4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters

Journal of Medicinal Chemistry

Volumn 44, Issue 14, 2001, Pages 2319-2332

  Hagen, S E ^a   Domagala, J ^a   Gajda, C ^a   Lovdahl, M ^a   Tait, B D ^a   Wise, E ^a   Holler, T ^a   Hupe, D ^a   Nouhan, C ^a   Urumov, A ^a   Zeikus, G ^a   Zeikus, E ^a   Lunney, E A ^a   Pavlovsky, A ^a   Gracheck, S J ^a   Saunders, J ^a   VanderRoest, S ^a   Brodfuehrer, J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 TERT BUTYL 4 HYDROXYMETHYL 5 METHYLPHENYLSULFANYL) 4 HYDROXY 6 ISOPROPYL 6 (2 THIOPHEN 3 YLETHYL) 5,6 DIHYDROPYRAN 2 ONE DERIVATIVE; 4 HYDROXY 5,6 DIHYDROPYRONE; 6 [2 (4 AMINOPHENYL)ETHYL] 3 (2 TERT BUTYL 4 HYDROXY 5 METHYLPHENYLTHIO) 5,6 DIHYDRO 4 HYDROXY 6 ISOPROPYL 2 PYRANONE; DIHYDROPYRIDINE DERIVATIVE; HETEROCYCLIC COMPOUND; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MICROSOME; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MICROBIAL; HIV; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LYMPHOCYTES; MICE; MUTATION; PYRONES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 0035811452     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0003844     Document Type: Article

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