메뉴 건너뛰기




Volumn 56, Issue 1, 2007, Pages 57-64

Tissue-specific deletion of the retinoblastoma protein in the pancreatic β-cell has limited effects on β-cell replication, mass, and function

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROTEIN P107; PROTEIN P130; RETINOBLASTOMA PROTEIN;

EID: 33847035971     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0517     Document Type: Article
Times cited : (26)

References (50)
  • 2
    • 0021885273 scopus 로고
    • Glucose-stimulated DNA replication in the pancreatic islets during the development of the rat fetus
    • Swenne I: Glucose-stimulated DNA replication in the pancreatic islets during the development of the rat fetus. Diabetes 34:803-807, 1985
    • (1985) Diabetes , vol.34 , pp. 803-807
    • Swenne, I.1
  • 3
    • 0028987251 scopus 로고
    • Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner-Weir S: Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44:249-256, 1995
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 6
    • 0033853921 scopus 로고    scopus 로고
    • β-Cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
    • Kassem SA, Ariel I, Thornton PS, Scheimberg I, Glaser B: β-Cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 49:1325-1333, 2000
    • (2000) Diabetes , vol.49 , pp. 1325-1333
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3    Scheimberg, I.4    Glaser, B.5
  • 7
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46, 2004
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 10
    • 0033864297 scopus 로고    scopus 로고
    • Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity
    • Franklin DS, Godfrey VL, O'Brien DA, Deng C, Xiong Y: Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol 20:6147-6158, 2000
    • (2000) Mol Cell Biol , vol.20 , pp. 6147-6158
    • Franklin, D.S.1    Godfrey, V.L.2    O'Brien, D.A.3    Deng, C.4    Xiong, Y.5
  • 11
    • 33644754585 scopus 로고    scopus 로고
    • Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    • Fatrai S, Elghazi L, Balcazar N, Cras-Meneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E: Akt induces β-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 55:318-325, 2006
    • (2006) Diabetes , vol.55 , pp. 318-325
    • Fatrai, S.1    Elghazi, L.2    Balcazar, N.3    Cras-Meneur, C.4    Krits, I.5    Kiyokawa, H.6    Bernal-Mizrachi, E.7
  • 16
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan D: Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122, 1985
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 18
    • 0033304945 scopus 로고    scopus 로고
    • The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
    • Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ, Arnold A: The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20:501-534, 1999
    • (1999) Endocr Rev , vol.20 , pp. 501-534
    • Pestell, R.G.1    Albanese, C.2    Reutens, A.T.3    Segall, J.E.4    Lee, R.J.5    Arnold, A.6
  • 19
    • 4444350468 scopus 로고    scopus 로고
    • Wagging the dogma: Tissue-specific cell cycle control in the mouse embryo
    • Pagano M, Jackson PK: Wagging the dogma: tissue-specific cell cycle control in the mouse embryo. Cell 118:535-538, 2004
    • (2004) Cell , vol.118 , pp. 535-538
    • Pagano, M.1    Jackson, P.K.2
  • 20
    • 0037418169 scopus 로고    scopus 로고
    • Clefts, grooves and (small) pockets: The structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled
    • Munger K: Clefts, grooves and (small) pockets: the structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled. Proc Nat Acad Sci U S A 100:2165-2167, 2005
    • (2005) Proc Nat Acad Sci U S A , vol.100 , pp. 2165-2167
    • Munger, K.1
  • 21
    • 0037313618 scopus 로고    scopus 로고
    • Coordinated regulation of life and death by RB
    • Chau BN, Wang JYJ: Coordinated regulation of life and death by RB. Nat Rev Cancer 3:130-138, 2003
    • (2003) Nat Rev Cancer , vol.3 , pp. 130-138
    • Chau, B.N.1    Wang, J.Y.J.2
  • 24
    • 0032937751 scopus 로고    scopus 로고
    • Loss of expression of cdk4 causes insulin-deficient diabetes and cdk4 activation results in beta cell hyperplasia
    • Rane S, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M: Loss of expression of cdk4 causes insulin-deficient diabetes and cdk4 activation results in beta cell hyperplasia. Nat Genet 22:44-52, 1999
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 26
    • 9644266753 scopus 로고    scopus 로고
    • β Cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S, Bhushan A: β Cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114:963-968, 2004
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 28
    • 14644422601 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in pancreatic β-cells in vivo results in islet hyperplasia without hypoglycemia
    • Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC: Overexpression of cyclin D1 in pancreatic β-cells in vivo results in islet hyperplasia without hypoglycemia. Diabetes 54:712-719, 2005
    • (2005) Diabetes , vol.54 , pp. 712-719
    • Zhang, X.1    Gaspard, J.P.2    Mizukami, Y.3    Li, J.4    Graeme-Cook, F.5    Chung, D.C.6
  • 29
    • 0028937476 scopus 로고
    • Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin
    • Harvey M, Vogel H, Lee EY-P, Bradley A, Donehower LA: Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res 55:1146-1151, 1995
    • (1995) Cancer Res , vol.55 , pp. 1146-1151
    • Harvey, M.1    Vogel, H.2    Lee, E.Y.-P.3    Bradley, A.4    Donehower, L.A.5
  • 32
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van der Gulden H, Jonkers J, Berns A: Induction of medulloblastomas in p53-mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14:994-1004, 2000
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    van der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 34
    • 21344442148 scopus 로고    scopus 로고
    • Targeted inactivation of hepatocyte growth factor receptor c-met in β-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of β-cell mass
    • Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocana A: Targeted inactivation of hepatocyte growth factor receptor c-met in β-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of β-cell mass. Diabetes 54:2090-2102, 2005
    • (2005) Diabetes , vol.54 , pp. 2090-2102
    • Roccisana, J.1    Reddy, V.2    Vasavada, R.C.3    Gonzalez-Pertusa, J.A.4    Magnuson, M.A.5    Garcia-Ocana, A.6
  • 35
    • 0034686028 scopus 로고    scopus 로고
    • Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia
    • Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann PS, Ogren L, Talamantes F, Stewart AF: Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem 275:15399-15406, 2000
    • (2000) J Biol Chem , vol.275 , pp. 15399-15406
    • Vasavada, R.C.1    Garcia-Ocaña, A.2    Zawalich, W.S.3    Sorenson, R.L.4    Dann, P.S.5    Ogren, L.6    Talamantes, F.7    Stewart, A.F.8
  • 36
    • 9444254643 scopus 로고    scopus 로고
    • Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: A novel role for placental lactogen in pancreatic β-cell survival
    • Fujinaka Y, Sipula D, Garcia-Ocana A, Vasavada RC: Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic β-cell survival. Diabetes 53:3120-3130, 2004
    • (2004) Diabetes , vol.53 , pp. 3120-3130
    • Fujinaka, Y.1    Sipula, D.2    Garcia-Ocana, A.3    Vasavada, R.C.4
  • 37
    • 0035650568 scopus 로고    scopus 로고
    • Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes
    • Garcia-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, Lopez-Talavera J-C, Stewart AF: Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes. Diabetes 50:2752-2762, 2001
    • (2001) Diabetes , vol.50 , pp. 2752-2762
    • Garcia-Ocaña, A.1    Vasavada, R.C.2    Cebrian, A.3    Reddy, V.4    Takane, K.K.5    Lopez-Talavera, J.-C.6    Stewart, A.F.7
  • 39
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • Cobrinik D: Pocket proteins and cell cycle control. Oncogene 24:2796-2809, 2005
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 40
    • 0030922363 scopus 로고    scopus 로고
    • The retinoblastoma gene family is differentially expressed during embryogenesis
    • Jiang Z, Zacksenhaus E, Gallie BL, Phillips RA: The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene 14:1789-1797, 1997
    • (1997) Oncogene , vol.14 , pp. 1789-1797
    • Jiang, Z.1    Zacksenhaus, E.2    Gallie, B.L.3    Phillips, R.A.4
  • 41
    • 0031782695 scopus 로고    scopus 로고
    • Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the pRb-related p107 gene
    • LeCouter JE, Kablar B, Hardy WR, Ying C, Megeney LA, May LL, Rudnicki MA: Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the pRb-related p107 gene. Mol Cell Biol 18:7455-7465, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 7455-7465
    • LeCouter, J.E.1    Kablar, B.2    Hardy, W.R.3    Ying, C.4    Megeney, L.A.5    May, L.L.6    Rudnicki, M.A.7
  • 42
    • 0032433267 scopus 로고    scopus 로고
    • Strain dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
    • LeCouter JE, Kablar B, Whyte PF, Ying C, Rudnicki MA: Strain dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development 125:4669-4665, 1998
    • (1998) Development , vol.125 , pp. 4669-4665
    • LeCouter, J.E.1    Kablar, B.2    Whyte, P.F.3    Ying, C.4    Rudnicki, M.A.5
  • 43
    • 0035875068 scopus 로고    scopus 로고
    • Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother
    • Paggi MG, Giordano A: Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother. Cancer Res 61:4651-4654, 2001
    • (2001) Cancer Res , vol.61 , pp. 4651-4654
    • Paggi, M.G.1    Giordano, A.2
  • 44
    • 0037157786 scopus 로고    scopus 로고
    • Cancer genetics
    • Knudson AG: Cancer genetics. Am J Med Genet 111:96-102, 2002
    • (2002) Am J Med Genet , vol.111 , pp. 96-102
    • Knudson, A.G.1
  • 45
    • 0037872709 scopus 로고    scopus 로고
    • Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    • Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR: Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52:1528-1534, 2003
    • (2003) Diabetes , vol.52 , pp. 1528-1534
    • Kulkarni, R.N.1    Almind, K.2    Goren, H.J.3    Winnay, J.N.4    Ueki, K.5    Okada, T.6    Kahn, C.R.7
  • 46
    • 0037677695 scopus 로고    scopus 로고
    • Increased islet volume but unchanged islet number in ob/ob mice
    • Bock T, Pakkenberg B, Buschard K: Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52:1716-1722, 2003
    • (2003) Diabetes , vol.52 , pp. 1716-1722
    • Bock, T.1    Pakkenberg, B.2    Buschard, K.3
  • 49
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T: Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223-227, 2003
    • (2003) Nature , vol.424 , pp. 223-227
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.