Article

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